Jack H. Freed National Biomedical Center for Advanced ESR Technology (ACERT), Department of Chemistry and Chemical Biology Cornell University Biography Publications Institution JoVE Articles Jack H. Freed has not added a biography. If you are Jack H. Freed and would like to personalize this page please email our Author Liaison for assistance. Publications Conformational Distributions and Hydrogen Bonding in Gel and Frozen Lipid Bilayers: A High Frequency Spin-Label ESR Study The Journal of Physical Chemistry. B. Feb, 2012 | Pubmed ID: 22324811 2D-ELDOR Study of Heterogeneity and Domain Structure Changes in Plasma Membrane Vesicles Upon Cross-linking of Receptors The Journal of Physical Chemistry. B. Sep, 2011 | Pubmed ID: 21780815 A New Lanczos-based Algorithm for Simulating High-frequency Two-dimensional Electron Spin Resonance Spectra The Journal of Chemical Physics. Jan, 2011 | Pubmed ID: 21261335 Two Conserved Residues Are Important for Inducing Highly Ordered Membrane Domains by the Transmembrane Domain of Influenza Hemagglutinin Biophysical Journal. Jan, 2011 | Pubmed ID: 21190660 Methyl Dynamics of a Ca2+-calmodulin-peptide Complex from NMR/SRLS The Journal of Physical Chemistry. B. Jan, 2011 | Pubmed ID: 21166433 Backbone Dynamics of Deoxy and Carbonmonoxy Hemoglobin by NMR/SRLS The Journal of Physical Chemistry. B. Jan, 2011 | Pubmed ID: 21162544 Channel and Nonchannel Forms of Spin-labeled Gramicidin in Membranes and Their Equilibria The Journal of Physical Chemistry. B. Jan, 2011 | Pubmed ID: 21142163 Mechanistic Understanding of Pyrococcus Horikoshii Dph2, a [4Fe-4S] Enzyme Required for Diphthamide Biosynthesis Molecular BioSystems. Jan, 2011 | Pubmed ID: 20931132 Structural Dynamics of Bio-macromolecules by NMR: the Slowly Relaxing Local Structure Approach Progress in Nuclear Magnetic Resonance Spectroscopy. May, 2010 | Pubmed ID: 20625480 The Lipid-binding Domain of Wild Type and Mutant Alpha-synuclein: Compactness and Interconversion Between the Broken and Extended Helix Forms The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20592036 Comment on "The Physical Basis of Model-free Analysis of NMR Relaxation Data from Proteins and Complex Fluids" [J. Chem. Phys. 131, 224507 (2009)] The Journal of Chemical Physics. May, 2010 | Pubmed ID: 20515116 A Multifrequency EPR Study of Fe2+ and Mn2+ Ions in a ZnSiF(6).6H2O Single Crystal at Liquid-helium Temperatures Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jul, 2010 | Pubmed ID: 20395160 Multifrequency Electron Spin Resonance Study of the Dynamics of Spin Labeled T4 Lysozyme The Journal of Physical Chemistry. B. Apr, 2010 | Pubmed ID: 20361789 Structure of the Ternary Complex Formed by a Chemotaxis Receptor Signaling Domain, the CheA Histidine Kinase, and the Coupling Protein CheW As Determined by Pulsed Dipolar ESR Spectroscopy Biochemistry. May, 2010 | Pubmed ID: 20355710 Calculation of Double-Quantum-Coherence Two-dimensional Spectra: Distance Measurements and Orientational Correlations Applied Magnetic Resonance. Dec, 2009 | Pubmed ID: 20161423 Scanned-probe Detection of Electron Spin Resonance from a Nitroxide Spin Probe Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20018707 Determination of Tie-line Fields for Coexisting Lipid Phases: an ESR Study The Journal of Physical Chemistry. B. Mar, 2009 | Pubmed ID: 19673072 Fusion Peptide from Influenza Hemagglutinin Increases Membrane Surface Order: an Electron-spin Resonance Study Biophysical Journal. Jun, 2009 | Pubmed ID: 19527651 Molecular-scale Force Measurement in a Coiled-coil Peptide Dimer by Electron Spin Resonance Journal of the American Chemical Society. Apr, 2009 | Pubmed ID: 19331323 A Scissors Mechanism for Stimulation of SNARE-mediated Lipid Mixing by Cholesterol Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251653 Multifrequency Electron Spin Resonance Spectra of a Spin-labeled Protein Calculated from Molecular Dynamics Simulations Journal of the American Chemical Society. Feb, 2009 | Pubmed ID: 19191603 Membrane-bound Alpha-synuclein Forms an Extended Helix: Long-distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles Journal of the American Chemical Society. Oct, 2008 | Pubmed ID: 18774805 Using Markov Models to Simulate Electron Spin Resonance Spectra from Molecular Dynamics Trajectories The Journal of Physical Chemistry. B. Sep, 2008 | Pubmed ID: 18698714 Simulating Electron Spin Resonance Spectra of Nitroxide Spin Labels from Molecular Dynamics and Stochastic Trajectories The Journal of Chemical Physics. Apr, 2008 | Pubmed ID: 18447510 Parametrization, Molecular Dynamics Simulation, and Calculation of Electron Spin Resonance Spectra of a Nitroxide Spin Label on a Polyalanine Alpha-helix The Journal of Physical Chemistry. B. May, 2008 | Pubmed ID: 18412413 Determination of the Oligomeric States of Human and Rat Monoamine Oxidases in the Outer Mitochondrial Membrane and Octyl Beta-D-glucopyranoside Micelles Using Pulsed Dipolar Electron Spin Resonance Spectroscopy Biochemistry. Feb, 2008 | Pubmed ID: 18198902 Oxygen Effects on the EPR Signals from Wood Charcoals: Experimental Results and the Development of a Model The Journal of Physical Chemistry. B. Nov, 2007 | Pubmed ID: 17973414 An Improved Picture of Methyl Dynamics in Proteins from Slowly Relaxing Local Structure Analysis of 2H Spin Relaxation The Journal of Physical Chemistry. B. Nov, 2007 | Pubmed ID: 17941658 Conformational Motion of the ABC Transporter MsbA Induced by ATP Hydrolysis PLoS Biology. Oct, 2007 | Pubmed ID: 17927448 Dynamic Molecular Structure and Phase Diagram of DPPC-cholesterol Binary Mixtures: a 2D-ELDOR Study The Journal of Physical Chemistry. B. Sep, 2007 | Pubmed ID: 17760438 2D-ELDOR Using Full S(c-) Fitting and Absorption Lineshapes Journal of Magnetic Resonance (San Diego, Calif. : 1997). Oct, 2007 | Pubmed ID: 17681478 Rigid Body Refinement of Protein Complexes with Long-range Distance Restraints from Pulsed Dipolar ESR Methods in Enzymology. 2007 | Pubmed ID: 17609128 Measuring Distances by Pulsed Dipolar ESR Spectroscopy: Spin-labeled Histidine Kinases Methods in Enzymology. 2007 | Pubmed ID: 17609127 Characterizing the Structure and Dynamics of Folded Oligomers: Pulsed ESR Studies of Peptoid Helices Chemical Communications (Cambridge, England). Jan, 2007 | Pubmed ID: 17220976 Modeling the Effects of Structure and Dynamics of the Nitroxide Side Chain on the ESR Spectra of Spin-labeled Proteins The Journal of Physical Chemistry. B. Dec, 2006 | Pubmed ID: 17181284 Dynamics of the Nitroxide Side Chain in Spin-labeled Proteins The Journal of Physical Chemistry. B. Dec, 2006 | Pubmed ID: 17181283 Collective Fluctuations in Ordered Fluids Investigated by Two-dimensional Electron-electron Double Resonance Spectroscopy The Journal of Physical Chemistry. B. Nov, 2006 | Pubmed ID: 17125397 Methyl Dynamics in Proteins from NMR Slowly Relaxing Local Structure Spin Relaxation Analysis: A New Perspective The Journal of Physical Chemistry. B. Oct, 2006 | Pubmed ID: 17034251 Inter-helix Distances in Lysophospholipid Micelle-bound Alpha-synuclein from Pulsed ESR Measurements Journal of the American Chemical Society. Aug, 2006 | Pubmed ID: 16881616 Protein Dynamics from NMR: the Slowly Relaxing Local Structure Analysis Compared with Model-free Analysis The Journal of Physical Chemistry. A. Jul, 2006 | Pubmed ID: 16821820 Reconstruction of the Chemotaxis Receptor-kinase Assembly Nature Structural & Molecular Biology. May, 2006 | Pubmed ID: 16622408 Coexisting Domains in the Plasma Membranes of Live Cells Characterized by Spin-label ESR Spectroscopy Biophysical Journal. Jun, 2006 | Pubmed ID: 16565045 Electron Spin Resonance Microscopy Applied to the Study of Controlled Drug Release Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2006 | Pubmed ID: 16460828 EPR Distance Measurements Support a Model for Long-range Radical Initiation in E. Coli Ribonucleotide Reductase Journal of the American Chemical Society. Nov, 2005 | Pubmed ID: 16248626 High-frequency ESR at ACERT Magnetic Resonance in Chemistry : MRC. Nov, 2005 | Pubmed ID: 16235203 Effects of Finite Pulse Width on Two-dimensional Fourier Transform Electron Spin Resonance Journal of Magnetic Resonance (San Diego, Calif. : 1997). Dec, 2005 | Pubmed ID: 16150620 Maximum Entropy: a Complement to Tikhonov Regularization for Determination of Pair Distance Distributions by Pulsed ESR Journal of Magnetic Resonance (San Diego, Calif. : 1997). Dec, 2005 | Pubmed ID: 16137901 A Variable Temperature EPR Study of Mn(2+)-doped NH(4)Cl(0.9)I(0.1) Single Crystal at 170 GHz: Zero-field Splitting Parameter and Its Absolute Sign Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jun, 2005 | Pubmed ID: 15862243 New Method for Determining Tie-lines in Coexisting Membrane Phases Using Spin-label ESR Biochimica Et Biophysica Acta. Feb, 2005 | Pubmed ID: 15670735 The Determination of Pair Distance Distributions by Pulsed ESR Using Tikhonov Regularization Journal of Magnetic Resonance (San Diego, Calif. : 1997). Feb, 2005 | Pubmed ID: 15649755 Dynamic Molecular Structure of DPPC-DLPC-cholesterol Ternary Lipid System by Spin-label Electron Spin Resonance Biophysical Journal. Oct, 2004 | Pubmed ID: 15454445 Spin-labeled Gramicidin A: Channel Formation and Dissociation Biophysical Journal. Nov, 2004 | Pubmed ID: 15326023 Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids: Implications for Depletion of Endoplasmic Reticulum Calcium Stores and Apoptosis in Cholesterol-loaded Macrophages The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15215242 Measurement of Large Distances in Biomolecules Using Double-quantum Filtered Refocused Electron Spin-echoes Journal of the American Chemical Society. Jun, 2004 | Pubmed ID: 15212500 Hydration, Structure, and Molecular Interactions in the Headgroup Region of Dioleoylphosphatidylcholine Bilayers: an Electron Spin Resonance Study Biophysical Journal. Dec, 2003 | Pubmed ID: 14645091 High Resolution Electron Spin Resonance Microscopy Journal of Magnetic Resonance (San Diego, Calif. : 1997). Nov, 2003 | Pubmed ID: 14568522 Ordered and Disordered Phases Coexist in Plasma Membrane Vesicles of RBL-2H3 Mast Cells. An ESR Study Biophysical Journal. Aug, 2003 | Pubmed ID: 12885671 Lipid-gramicidin Interactions: Dynamic Structure of the Boundary Lipid by 2D-ELDOR Biophysical Journal. May, 2003 | Pubmed ID: 12719265 A 2D-ELDOR Study of the Liquid Ordered Phase in Multilamellar Vesicle Membranes Biophysical Journal. Apr, 2003 | Pubmed ID: 12668470 End-to-end Correlation for a C-12 Hydrocarbon Chain Journal of Magnetic Resonance (San Diego, Calif. : 1997). Feb, 2003 | Pubmed ID: 12615159 Variable-frequency EPR Study of Mn(2+)-doped NH(4)Cl(0.9)I(0.1) Single Crystal at 9.6, 36, and 249.9 GHz: Structural Phase Transition Journal of Magnetic Resonance (San Diego, Calif. : 1997). Feb, 2003 | Pubmed ID: 12615154 Domain Flexibility in Ligand-free and Inhibitor-bound Escherichia Coli Adenylate Kinase Based on a Mode-coupling Analysis of 15N Spin Relaxation Biochemistry. May, 2002 | Pubmed ID: 12009888 Protein Structure Determination Using Long-distance Constraints from Double-quantum Coherence ESR: Study of T4 Lysozyme Journal of the American Chemical Society. May, 2002 | Pubmed ID: 11996571 A Novel View of Domain Flexibility in E. Coli Adenylate Kinase Based on Structural Mode-coupling (15)N NMR Relaxation Journal of Molecular Biology. Jan, 2002 | Pubmed ID: 11779236 A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke Long-Xi Yu1, Boris G. Dzikovski2, Jack H. Freed2 1CDCF-AOX Lab, 2National Biomedical Center for Advanced ESR Technology (ACERT), Department of Chemistry and Chemical Biology, Cornell University JoVE 3406 Bioingegneria
A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke Long-Xi Yu1, Boris G. Dzikovski2, Jack H. Freed2 1CDCF-AOX Lab, 2National Biomedical Center for Advanced ESR Technology (ACERT), Department of Chemistry and Chemical Biology, Cornell University JoVE 3406 Bioingegneria