Gabriele Kaminski Schierle Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology University of Cambridge Biography Publications Institution JoVE Articles Gabriele Kaminski Schierle has not added a biography. If you are Gabriele Kaminski Schierle and would like to personalize this page please email our Author Liaison for assistance. Publications A Waveguide Imaging Platform for Live-cell TIRF Imaging of Neurons over Large Fields of View Journal of Biophotonics. Feb, 2020 | Pubmed ID: 32067356 Observation of High-temperature Macromolecular Confinement in Lyophilised Protein Formulations Using Terahertz Spectroscopy International Journal of Pharmaceutics: X. Dec, 2019 | Pubmed ID: 31517287 Mitochondrial Degradation of Amyloidogenic Proteins - A New Perspective for Neurodegenerative Diseases Progress in Neurobiology. 10, 2019 | Pubmed ID: 31301323 The Role of Water in Amyloid Aggregation Kinetics Current Opinion in Structural Biology. 10, 2019 | Pubmed ID: 31299481 Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging ACS Chemical Biology. Jul, 2019 | Pubmed ID: 31246415 Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres Pharmaceutics. Jun, 2019 | Pubmed ID: 31226751 Intrinsically Aggregation-prone Proteins Form Amyloid-like Aggregates and Contribute to Tissue Aging in ELife. May, 2019 | Pubmed ID: 31050339 The Cellular Environment Affects Monomeric α-Synuclein Structure Trends in Biochemical Sciences. 05, 2019 | Pubmed ID: 30527975 Structural Progression of Amyloid-β Arctic Mutant Aggregation in Cells Revealed by Multiparametric Imaging The Journal of Biological Chemistry. 02, 2019 | Pubmed ID: 30504224 Live-cell Super-resolution Microscopy Reveals a Primary Role for Diffusion in Polyglutamine-driven Aggresome Assembly The Journal of Biological Chemistry. 01, 2019 | Pubmed ID: 30401748 Opal-like Multicolor Appearance of Self-Assembled Photonic Array ACS Applied Materials & Interfaces. Jun, 2018 | Pubmed ID: 29842782 Different Structural Conformers of Monomeric α-Synuclein Identified After Lyophilizing and Freezing Analytical Chemistry. 06, 2018 | Pubmed ID: 29750859 FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions Cell. Apr, 2018 | Pubmed ID: 29677515 An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures Frontiers in Cellular Neuroscience. 2018 | Pubmed ID: 29556177 C-terminal Calcium Binding of α-synuclein Modulates Synaptic Vesicle Interaction Nature Communications. 02, 2018 | Pubmed ID: 29459792 Biophotonics of Native Silk Fibrils Macromolecular Bioscience. Apr, 2018 | Pubmed ID: 29377575 Imaging Aβ(1-42) Fibril Elongation Reveals Strongly Polarised Growth and Growth Incompetent States Physical Chemistry Chemical Physics : PCCP. Oct, 2017 | Pubmed ID: 29026905 α-Synuclein - Regulator of Exocytosis, Endocytosis, or Both? Trends in Cell Biology. 07, 2017 | Pubmed ID: 28259601 Super-resolution Imaging of Alpha-synuclein Polymorphisms and Their Potential Role in Neurodegeneration Integrative Biology : Quantitative Biosciences from Nano to Macro. 03, 2017 | Pubmed ID: 28180219 A Computational Study on How Structure Influences the Optical Properties in Model Crystal Structures of Amyloid Fibrils Physical Chemistry Chemical Physics : PCCP. Feb, 2017 | Pubmed ID: 28111679 Fluorescence Self-Quenching from Reporter Dyes Informs on the Structural Properties of Amyloid Clusters Formed in Vitro and in Cells Nano Letters. 01, 2017 | Pubmed ID: 28073262 Structural Basis of Synaptic Vesicle Assembly Promoted by α-synuclein Nature Communications. 09, 2016 | Pubmed ID: 27640673 Probing Amyloid Protein Aggregation with Optical Superresolution Methods: from the Test Tube to Models of Disease Neurophotonics. Oct, 2016 | Pubmed ID: 27413767 Nanoscopic Insights into Seeding Mechanisms and Toxicity of α-synuclein Species in Neurons Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26993805 Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures Journal of the American Chemical Society. Mar, 2016 | Pubmed ID: 26824778 Optical Super-Resolution Imaging of β-Amyloid Aggregation In Vitro and In Vivo: Method and Techniques Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26235063 CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation PLoS Biology. Apr, 2015 | Pubmed ID: 25875822 Highly Potent Soluble Amyloid-β Seeds in Human Alzheimer Brain but Not Cerebrospinal Fluid Brain : a Journal of Neurology. Nov, 2014 | Pubmed ID: 25212850 Direct Observations of Amyloid β Self-assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1-40) and Aβ(1-42) Aggregation Chemistry & Biology. Jun, 2014 | Pubmed ID: 24856820 Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics Via Two-color Super-resolution Microscopy Nano Letters. Jan, 2014 | Pubmed ID: 24303845 Extracellular Monomeric Tau Protein is Sufficient to Initiate the Spread of Tau Protein Pathology The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24235150 A Label-free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence Chembiochem : a European Journal of Chemical Biology. May, 2013 | Pubmed ID: 23592254 Lifetime Imaging of a Fluorescent Protein Sensor Reveals Surprising Stability of ER Thiol Redox The Journal of Cell Biology. Apr, 2013 | Pubmed ID: 23589496 Protein Amyloids Develop an Intrinsic Fluorescence Signature During Aggregation The Analyst. Apr, 2013 | Pubmed ID: 23420088 Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme PloS One. 2012 | Pubmed ID: 23166837 ALS Mutations in FUS Cause Neuronal Dysfunction and Death in Caenorhabditis Elegans by a Dominant Gain-of-function Mechanism Human Molecular Genetics. Jan, 2012 | Pubmed ID: 21949354 Intrinsically Disordered Proteins As Molecular Shields Molecular BioSystems. Jan, 2012 | Pubmed ID: 21909508 In Situ Measurements of the Formation and Morphology of Intracellular β-amyloid Fibrils by Super-resolution Fluorescence Imaging Journal of the American Chemical Society. Aug, 2011 | Pubmed ID: 21793568 HomoFRET Fluorescence Anisotropy Imaging As a Tool to Study Molecular Self-assembly in Live Cells Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Feb, 2011 | Pubmed ID: 21344590 A FRET Sensor for Non-invasive Imaging of Amyloid Formation in Vivo Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Feb, 2011 | Pubmed ID: 21308945 Catalytic and Chaperone-like Functions in an Intrinsically Disordered Protein Associated with Desiccation Tolerance Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20805515 Karakterisering af Amyloid strukturer i Aging C. Elegans Brug Fluorescens Lifetime Imaging Maria Lucia Pigazzini*1,2, Christian Gallrein*1, Manuel Iburg*1, Gabriele Kaminski Schierle3, Janine Kirstein1,4 1Leibniz Research Institute for Molecular Pharmacology im Forschungsverbund Berlin, 2NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin, 3Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, 4Cell Biology, University of Bremen JoVE 61004 Biochimica
Karakterisering af Amyloid strukturer i Aging C. Elegans Brug Fluorescens Lifetime Imaging Maria Lucia Pigazzini*1,2, Christian Gallrein*1, Manuel Iburg*1, Gabriele Kaminski Schierle3, Janine Kirstein1,4 1Leibniz Research Institute for Molecular Pharmacology im Forschungsverbund Berlin, 2NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin, 3Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, 4Cell Biology, University of Bremen JoVE 61004 Biochimica