Holger Wille Centre for Prions and Protein Folding Diseases & Department of Biochemistry University of Alberta Biography Publications Institution JoVE Articles Holger Wille has not added a biography. If you are Holger Wille and would like to personalize this page please email our Author Liaison for assistance. Publications The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy PLoS Pathogens. Sep, 2016 | Pubmed ID: 27606840 Neuroinvasion of α-Synuclein Prionoids After Intraperitoneal and Intraglossal Inoculation Journal of Virology. Oct, 2016 | Pubmed ID: 27489279 A Neuronal Culture System to Detect Prion Synaptotoxicity PLoS Pathogens. May, 2016 | Pubmed ID: 27227882 Secretory Pathway Retention of Mutant Prion Protein Induces P38-MAPK Activation and Lethal Disease in Mice Scientific Reports. Apr, 2016 | Pubmed ID: 27117504 The Detection of Infectious Prions: In Vitro Conversion Assays Change the (Folding) Landscape The Journal of Molecular Diagnostics : JMD. May, 2016 | Pubmed ID: 27020948 Toll-like Receptor-mediated Immune Response Inhibits Prion Propagation Glia. Jun, 2016 | Pubmed ID: 26880394 Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains Journal of Virology. Dec, 2015 | Pubmed ID: 26423950 Structural Studies of Truncated Forms of the Prion Protein PrP Biophysical Journal. Mar, 2015 | Pubmed ID: 25809267 Mechanism of Scrapie Prion Precipitation with Phosphotungstate Anions ACS Chemical Biology. May, 2015 | Pubmed ID: 25695325 Subcellular Distribution of the Prion Protein in Sickness and in Health Virus Research. Sep, 2015 | Pubmed ID: 25683509 Octarepeat Region Flexibility Impacts Prion Function, Endoproteolysis and Disease Manifestation EMBO Molecular Medicine. Mar, 2015 | Pubmed ID: 25661904 The Structure of Human Prions: from Biology to Structural Models-considerations and Pitfalls Viruses. Oct, 2014 | Pubmed ID: 25333467 The Structure of the Infectious Prion Protein: Experimental Data and Molecular Models Prion. Jan-Feb, 2014 | Pubmed ID: 24583975 The ZIP5 Ectodomain Co-localizes with PrP and May Acquire a PrP-like Fold That Assembles into a Dimer PloS One. 2013 | Pubmed ID: 24039764 Plasma Membrane Invaginations Containing Clusters of Full-length PrPSc Are an Early Form of Prion-associated Neuropathology in Vivo Neurobiology of Aging. Jun, 2013 | Pubmed ID: 23481568 Degradation of Fungal Prion HET-s(218-289) Induces Formation of a Generic Amyloid Fold Biophysical Journal. May, 2012 | Pubmed ID: 22677387 Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites PLoS Pathogens. Dec, 2011 | Pubmed ID: 22216002 Protease-resistant Prions Selectively Decrease Shadoo Protein PLoS Pathogens. Nov, 2011 | Pubmed ID: 22163178 Spontaneous Generation of Anchorless Prions in Transgenic Mice Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22160704 Self-assembling Small Molecules Form Nanofibrils That Bind Procaspase-3 to Promote Activation Journal of the American Chemical Society. Dec, 2011 | Pubmed ID: 22066605 In Vitro Conversion and Seeded Fibrillization of Posttranslationally Modified Prion Protein Biological Chemistry. May, 2011 | Pubmed ID: 21476870 Family Reunion--the ZIP/prion Gene Family Progress in Neurobiology. Mar, 2011 | Pubmed ID: 21163327 Colloid Formation by Drugs in Simulated Intestinal Fluid Journal of Medicinal Chemistry. May, 2010 | Pubmed ID: 20426472 Molecular Modeling of the Misfolded Insulin Subunit and Amyloid Fibril Biophysical Journal. Dec, 2009 | Pubmed ID: 20006956 Design and Construction of Diverse Mammalian Prion Strains Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19915150 Natural and Synthetic Prion Structure from X-ray Fiber Diffraction Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19805070 Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters PloS One. Sep, 2009 | Pubmed ID: 19784368 Surface Charge of Polyoxometalates Modulates Polymerization of the Scrapie Prion Protein Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19223590 Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19010781 Cryo-immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2008 | Pubmed ID: 19020041 Genes Contributing to Prion Pathogenesis The Journal of General Virology. Jul, 2008 | Pubmed ID: 18559949 Mechanisms of Prion Protein Assembly into Amyloid Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18268326 Small-molecule Aggregates Inhibit Amyloid Polymerization Nature Chemical Biology. Mar, 2008 | Pubmed ID: 18223646 Electron Crystallography of the Scrapie Prion Protein Complexed with Heavy Metals Archives of Biochemistry and Biophysics. Nov, 2007 | Pubmed ID: 17935686 Influence of Water, Fat, and Glycerol on the Mechanism of Thermal Prion Inactivation The Journal of Biological Chemistry. Dec, 2007 | Pubmed ID: 17878157 Human Prions and Plasma Lipoproteins Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16849426 Assembly of Natural and Recombinant Prion Protein into Fibrils Biological Chemistry. Jun, 2005 | Pubmed ID: 16006244 Engineering a 2D Protein-DNA Crystal Angewandte Chemie (International Ed. in English). May, 2005 | Pubmed ID: 15828044 Evidence for Assembly of Prions with Left-handed Beta-helices into Trimers Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15155909 Cytosolic Prion Protein in Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2003 | Pubmed ID: 12904479 Structural Studies of the Scrapie Prion Protein by Electron Crystallography Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11891310 Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils Sara Breid1, Maria E. Bernis1, Julius B. Tachu1, Maria C. Garza2, Holger Wille2, Gültekin Tamgüney1 1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta JoVE 55503 Neuroscienze
Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils Sara Breid1, Maria E. Bernis1, Julius B. Tachu1, Maria C. Garza2, Holger Wille2, Gültekin Tamgüney1 1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta JoVE 55503 Neuroscienze