Devesh Kumar Department of Pharmacology and Toxicology University of Saarland School of Medicine Biography Publications Institution JoVE Articles Devesh Kumar has not added a biography. If you are Devesh Kumar and would like to personalize this page please email our Author Liaison for assistance. Publications Long-Range Electron Transfer Triggers Mechanistic Differences Between Iron(IV)-Oxo and Iron(IV)-Imido Oxidants Journal of the American Chemical Society. Dec, 2014 | Pubmed ID: 25392052 Specialized Subpopulations of Kisspeptin Neurons Communicate with GnRH Neurons in Female Mice Endocrinology. Oct, 2014 | Pubmed ID: 25337655 Properties and Reactivities of Nonheme Iron(IV)-oxo Versus Iron(V)-oxo: Long-range Electron Transfer Versus Hydrogen Atom Abstraction Physical Chemistry Chemical Physics : PCCP. Nov, 2014 | Pubmed ID: 25231726 Thioether-ligated Iron(II) and Iron(III)-hydroperoxo/alkylperoxo Complexes with an H-bond Donor in the Second Coordination Sphere Dalton Transactions (Cambridge, England : 2003). May, 2014 | Pubmed ID: 24705907 Murine Arcuate Nucleus Kisspeptin Neurons Communicate with GnRH Neurons in Utero The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2014 | Pubmed ID: 24599473 Quantum Mechanics/molecular Mechanics Study on the Oxygen Binding and Substrate Hydroxylation Step in AlkB Repair Enzymes Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2014 | Pubmed ID: 24339041 Comparison of the Reactivity of Nonheme Iron(IV)-oxo Versus Iron(IV)-imido Complexes: Which is the Better Oxidant? Angewandte Chemie (International Ed. in English). Nov, 2013 | Pubmed ID: 24222577 Mechanistic Insight into Halide Oxidation by Non-heme Iron Complexes. Haloperoxidase Versus Halogenase Activity Chemical Communications (Cambridge, England). Dec, 2013 | Pubmed ID: 24136302 Synthesis and Ligand Non-innocence of Thiolate-ligated (N4S) Iron(II) and Nickel(II) Bis(imino)pyridine Complexes Inorganic Chemistry. Sep, 2013 | Pubmed ID: 23992096 Genetic Dissection of Puberty in Mice Experimental Physiology. Nov, 2013 | Pubmed ID: 23955307 Three-dimensional Echocardiographic Delineation of an Acquired Aorto-left Atrial Fistula Complicating Native Aortic Valve Endocarditis - "advantage of Three Dimensions" Echocardiography (Mount Kisco, N.Y.). Nov, 2013 | Pubmed ID: 23931072 Inversion of Enantioselectivity of a Mononuclear Non-heme Iron(II)-dependent Hydroxylase by Tuning the Interplay of Metal-center Geometry and Protein Structure Angewandte Chemie (International Ed. in English). Sep, 2013 | Pubmed ID: 23881738 Rationalization of the Barrier Height for P-Z-styrene Epoxidation by Iron(IV)-oxo Porphyrin Cation Radicals with Variable Axial Ligands Inorganic Chemistry. Jul, 2013 | Pubmed ID: 23822112 The Serum C Peptide Levels Among the Offsprings of the People with Type 2 Diabetes Journal of Clinical and Diagnostic Research : JCDR. May, 2013 | Pubmed ID: 23814721 Generation of a High-valent Iron Imido Corrolazine Complex and NR Group Transfer Reactivity Inorganic Chemistry. Apr, 2013 | Pubmed ID: 23527920 Axial and Equatorial Ligand Effects on Biomimetic Cysteine Dioxygenase Model Complexes Organic & Biomolecular Chemistry. Jul, 2012 | Pubmed ID: 22714822 Axial Ligand Effect on the Rate Constant of Aromatic Hydroxylation by Iron(IV)-oxo Complexes Mimicking Cytochrome P450 Enzymes The Journal of Physical Chemistry. B. Jan, 2012 | Pubmed ID: 22132821 Mechanism of S-oxygenation by a Cysteine Dioxygenase Model Complex The Journal of Physical Chemistry. A. Jan, 2012 | Pubmed ID: 22091701 Nonheme Ferric Hydroperoxo Intermediates Are Efficient Oxidants of Bromide Oxidation Chemical Communications (Cambridge, England). Oct, 2011 | Pubmed ID: 21904759 Oxidative Properties of a Nonheme Ni(II)(O2) Complex: Reactivity Patterns for C-H Activation, Aromatic Hydroxylation and Heteroatom Oxidation Chemical Communications (Cambridge, England). Oct, 2011 | Pubmed ID: 21892444 Study of Occupational Stress Among Railway Engine Pilots Indian Journal of Occupational and Environmental Medicine. Jan, 2011 | Pubmed ID: 21808497 Effect of the Axial Ligand on Substrate Sulfoxidation Mediated by Iron(IV)-oxo Porphyrin Cation Radical Oxidants Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2011 | Pubmed ID: 21469227 Comparison of Computational Methods to Model DNA Minor Groove Binders Journal of Chemical Information and Modeling. Mar, 2011 | Pubmed ID: 21375336 Theoretical Study on the Mechanism of the Oxygen Activation Process in Cysteine Dioxygenase Enzymes Journal of the American Chemical Society. Mar, 2011 | Pubmed ID: 21344861 Water As Biocatalyst in Cytochrome P450 Faraday Discussions. 2011 | Pubmed ID: 21322494 Steric Factors Override Thermodynamic Driving Force in Regioselectivity of Proline Hydroxylation by Prolyl-4-hydroxylase Enzymes The Journal of Physical Chemistry. A. Dec, 2010 | Pubmed ID: 21114303 What Factors Influence the Rate Constant of Substrate Epoxidation by Compound I of Cytochrome P450 and Analogous Iron(IV)-oxo Oxidants? Journal of the American Chemical Society. Jun, 2010 | Pubmed ID: 20481499 Coupling and Uncoupling Mechanisms in the Methoxythreonine Mutant of Cytochrome P450cam: a Quantum Mechanical/molecular Mechanical Study Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Mar, 2010 | Pubmed ID: 20225401 P450 Enzymes: Their Structure, Reactivity, and Selectivity-modeled by QM/MM Calculations Chemical Reviews. Feb, 2010 | Pubmed ID: 19813749 Electronic Properties of Pentacoordinated Heme Complexes in Cytochrome P450 Enzymes: Search for an Fe(I) Oxidation State Physical Chemistry Chemical Physics : PCCP. Nov, 2009 | Pubmed ID: 19865780 Effect of Porphyrin Ligands on the Regioselective Dehydrogenation Versus Epoxidation of Olefins by Oxoiron(IV) Mimics of Cytochrome P450 The Journal of Physical Chemistry. A. Oct, 2009 | Pubmed ID: 19658379 QM/MM Study of the Second Proton Transfer in the Catalytic Cycle of the D251N Mutant of Cytochrome P450cam The Journal of Physical Chemistry. B. Jul, 2009 | Pubmed ID: 19537775 How is the Reactivity of Cytochrome P450cam Affected by Thr252X Mutation? A QM/MM Study for X = Serine, Valine, Alanine, Glycine Journal of the American Chemical Society. Apr, 2009 | Pubmed ID: 19281168 A Tribute to Sason Shaik The Journal of Physical Chemistry. A. Dec, 2008 | Pubmed ID: 19072248 A Valence Bond Modeling of Trends in Hydrogen Abstraction Barriers and Transition States of Hydroxylation Reactions Catalyzed by Cytochrome P450 Enzymes Journal of the American Chemical Society. Aug, 2008 | Pubmed ID: 18616242 Multireference Ab Initio Quantum Mechanics/molecular Mechanics Study on Intermediates in the Catalytic Cycle of Cytochrome P450(cam) The Journal of Physical Chemistry. A. Dec, 2008 | Pubmed ID: 18543897 Theoretical Study of N-demethylation of Substituted N,N-dimethylanilines by Cytochrome P450: the Mechanistic Significance of Kinetic Isotope Effect Profiles The Journal of Physical Chemistry. B. Jul, 2007 | Pubmed ID: 17559261 Reactivity Patterns of Cytochrome P450 Enzymes: Multifunctionality of the Active Species, and the Two States-two Oxidants Conundrum Natural Product Reports. Jun, 2007 | Pubmed ID: 17534529 Reactivity of High-valent Iron-oxo Species in Enzymes and Synthetic Reagents: a Tale of Many States Accounts of Chemical Research. Jul, 2007 | Pubmed ID: 17488054 Singlet Diradical Character of an Oxidized Ruthenium Trithiolate: Electronic Structure and Reactivity Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17450515 Formation of the Active Species of Cytochrome P450 by Using Iodosylbenzene: a Case for Spin-selective Reactivity Chemistry (Weinheim an Der Bergstrasse, Germany). 2007 | Pubmed ID: 17367100 Proton-shuffle Mechanism of O-O Activation for Formation of a High-valent Oxo-iron Species of Bleomycin Journal of the American Chemical Society. Dec, 2006 | Pubmed ID: 17165768 Characterization of Manganese(V)-oxo Polyoxometalate Intermediates and Their Properties in Oxygen-transfer Reactions Journal of the American Chemical Society. Dec, 2006 | Pubmed ID: 17132012 On the Identity and Reactivity Patterns of the "second Oxidant" of the T252A Mutant of Cytochrome P450cam in the Oxidation of 5-methylenenylcamphor Journal of Inorganic Biochemistry. Dec, 2006 | Pubmed ID: 17084458 Catalysts for Monooxygenations Made from Polyoxometalate: an Iron(V)-oxo Derivative of the Lindqvist Anion Inorganic Chemistry. Oct, 2006 | Pubmed ID: 17029376 Ferromagnetic Bonding: High Spin Copper Clusters (n+1)Cu(n); N = 2-14) Devoid of Electron Pairs but Possessing Strong Bonding The Journal of Physical Chemistry. A. Jul, 2006 | Pubmed ID: 16821835 Two-state Reactivity in Alkane Hydroxylation by Non-heme Iron-oxo Complexes Journal of the American Chemical Society. Jul, 2006 | Pubmed ID: 16802826 In Silico Design of a Mutant of Cytochrome P450 Containing Selenocysteine Journal of the American Chemical Society. Mar, 2006 | Pubmed ID: 16492051 Gauging the Relative Oxidative Powers of Compound I, Ferric-hydroperoxide, and the Ferric-hydrogen Peroxide Species of Cytochrome P450 Toward C-H Hydroxylation of a Radical Clock Substrate Journal of the American Chemical Society. Jan, 2006 | Pubmed ID: 16402834 Kinetic Isotope Effect is a Sensitive Probe of Spin State Reactivity in C-H Hydroxylation of N,N-dimethylaniline by Cytochrome P450 Journal of the American Chemical Society. Jan, 2006 | Pubmed ID: 16402810 New Features in the Catalytic Cycle of Cytochrome P450 During the Formation of Compound I from Compound 0 The Journal of Physical Chemistry. B. Oct, 2005 | Pubmed ID: 16853579 The High-valent Iron-oxo Species of Polyoxometalate, if It Can Be Made, Will Be a Highly Potent Catalyst for C-H Hydroxylation and Double-bond Epoxidation Journal of the American Chemical Society. Dec, 2005 | Pubmed ID: 16351100 Two States and Two More in the Mechanisms of Hydroxylation and Epoxidation by Cytochrome P450 Journal of the American Chemical Society. Sep, 2005 | Pubmed ID: 16159296 Theoretical Perspective on the Structure and Mechanism of Cytochrome P450 Enzymes Chemical Reviews. Jun, 2005 | Pubmed ID: 15941215 Theory Favors a Stepwise Mechanism of Porphyrin Degradation by a Ferric Hydroperoxide Model of the Active Species of Heme Oxygenase Journal of the American Chemical Society. Jun, 2005 | Pubmed ID: 15926850 Theoretical Investigation of C--H Hydroxylation by (N4Py)Fe(IV)=O(2+): an Oxidant More Powerful Than P450? Journal of the American Chemical Society. Jun, 2005 | Pubmed ID: 15926822 Sulfoxidation Mechanisms Catalyzed by Cytochrome P450 and Horseradish Peroxidase Models: Spin Selection Induced by the Ligand Biochemistry. Jun, 2005 | Pubmed ID: 15924434 Multistate Reactivity in Styrene Epoxidation by Compound I of Cytochrome P450: Mechanisms of Products and Side Products Formation Chemistry (Weinheim an Der Bergstrasse, Germany). Apr, 2005 | Pubmed ID: 15744771 The Intrinsic Axial Ligand Effect on Propene Oxidation by Horseradish Peroxidase Versus Cytochrome P450 Enzymes Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Mar, 2005 | Pubmed ID: 15723206 Computer-generated High-valent Iron--oxo and Manganese--oxo Species with Polyoxometalate Ligands: How Do They Compare with the Iron--oxo Active Species of Heme Enzymes? Angewandte Chemie (International Ed. in English). Oct, 2004 | Pubmed ID: 15495193 External Electric Field Will Control the Selectivity of Enzymatic-like Bond Activations Journal of the American Chemical Society. Sep, 2004 | Pubmed ID: 15366922 One Oxidant, Many Pathways: a Theoretical Perspective of Monooxygenation Mechanisms by Cytochrome P450 Enzymes Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Sep, 2004 | Pubmed ID: 15365903 A Predictive Pattern of Computed Barriers for C-h Hydroxylation by Compound I of Cytochrome P450 Journal of the American Chemical Society. Jul, 2004 | Pubmed ID: 15237977 How Do Aldehyde Side Products Occur During Alkene Epoxidation by Cytochrome P450? Theory Reveals a State-specific Multi-state Scenario Where the High-spin Component Leads to All Side Products Journal of Inorganic Biochemistry. Jul, 2004 | Pubmed ID: 15219984 Oxygen Economy of Cytochrome P450: What is the Origin of the Mixed Functionality As a Dehydrogenase-oxidase Enzyme Compared with Its Normal Function? Journal of the American Chemical Society. Apr, 2004 | Pubmed ID: 15099082 Porphyrin Traps Its Terminator! Concerted and Stepwise Porphyrin Degradation Mechanisms Induced by Heme-oxygenase and Cytochrome P450 Angewandte Chemie (International Ed. in English). Feb, 2004 | Pubmed ID: 14983454 Radical Clock Substrates, Their C-H Hydroxylation Mechanism by Cytochrome P450, and Other Reactivity Patterns: What Does Theory Reveal About the Clocks' Behavior? Journal of the American Chemical Society. Feb, 2004 | Pubmed ID: 14871124 Active Species of Horseradish Peroxidase (HRP) and Cytochrome P450: Two Electronic Chameleons Journal of the American Chemical Society. Dec, 2003 | Pubmed ID: 14677968 How Does Product Isotope Effect Prove the Operation of a Two-state "rebound" Mechanism in C-H Hydroxylation by Cytochrome P450? Journal of the American Chemical Society. Oct, 2003 | Pubmed ID: 14570465 Betinget Genetisk transsynaptisk sporing i den embryoniske musehjerne Devesh Kumar1, Ulrich Boehm1 1Department of Pharmacology and Toxicology, University of Saarland School of Medicine Neuroscienze
Betinget Genetisk transsynaptisk sporing i den embryoniske musehjerne Devesh Kumar1, Ulrich Boehm1 1Department of Pharmacology and Toxicology, University of Saarland School of Medicine Neuroscienze