Edward W. Tate Chemical Biology Section, Department of Chemistry Imperial College London Biography Publications Institution JoVE Articles Edward W. Tate has not added a biography. If you are Edward W. Tate and would like to personalize this page please email our Author Liaison for assistance. Publications Conformational Transition of FGFR Kinase Activation Revealed by Site-specific Unnatural Amino Acid Reporter and Single Molecule FRET Scientific Reports. Jan, 2017 | Pubmed ID: 28045057 Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design Current Topics in Medicinal Chemistry. 2017 | Pubmed ID: 27530972 Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells ACS Chemical Biology. Dec, 2016 | Pubmed ID: 27779865 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells ACS Chemical Biology. Dec, 2016 | Pubmed ID: 27779380 Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma Brucei ACS Infectious Diseases. Jun, 2016 | Pubmed ID: 27331140 N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells ACS Chemical Biology. Aug, 2016 | Pubmed ID: 27267252 Synthesis and Characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine Inhibitors of Hedgehog Acyltransferase Data in Brief. Jun, 2016 | Pubmed ID: 27077078 Design and Development of Histone Deacetylase (HDAC) Chemical Probes for Cell-based Profiling Molecular BioSystems. May, 2016 | Pubmed ID: 27021930 The Rab-binding Profiles of Bacterial Virulence Factors During Infection The Journal of Biological Chemistry. Mar, 2016 | Pubmed ID: 26755725 Global Profiling of Huntingtin-associated Protein E (HYPE)-Mediated AMPylation Through a Chemical Proteomic Approach Molecular & Cellular Proteomics : MCP. Feb, 2016 | Pubmed ID: 26604261 Time-resolved FRET Reports FGFR1 Dimerization and Formation of a Complex with Its Effector PLCγ1 Advances in Biological Regulation. Jan, 2016 | Pubmed ID: 26482290 Discovery of Pyridyl-based Inhibitors of Plasmodium Falciparum N-myristoyltransferase MedChemComm. Oct, 2015 | Pubmed ID: 26962430 Discovery of High Affinity Inhibitors of Leishmania Donovani N-myristoyltransferase MedChemComm. Oct, 2015 | Pubmed ID: 26962429 Quantitative Lipoproteomics in Clostridium Difficile Reveals a Role for Lipoproteins in Sporulation Chemistry & Biology. Nov, 2015 | Pubmed ID: 26584780 Click Chemistry Armed Enzyme-linked Immunosorbent Assay to Measure Palmitoylation by Hedgehog Acyltransferase Analytical Biochemistry. Dec, 2015 | Pubmed ID: 26334609 Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics Chemistry & Biology. Aug, 2015 | Pubmed ID: 26256475 Myristoylation Profiling in Human Cells and Zebrafish Data in Brief. Sep, 2015 | Pubmed ID: 26217820 Legionella Pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor Infection and Immunity. Oct, 2015 | Pubmed ID: 26216420 Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2015 | Pubmed ID: 26079733 Creating a Customized Intracellular Niche: Subversion of Host Cell Signaling by Legionella Type IV Secretion System Effectors Canadian Journal of Microbiology. Sep, 2015 | Pubmed ID: 26059316 Cholesterylation: a Tail of Hedgehog Biochemical Society Transactions. Apr, 2015 | Pubmed ID: 25849927 Membrane Bound O-acyltransferases and Their Inhibitors Biochemical Society Transactions. Apr, 2015 | Pubmed ID: 25849925 Multifunctional Reagents for Quantitative Proteome-wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development Angewandte Chemie (International Ed. in English). May, 2015 | Pubmed ID: 25807930 The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25802338 Global Analysis of Protein N-myristoylation and Exploration of N-myristoyltransferase As a Drug Target in the Neglected Human Pathogen Leishmania Donovani Chemistry & Biology. Mar, 2015 | Pubmed ID: 25728269 Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines The Journal of Organic Chemistry. May, 2015 | Pubmed ID: 25713927 Target Profiling of Zerumbone Using a Novel Cell-permeable Clickable Probe and Quantitative Chemical Proteomics Chemical Communications (Cambridge, England). Mar, 2015 | Pubmed ID: 25598414 Synthesis of Unsaturated Phosphatidylinositol 4-phosphates and the Effects of Substrate Unsaturation on SopB Phosphatase Activity Organic & Biomolecular Chemistry. Feb, 2015 | Pubmed ID: 25515724 Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25505265 Global Profiling of Protein Lipidation Using Chemical Proteomic Technologies Current Opinion in Chemical Biology. Feb, 2015 | Pubmed ID: 25461723 Targeting a Dynamic Protein-protein Interaction: Fragment Screening Against the Malaria Myosin A Motor Complex ChemMedChem. Jan, 2015 | Pubmed ID: 25367834 New Chemical Probes Targeting Cholesterylation of Sonic Hedgehog in Human Cells and Zebrafish Chemical Science. May, 2014 | Pubmed ID: 25574372 Using a Non-image-based Medium-throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes PLoS Neglected Tropical Diseases. Dec, 2014 | Pubmed ID: 25522361 Crystal Structure of the Human, FIC-domain Containing Protein HYPE and Implications for Its Functions Structure (London, England : 1993). Dec, 2014 | Pubmed ID: 25435325 Global Profiling of Co- and Post-translationally N-myristoylated Proteomes in Human Cells Nature Communications. Sep, 2014 | Pubmed ID: 25255805 Structure-based Design of Potent and Selective Leishmania N-myristoyltransferase Inhibitors Journal of Medicinal Chemistry. Oct, 2014 | Pubmed ID: 25238611 Peptidomimetic Inhibitors of N-myristoyltransferase from Human Malaria and Leishmaniasis Parasites Organic & Biomolecular Chemistry. Nov, 2014 | Pubmed ID: 25230674 Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-helix Interaction ACS Chemical Biology. Oct, 2014 | Pubmed ID: 25084543 Diverse Modes of Binding in Structures of Leishmania Major N-myristoyltransferase with Selective Inhibitors IUCrJ. Jul, 2014 | Pubmed ID: 25075346 Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation Cell Host & Microbe. Jul, 2014 | Pubmed ID: 25011111 A Succinyl Lysine-based Photo-cross-linking Peptide Probe for Sirtuin 5 Organic & Biomolecular Chemistry. Jul, 2014 | Pubmed ID: 24848608 Design and Synthesis of High Affinity Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) Journal of Medicinal Chemistry. Mar, 2014 | Pubmed ID: 24641010 Attenuation of Hedgehog Acyltransferase-catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells PloS One. 2014 | Pubmed ID: 24608521 Validation of N-myristoyltransferase As an Antimalarial Drug Target Using an Integrated Chemical Biology Approach Nature Chemistry. Feb, 2014 | Pubmed ID: 24451586 N-Myristoyltransferase As a Potential Drug Target in Malaria and Leishmaniasis Parasitology. Jan, 2014 | Pubmed ID: 23611109 Unique Apicomplexan IMC Sub-compartment Proteins Are Early Markers for Apical Polarity in the Malaria Parasite Biology Open. 2013 | Pubmed ID: 24244852 Chemical Proteomics: a Powerful Tool for Exploring Protein Lipidation Biochemical Society Transactions. Feb, 2013 | Pubmed ID: 23356258 Automated Fluorescence Lifetime Imaging Plate Reader and Its Application to Förster Resonant Energy Transfer Readout of Gag Protein Aggregation Journal of Biophotonics. May, 2013 | Pubmed ID: 23184449 Discovery of Novel and Ligand-efficient Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-myristoyltransferase Journal of Medicinal Chemistry. Jan, 2013 | Pubmed ID: 23170970 Design and Synthesis of Inhibitors of Plasmodium Falciparum N-myristoyltransferase, a Promising Target for Antimalarial Drug Discovery Journal of Medicinal Chemistry. Oct, 2012 | Pubmed ID: 23035716 Regulation of the Plasmodium Motor Complex: Phosphorylation of Myosin A Tail-interacting Protein (MTIP) Loosens Its Grip on MyoA The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22932904 A Role for the Vesicle-associated Tubulin Binding Protein ARL6 (BBS3) in Flagellum Extension in Trypanosoma Brucei Biochimica Et Biophysica Acta. Jul, 2012 | Pubmed ID: 22609302 Selective Inhibitors of Protozoan Protein N-myristoyltransferases As Starting Points for Tropical Disease Medicinal Chemistry Programs PLoS Neglected Tropical Diseases. 2012 | Pubmed ID: 22545171 Discovery of Plasmodium Vivax N-myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of Their Binding Mode Journal of Medicinal Chemistry. Apr, 2012 | Pubmed ID: 22439843 A New Chemical Handle for Protein AMPylation at the Host-pathogen Interface Chembiochem : a European Journal of Chemical Biology. Jan, 2012 | Pubmed ID: 22213418 Multifunctional Protein Labeling Via Enzymatic N-terminal Tagging and Elaboration by Click Chemistry Nature Protocols. Jan, 2012 | Pubmed ID: 22193303 Application of Activity-based Protein Profiling to the Study of Microbial Pathogenesis Topics in Current Chemistry. 2012 | Pubmed ID: 22102218 A Fluorescence-based Assay for N-myristoyltransferase Activity Analytical Biochemistry. Feb, 2012 | Pubmed ID: 22051857 Novel Inhibitors of Surface Layer Processing in Clostridium Difficile Bioorganic & Medicinal Chemistry. Jan, 2012 | Pubmed ID: 21752656 Highlights from the 46th EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, May 2011 Chemical Communications (Cambridge, England). Oct, 2011 | Pubmed ID: 21874182 Roles of Cysteine Proteases Cwp84 and Cwp13 in Biogenesis of the Cell Wall of Clostridium Difficile Journal of Bacteriology. Jul, 2011 | Pubmed ID: 21531808 Activity-based Profiling for Drug Discovery Chemistry & Biology. Apr, 2011 | Pubmed ID: 21513874 Bioorthogonal Chemical Tagging of Protein Cholesterylation in Living Cells Chemical Communications (Cambridge, England). Apr, 2011 | Pubmed ID: 21221452 Activity-based Probes: Discovering New Biology and New Drug Targets Chemical Society Reviews. Jan, 2011 | Pubmed ID: 20886146 Comparing Experimental and Computational Alanine Scanning Techniques for Probing a Prototypical Protein-protein Interaction Protein Engineering, Design & Selection : PEDS. Jan, 2011 | Pubmed ID: 20656696 Membrane Enhanced Peptide Synthesis Chemical Communications (Cambridge, England). Apr, 2010 | Pubmed ID: 20369190 Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry Chembiochem : a European Journal of Chemical Biology. Apr, 2010 | Pubmed ID: 20209562 Interaction and Dynamics of the Plasmodium Falciparum MTIP-MyoA Complex, a Key Component of the Invasion Motor in the Malaria Parasite Molecular BioSystems. Mar, 2010 | Pubmed ID: 20174678 Getting a Chemical Handle on Protein Post-translational Modification Organic & Biomolecular Chemistry. Feb, 2010 | Pubmed ID: 20135026 Chemical Probes of Surface Layer Biogenesis in Clostridium Difficile ACS Chemical Biology. Mar, 2010 | Pubmed ID: 20067320 N-myristoyltransferase from Leishmania Donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis Journal of Molecular Biology. Mar, 2010 | Pubmed ID: 20036251 Protein Myristoylation in Health and Disease Journal of Chemical Biology. Nov, 2009 | Pubmed ID: 19898886 Potent Inhibitors of Beta-tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold Journal of Medicinal Chemistry. Oct, 2009 | Pubmed ID: 19772295 Recent Advances in Chemical Proteomics: Exploring the Post-translational Proteome Journal of Chemical Biology. Nov, 2008 | Pubmed ID: 19568795 Specific N-terminal Protein Labelling: Use of FMDV 3C Pro Protease and Native Chemical Ligation Chemical Communications (Cambridge, England). Aug, 2008 | Pubmed ID: 18633492 N-Myristoyl Transferase-mediated Protein Labelling in Vivo Organic & Biomolecular Chemistry. Jul, 2008 | Pubmed ID: 18563263 Chemical and Biomimetic Total Syntheses of Natural and Engineered MCoTI Cyclotides Organic & Biomolecular Chemistry. Apr, 2008 | Pubmed ID: 18385853 N-myristoyltransferase: a Prospective Drug Target for Protozoan Parasites ChemMedChem. Mar, 2008 | Pubmed ID: 18324715 Site-specific N-terminal Labelling of Proteins in Vitro and in Vivo Using N-myristoyl Transferase and Bioorthogonal Ligation Chemistry Chemical Communications (Cambridge, England). Jan, 2008 | Pubmed ID: 18188474 Molecules Incorporating a Benzothiazole Core Scaffold Inhibit the N-myristoyltransferase of Plasmodium Falciparum The Biochemical Journal. Dec, 2007 | Pubmed ID: 17714074 Immobilized Protease-assisted Synthesis of Engineered Cysteine-knot Microproteins Chembiochem : a European Journal of Chemical Biology. Jul, 2007 | Pubmed ID: 17526063 Total Synthesis of the Macrocyclic Cysteine Knot Microprotein MCoTI-II Chemical Communications (Cambridge, England). Jul, 2006 | Pubmed ID: 17007393 A Highly Enantioselective Total Synthesis of (+)-goniodiol Organic & Biomolecular Chemistry. May, 2006 | Pubmed ID: 16633562 Open Source High Content Analysis Door gebruik te maken van de automaten Fluorescence Lifetime Imaging Microscopy Frederik Görlitz*1, Douglas J. Kelly*1, Sean C. Warren1, Dominic Alibhai2, Lucien West3, Sunil Kumar1, Yuriy Alexandrov1, Ian Munro1, Edwin Garcia1, James McGinty1, Clifford Talbot1, Remigiusz A. Serwa4, Emmanuelle Thinon4, Vincenzo da Paola3, Edward J. Murray5, Frank Stuhmeier6, Mark A. A. Neil1, Edward W. Tate4, Christopher Dunsby1,7, Paul M. W. French1 1Photonics Group, Department of Physics, Imperial College London, 2Institute for Chemical Biology, Department of Chemistry, Imperial College London, 3MRC Clinical Sciences Centre, Hammersmith Hospital, 4Chemical Biology Section, Department of Chemistry, Imperial College London, 5Retroscreen Virology Ltd, 6Pfizer Global Research and Development, Pfizer Limited, Sandwich, Kent, UK, 7Centre for Histopathology, Imperial College London JoVE 55119 Biologia
Open Source High Content Analysis Door gebruik te maken van de automaten Fluorescence Lifetime Imaging Microscopy Frederik Görlitz*1, Douglas J. Kelly*1, Sean C. Warren1, Dominic Alibhai2, Lucien West3, Sunil Kumar1, Yuriy Alexandrov1, Ian Munro1, Edwin Garcia1, James McGinty1, Clifford Talbot1, Remigiusz A. Serwa4, Emmanuelle Thinon4, Vincenzo da Paola3, Edward J. Murray5, Frank Stuhmeier6, Mark A. A. Neil1, Edward W. Tate4, Christopher Dunsby1,7, Paul M. W. French1 1Photonics Group, Department of Physics, Imperial College London, 2Institute for Chemical Biology, Department of Chemistry, Imperial College London, 3MRC Clinical Sciences Centre, Hammersmith Hospital, 4Chemical Biology Section, Department of Chemistry, Imperial College London, 5Retroscreen Virology Ltd, 6Pfizer Global Research and Development, Pfizer Limited, Sandwich, Kent, UK, 7Centre for Histopathology, Imperial College London JoVE 55119 Biologia