J. Julie Kim Department of Obstetrics and Gynecology Northwestern University Biography Publications Institution JoVE Articles J. Julie Kim has not added a biography. If you are J. Julie Kim and would like to personalize this page please email our Author Liaison for assistance. Publications Selective Progesterone Receptor Modulators in Early Stage Breast Cancer: a Randomized, Placebo-controlled Phase II Window of Opportunity Trial Using Telapristone Acetate Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2019 | Pubmed ID: 31570566 A Small Molecule Inhibitor of the Perinucleolar Compartment, ML246, Attenuates Growth and Spread of Ovarian Cancer Gynecologic Oncology Research and Practice. Month, 2018 | Pubmed ID: 30305911 Application of Ex-vivo Spheroid Model System for the Analysis of Senescence and Senolytic Phenotypes in Uterine Leiomyoma Laboratory Investigation; a Journal of Technical Methods and Pathology. 12, 2018 | Pubmed ID: 30206313 Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells Endocrinology. 10, 2018 | Pubmed ID: 30203004 Oxidative Stress-induced MiRNAs Modulate AKT Signaling and Promote Cellular Senescence in Uterine Leiomyoma Journal of Molecular Medicine (Berlin, Germany). 10, 2018 | Pubmed ID: 30097674 Hormonal Strategies in Gynecologic Cancer: Bridging Biology and Therapy Gynecologic Oncology. 08, 2018 | Pubmed ID: 29933928 Comparative Analysis of AKT and the Related Biomarkers in Uterine Leiomyomas with MED12, HMGA2, and FH Mutations Genes, Chromosomes & Cancer. 10, 2018 | Pubmed ID: 29790226 Mentorship 2.0 Endocrinology. 06, 2018 | Pubmed ID: 29750277 The AKT/BCL-2 Axis Mediates Survival of Uterine Leiomyoma in a Novel 3D Spheroid Model Endocrinology. 03, 2018 | Pubmed ID: 29381777 Microphysiologic Systems in Female Reproductive Biology Experimental Biology and Medicine (Maywood, N.J.). 11, 2017 | Pubmed ID: 29065798 CD55 Regulates Self-renewal and Cisplatin Resistance in Endometrioid Tumors The Journal of Experimental Medicine. Sep, 2017 | Pubmed ID: 28838952 Endometrial Receptivity in the Eutopic Endometrium of Women with Endometriosis: It is Affected, and Let Me Show You Why Fertility and Sterility. 07, 2017 | Pubmed ID: 28602477 Association of Body Mass Index with ER, PR and 14-3-3σ Expression in Tumor and Stroma of Type I and Type II Endometrial Carcinoma Oncotarget. Jun, 2017 | Pubmed ID: 28476021 Development of a Novel Human Recellularized Endometrium That Responds to a 28-day Hormone Treatment Biology of Reproduction. May, 2017 | Pubmed ID: 28449068 A Microfluidic Culture Model of the Human Reproductive Tract and 28-day Menstrual Cycle Nature Communications. 03, 2017 | Pubmed ID: 28350383 Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A The Journal of Clinical Endocrinology and Metabolism. 05, 2017 | Pubmed ID: 28324020 The Allosteric AKT Inhibitor, MK2206, Decreases Tumor Growth and Invasion in Patient Derived Xenografts of Endometrial Cancer Cancer Biology & Therapy. Dec, 2017 | Pubmed ID: 28112582 Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells The Journal of Biological Chemistry. 02, 2017 | Pubmed ID: 28035005 Synuclein-γ in Uterine Serous Carcinoma Impacts Survival: An NRG Oncology/Gynecologic Oncology Group Study Cancer. 04, 2017 | Pubmed ID: 27926776 Dysfunctional MnSOD Leads to Redox Dysregulation and Activation of Prosurvival AKT Signaling in Uterine Leiomyomas Science Advances. Nov, 2016 | Pubmed ID: 27847869 Synuclein-γ (SNCG) Expression in Ovarian Cancer is Associated with High-risk Clinicopathologic Disease Journal of Ovarian Research. Nov, 2016 | Pubmed ID: 27809878 Histologic and Molecular Analysis of Patient Derived Xenografts of High-grade Serous Ovarian Carcinoma Journal of Hematology & Oncology. Sep, 2016 | Pubmed ID: 27655386 Human Fallopian Tube Epithelium Co-culture with Murine Ovarian Follicles Reveals Crosstalk in the Reproductive Cycle Molecular Human Reproduction. 11, 2016 | Pubmed ID: 27542947 Progesterone Receptor Blockade in Human Breast Cancer Cells Decreases Cell Cycle Progression Through G2/M by Repressing G2/M Genes BMC Cancer. 05, 2016 | Pubmed ID: 27215412 Transcriptional Profiling of Human Endocervical Tissues Reveals Distinct Gene Expression in the Follicular and Luteal Phases of the Menstrual Cycle Biology of Reproduction. 06, 2016 | Pubmed ID: 27170437 Two Subtypes of Atypical Leiomyoma: Clinical, Histologic, and Molecular Analysis The American Journal of Surgical Pathology. 07, 2016 | Pubmed ID: 27015034 Akt Regulates Progesterone Receptor B-dependent Transcription and Angiogenesis in Endometrial Cancer Cells Oncogene. 09, 2016 | Pubmed ID: 26996671 Fenretinide: A Potential Treatment for Endometriosis Reproductive Sciences (Thousand Oaks, Calif.). 09, 2016 | Pubmed ID: 26919975 Uterine Leiomyoma Stem Cells: Linking Progesterone to Growth Seminars in Reproductive Medicine. Sep, 2015 | Pubmed ID: 26251118 Human Uterine Leiomyoma Stem/progenitor Cells Expressing CD34 and CD49b Initiate Tumors in Vivo The Journal of Clinical Endocrinology and Metabolism. Apr, 2015 | Pubmed ID: 25658015 Novel Three Dimensional Human Endocervix Cultures Respond to 28-day Hormone Treatment Endocrinology. Apr, 2015 | Pubmed ID: 25635622 Three-dimensional Modeling of the Human Fallopian Tube Fimbriae Gynecologic Oncology. Feb, 2015 | Pubmed ID: 25527363 Ovarian Steroids, Stem Cells and Uterine Leiomyoma: Therapeutic Implications Human Reproduction Update. Jan-Feb, 2015 | Pubmed ID: 25205766 Establishment of Human Patient-derived Endometrial Cancer Xenografts in NOD Scid Gamma Mice for the Study of Invasion and Metastasis PloS One. Month, 2014 | Pubmed ID: 25542024 Influence of AKT on Progesterone Action in Endometrial Diseases Biology of Reproduction. Sep, 2014 | Pubmed ID: 25100707 Molecular Analyses of 6 Different Types of Uterine Smooth Muscle Tumors: Emphasis in Atypical Leiomyoma Cancer. Oct, 2014 | Pubmed ID: 24986214 Microphysiological Modeling of the Reproductive Tract: a Fertile Endeavor Experimental Biology and Medicine (Maywood, N.J.). Sep, 2014 | Pubmed ID: 24737736 Nonobese Diabetic/severe Combined Immunodeficient Murine Xenograft Model for Human Uterine Leiomyoma Fertility and Sterility. May, 2014 | Pubmed ID: 24636398 Activated AKT Pathway Promotes Establishment of Endometriosis Endocrinology. May, 2014 | Pubmed ID: 24605828 Inactivation of AKT Induces Cellular Senescence in Uterine Leiomyoma Endocrinology. Apr, 2014 | Pubmed ID: 24476133 Recreating the Female Reproductive Tract in Vitro Using IPSC Technology in a Linked Microfluidics Environment Stem Cell Research & Therapy. Month, 2013 | Pubmed ID: 24565375 Paracrine Activation of WNT/β-catenin Pathway in Uterine Leiomyoma Stem Cells Promotes Tumor Growth Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24082114 Increased AKT or MEK1/2 Activity Influences Progesterone Receptor Levels and Localization in Endometriosis The Journal of Clinical Endocrinology and Metabolism. Dec, 2013 | Pubmed ID: 24064688 MK-2206, an AKT Inhibitor, Promotes Caspase-independent Cell Death and Inhibits Leiomyoma Growth Endocrinology. Nov, 2013 | Pubmed ID: 24002033 Expression Profiling of Nuclear Receptors Identifies Key Roles of NR4A Subfamily in Uterine Fibroids Molecular Endocrinology (Baltimore, Md.). Apr, 2013 | Pubmed ID: 23550059 Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer Endocrine Reviews. Feb, 2013 | Pubmed ID: 23303565 Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin PloS One. Month, 2012 | Pubmed ID: 22911820 Genome-wide Progesterone Receptor Binding: Cell Type-specific and Shared Mechanisms in T47D Breast Cancer Cells and Primary Leiomyoma Cells PloS One. Month, 2012 | Pubmed ID: 22272226 Increased Activation of the PI3K/AKT Pathway Compromises Decidualization of Stromal Cells from Endometriosis The Journal of Clinical Endocrinology and Metabolism. Jan, 2012 | Pubmed ID: 22072736 The Role of Progesterone Signaling in the Pathogenesis of Uterine Leiomyoma Molecular and Cellular Endocrinology. Jul, 2012 | Pubmed ID: 21672608 Progesterone Receptor-B Induction of BIRC3 Protects Endometrial Cancer Cells from AP1-59-mediated Apoptosis Hormones & Cancer. Jun, 2011 | Pubmed ID: 21760855 Transcription Factor KLF11 Integrates Progesterone Receptor Signaling and Proliferation in Uterine Leiomyoma Cells Cancer Research. Feb, 2010 | Pubmed ID: 20124487 Role of Progesterone in Endometrial Cancer Seminars in Reproductive Medicine. Jan, 2010 | Pubmed ID: 20104432 Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis Seminars in Reproductive Medicine. Jan, 2010 | Pubmed ID: 20104427 Synuclein-gamma (SNCG) May Be a Novel Prognostic Biomarker in Uterine Papillary Serous Carcinoma Gynecologic Oncology. Aug, 2009 | Pubmed ID: 19476987 Progestins Activate the AKT Pathway in Leiomyoma Cells and Promote Survival The Journal of Clinical Endocrinology and Metabolism. May, 2009 | Pubmed ID: 19240153 Induction of Apoptosis in Endometrial Cancer Cells by Psammaplysene A Involves FOXO1 Gynecologic Oncology. Feb, 2009 | Pubmed ID: 19041124 Absence of Progesterone Receptors in a Failed Case of Fertility-sparing Treatment in Early Endometrial Cancer: a Case Report The Journal of Reproductive Medicine. Nov, 2008 | Pubmed ID: 19097521 Perinucleolar Compartment Prevalence is a Phenotypic Pancancer Marker of Malignancy Cancer. Aug, 2008 | Pubmed ID: 18543322 The Androgen and Progesterone Receptors Regulate Distinct Gene Networks and Cellular Functions in Decidualizing Endometrium Endocrinology. Sep, 2008 | Pubmed ID: 18511503 Chemosensitization of Endometrial Cancer Cells Through AKT Inhibition Involves FOXO1 Gynecologic Oncology. Mar, 2008 | Pubmed ID: 18234299 Upstream Stimulatory Factor-2 Regulates Steroidogenic Factor-1 Expression in Endometriosis Molecular Endocrinology (Baltimore, Md.). Apr, 2008 | Pubmed ID: 18165439 The Regulation and Function of the Forkhead Transcription Factor, Forkhead Box O1, is Dependent on the Progesterone Receptor in Endometrial Carcinoma Endocrinology. Apr, 2008 | Pubmed ID: 18096667 Progesterone Receptor Regulates Bcl-2 Gene Expression Through Direct Binding to Its Promoter Region in Uterine Leiomyoma Cells The Journal of Clinical Endocrinology and Metabolism. Nov, 2007 | Pubmed ID: 17785366 Altered Expression of HOXA10 in Endometriosis: Potential Role in Decidualization Molecular Human Reproduction. May, 2007 | Pubmed ID: 17350963 FOXO1A Differentially Regulates Genes of Decidualization Endocrinology. Aug, 2006 | Pubmed ID: 16690806 Role of FOXO1A in the Regulation of Insulin-like Growth Factor-binding Protein-1 in Human Endometrial Cells: Interaction with Progesterone Receptor Biology of Reproduction. Oct, 2005 | Pubmed ID: 15987820 Uterine Receptivity and Implantation: the Regulation and Action of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1), HOXA10 and Forkhead Transcription Factor-1 (FOXO-1) in the Baboon Endometrium Reproductive Biology and Endocrinology : RB&E. Jun, 2004 | Pubmed ID: 15200677 Generation of Multicellular Human Primary Endometrial Organoids Alina R. Murphy*1, Teerawat Wiwatpanit*2, Zhenxiao Lu1, Batzaya Davaadelger1, J. Julie Kim1 1Department of Obstetrics and Gynecology, Northwestern University, 2National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) JoVE 60384 Biologia dello sviluppo
Generation of Multicellular Human Primary Endometrial Organoids Alina R. Murphy*1, Teerawat Wiwatpanit*2, Zhenxiao Lu1, Batzaya Davaadelger1, J. Julie Kim1 1Department of Obstetrics and Gynecology, Northwestern University, 2National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) JoVE 60384 Biologia dello sviluppo