Hamed Jafar-Nejad Department of Molecular and Human Genetics Baylor College of Medicine Biography Publications Institution JoVE Articles Hamed Jafar-Nejad Hamed Jafar-Nejad is an Associate Professor in the Department of Molecular & Human Genetics and the Program in Developmental Biology at Baylor College of Medicine. His group is interested in the roles of glycosylation and deglycosylation in the regulation of animal development and human disease pathogenesis. He received his MD degree from Tehran University of Medical Sciences and learned basic molecular biology techniques in a research institute in Iran. He spent one year in the Neuroscience Research Institute at the University of Ottawa, studying the transcriptional regulation of a serotonin receptor implicated in mood disorders with Dr. Paul Albert. He then moved to Houston and started his postdoctoral training in the area of Notch signaling and Drosophila neurogenesis with Dr. Hugo Bellen at Baylor College of Medicine/HHMI. In December 2006, he joined the faculty at the University of Texas Health Science Center at Houston, focusing on a glycosyltransferase called Rumi which he had identified in Drosophila as a key regulator of the Notch signaling pathway. In 2012, he was recruited back to the Department of Molecular & Human Genetics at Baylor, where his group continues their work on the role of glycosylation in animal development and human disease. Hamed’s lab has established a mouse model for a rare disease called Alagille syndrome and has identified Rumi (Poglut1) as a dominant genetic suppressor of the Alagille biliary phenotypes in the mouse. The Jafar-Nejad group is also using Drosophila and mammalian cell culture assays to understand the role of a deglycosylation enzyme called N-glycanase 1 (NGLY1) in animal development and BMP signaling, in hopes of shedding light on the pathophysiology of NGLY1 deficiency in human patients and identifying drug targets for this disease. Publications Unbiased Glycomics: a Powerful Tool in Rare Disease Diagnosis and Research Translational Research : the Journal of Laboratory and Clinical Medicine. 04, 2019 | Pubmed ID: 30528322 Sensitized Genetic Backgrounds Reveal Differential Roles for EGF Repeat Xylosyltransferases In Drosophila Notch Signaling Glycobiology. Aug, 2018 | Pubmed ID: 30169771 A New Model of Alagille Syndrome With Broad Phenotypic Representation Gastroenterology. 03, 2018 | Pubmed ID: 29425927 Generation of an Induced Pluripotent Stem Cell Line (CSCRMi001-A) from a Patient with a New Type of Limb-girdle Muscular Dystrophy (LGMD) Due to a Missense Mutation in POGLUT1 (Rumi) Stem Cell Research. Oct, 2017 | Pubmed ID: 29034878 Tissue-specific Regulation of BMP Signaling by Drosophila N-glycanase 1 ELife. Aug, 2017 | Pubmed ID: 28826503 Xylosylation of the Notch Receptor Preserves the Balance Between Its Activation by Trans-Delta and Inhibition by Cis-ligands in Drosophila PLoS Genetics. Apr, 2017 | Pubmed ID: 28394891 A POGLUT1 Mutation Causes a Muscular Dystrophy with Reduced Notch Signaling and Satellite Cell Loss EMBO Molecular Medicine. 11, 2016 | Pubmed ID: 27807076 Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch The Journal of Biological Chemistry. 07, 2016 | Pubmed ID: 27268051 Jagged1 Heterozygosity in Mice Results in a Congenital Cholangiopathy Which is Reversed by Concomitant Deletion of One Copy of Poglut1 (Rumi) Hepatology (Baltimore, Md.). Feb, 2016 | Pubmed ID: 26235536 The Multiple Roles of Epidermal Growth Factor Repeat O-glycans in Animal Development Glycobiology. Oct, 2015 | Pubmed ID: 26175457 A Congenital Disorder of Deglycosylation: Biochemical Characterization of N-glycanase 1 Deficiency in Patient Fibroblasts Glycobiology. Aug, 2015 | Pubmed ID: 25900930 The Protein O-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in Drosophila PLoS Genetics. Nov, 2014 | Pubmed ID: 25412384 Fringe Proteins Modulate Notch-ligand Cis and Trans Interactions to Specify Signaling States ELife. Sep, 2014 | Pubmed ID: 25255098 Structure-function Analysis of Drosophila Notch Using Genomic Rescue Transgenes Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25053479 Negative Regulation of Notch Signaling by Xylose PLoS Genetics. Jun, 2013 | Pubmed ID: 23754965 Multiple O-glucosylation Sites on Notch Function As a Buffer Against Temperature-dependent Loss of Signaling Development (Cambridge, England). Aug, 2011 | Pubmed ID: 21771811 Regulation of Mammalian Notch Signaling and Embryonic Development by the Protein O-glucosyltransferase Rumi Development (Cambridge, England). May, 2011 | Pubmed ID: 21490058 Role of Glycans and Glycosyltransferases in the Regulation of Notch Signaling Glycobiology. Aug, 2010 | Pubmed ID: 20368670 Novel Function of the Class I BHLH Protein Daughterless in the Negative Regulation of Proneural Gene Expression in the Drosophila Eye EMBO Reports. Nov, 2008 | Pubmed ID: 18758436 Rumi is a CAP10 Domain Glycosyltransferase That Modifies Notch and is Required for Notch Signaling Cell. Jan, 2008 | Pubmed ID: 18243100 Senseless Physically Interacts with Proneural Proteins and Functions As a Transcriptional Co-activator Development (Cambridge, England). May, 2006 | Pubmed ID: 16624856 Senseless and Daughterless Confer Neuronal Identity to Epithelial Cells in the Drosophila Wing Margin Development (Cambridge, England). May, 2006 | Pubmed ID: 16554363 The Tumour-suppressor Genes NF2/Merlin and Expanded Act Through Hippo Signalling to Regulate Cell Proliferation and Apoptosis Nature Cell Biology. Jan, 2006 | Pubmed ID: 16341207 Sec15, a Component of the Exocyst, Promotes Notch Signaling During the Asymmetric Division of Drosophila Sensory Organ Precursors Developmental Cell. Sep, 2005 | Pubmed ID: 16137928 The AXH Domain of Ataxin-1 Mediates Neurodegeneration Through Its Interaction with Gfi-1/Senseless Proteins Cell. Aug, 2005 | Pubmed ID: 16122429 Gfi/Pag-3/senseless Zinc Finger Proteins: a Unifying Theme? Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15456856 Senseless Acts As a Binary Switch During Sensory Organ Precursor Selection Genes & Development. Dec, 2003 | Pubmed ID: 14665671 Mapping Drosophila Mutations with Molecularly Defined P Element Insertions Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12960394 Bestämning av gallgången densitet i mus levern Joshua M. Adams1,2,3, Hamed Jafar-Nejad1,3 1Program in Developmental Biology, Baylor College of Medicine, 2Medical Scientist Training Program (MSTP), Baylor College of Medicine, 3Department of Molecular and Human Genetics, Baylor College of Medicine JoVE 59587 Biologia dello sviluppo Cell Aggregation analyser att utvärdera bindningen av Drosophila skåran med Trans-ligander och dess hämning av Cis-ligander Ashutosh Pandey1, Hamed Jafar-Nejad1,2 1Department of Molecular and Human Genetics, Baylor College of Medicine, 2Program in Developmental Biology, Baylor College of Medicine JoVE 56919 Biologia dello sviluppo
Bestämning av gallgången densitet i mus levern Joshua M. Adams1,2,3, Hamed Jafar-Nejad1,3 1Program in Developmental Biology, Baylor College of Medicine, 2Medical Scientist Training Program (MSTP), Baylor College of Medicine, 3Department of Molecular and Human Genetics, Baylor College of Medicine JoVE 59587 Biologia dello sviluppo
Cell Aggregation analyser att utvärdera bindningen av Drosophila skåran med Trans-ligander och dess hämning av Cis-ligander Ashutosh Pandey1, Hamed Jafar-Nejad1,2 1Department of Molecular and Human Genetics, Baylor College of Medicine, 2Program in Developmental Biology, Baylor College of Medicine JoVE 56919 Biologia dello sviluppo