Hiroshi Nakagawa Herbert Irving Comprehensive Cancer Center Columbia University Biography Publications Institution JoVE Articles Hiroshi Nakagawa has not added a biography. If you are Hiroshi Nakagawa and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor Suppressor Mediated Ubiquitylation of HnRNPK is a Barrier to Oncogenic Translation Nature Communications. Nov, 2022 | Pubmed ID: 36329064 HPV E6 Regulates Therapy Responses in Oropharyngeal Cancer by Repressing the PGC-1α/ERRα Axis JCI Insight. Sep, 2022 | Pubmed ID: 36134662 Detergent Exposure Induces Epithelial Barrier Dysfunction and Eosinophilic Inflammation in the Esophagus Allergy. Jul, 2022 | Pubmed ID: 35899466 CD73 Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis Cellular and Molecular Gastroenterology and Hepatology. 2022 | Pubmed ID: 35108658 Pan-ERBB Kinase Inhibition Augments CDK4/6 Inhibitor Efficacy in Oesophageal Squamous Cell Carcinoma Gut. Apr, 2022 | Pubmed ID: 33789967 3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers Microorganisms. Oct, 2021 | Pubmed ID: 34835308 Patient-derived Organoids As a Platform for Modeling a Patient's Response to Chemoradiotherapy in Esophageal Cancer Scientific Reports. Oct, 2021 | Pubmed ID: 34716381 Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress Via Autophagy Biomolecules. Oct, 2021 | Pubmed ID: 34680112 FANCD2 Limits Acetaldehyde-induced Genomic Instability During DNA Replication in Esophageal Keratinocytes Molecular Oncology. Nov, 2021 | Pubmed ID: 34328261 Stem Cells and Origins of Cancer in the Upper Gastrointestinal Tract Cell Stem Cell. Aug, 2021 | Pubmed ID: 34129814 NOTCH3 Limits the Epithelial-mesenchymal Transition and Predicts a Favorable Clinical Outcome in Esophageal Cancer Cancer Medicine. Jun, 2021 | Pubmed ID: 34042293 Reprogramming of the Esophageal Squamous Carcinoma Epigenome by SOX2 Promotes ADAR1 Dependence Nature Genetics. Jun, 2021 | Pubmed ID: 33972779 Understanding the Cellular Origin and Progression of Esophageal Cancer Using Esophageal Organoids Cancer Letters. Jul, 2021 | Pubmed ID: 33838281 Mutant P53 Regulates Survivin to Foster Lung Metastasis Genes & Development. Apr, 2021 | Pubmed ID: 33737385 MicroRNA-Based Cancer Mortality Risk Scoring System and HTERT Expression in Early-Stage Oral Squamous Cell Carcinoma Journal of Oncology. 2021 | Pubmed ID: 33510789 Rab11-FIP1 Mediates Epithelial-mesenchymal Transition and Invasion in Esophageal Cancer EMBO Reports. Feb, 2021 | Pubmed ID: 33403789 Mitochondrial Dysfunction in Inflammatory Bowel Disease Alters Intestinal Epithelial Metabolism of Hepatic Acylcarnitines The Journal of Clinical Investigation. Jan, 2021 | Pubmed ID: 33141762 Autophagy Mitigates Ethanol-induced Mitochondrial Dysfunction and Oxidative Stress in Esophageal Keratinocytes PloS One. 2020 | Pubmed ID: 32966340 Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury Cerebral Cortex (New York, N.Y. : 1991). Oct, 2020 | Pubmed ID: 32564090 Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma Gastroenterology. Aug, 2020 | Pubmed ID: 32325086 Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids Current Protocols in Stem Cell Biology. Jun, 2020 | Pubmed ID: 32294323 Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three-Dimensional Esophageal Organoids Current Protocols in Stem Cell Biology. Mar, 2020 | Pubmed ID: 32105412 Outcomes of Patients with Submucosal (T1b) Esophageal Adenocarcinoma: a Multicenter Cohort Study Gastrointestinal Endoscopy. Jul, 2020 | Pubmed ID: 31953189 Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Jun, 2020 | Pubmed ID: 31499251 Use of HPSC-derived 3D Organoids and Mouse Genetics to Define the Roles of YAP in the Development of the Esophagus Development (Cambridge, England). Dec, 2019 | Pubmed ID: 31748205 Esophageal 3D Organoids of Mouse Model of Mitochondrial DNA Depletion Show Epithelial Cell Plasticity and Telomere Attrition Oncotarget. Oct, 2019 | Pubmed ID: 31692873 Interplay Between Notch1 and Notch3 Promotes EMT and Tumor Initiation in Squamous Cell Carcinoma Nature Communications. Nov, 2017 | Pubmed ID: 29170450 Long-lived Keratin 15+ Esophageal Progenitor Cells Contribute to Homeostasis and Regeneration The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28481227 Autophagy Mediates Epithelial Cytoprotection in Eosinophilic Oesophagitis Gut. Jul, 2017 | Pubmed ID: 26884425 Immature Myeloid Progenitors Promote Disease Progression in a Mouse Model of Barrett's-like Metaplasia Oncotarget. Oct, 2015 | Pubmed ID: 26460825 Inhibition of Notch Signaling Enhances Transdifferentiation of the Esophageal Squamous Epithelium Towards a Barrett's-like Metaplasia Via KLF4 Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 25558829 Optical Imaging of Periostin Enables Early Endoscopic Detection and Characterization of Esophageal Cancer in Mice Gastroenterology. Feb, 2013 | Pubmed ID: 23085486 3D 오가노이드에서 구강-식도 편평 세포 암종 모델링 Samuel Flashner*1, Cecilia Martin*1,2, Norihiro Matsuura1, Masataka Shimonosono1, Yasuto Tomita1, Masaki Morimoto1, Ogoegbunam Okolo1, Victoria X. Yu1,3, Anuraag S. Parikh1,3, Andres J. P. Klein-Szanto4, Kelley Yan1,2, Joel T. Gabre1,5, Chao Lu1,6, Fatemeh Momen-Heravi1,7, Anil K. Rustgi1,5, Hiroshi Nakagawa1,2,5 1Herbert Irving Comprehensive Cancer Center, Columbia University, 2Organoid and Cell Culture Core, Columbia University Digestive and Liver Diseases Research Center, Columbia University, 3Department of Otolaryngology, Head and Neck Surgery, Columbia University, 4Histopathology Facility, Fox Chase Cancer Center, 5Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, 6Department of Genetics and Development, Columbia University, 7Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University JoVE 64676 Ricerca sul cancro
3D 오가노이드에서 구강-식도 편평 세포 암종 모델링 Samuel Flashner*1, Cecilia Martin*1,2, Norihiro Matsuura1, Masataka Shimonosono1, Yasuto Tomita1, Masaki Morimoto1, Ogoegbunam Okolo1, Victoria X. Yu1,3, Anuraag S. Parikh1,3, Andres J. P. Klein-Szanto4, Kelley Yan1,2, Joel T. Gabre1,5, Chao Lu1,6, Fatemeh Momen-Heravi1,7, Anil K. Rustgi1,5, Hiroshi Nakagawa1,2,5 1Herbert Irving Comprehensive Cancer Center, Columbia University, 2Organoid and Cell Culture Core, Columbia University Digestive and Liver Diseases Research Center, Columbia University, 3Department of Otolaryngology, Head and Neck Surgery, Columbia University, 4Histopathology Facility, Fox Chase Cancer Center, 5Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, 6Department of Genetics and Development, Columbia University, 7Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University JoVE 64676 Ricerca sul cancro