Deepak Shukla Department of Ophthalmology and Visual Sciences University of Illinois at Chicago Biography Publications Institution JoVE Articles Deepak Shukla has not added a biography. If you are Deepak Shukla and would like to personalize this page please email our Author Liaison for assistance. Publications COVID-19 and Oral Diseases: Assessing Manifestations of a New Pathogen in Oral Infections International Reviews of Immunology. Sep, 2021 | Pubmed ID: 34525891 OPTN is a Host Intrinsic Restriction Factor Against Neuroinvasive HSV-1 Infection Nature Communications. Sep, 2021 | Pubmed ID: 34518549 Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360629 Prophylactic Treatment with BX795 Blocks Activation of AKT and Its Downstream Targets to Protect Vaginal Keratinocytes and Vaginal Epithelium from HSV-2 Infection Antiviral Research. Oct, 2021 | Pubmed ID: 34303747 Histatin-1 is an Endogenous Ligand of the Sigma-2 Receptor The FEBS Journal. Jul, 2021 | Pubmed ID: 34233061 Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry Pathogens (Basel, Switzerland). Jun, 2021 | Pubmed ID: 34202835 Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer Frontiers in Immunology. Month, 2021 | Pubmed ID: 34194434 Emerging Roles of Heparan Sulfate Proteoglycans in Viral Pathogenesis Seminars in Thrombosis and Hemostasis. Apr, 2021 | Pubmed ID: 33851373 Entry Receptor Bias in Evolutionarily Distant HSV-1 Clinical Strains Drives Divergent Ocular and Nervous System Pathologies The Ocular Surface. Jul, 2021 | Pubmed ID: 33766740 Dissociation of DNA Damage Sensing by Endoglycosidase HPSE IScience. Mar, 2021 | Pubmed ID: 33748723 Disruption of Innate Defense Responses by Endoglycosidase HPSE Promotes Cell Survival JCI Insight. 04, 2021 | Pubmed ID: 33621216 Pathobiology and Treatment of Viral Keratitis Experimental Eye Research. 04, 2021 | Pubmed ID: 33556334 Dysregulation of Cell Signaling by SARS-CoV-2 Trends in Microbiology. 03, 2021 | Pubmed ID: 33451855 The 3--sulfation of Heparan Sulfate Modulates Protein Binding and Lyase Degradation Proceedings of the National Academy of Sciences of the United States of America. 01, 2021 | Pubmed ID: 33441484 Infection-Induced Porcine Ex Vivo Corneal Wound Model to Study the Efficacy of Herpes Simplex Virus-1 Entry and Replication Inhibitors Methods in Molecular Biology (Clifton, N.J.). Month, 2021 | Pubmed ID: 32808270 Herpes Simplex Virus Cell Entry Mechanisms: An Update Frontiers in Cellular and Infection Microbiology. Month, 2020 | Pubmed ID: 33537244 Standalone or Combinatorial Phenylbutyrate Therapy Shows Excellent Antiviral Activity and Mimics CREB3 Silencing Science Advances. Dec, 2020 | Pubmed ID: 33277262 Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity Against HSV-1 and HSV-2 and Synergy with Antiviral Drugs ACS Infectious Diseases. 11, 2020 | Pubmed ID: 33078609 and Activity, Tolerability, and Mechanism of Action of BX795 As an Antiviral Against Herpes Simplex Virus 2 Genital Infection Antimicrobial Agents and Chemotherapy. 08, 2020 | Pubmed ID: 32601167 Vaccines and Therapies in Development for SARS-CoV-2 Infections Journal of Clinical Medicine. Jun, 2020 | Pubmed ID: 32560227 Heparanase, Cell Signaling, and Viral Infections Cellular and Molecular Life Sciences : CMLS. Dec, 2020 | Pubmed ID: 32462405 BX795 Demonstrates Potent Antiviral Benefits Against Herpes Simplex Virus-1 Infection of Human Cell Lines Antiviral Research. 08, 2020 | Pubmed ID: 32380150 Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration Molecular Therapy. Methods & Clinical Development. Jun, 2020 | Pubmed ID: 32346548 Bacterial Pigment Prodigiosin Demonstrates a Unique Antiherpesvirus Activity That Is Mediated Through Inhibition of Prosurvival Signal Transducers Journal of Virology. 06, 2020 | Pubmed ID: 32295926 Heparanase, Heparan Sulfate and Viral Infection Advances in Experimental Medicine and Biology. Month, 2020 | Pubmed ID: 32274736 Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress Journal of Virology. 02, 2020 | Pubmed ID: 31827001 Prior Inhibition of AKT Phosphorylation by BX795 Can Define a Safer Strategy to Prevent Herpes Simplex Virus-1 Infection of the Eye The Ocular Surface. 04, 2020 | Pubmed ID: 31770600 Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections Microorganisms. Oct, 2019 | Pubmed ID: 31658632 Drug-encapsulated Carbon (DECON): A Novel Platform for Enhanced Drug Delivery Science Advances. 08, 2019 | Pubmed ID: 31453334 CRISPR-Cas Based Targeting of Host and Viral Genes As an Antiviral Strategy Seminars in Cell & Developmental Biology. 12, 2019 | Pubmed ID: 30953741 Pathological Processes Activated by Herpes Simplex Virus-1 (HSV-1) Infection in the Cornea Cellular and Molecular Life Sciences : CMLS. Feb, 2019 | Pubmed ID: 30327839 Pathogenesis of Herpes Simplex Keratitis: The Host Cell Response and Ocular Surface Sequelae to Infection and Inflammation The Ocular Surface. 01, 2019 | Pubmed ID: 30317007 Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease? Frontiers in Immunology. Month, 2018 | Pubmed ID: 30319604 Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells Journal of Virology. 12, 2018 | Pubmed ID: 30232188 Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures Journal of Virology. 10, 2018 | Pubmed ID: 30045986 Prediction of Cellular Gene Targets of Herpesvirus Encoded MicroRNAs Data in Brief. Aug, 2018 | Pubmed ID: 29892642 Viral MiRNAs Alter Host Cell MiRNA Profiles and Modulate Innate Immune Responses Frontiers in Immunology. Month, 2018 | Pubmed ID: 29559974 Herpesvirus-encoded MicroRNAs Detected in Human Gingiva Alter Host Cell Transcriptome and Regulate Viral Infection Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. May, 2018 | Pubmed ID: 29550353 Targeting Herpes Simplex Virus-1 GD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection Molecular Therapy. Nucleic Acids. Dec, 2017 | Pubmed ID: 29246315 Emerging Roles of Heparanase in Viral Pathogenesis Pathogens (Basel, Switzerland). Sep, 2017 | Pubmed ID: 28927006 Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1 Cell Reports. 07, 2017 | Pubmed ID: 28700944 Effects of Histatin-1 Peptide on Human Corneal Epithelial Cells PloS One. Month, 2017 | Pubmed ID: 28542418 Zinc Oxide Tetrapods Inhibit Herpes Simplex Virus Infection of Cultured Corneas Molecular Vision. Month, 2017 | Pubmed ID: 28275313 Cultured Corneas Show Dendritic Spread and Restrict Herpes Simplex Virus Infection That is Not Observed with Cultured Corneal Cells Scientific Reports. 02, 2017 | Pubmed ID: 28198435 Role of Metal and Metal Oxide Nanoparticles As Diagnostic and Therapeutic Tools for Highly Prevalent Viral Infections Nanomedicine : Nanotechnology, Biology, and Medicine. 01, 2017 | Pubmed ID: 27575283 Genital Herpes: Insights into Sexually Transmitted Infectious Disease Microbial Cell (Graz, Austria). Jun, 2016 | Pubmed ID: 28357380 Could Zinc Oxide Tetrapod Nanoparticles Be Used As an Effective Immunotherapy Against HSV-2? Nanomedicine (London, England). 09, 2016 | Pubmed ID: 27527812 Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms Frontiers in Microbiology. Month, 2016 | Pubmed ID: 27014223 Extended Release of an Anti-Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection Investigative Ophthalmology & Visual Science. Jan, 2016 | Pubmed ID: 26780322 Cell Entry Mechanisms of HSV: What We Have Learned in Recent Years Future Virology. Oct, 2015 | Pubmed ID: 27066105 Heparanase is a Host Enzyme Required for Herpes Simplex Virus-1 Release from Cells Nature Communications. Apr, 2015 | Pubmed ID: 25912399 A Role for 3-O-sulfated Heparan Sulfate in Promoting Human Cytomegalovirus Infection in Human Iris Cells Journal of Virology. May, 2015 | Pubmed ID: 25717110 Diversity of Heparan Sulfate and HSV Entry: Basic Understanding and Treatment Strategies Molecules (Basel, Switzerland). Month, 2015 | Pubmed ID: 25665065 Corneal Lymphangiogenesis in Herpetic Stromal Keratitis Survey of Ophthalmology. Jan-Feb, 2015 | Pubmed ID: 25444520 Characterization of a Proteolytically Stable D-peptide That Suppresses Herpes Simplex Virus 1 Infection: Implications for the Development of Entry-based Antiviral Therapy Journal of Virology. Feb, 2015 | Pubmed ID: 25428865 Comprehensive Analysis of Herpes Simplex Virus 1 (HSV-1) Entry Mediated by Zebrafish 3-O-Sulfotransferase Isoforms: Implications for the Development of a Zebrafish Model of HSV-1 Infection Journal of Virology. Nov, 2014 | Pubmed ID: 25142596 Zebrafish 3-O-sulfotransferase-4 Generated Heparan Sulfate Mediates HSV-1 Entry and Spread PloS One. Month, 2014 | Pubmed ID: 24498308 Zebrafish: Modeling for Herpes Simplex Virus Infections Zebrafish. Feb, 2014 | Pubmed ID: 24266790 Inhibition of Myosin Light Chain Kinase Can Be Targeted for the Development of New Therapies Against Herpes Simplex Virus Type-1 Infection Antiviral Therapy. Month, 2014 | Pubmed ID: 23813409 An Investigative Peptide-acyclovir Combination to Control Herpes Simplex Virus Type 1 Ocular Infection Investigative Ophthalmology & Visual Science. Sep, 2013 | Pubmed ID: 23989188 Exploiting Herpes Simplex Virus Entry for Novel Therapeutics Viruses. Jun, 2013 | Pubmed ID: 23752649 Role of Filopodia in HSV-1 Entry into Zebrafish 3-O-Sulfotransferase-3-Expressing Cells The Open Virology Journal. Month, 2013 | Pubmed ID: 23667409 Recent Advances in Vaccine Development for Herpes Simplex Virus Types I and II Human Vaccines & Immunotherapeutics. Apr, 2013 | Pubmed ID: 23442925 Glycoprotein Targeted Therapeutics: a New Era of Anti-herpes Simplex Virus-1 Therapeutics Reviews in Medical Virology. May, 2013 | Pubmed ID: 23440920 Role of Heparan Sulfate in Ocular Diseases Experimental Eye Research. May, 2013 | Pubmed ID: 23410824 Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool from Zebrafish to Humans for Understanding Herpes Simplex Virus Entry The Open Virology Journal. Month, 2013 | Pubmed ID: 23358893 Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry Journal of Virology. Apr, 2013 | Pubmed ID: 23345512 Increased Axonal Expression of Nectin-1 in Multiple Sclerosis Plaques Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Apr, 2013 | Pubmed ID: 22460696 Tin Oxide Nanowires Suppress Herpes Simplex Virus-1 Entry and Cell-to-cell Membrane Fusion PloS One. Month, 2012 | Pubmed ID: 23110193 Prophylactic, Therapeutic and Neutralizing Effects of Zinc Oxide Tetrapod Structures Against Herpes Simplex Virus Type-2 Infection Antiviral Research. Dec, 2012 | Pubmed ID: 23047013 Role of Heparan Sulfate in Sexually Transmitted Infections Glycobiology. Nov, 2012 | Pubmed ID: 22773448 Herpes Simplex Epithelial and Stromal Keratitis: an Epidemiologic Update Survey of Ophthalmology. Sep, 2012 | Pubmed ID: 22542912 A 3-O-sulfated Heparan Sulfate Binding Peptide Preferentially Targets Herpes Simplex Virus 2-infected Cells Journal of Virology. Jun, 2012 | Pubmed ID: 22491462 Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells Clinical & Developmental Immunology. Month, 2012 | Pubmed ID: 22481969 Stem Cell Marker CD271 is Expressed by Vasculogenic Mimicry-forming Uveal Melanoma Cells in Three-dimensional Cultures Molecular Vision. Month, 2012 | Pubmed ID: 22419851 Early Events in Herpes Simplex Virus Lifecycle with Implications for an Infection of Lifetime The Open Virology Journal. Month, 2012 | Pubmed ID: 22291864 Herpes Simplex Virus Infects Most Cell Types in Vitro: Clues to Its Success Virology Journal. Oct, 2011 | Pubmed ID: 22029482 An Important Role for Syndecan-1 in Herpes Simplex Virus Type-1 Induced Cell-to-cell Fusion and Virus Spread PloS One. Month, 2011 | Pubmed ID: 21957484 Virostatic Potential of Micro-nano Filopodia-like ZnO Structures Against Herpes Simplex Virus-1 Antiviral Research. Nov, 2011 | Pubmed ID: 21893101 Corneal Latency and Transmission of Herpes Simplex Virus-1 Future Virology. Jan, 2011 | Pubmed ID: 21436960 Chronic Progressive Deficits in Neuron Size, Density and Number in the Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus Brain Pathology (Zurich, Switzerland). Sep, 2011 | Pubmed ID: 21371157 Syndecan-1 and Syndecan-2 Play Key Roles in Herpes Simplex Virus Type-1 Infection The Journal of General Virology. Apr, 2011 | Pubmed ID: 21148276 HSV-1 Infection of Human Corneal Epithelial Cells: Receptor-mediated Entry and Trends of Re-infection Molecular Vision. Month, 2010 | Pubmed ID: 21139972 Phosphoinositide 3 Kinase Signalling May Affect Multiple Steps During Herpes Simplex Virus Type-1 Entry The Journal of General Virology. Dec, 2010 | Pubmed ID: 20810749 Mediators and Mechanisms of Herpes Simplex Virus Entry into Ocular Cells Current Eye Research. Jun, 2010 | Pubmed ID: 20465436 In Vitro Antiviral Activity of Neem (Azardirachta Indica L.) Bark Extract Against Herpes Simplex Virus Type-1 Infection Phytotherapy Research : PTR. Aug, 2010 | Pubmed ID: 20041417 Expanding the Role of 3-O Sulfated Heparan Sulfate in Herpes Simplex Virus Type-1 Entry Virology. Feb, 2010 | Pubmed ID: 20004926 A Role for Heparan Sulfate in Viral Surfing Biochemical and Biophysical Research Communications. Jan, 2010 | Pubmed ID: 19909728 Expression of Herpes Virus Entry Mediator (HVEM) in the Cornea and Trigeminal Ganglia of Normal and HSV-1 Infected Mice Current Eye Research. Oct, 2009 | Pubmed ID: 19895317 Viral Entry Mechanisms: Simplicity Drives Complexity The FEBS Journal. Dec, 2009 | Pubmed ID: 19878309 Viral Entry Mechanisms: Cellular and Viral Mediators of Herpes Simplex Virus Entry The FEBS Journal. Dec, 2009 | Pubmed ID: 19878306 An Unusual Dependence of Human Herpesvirus-8 Glycoproteins-induced Cell-to-cell Fusion on Heparan Sulfate Biochemical and Biophysical Research Communications. Dec, 2009 | Pubmed ID: 19747451 A Sugar Binding Protein Cyanovirin-N Blocks Herpes Simplex Virus Type-1 Entry and Cell Fusion Antiviral Research. Oct, 2009 | Pubmed ID: 19665490 Role of Nectin-1, HVEM, and PILR-alpha in HSV-2 Entry into Human Retinal Pigment Epithelial Cells Investigative Ophthalmology & Visual Science. Jun, 2009 | Pubmed ID: 19234349 The Importance of Heparan Sulfate in Herpesvirus Infection Virologica Sinica. Dec, 2008 | Pubmed ID: 19956628 Antiviral Activity of Phytochemicals: a Comprehensive Review Mini Reviews in Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18855727 Herpes Simplex Virus Type 1 Induces Filopodia in Differentiated P19 Neural Cells to Facilitate Viral Spread Neuroscience Letters. Aug, 2008 | Pubmed ID: 18554796 HVEM and Nectin-1 Are the Major Mediators of Herpes Simplex Virus 1 (HSV-1) Entry into Human Conjunctival Epithelium Investigative Ophthalmology & Visual Science. Sep, 2008 | Pubmed ID: 18502984 Using a 3-O-sulfated Heparin Octasaccharide to Inhibit the Entry of Herpes Simplex Virus Type 1 Biochemistry. May, 2008 | Pubmed ID: 18457417 Herpes Simplex Virus Type 1 Infection Induces Oxidative Stress and the Release of Bioactive Lipid Peroxidation By-products in Mouse P19N Neural Cell Cultures Journal of Neurovirology. Oct, 2007 | Pubmed ID: 17994426 Role of 3-O-sulfated Heparan Sulfate in Virus-induced Polykaryocyte Formation FEBS Letters. Sep, 2007 | Pubmed ID: 17765228 Herpes Simplex Virus Type 2 Entry into Cultured Human Corneal Fibroblasts is Mediated by Herpesvirus Entry Mediator The Journal of General Virology. Aug, 2007 | Pubmed ID: 17622611 Viral Inhibition Studies on Sulfated Lignin, a Chemically Modified Biopolymer and a Potential Mimic of Heparan Sulfate Biomacromolecules. May, 2007 | Pubmed ID: 17439173 Soluble 3-O-sulfated Heparan Sulfate Can Trigger Herpes Simplex Virus Type 1 Entry into Resistant Chinese Hamster Ovary (CHO-K1) Cells The Journal of General Virology. Apr, 2007 | Pubmed ID: 17374750 A Novel Role for Phagocytosis-like Uptake in Herpes Simplex Virus Entry The Journal of Cell Biology. Sep, 2006 | Pubmed ID: 17000878 Role for 3-O-sulfated Heparan Sulfate As the Receptor for Herpes Simplex Virus Type 1 Entry into Primary Human Corneal Fibroblasts Journal of Virology. Sep, 2006 | Pubmed ID: 16940509 Expression of Nectin-1 in Normal and Herpes Simplex Virus Type 1-infected Murine Brain Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication of the Society for Applied Immunohistochemistry. Sep, 2006 | Pubmed ID: 16932027 A Role for Heparan Sulfate 3-O-sulfotransferase Isoform 2 in Herpes Simplex Virus Type 1 Entry and Spread Virology. Mar, 2006 | Pubmed ID: 16336986 A Role for 3-O-sulfotransferase Isoform-4 in Assisting HSV-1 Entry and Spread Biochemical and Biophysical Research Communications. Dec, 2005 | Pubmed ID: 16259945 A Role for Herpesvirus Entry Mediator As the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells Journal of Virology. Oct, 2005 | Pubmed ID: 16189018 Spinoculation of Heparan Sulfate Deficient Cells Enhances HSV-1 Entry, but Does Not Abolish the Need for Essential Glycoproteins in Viral Fusion Journal of Virological Methods. Sep, 2005 | Pubmed ID: 15908019 Characterization of Heparan Sulphate 3-O-sulphotransferase Isoform 6 and Its Role in Assisting the Entry of Herpes Simplex Virus Type 1 The Biochemical Journal. Jan, 2005 | Pubmed ID: 15303968 Herpes Simplex Virus Entry Receptor Nectin-1 is Widely Expressed in the Murine Eye Current Eye Research. Oct-Nov, 2004 | Pubmed ID: 15590476 A Role for 3-O-sulfated Heparan Sulfate in Cell Fusion Induced by Herpes Simplex Virus Type 1 The Journal of General Virology. Apr, 2004 | Pubmed ID: 15039523 Cellular Expression of GH Confers Resistance to Herpes Simplex Virus Type-1 Entry Virology. Jul, 2003 | Pubmed ID: 12890617 Explante de tejido corneal porcino para estudiar la eficacia de los antivirales del virus del herpes simple-1 Tejabhiram Yadavalli1, Ipsita Volety1, Deepak Shukla1,2 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 2Department of Microbiology and Immunology, University of Illinois at Chicago JoVE 62195 Immunologia e infezioni
Explante de tejido corneal porcino para estudiar la eficacia de los antivirales del virus del herpes simple-1 Tejabhiram Yadavalli1, Ipsita Volety1, Deepak Shukla1,2 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 2Department of Microbiology and Immunology, University of Illinois at Chicago JoVE 62195 Immunologia e infezioni