Hongbo R. Luo Joint Program in Transfusion Medicine, Department of Pathology, Harvard Medical School; Division of Blood Bank, Department of Laboratory Medicine, The Stem Cell Program, Boston Children's Hospital Dana-Farber /Harvard Cancer Center Biography Publications Institution JoVE Articles Hongbo R. Luo has not added a biography. If you are Hongbo R. Luo and would like to personalize this page please email our Author Liaison for assistance. Publications Neutrophil-specific Depletion of Gasdermin D Does Not Protect Against Murine Sepsis Blood. Feb, 2023 | Pubmed ID: 36332166 Heterogeneity of Neutrophils in Cancer: One Size Does Not Fit All Cancer Biology & Medicine. Dec, 2022 | Pubmed ID: 36514901 Identification of the Transgene Integration Site and Host Genome Changes in MRP8-Cre/ires-EGFP Transgenic Mice by Targeted Locus Amplification Frontiers in Immunology. 2022 | Pubmed ID: 35464448 Enzyme-Responsive Peptide Thioesters for Targeting Golgi Apparatus Journal of the American Chemical Society. Apr, 2022 | Pubmed ID: 35404599 Inflammasome-mediated GSDMD Activation Facilitates Escape of Candida Albicans from Macrophages Nature Communications. Nov, 2021 | Pubmed ID: 34795266 Myeloid Lineage Contributes to Pathological Choroidal Neovascularization Formation Via SOCS3 EBioMedicine. Nov, 2021 | Pubmed ID: 34688035 Targeting Multiple Cell Death Pathways Extends the Shelf Life and Preserves the Function of Human and Mouse Neutrophils for Transfusion Science Translational Medicine. 07, 2021 | Pubmed ID: 34321317 -Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation Mesenchymal Stem Cells Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 34124040 Single-cell Transcriptome Profiling Reveals Neutrophil Heterogeneity in Homeostasis and Infection Nature Immunology. 09, 2020 | Pubmed ID: 32719519 Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells Frontiers in Immunology. 2020 | Pubmed ID: 32373117 FDA-approved Disulfiram Inhibits Pyroptosis by Blocking Gasdermin D Pore Formation Nature Immunology. Jul, 2020 | Pubmed ID: 32367036 Interleukin-1β Inhibits Normal Hematopoietic Expansion and Promotes Acute Myeloid Leukemia Progression Via the Bone Marrow Niche Cytotherapy. Mar, 2020 | Pubmed ID: 32024607 Glutaredoxin 1 Up-regulates Deglutathionylation of α4 Integrin and Thereby Restricts Neutrophil Mobilization from Bone Marrow The Journal of Biological Chemistry. Feb, 2019 | Pubmed ID: 30598505 The Role of CXCR2 in Acute Inflammatory Responses and Its Antagonists As Anti-inflammatory Therapeutics Current Opinion in Hematology. Jan, 2019 | Pubmed ID: 30407218 Rheb1 Loss Leads to Increased Hematopoietic Stem Cell Proliferation and Myeloid-biased Differentiation Haematologica. Feb, 2019 | Pubmed ID: 30262562 Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow Stem Cell Reports. 11, 2018 | Pubmed ID: 30392974 Histone Deacetylase 6 Modulates Macrophage Infiltration During Inflammation Theranostics. 2018 | Pubmed ID: 29896294 GSDMD is Critical for Autoinflammatory Pathology in a Mouse Model of Familial Mediterranean Fever The Journal of Experimental Medicine. Jun, 2018 | Pubmed ID: 29793924 Inhibition of IP6K1 Suppresses Neutrophil-mediated Pulmonary Damage in Bacterial Pneumonia Science Translational Medicine. 04, 2018 | Pubmed ID: 29618559 Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death Cell Reports. 03, 2018 | Pubmed ID: 29539421 Positive Regulation of Interleukin-1β Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation Cell Reports. 07, 2017 | Pubmed ID: 28683316 Heterogeneity of Neutrophil Spontaneous Death American Journal of Hematology. Aug, 2017 | Pubmed ID: 28437875 Reactive Oxygen Species-Producing Myeloid Cells Act As a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis Journal of Immunology (Baltimore, Md. : 1950). 04, 2017 | Pubmed ID: 28235862 G-CSF Maintains Controlled Neutrophil Mobilization During Acute Inflammation by Negatively Regulating CXCR2 Signaling The Journal of Experimental Medicine. 09, 2016 | Pubmed ID: 27551153 Myeloid Cell-derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis Immunity. Jan, 2015 | Pubmed ID: 25579427 Molecular Control of PtdIns(3,4,5)P3 Signaling in Neutrophils EMBO Reports. Feb, 2015 | Pubmed ID: 25576302 Proteinase 3 and Serpin B1: a Novel Pathway in the Regulation of Caspase-3 Activation, Neutrophil Spontaneous Apoptosis, and Inflammation Inflammation and Cell Signaling. 2014 | Pubmed ID: 26029732 De Novo Chemoattractants Form Supramolecular Hydrogels for Immunomodulating Neutrophils in Vivo Bioconjugate Chemistry. Dec, 2014 | Pubmed ID: 25398017 Proteinase 3-dependent Caspase-3 Cleavage Modulates Neutrophil Death and Inflammation The Journal of Clinical Investigation. Oct, 2014 | Pubmed ID: 25180606 Microtubule Dynamics Regulates Akt Signaling Via Dynactin P150 Cellular Signalling. Aug, 2014 | Pubmed ID: 24726838 Deficiency of Lipid Phosphatase SHIP Enables Long-term Reconstitution of Hematopoietic Inductive Bone Marrow Microenvironment Developmental Cell. May, 2013 | Pubmed ID: 23725762 Reactive Oxygen Species-induced Actin Glutathionylation Controls Actin Dynamics in Neutrophils Immunity. Dec, 2012 | Pubmed ID: 23159440 Small Molecule-induced Cytosolic Activation of Protein Kinase Akt Rescues Ischemia-elicited Neuronal Death Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22689977 Inositol Hexakisphosphate Kinase 1 Regulates Neutrophil Function in Innate Immunity by Inhibiting Phosphatidylinositol-(3,4,5)-trisphosphate Signaling Nature Immunology. Jun, 2011 | Pubmed ID: 21685907 Phosphoinositide 3-kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21632930 Guanine Nucleotide Exchange Factor Vav1 Regulates Perivascular Homing and Bone Marrow Retention of Hematopoietic Stem and Progenitor Cells Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606370 Pretreatment with Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibitor SF1670 Augments the Efficacy of Granulocyte Transfusion in a Clinically Relevant Mouse Model Blood. Jun, 2011 | Pubmed ID: 21521784 Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21464312 Reactive Oxygen Species As Signaling Molecules in Neutrophil Chemotaxis Communicative & Integrative Biology. May, 2010 | Pubmed ID: 20714413 Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-targeting Anti-cancer Drugs PloS One. Apr, 2010 | Pubmed ID: 20428237 Small-molecule Screen Identifies Reactive Oxygen Species As Key Regulators of Neutrophil Chemotaxis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20142487 Focal Adhesion Kinase Regulates Pathogen-killing Capability and Life Span of Neutrophils Via Mediating Both Adhesion-dependent and -independent Cellular Signals Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19561112 Targeted Deletion of Tumor Suppressor PTEN Augments Neutrophil Function and Enhances Host Defense in Neutropenia-associated Pneumonia Blood. May, 2009 | Pubmed ID: 19286998 Regulation of Innate Immunity by Inositol 1,3,4,5-tetrakisphosphate Cell Cycle (Georgetown, Tex.). Sep, 2008 | Pubmed ID: 18769148 Cancer Cell-derived Clusterin Modulates the Phosphatidylinositol 3'-kinase-Akt Pathway Through Attenuation of Insulin-like Growth Factor 1 During Serum Deprivation Molecular and Cellular Biology. Jul, 2008 | Pubmed ID: 18458059 Inositol Trisphosphate 3-kinase B (InsP3KB) As a Physiological Modulator of Myelopoiesis Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18339802 Constitutive Neutrophil Apoptosis: Mechanisms and Regulation American Journal of Hematology. Apr, 2008 | Pubmed ID: 17924549 Inositol 1,3,4,5-tetrakisphosphate Negatively Regulates Phosphatidylinositol-3,4,5- Trisphosphate Signaling in Neutrophils Immunity. Sep, 2007 | Pubmed ID: 17825589 Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay Yuping Fan*1,2, Yan Teng*3, Fu tong Liu*4, Fengxia Ma1,2, Alan Y. Hsu5, Sizhou Feng1,2, Hongbo R. Luo5 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 2Tianjin Institutes of Health Science, 3Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 4Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, 5Joint Program in Transfusion Medicine, Department of Pathology, Harvard Medical School; Division of Blood Bank, Department of Laboratory Medicine, The Stem Cell Program, Boston Children's Hospital, Dana-Farber /Harvard Cancer Center JoVE 65132 Biologia
Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay Yuping Fan*1,2, Yan Teng*3, Fu tong Liu*4, Fengxia Ma1,2, Alan Y. Hsu5, Sizhou Feng1,2, Hongbo R. Luo5 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 2Tianjin Institutes of Health Science, 3Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 4Haihe Laboratory of Cell Ecosystem, Tianjin Medical University, 5Joint Program in Transfusion Medicine, Department of Pathology, Harvard Medical School; Division of Blood Bank, Department of Laboratory Medicine, The Stem Cell Program, Boston Children's Hospital, Dana-Farber /Harvard Cancer Center JoVE 65132 Biologia