Gareth Thomas Cancer Sciences Unit University of Southampton School of Medicine Biography Publications Institution JoVE Articles Gareth Thomas has not added a biography. If you are Gareth Thomas and would like to personalize this page please email our Author Liaison for assistance. Publications The Immune Response in HPV(+) Oropharyngeal Cancer Oncoimmunology. Jan, 2014 | Pubmed ID: 24575385 Suppression of Hedgehog Signalling Promotes Pro-tumourigenic Integrin Expression and Function The Journal of Pathology. Feb, 2014 | Pubmed ID: 24573955 Identification of ZDHHC14 As a Novel Human Tumour Suppressor Gene The Journal of Pathology. Apr, 2014 | Pubmed ID: 24407904 In Vitro Effect of Bisphosphonates on Oral Keratinocytes and Fibroblasts Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. Mar, 2014 | Pubmed ID: 24342576 Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2014 | Pubmed ID: 24150233 DHHC8-dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-term Synaptic Depression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24068808 Generation and Characterization of a Diabody Targeting the αvβ6 Integrin PloS One. 2013 | Pubmed ID: 24023846 MiR-153 Supports Colorectal Cancer Progression Via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Cancer Research. Nov, 2013 | Pubmed ID: 23950211 Smarter Neuronal Signaling Complexes from Existing Components: How Regulatory Modifications Were Acquired During Animal Evolution: Evolution of Palmitoylation-dependent Regulation of AMPA-type Ionotropic Glutamate Receptors BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Nov, 2013 | Pubmed ID: 23943381 Tumor-stromal Interactions in Pancreatic Cancer Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. Jan-Feb, 2013 | Pubmed ID: 23395563 Progression of Genotype-specific Oral Cancer Leads to Senescence of Cancer-associated Fibroblasts and is Mediated by Oxidative Stress and TGF-β Carcinogenesis. Jun, 2013 | Pubmed ID: 23358854 Palmitoylation-dependent Regulation of Glutamate Receptors and Their PDZ Domain-containing Partners Biochemical Society Transactions. Feb, 2013 | Pubmed ID: 23356261 Combined Fiber Modifications Both to Target α(v)β(6) and Detarget the Coxsackievirus-adenovirus Receptor Improve Virus Toxicity Profiles in Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5 Human Gene Therapy. Jun, 2012 | Pubmed ID: 22708837 Cardiorespiratory Safety Evaluation in Non-human Primates Journal of Pharmacological and Toxicological Methods. Sep, 2012 | Pubmed ID: 22521338 Palmitoylation by DHHC5/8 Targets GRIP1 to Dendritic Endosomes to Regulate AMPA-R Trafficking Neuron. Feb, 2012 | Pubmed ID: 22325201 SynaptomeDB: an Ontology-based Knowledgebase for Synaptic Genes Bioinformatics (Oxford, England). Mar, 2012 | Pubmed ID: 22285564 A Rare Case of Iron Deficiency European Journal of Gastroenterology & Hepatology. Jan, 2012 | Pubmed ID: 22008628 The Role of Tumour Stroma in Colorectal Cancer Invasion and Metastasis Cancers. 2011 | Pubmed ID: 24212801 Measuring Invasion in an Organotypic Model Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21748679 GLI1 Confers Profound Phenotypic Changes Upon LNCaP Prostate Cancer Cells That Include the Acquisition of a Hormone Independent State PloS One. 2011 | Pubmed ID: 21633508 Cell Migration and Invasion Assays Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21516419 Gain-of-function Glutamate Receptor Interacting Protein 1 Variants Alter GluA2 Recycling and Surface Distribution in Patients with Autism Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383172 Stromal Features Are Predictive of Disease Mortality in Oral Cancer Patients The Journal of Pathology. Mar, 2011 | Pubmed ID: 21294121 Betel-derived Alkaloid Up-regulates Keratinocyte Alphavbeta6 Integrin Expression and Promotes Oral Submucous Fibrosis The Journal of Pathology. Feb, 2011 | Pubmed ID: 21171082 A Rare Complication with a Single Dose of Alendronate BMJ Case Reports. 2010 | Pubmed ID: 22778283 GRIP1 and 2 Regulate Activity-dependent AMPA Receptor Recycling Via Exocyst Complex Interactions Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20956289 A Comparison of Primary Oesophageal Squamous Epithelial Cells with HET-1A in Organotypic Culture Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Dec, 2010 | Pubmed ID: 20843300 High-resolution in Vivo Imaging of Breast Cancer by Targeting the Pro-invasive Integrin Alphavbeta6 The Journal of Pathology. Sep, 2010 | Pubmed ID: 20629113 Dual Actions of Lindane (γ-hexachlorocyclohexane) on Calcium Homeostasis and Exocytosis in Rat PC12 Cells Toxicology and Applied Pharmacology. Oct, 2010 | Pubmed ID: 20600211 Clinicopathological Parameters, Recurrence, Locoregional and Distant Metastasis in 115 T1-T2 Oral Squamous Cell Carcinoma Patients Head & Neck Oncology. 2010 | Pubmed ID: 20406474 Endothelial-Rac1 is Not Required for Tumor Angiogenesis Unless Alphavbeta3-integrin is Absent PloS One. 2010 | Pubmed ID: 20339539 Regulation of Lymphatic-blood Vessel Separation by Endothelial Rac1 Development (Cambridge, England). Dec, 2009 | Pubmed ID: 19906871 Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking Neuron. Oct, 2009 | Pubmed ID: 19874789 Exposure to Persistent Organic Pollutants and First-year Survival Probability in Gray Seal Pups Environmental Science & Technology. Aug, 2009 | Pubmed ID: 19746738 Polybrominated Diphenyl Ether-associated Alterations in Cell Biochemistry As Determined by Attenuated Total Reflection Fourier-transform Infrared Spectroscopy: a Comparison with DNA-reactive And/or Endocrine-disrupting Agents Environmental Science & Technology. May, 2009 | Pubmed ID: 19534158 A Mass Balance of Tri-hexabrominated Diphenyl Ethers in Lactating Cows Environmental Science & Technology. Apr, 2009 | Pubmed ID: 19452923 In Vivo Retargeting of Adenovirus Type 5 to Alphavbeta6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake Following Systemic Delivery Journal of Virology. Jul, 2009 | Pubmed ID: 19369326 Use of Quantitative Structural Analysis to Predict Fish Bioconcentration Factors for Pesticides Journal of Agricultural and Food Chemistry. Feb, 2009 | Pubmed ID: 19138085 Determination of Protein Denaturation and Glass Transition Temperatures Using High-frequency Time Domain Reflectometry The Journal of Physical Chemistry. B. Dec, 2008 | Pubmed ID: 19368035 Engineering a Single-chain Fv Antibody to Alpha V Beta 6 Integrin Using the Specificity-determining Loop of a Foot-and-mouth Disease Virus Journal of Molecular Biology. Oct, 2008 | Pubmed ID: 18656482 Alpha Vbeta 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma Through Stromal Modulation Cancer Research. May, 2008 | Pubmed ID: 18451156 Uptake and Storage of PCBs by Plant Cuticles Environmental Science & Technology. Jan, 2008 | Pubmed ID: 18350882 Antibody-mediated Blockade of Integrin Alpha V Beta 6 Inhibits Tumor Progression in Vivo by a Transforming Growth Factor-beta-regulated Mechanism Cancer Research. Jan, 2008 | Pubmed ID: 18199553 Rapid and Bi-directional Regulation of AMPA Receptor Phosphorylation and Trafficking by JNK The EMBO Journal. Jan, 2008 | Pubmed ID: 18188153 Decabromodiphenyl Ether (deca-BDE) Commercial Mixture Components, and Other PBDEs, in Airborne Particles at a UK Site Environment International. Apr, 2008 | Pubmed ID: 17961649 PAHs in Background Soils from Western Europe: Influence of Atmospheric Deposition and Soil Organic Matter Chemosphere. Feb, 2008 | Pubmed ID: 17888489 Inducible Nitric Oxide Synthase: Correlation with Extracapsular Spread and Enhancement of Tumor Cell Invasion in Head and Neck Squamous Cell Carcinoma Head & Neck. Feb, 2008 | Pubmed ID: 17657783 The Consequences of Smoking and Tobacco on Lung Disease in Developing Countries: Plenary Lecture Given During the 37th Union World Conference on Lung Health, Palais Des Congrès, Paris, France, 31 October-4 November 2006 The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. Dec, 2007 | Pubmed ID: 18034946 Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell Inflammation and Migration Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2007 | Pubmed ID: 18029909 The 120 KDa Cell-binding Fragment of Fibronectin Up-regulates Migration of Alphavbeta6-expressing Cells by Increasing Matrix Metalloproteinase-2 and -9 Secretion European Journal of Oral Sciences. Dec, 2007 | Pubmed ID: 18028052 Use of Two-photon Excitation Microscopy and Autofluorescence for Visualizing the Fate and Behavior of Semivolatile Organic Chemicals Within Living Vegetation Environmental Toxicology and Chemistry / SETAC. Dec, 2007 | Pubmed ID: 18020674 Hyaluronan Induces the Selective Accumulation of Matrix- and Cell-associated Proteoglycans by Mesangial Cells The American Journal of Pathology. Dec, 2007 | Pubmed ID: 17974600 Validation of a Passive Atmospheric Deposition Sampler for Polybrominated Diphenyl Ethers Journal of Environmental Monitoring : JEM. Nov, 2007 | Pubmed ID: 17968443 Infrared Spectral Analysis of MCF-7 Cells Treated with Serum-lipid Extracts Segregates Predominantly Brominated Flame Retardant-exposed Subjects from Those with Mainly Organochlorine Exposures Environmental Science & Technology. Aug, 2007 | Pubmed ID: 17874806 Exposure of Electronics Dismantling Workers to Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Organochlorine Pesticides in South China Environmental Science & Technology. Aug, 2007 | Pubmed ID: 17874768 GRASP-1 is a Neuronal Scaffold Protein for the JNK Signaling Pathway FEBS Letters. Sep, 2007 | Pubmed ID: 17761173 Pseudosubarachnoid Haemorrhage on CT Brain Scan: an Unusual Presentation of Diffuse Hypoxic Brain Injury Intensive Care Medicine. Nov, 2007 | Pubmed ID: 17576538 HS1-associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion Via Clathrin-mediated Endocytosis of Integrin Alphavbeta6 Cancer Research. Jun, 2007 | Pubmed ID: 17545607 Polychlorinated Biphenyls, DDT, Polybrominated Diphenyl Ethers, and Organic Pesticides in United Kingdom Harbor Seals (Phoca Vitulina)--mixed Exposures and Thyroid Homeostasis Environmental Toxicology and Chemistry / SETAC. May, 2007 | Pubmed ID: 17521129 Prospective Randomized Clinical Trial of the Effect of Needle Size on Pain, Sample Adequacy and Accuracy in Head and Neck Fine-needle Aspiration Cytology Head & Neck. Oct, 2007 | Pubmed ID: 17405171 Fate of Higher Brominated PBDEs in Lactating Cows Environmental Science & Technology. Jan, 2007 | Pubmed ID: 17310701 Sex, Politics, and Money Lancet. Dec, 2006 | Pubmed ID: 17141686 Cyclooxygenase-2 Inhibition Suppresses Alphavbeta6 Integrin-dependent Oral Squamous Carcinoma Invasion Cancer Research. Nov, 2006 | Pubmed ID: 17108119 Persistent Organic Pollutants in European Background Air: Derivation of Temporal and Latitudinal Trends Journal of Environmental Monitoring : JEM. Jul, 2006 | Pubmed ID: 16826283 Chlorinated Paraffins: a Review of Analysis and Environmental Occurrence Environment International. Sep, 2006 | Pubmed ID: 16814386 Inflammatory External Root Resorption Following Surgical Treatment for Intra-bony Defects: a Report of Two Cases Involving Emdogain and a Review of the Literature Journal of Clinical Periodontology. Jun, 2006 | Pubmed ID: 16677335 Targeted in Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-term Depression Neuron. Mar, 2006 | Pubmed ID: 16543133 Visualizing the Air-to-leaf Transfer and Within-leaf Movement and Distribution of Phenanthrene: Further Studies Utilizing Two-photon Excitation Microscopy Environmental Science & Technology. Feb, 2006 | Pubmed ID: 16509336 Nitric Oxide is a Factor in the Stabilization of Hypoxia-inducible Factor-1alpha in Cancer: Role of Free Radical Formation Cancer Research. Jan, 2006 | Pubmed ID: 16424008 Organohalogen Chemicals in Human Blood from the United Kingdom Environmental Pollution (Barking, Essex : 1987). May, 2006 | Pubmed ID: 16236409 Short and Medium Chain Length Chlorinated Paraffins in UK Human Milk Fat Environment International. Jan, 2006 | Pubmed ID: 15979717 Mechanisms of Disease: Nicotine--a Review of Its Actions in the Context of Gastrointestinal Disease Nature Clinical Practice. Gastroenterology & Hepatology. Nov, 2005 | Pubmed ID: 16355159 Preliminary Observations of Oral Nicotine Therapy for Inflammatory Bowel Disease: an Open-label Phase I-II Study of Tolerance Inflammatory Bowel Diseases. Dec, 2005 | Pubmed ID: 16306772 Comment on "Early Treatment with Activated Protein C for Meningococcal Septic Shock: Case Report and Literature Review" by Hasin Et Al Intensive Care Medicine. Dec, 2005 | Pubmed ID: 16283165 A Randomized Trial of Nicotine Enemas for Active Ulcerative Colitis Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Nov, 2005 | Pubmed ID: 16271342 Ribosomal S6 Kinase 2 Interacts with and Phosphorylates PDZ Domain-containing Proteins and Regulates AMPA Receptor Transmission Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16217014 Squamous Cell Carcinoma Arising in a Residual Odontogenic Cyst: Case Report Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. Aug, 2005 | Pubmed ID: 16094597 Detailed Study of Factors Controlling Atmospheric Concentrations of PCNs Environmental Science & Technology. Jul, 2005 | Pubmed ID: 16053070 Spatial and Temporal Variability in Air Concentrations of Short-chain (C10-C13) and Medium-chain (C14-C17) Chlorinated N-alkanes Measured in the U.K. Atmosphere Environmental Science & Technology. Jun, 2005 | Pubmed ID: 16047774 Direct Observation of Organic Contaminant Uptake, Storage, and Metabolism Within Plant Roots Environmental Science & Technology. May, 2005 | Pubmed ID: 15952374 Time Trends of Atmospheric PBDEs Inferred from Archived U.K. Herbage Environmental Science & Technology. Apr, 2005 | Pubmed ID: 15884332 Digital Ischemia Associated with Squamous Cell Carcinoma of the Esophagus Digestive Diseases and Sciences. Apr, 2005 | Pubmed ID: 15844703 Retrieval of Aerosol Refractive Index from Extinction Spectra with a Damped Harmonic-oscillator Band Model Applied Optics. Mar, 2005 | Pubmed ID: 15765714 Real-time Visualization and Quantification of PAH Photodegradation on and Within Plant Leaves Environmental Science & Technology. Jan, 2005 | Pubmed ID: 15667104 Absorption of Decabromodiphenyl Ether and Other Organohalogen Chemicals by Grey Seals (Halichoerus Grypus) Environmental Pollution (Barking, Essex : 1987). Feb, 2005 | Pubmed ID: 15519732 Calculation of Mie Derivatives Applied Optics. Oct, 2004 | Pubmed ID: 15495430 A Novel Analytical Approach for Visualizing and Tracking Organic Chemicals in Plants Environmental Science & Technology. Aug, 2004 | Pubmed ID: 15352460 Exchange of Polychlorinated Biphenyls (PCBs) and Polychlorinated Naphthalenes (PCNs) Between Air and a Mixed Pasture Sward Environmental Science & Technology. Jul, 2004 | Pubmed ID: 15298198 Inter-individual Differences in the Ability of Human Milk-fat Extracts to Enhance the Genotoxic Potential of the Procarcinogen Benzo[a]pyrene in MCF-7 Breast Cells Environmental Science & Technology. Jul, 2004 | Pubmed ID: 15296313 New Magnetic Nanoparticles for Biotechnology Journal of Biotechnology. Aug, 2004 | Pubmed ID: 15288940 Myofibroblastic Differentiation Leads to Hyaluronan Accumulation Through Reduced Hyaluronan Turnover The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15271981 Different Levels of Polybrominated Diphenyl Ethers (PBDEs) and Chlorinated Compounds in Breast Milk from Two U.K. Regions Environmental Health Perspectives. Jul, 2004 | Pubmed ID: 15238282 Further Studies on the Latitudinal and Temporal Trends of Persistent Organic Pollutants in Norwegian and U.K. Background Air Environmental Science & Technology. May, 2004 | Pubmed ID: 15180046 Catabolism of Newly Synthesized Decorin in Vitro by Human Peritoneal Mesothelial Cells Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis. Mar-Apr, 2004 | Pubmed ID: 15119635 Attenuated Type II TGF-beta Receptor Signalling in Human Malignant Oral Keratinocytes Induces a Less Differentiated and More Aggressive Phenotype That is Associated with Metastatic Dissemination International Journal of Cancer. Journal International Du Cancer. Jun, 2004 | Pubmed ID: 15069677 The Integrin Cytoplasmic-tail Motif EKQKVDLSTDC is Sufficient to Promote Tumor Cell Invasion Mediated by Matrix Metalloproteinase (MMP)-2 or MMP-9 The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15067014 Modulation of the Urokinase-type Plasminogen Activator Receptor by the Beta6 Integrin Subunit Biochemical and Biophysical Research Communications. Apr, 2004 | Pubmed ID: 15047152 MAPK Cascade Signalling and Synaptic Plasticity Nature Reviews. Neuroscience. Mar, 2004 | Pubmed ID: 14976517 PBDEs in European Background Soils: Levels and Factors Controlling Their Distribution Environmental Science & Technology. Feb, 2004 | Pubmed ID: 14968858 PBDEs in the Atmosphere of Three Locations in Western Europe Environmental Science & Technology. Feb, 2004 | Pubmed ID: 14968853 Stress- and Mitogen-induced Phosphorylation of the Synapse-associated Protein SAP90/PSD-95 by Activation of SAPK3/p38gamma and ERK1/ERK2 The Biochemical Journal. May, 2004 | Pubmed ID: 14741046 Low Dose Induction of Micronuclei by Lindane Carcinogenesis. Apr, 2004 | Pubmed ID: 14688026 Current Issues and Uncertainties in the Measurement and Modelling of Air-vegetation Exchange and Within-plant Processing of POPs Environmental Pollution (Barking, Essex : 1987). 2004 | Pubmed ID: 14667723 Occurrence of Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Green Mussels (Perna Viridis) from Singapore, Southeast Asia Environmental Toxicology and Chemistry / SETAC. Oct, 2003 | Pubmed ID: 14552008 A Multicenter, Single-masked Study of Medial, Neutral, and Lateral Patellar Taping in Individuals with Patellofemoral Pain Syndrome The Journal of Orthopaedic and Sports Physical Therapy. Aug, 2003 | Pubmed ID: 12968857 Study of Plant-air Transfer of PCBs from an Evergreen Shrub: Implications for Mechanisms and Modeling Environmental Science & Technology. Sep, 2003 | Pubmed ID: 12967103 Polybrominated Diphenyl Ethers (PBDEs) in Grey Seals During Their First Year of Life--are They Thyroid Hormone Endocrine Disrupters? Environmental Pollution (Barking, Essex : 1987). 2003 | Pubmed ID: 12860100 Scatter Factor Regulation of Integrin Expression and Function on Oral Epithelial Cells Archives of Dermatological Research. Jun, 2003 | Pubmed ID: 12750924 Structural and Functional Changes in Heparan Sulfate Proteoglycan Expression Associated with the Myofibroblastic Phenotype The American Journal of Pathology. Mar, 2003 | Pubmed ID: 12598330 Investigation into the Importance of the Stomatal Pathway in the Exchange of PCBs Between Air and Plants Environmental Science & Technology. Oct, 2002 | Pubmed ID: 12387399 An Input-output Balance Study for PCBs in Humans Environment International. Jul, 2002 | Pubmed ID: 12222617 Air-side and Plant-side Resistances Influence the Uptake of Airborne PCBs by Evergreen Plants Environmental Science & Technology. Aug, 2002 | Pubmed ID: 12188344 Polychlorinated Dibenzo-p-dioxin and Furan (PCDD/F) Uptake by Pasture Environmental Science & Technology. Jun, 2002 | Pubmed ID: 12075792 The Statistical Merits of Various Methods of Calculating Transfer Coefficients Between Environmental Media--development of the Ideal Formula for Data-sets with a Log-normal Distribution Chemosphere. Feb, 2002 | Pubmed ID: 11999772 Profiling Molecular do microambiente do tumor invasivo em um modelo 3-Dimensional de células de câncer colorretal e Marc D. Bullock1,2, Max Mellone1, Karen M. Pickard1, Abdulkadir Emre Sayan1, Richard Mitter3, John N. Primrose2, Graham K. Packham1, Gareth Thomas1, Alexander H. Mirnezami1,2 1Cancer Sciences Unit, University of Southampton School of Medicine, 2University Surgical Unit, University of Southampton School of Medicine, 3Bioinformatics Unit, London Research Institute, Cancer Research UK JoVE 51475 Medicina
Profiling Molecular do microambiente do tumor invasivo em um modelo 3-Dimensional de células de câncer colorretal e Marc D. Bullock1,2, Max Mellone1, Karen M. Pickard1, Abdulkadir Emre Sayan1, Richard Mitter3, John N. Primrose2, Graham K. Packham1, Gareth Thomas1, Alexander H. Mirnezami1,2 1Cancer Sciences Unit, University of Southampton School of Medicine, 2University Surgical Unit, University of Southampton School of Medicine, 3Bioinformatics Unit, London Research Institute, Cancer Research UK JoVE 51475 Medicina