George R. Douglas Environmental Health Science and Research Bureau, Health Canada Environmental Health Centre Biography Publications Institution JoVE Articles George R. Douglas has not added a biography. If you are George R. Douglas and would like to personalize this page please email our Author Liaison for assistance. Publications No Evidence for Transgenerational Genomic Instability in the F1 or F2 Descendants of Muta™Mouse Males Exposed to N-ethyl-N-nitrosourea Mutation Research. Jan-Feb, 2013 | Pubmed ID: 23499255 The Development of Adverse Outcome Pathways for Mutagenic Effects for the Organization for Economic Co-operation and Development Environmental and Molecular Mutagenesis. Mar, 2013 | Pubmed ID: 23355186 Harnessing Genomics to Identify Environmental Determinants of Heritable Disease Mutation Research. Aug, 2012 | Pubmed ID: 22935230 Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and LacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse Environmental and Molecular Mutagenesis. Dec, 2011 | Pubmed ID: 21976233 Suitable Top Concentration for Tests with Mammalian Cells: Mouse Lymphoma Assay Workgroup Mutation Research. Aug, 2011 | Pubmed ID: 21514400 Assessment of Subclinical, Toxicant-induced Hepatic Gene Expression Profiles After Low-dose, Short-term Exposures in Mice Regulatory Toxicology and Pharmacology : RTP. Jun, 2011 | Pubmed ID: 21335049 Mutation Spectrum in FE1-MUTA(TM) Mouse Lung Epithelial Cells Exposed to Nanoparticulate Carbon Black Environmental and Molecular Mutagenesis. May, 2011 | Pubmed ID: 20963790 New and Emerging Technologies for Genetic Toxicity Testing Environmental and Molecular Mutagenesis. Apr, 2011 | Pubmed ID: 20740635 Characterisation of Muta™Mouse λgt10-lacZ Transgene: Evidence for in Vivo Rearrangements Mutagenesis. Nov, 2010 | Pubmed ID: 20724577 Induction of LacZ Mutations in MutaMouse Primary Hepatocytes Environmental and Molecular Mutagenesis. May, 2010 | Pubmed ID: 19953605 The Genotoxicity of Mainstream and Sidestream Marijuana and Tobacco Smoke Condensates Chemical Research in Toxicology. Aug, 2009 | Pubmed ID: 19947653 Mutagenicity Testing for Chemical Risk Assessment: Update of the WHO/IPCS Harmonized Scheme Mutagenesis. Jul, 2009 | Pubmed ID: 19535363 Toxicogenomic Analysis of Mainstream Tobacco Smoke-exposed Mice Reveals Repression of Plasminogen Activator Inhibitor-1 Gene in Heart Inhalation Toxicology. Jan, 2009 | Pubmed ID: 18925475 Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and Lung Epithelial Cells Derived from MutaMouse Mutagenesis. Nov, 2008 | Pubmed ID: 18635558 Tissue-specific Metabolic Activation and Mutagenicity of 3-nitrobenzanthrone in MutaMouse Environmental and Molecular Mutagenesis. Oct, 2008 | Pubmed ID: 18613036 Mutagenic and Carcinogenic Hazards of Settled House Dust. II: Salmonella Mutagenicity Environmental Science & Technology. Mar, 2008 | Pubmed ID: 18441831 Mutagenic and Carcinogenic Hazards of Settled House Dust. I: Polycyclic Aromatic Hydrocarbon Content and Excess Lifetime Cancer Risk from Preschool Exposure Environmental Science & Technology. Mar, 2008 | Pubmed ID: 18441830 Germ-line Mutations, DNA Damage, and Global Hypermethylation in Mice Exposed to Particulate Air Pollution in an Urban/industrial Location Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18195365 Analysis of Gene Expression in Two Human-derived Cell Lines Exposed in Vitro to a 1.9 GHz Pulse-modulated Radiofrequency Field Proteomics. Nov, 2007 | Pubmed ID: 17902192 Increased Mutant Frequency by Carbon Black, but Not Quartz, in the LacZ and CII Transgenes of Muta Mouse Lung Epithelial Cells Environmental and Molecular Mutagenesis. Jul, 2007 | Pubmed ID: 17584883 Mainstream Tobacco Smoke Causes Paternal Germ-line DNA Mutation Cancer Research. Jun, 2007 | Pubmed ID: 17545587 Hepatic Gene Expression Changes in Hypothyroid Juvenile Mice: Characterization of a Novel Negative Thyroid-responsive Element Endocrinology. Aug, 2007 | Pubmed ID: 17463053 Novel Design and Controls for Focused DNA Microarrays: Applications in Quality Assurance/control and Normalization for the Health Canada ToxArray BMC Genomics. 2006 | Pubmed ID: 17052352 Detection of Induced Male Germline Mutation: Correlations and Comparisons Between Traditional Germline Mutation Assays, Transgenic Rodent Assays and Expanded Simple Tandem Repeat Instability Assays Mutation Research. Jun, 2006 | Pubmed ID: 16542687 Instability of Expanded Simple Tandem Repeats is Induced in Cell Culture by a Variety of Agents: N-Nitroso-N-ethylurea, Benzo(a)pyrene, Etoposide and Okadaic Acid Mutation Research. Jun, 2006 | Pubmed ID: 16516931 Meeting Report: Validation of Toxicogenomics-based Test Systems: ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use Environmental Health Perspectives. Mar, 2006 | Pubmed ID: 16507466 Assessment of 3-nitrobenzanthrone Reductase Activity in Mammalian Tissues by Normal-phase HPLC with Fluorescence Detection Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2005 | Pubmed ID: 16095987 Detailed Review of Transgenic Rodent Mutation Assays Mutation Research. Sep, 2005 | Pubmed ID: 16081315 A LacZ Transgenic Mouse Assay for the Detection of Mutations in Follicular Granulosa Cells Mutation Research. Oct, 2005 | Pubmed ID: 16039675 Automation of CDNA Microarray Hybridization and Washing Yields Improved Data Quality Journal of Biochemical and Biophysical Methods. Jul, 2005 | Pubmed ID: 16005076 Molecular Insight into the Effects of Hypothyroidism on the Developing Cerebellum Biochemical and Biophysical Research Communications. May, 2005 | Pubmed ID: 15823568 Comprehensive Comparison of Six Microarray Technologies Nucleic Acids Research. 2004 | Pubmed ID: 15333675 Development and Characterization of a Stable Epithelial Cell Line from Muta Mouse Lung Environmental and Molecular Mutagenesis. 2003 | Pubmed ID: 14556224 In Vivo Transgenic Mutation Assays Mutation Research. Oct, 2003 | Pubmed ID: 14550498 Treatment and Sampling Protocols for Transgenic Mutation Assays Environmental and Molecular Mutagenesis. 2003 | Pubmed ID: 12552586 Mutagenicity of the Oral Carcinogen 4-nitroquinoline-1-oxide in Cultured BigBlue Rat Tongue Epithelial Cells and Fibroblasts Mutation Research. Jan, 2003 | Pubmed ID: 12517416 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced Mutagenesis in Cultured Big Blue Rat Mammary Epithelial and Fibroblast Cells Environmental and Molecular Mutagenesis. 2002 | Pubmed ID: 11921195 Transgen Gnagere analyse for Kvantifisering Mann Germ Cell Mutant Frequency Jason M. O'Brien1, Marc A. Beal1, John D. Gingerich1, Lynda Soper1, George R. Douglas1, Carole L. Yauk1, Francesco Marchetti1 1Environmental Health Science and Research Bureau, Health Canada, Environmental Health Centre Biologia
Transgen Gnagere analyse for Kvantifisering Mann Germ Cell Mutant Frequency Jason M. O'Brien1, Marc A. Beal1, John D. Gingerich1, Lynda Soper1, George R. Douglas1, Carole L. Yauk1, Francesco Marchetti1 1Environmental Health Science and Research Bureau, Health Canada, Environmental Health Centre Biologia