Joshua J. Breunig Board of Governor’s Regenerative Medicine Institute Cedars-Sinai Medical Center Biography Publications Institution JoVE Articles Joshua J. Breunig has not added a biography. If you are Joshua J. Breunig and would like to personalize this page please email our Author Liaison for assistance. Publications Tetracycline-Inducible and Reversible Stable Gene Expression in Human IPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain Current Protocols. Jun, 2023 | Pubmed ID: 37283517 Murine-Derived Glioma Organoids and Cell Line Culture Systems Current Protocols. Feb, 2023 | Pubmed ID: 36744986 First-line Immune Checkpoint Inhibitor Combinations in Metastatic Renal Cell Carcinoma: Where Are We Going, Where Have We Been? Drugs. Mar, 2022 | Pubmed ID: 35175588 SF3B1 Inhibition Disrupts Malignancy and Prolongs Survival in Glioblastoma Patients Through BCL2L1 splicing and MTOR/ß-catenin Pathways Imbalances Journal of Experimental & Clinical Cancer Research : CR. Jan, 2022 | Pubmed ID: 35086552 Neurosurgery at the Crossroads of Immunology and Nanotechnology. New Reality in the COVID-19 Pandemic Advanced Drug Delivery Reviews. Feb, 2022 | Pubmed ID: 34808227 Integrated Single-cell Transcriptome Analysis Reveals Heterogeneity of Esophageal Squamous Cell Carcinoma Microenvironment Nature Communications. Dec, 2021 | Pubmed ID: 34921160 Discovery of RNA Proximal Proteins Via Proximity-dependent Biotinylation RNA Biology. Dec, 2021 | Pubmed ID: 34006179 RELA Fusion-Positive Ependymoma in a Child with Down Syndrome: A Case Report Pediatric Neurosurgery. 2021 | Pubmed ID: 33690230 A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma Cancer Research. Mar, 2021 | Pubmed ID: 33402390 Preparation, Assembly, and Transduction of Transgenic Elements Using Mosaic Analysis with Dual Recombinases (MADR) STAR Protocols. Dec, 2020 | Pubmed ID: 33377093 Generation of Murine and Human MADR Recipient Cell Lines for Locus-Specific, Stable Integration of Transgenic Elements STAR Protocols. Dec, 2020 | Pubmed ID: 33377078 Splicing Machinery Dysregulation Drives Glioblastoma Development/aggressiveness: Oncogenic Role of SRSF3 Brain : a Journal of Neurology. Dec, 2020 | Pubmed ID: 33141183 Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements Cell. Sep, 2019 | Pubmed ID: 31539496 In Utero Electroporation-based Translating Ribosome Affinity Purification Identifies Age-dependent MRNA Expression in Cortical Pyramidal Neurons Neuroscience Research. Jun, 2019 | Pubmed ID: 29857015 Glioma Cell Proliferation is Enhanced in the Presence of Tumor-derived Cilia Vesicles Cilia. 2018 | Pubmed ID: 30410731 Inflammation-induced Gro1 Triggers Senescence in Neuronal Progenitors: Effects of Estradiol Journal of Neuroinflammation. Sep, 2018 | Pubmed ID: 30201019 Inducible Expression of GDNF in Transplanted IPSC-Derived Neural Progenitor Cells Stem Cell Reports. 06, 2018 | Pubmed ID: 29706501 Metabolic Characterization of Isocitrate Dehydrogenase (IDH) Mutant and IDH Wildtype Gliomaspheres Uncovers Cell Type-specific Vulnerabilities Cancer & Metabolism. 2018 | Pubmed ID: 29692895 Tetracycline-Inducible and Reversible Stable Gene Expression in Human IPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain Current Protocols in Stem Cell Biology. May, 2017 | Pubmed ID: 28510333 Lethal Giant Lineage Tracing: Mutating Locally, Acting Globally Neuron. May, 2017 | Pubmed ID: 28472645 BCL6 Promotes Glioma and Serves As a Therapeutic Target Proceedings of the National Academy of Sciences of the United States of America. Apr, 2017 | Pubmed ID: 28356518 Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma Cell Reports. Dec, 2016 | Pubmed ID: 28009307 Disruption of KIF3A in Patient-derived Glioblastoma Cells: Effects on Ciliogenesis, Hedgehog Sensitivity, and Tumorigenesis Oncotarget. Feb, 2016 | Pubmed ID: 26760767 In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2016 | Pubmed ID: 26666451 Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma Cell Reports. Jul, 2015 | Pubmed ID: 26146073 Lost Highway(s): Barriers to Postnatal Cortical Neurogenesis and Implications for Brain Repair Frontiers in Cellular Neuroscience. 2015 | Pubmed ID: 26136658 A Transposon-mediated System for Flexible Control of Transgene Expression in Stem and Progenitor-derived Lineages Stem Cell Reports. Mar, 2015 | Pubmed ID: 25702640 Mutations Within the Pathogenic Region of Herpes Simplex Virus 1 GK Signal Sequences Alter Cell Surface Expression and Neurovirulence Journal of Virology. Mar, 2015 | Pubmed ID: 25505072 T-cell TGF-β Signaling Abrogation Restricts Medulloblastoma Progression Proceedings of the National Academy of Sciences of the United States of America. Aug, 2014 | Pubmed ID: 25082897 Brain Injury, Neuroinflammation and Alzheimer's Disease Frontiers in Aging Neuroscience. 2013 | Pubmed ID: 23874297 A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2013 | Pubmed ID: 23575824 Arborization of Dendrites by Developing Neocortical Neurons is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23392690 Rapid Genetic Targeting of Pial Surface Neural Progenitors and Immature Neurons by Neonatal Electroporation Neural Development. 2012 | Pubmed ID: 22776033 Basic Biology and Mechanisms of Neural Ciliogenesis and the B9 Family Molecular Neurobiology. Jun, 2012 | Pubmed ID: 22644387 Development and Distribution of Neuronal Cilia in Mouse Neocortex The Journal of Comparative Neurology. Mar, 2012 | Pubmed ID: 22020803 FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-dependent Neurogenesis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011 | Pubmed ID: 22031906 Neural Stem Cells: Historical Perspective and Future Prospects Neuron. May, 2011 | Pubmed ID: 21609820 Coordinating Migratory Neuron Polarization by Numb-ing Communication Developmental Cell. May, 2011 | Pubmed ID: 21571215 Not(ch) Just Development: Notch Signalling in the Adult Brain Nature Reviews. Neuroscience. May, 2011 | Pubmed ID: 21505516 Failed Cytokinesis of Neural Progenitors in Citron Kinase-deficient Rats Leads to Multiciliated Neurons Cerebral Cortex (New York, N.Y. : 1991). Feb, 2011 | Pubmed ID: 20525772 Cilia in the Brain: Going with the Flow Nature Neuroscience. Jun, 2010 | Pubmed ID: 20498683 Profiling Identifies Precursor Suspects: Notch Family Again! Cell Stem Cell. May, 2010 | Pubmed ID: 20452310 Decision by Division: Making Cortical Maps Trends in Neurosciences. May, 2009 | Pubmed ID: 19380167 Primary Cilia Regulate Hippocampal Neurogenesis by Mediating Sonic Hedgehog Signaling Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18728187 The Stumpy Gene is Required for Mammalian Ciliogenesis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18287022 Everything That Glitters Isn't Gold: a Critical Review of Postnatal Neural Precursor Analyses Cell Stem Cell. Dec, 2007 | Pubmed ID: 18371403 Notch Regulates Cell Fate and Dendrite Morphology of Newborn Neurons in the Postnatal Dentate Gyrus Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18077357 Numb and Numbl Are Required for Maintenance of Cadherin-based Adhesion and Polarity of Neural Progenitors Nature Neuroscience. Jul, 2007 | Pubmed ID: 17589506 The PRb/E2F Cell-cycle Pathway Mediates Cell Death in Parkinson's Disease Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17360686 Glowing Green Pyramids: a False Positive for Neocortical Neurogenesis Reveals a Novel Neuronal-microglial Fusion in the Postnatal Brain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2007 | Pubmed ID: 17304702 Nestin-CreER Mice Reveal DNA Synthesis by Nonapoptotic Neurons Following Cerebral Ischemia Hypoxia Cerebral Cortex (New York, N.Y. : 1991). Nov, 2007 | Pubmed ID: 17259645 Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease Current Stem Cell Reports. | Pubmed ID: 28983454 Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures (Video) | JoVE Katie B. Grausam*1, Joshua J. Breunig*1,2,3,4,5 1Board of Governor’s Regenerative Medicine Institute, Cedars-Sinai Medical Center, 2Center for Neural Sciences in Medicine, Cedars-Sinai Medical Center, 3Department of Biomedical Sciences, Cedars-Sinai Medical Center, 4Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 5Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles JoVE 65286 Ricerca sul cancro Neonatal Pial Surface Electroporation Rachelle Levy1, Jessica Molina2, Moise Danielpour*1, Joshua J. Breunig*2 1Department of Neurosurgery, Regenerative Medicine Institute, Cedars-Sinai Medical Center, 2Department of Biomedical Sciences, Regenerative Medicine Institute, Cedars-Sinai Medical Center JoVE 51319 Neuroscienze
Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures (Video) | JoVE Katie B. Grausam*1, Joshua J. Breunig*1,2,3,4,5 1Board of Governor’s Regenerative Medicine Institute, Cedars-Sinai Medical Center, 2Center for Neural Sciences in Medicine, Cedars-Sinai Medical Center, 3Department of Biomedical Sciences, Cedars-Sinai Medical Center, 4Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 5Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles JoVE 65286 Ricerca sul cancro
Neonatal Pial Surface Electroporation Rachelle Levy1, Jessica Molina2, Moise Danielpour*1, Joshua J. Breunig*2 1Department of Neurosurgery, Regenerative Medicine Institute, Cedars-Sinai Medical Center, 2Department of Biomedical Sciences, Regenerative Medicine Institute, Cedars-Sinai Medical Center JoVE 51319 Neuroscienze