Karen Mossman Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research McMaster University Biography Publications Institution JoVE Articles Karen Mossman has not added a biography. If you are Karen Mossman and would like to personalize this page please email our Author Liaison for assistance. Publications Danger, Diversity and Priming in Innate Antiviral Immunity Cytokine & Growth Factor Reviews. Jul, 2014 | Pubmed ID: 25081316 Type-I Interferon Signaling Through ISGF3 Complex is Required for Sustained Rip3 Activation and Necroptosis in Macrophages Proceedings of the National Academy of Sciences of the United States of America. Aug, 2014 | Pubmed ID: 25049377 Extracellular DsRNA: Its Function and Mechanism of Cellular Uptake Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jun, 2014 | Pubmed ID: 24905198 Novel Roles of Cytoplasmic ICP0: Proteasome-independent Functions of the RING Finger Are Required to Block Interferon-stimulated Gene Production but Not to Promote Viral Replication Journal of Virology. Jul, 2014 | Pubmed ID: 24807717 Permissiveness of Human Cancer Cells to Oncolytic Bovine Herpesvirus 1 is Mediated in Part by KRAS Activity Journal of Virology. Jun, 2014 | Pubmed ID: 24696490 Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2014 | Pubmed ID: 24343053 Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2014 | Pubmed ID: 24048442 Combining Oncolytic HSV-1 with Immunogenic Cell Death-inducing Drug Mitoxantrone Breaks Cancer Immune Tolerance and Improves Therapeutic Efficacy Cancer Immunology Research. Nov, 2013 | Pubmed ID: 24777969 Rewiring Cancer Cell Death to Enhance Oncolytic Viro-immunotherapy Oncoimmunology. Dec, 2013 | Pubmed ID: 24498567 HIV-1 Gp120 Induces TLR2- and TLR4-mediated Innate Immune Activation in Human Female Genital Epithelium Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013 | Pubmed ID: 24043886 Novel Paradigms of Innate Immune Sensing of Viral Infections Cytokine. Sep, 2013 | Pubmed ID: 23800788 Proinflammatory Cytokines and Chemokines - but Not Interferon-β - Produced in Response to HSV-2 in Primary Human Genital Epithelial Cells Are Associated with Viral Replication and the Presence of the Virion Host Shutoff Protein American Journal of Reproductive Immunology (New York, N.Y. : 1989). Sep, 2013 | Pubmed ID: 23621693 The Herpes Simplex Virus 1-encoded Envelope Glycoprotein B Activates NF-κB Through the Toll-like Receptor 2 and MyD88/TRAF6-dependent Signaling Pathway PloS One. 2013 | Pubmed ID: 23382920 MARCO is Required for TLR2- and Nod2-mediated Responses to Streptococcus Pneumoniae and Clearance of Pneumococcal Colonization in the Murine Nasopharynx Journal of Immunology (Baltimore, Md. : 1950). Jan, 2013 | Pubmed ID: 23197261 Recent Advances in Understanding Viral Evasion of Type I Interferon Immunology. Mar, 2013 | Pubmed ID: 23173987 Comparative Functional Evaluation of Immunocompetent Mouse Breast Cancer Models Established from PyMT-tumors Using Small Animal PET with [(18)F]FDG and [(18)F]FLT American Journal of Nuclear Medicine and Molecular Imaging. 2012 | Pubmed ID: 23133804 Encefalite Di Anti-NMDA Receptor. La Malattia, La Diagnosi Ed Il Immunobiology Autoimmunity Reviews. Mar, 2012 | Pubmed ID: 22440397 The Nitric Oxide Pathway Provides Innate Antiviral Protection in Conjunction with the Type I Interferon Pathway in Fibroblasts PloS One. 2012 | Pubmed ID: 22363706 Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway Via Direct Interaction with RIG-I and MDA-5 Journal of Virology. Apr, 2012 | Pubmed ID: 22301138 Methods Related to Molecular Virology Methods (San Diego, Calif.). Oct, 2011 | Pubmed ID: 22050902 Varicella-zoster Virus Immediate-early Protein ORF61 Abrogates the IRF3-mediated Innate Immune Response Through Degradation of Activated IRF3 Journal of Virology. Nov, 2011 | Pubmed ID: 21835786 Membrane Perturbation Elicits an IRF3-dependent, Interferon-independent Antiviral Response Journal of Virology. Oct, 2011 | Pubmed ID: 21813605 Retroviral Expression of MIR2 Decreases Both Surface MHC Class I and the Alloimmune CTL Response Journal of Tissue Engineering and Regenerative Medicine. Jul, 2011 | Pubmed ID: 21695793 A Critical Role for IL-15 in TLR-mediated Innate Antiviral Immunity Against Genital HSV-2 Infection Immunology and Cell Biology. Aug, 2011 | Pubmed ID: 21339766 IL 15 E Il Tipo L'interferone Sono Necessari Per L'attivazione Delle Cellule NK Tumoricidal Dalle Cellule Dendritiche Infettate Da Virus Cancer Research. Apr, 2011 | Pubmed ID: 21307131 L'immunità Adattativa Antivirale è Un Fattore Determinante Del Successo Terapeutico Dell'oncolytic Virotherapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011 | Pubmed ID: 21119618 Treating Viral Exacerbations of Chronic Obstructive Pulmonary Disease: Insights from a Mouse Model of Cigarette Smoke and H1N1 Influenza Infection PloS One. 2010 | Pubmed ID: 20967263 Replication of Subgenomic Hepatitis C Virus Replicons in Mouse Fibroblasts is Facilitated by Deletion of Interferon Regulatory Factor 3 and Expression of Liver-specific MicroRNA 122 Journal of Virology. Sep, 2010 | Pubmed ID: 20592082 Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2010 | Pubmed ID: 20551916 Cellular Localization of the Herpes Simplex Virus ICP0 Protein Dictates Its Ability to Block IRF3-mediated Innate Immune Responses PloS One. 2010 | Pubmed ID: 20454685 An Accessory to the 'Trinity': SR-As Are Essential Pathogen Sensors of Extracellular DsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses PLoS Pathogens. Mar, 2010 | Pubmed ID: 20360967 Innate and Adaptive Immune Responses to Herpes Simplex Virus Viruses. Dec, 2009 | Pubmed ID: 21994578 Long Double-stranded RNA Induces an Antiviral Response Independent of IFN Regulatory Factor 3, IFN-beta Promoter Stimulator 1, and IFN Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19864603 Mechanisms Employed by Herpes Simplex Virus 1 to Inhibit the Interferon Response Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Sep, 2009 | Pubmed ID: 19694546 Exposure to Cigarette Smoke Suppresses IL-15 Generation and Its Regulatory NK Cell Functions in Poly I:C-augmented Human PBMCs Molecular Immunology. Sep, 2009 | Pubmed ID: 19592095 Cell Fusion-induced Activation of Interferon-stimulated Genes is Not Required for Restriction of a Herpes Simplex Virus VP16/ICP0 Mutant in Heterokarya Formed Between Permissive and Restrictive Cells Journal of Virology. Sep, 2009 | Pubmed ID: 19535444 Differential Modification of Interferon Regulatory Factor 3 Following Virus Particle Entry Journal of Virology. May, 2009 | Pubmed ID: 19211751 Characterization of the Interferon Regulatory Factor 3-mediated Antiviral Response in a Cell Line Deficient for IFN Production Molecular Immunology. Jan, 2009 | Pubmed ID: 19038458 Cigarette Smoke Attenuation of Poly I:C-induced Innate Antiviral Responses in Human PBMC is Mainly Due to Inhibition of IFN-beta Production Molecular Immunology. Feb, 2009 | Pubmed ID: 18930547 FimH Adhesin of Type 1 Fimbriae is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling PLoS Pathogens. Dec, 2008 | Pubmed ID: 19057665 Cutting Edge: FimH Adhesin of Type 1 Fimbriae is a Novel TLR4 Ligand Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18981086 Restoration of Vitamin C Synthesis in Transgenic Gulo-/- Mice by Helper-dependent Adenovirus-based Expression of Gulonolactone Oxidase Human Gene Therapy. Dec, 2008 | Pubmed ID: 18764764 Cigarette Smoke Suppresses Type I Interferon-mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Mar, 2008 | Pubmed ID: 18338949 Impairment of Human NK Cell Cytotoxic Activity and Cytokine Release by Cigarette Smoke Journal of Leukocyte Biology. Mar, 2008 | Pubmed ID: 18055568 Presentazione Dell'antigene Di Fatto Rilasciato Dalle Cellule Dendritiche Del Peptide-pulsato Non è Soppressa Dalla Presenza Di CTL Attivo Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17911587 Distinct Functional Motifs Within the IL-17 Receptor Regulate Signal Transduction and Target Gene Expression Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17456598 La Risposta Di IFN-indipendente All'ingresso Di Particelle Di Virus Fornisce Una Prima Linea Di Difesa Antivirale Che è Indipendente Da TLR E Retinoic Acid Inducible Gene I Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006 | Pubmed ID: 17114474 Induction of Innate Immunity Against Herpes Simplex Virus Type 2 Infection Via Local Delivery of Toll-like Receptor Ligands Correlates with Beta Interferon Production Journal of Virology. Oct, 2006 | Pubmed ID: 17005672 Identification of a Novel Pathway Essential for the Immediate-early, Interferon-independent Antiviral Response to Enveloped Virions Journal of Virology. Jan, 2006 | Pubmed ID: 16352547 ICP0 Prevents RNase L-independent RRNA Cleavage in Herpes Simplex Virus Type 1-infected Cells Journal of Virology. Jan, 2006 | Pubmed ID: 16352546 Functional Inaccessibility of Quiescent Herpes Simplex Virus Genomes Virology Journal. 2005 | Pubmed ID: 16300675 The Role of ICP0-Null HSV-1 and Interferon Signaling Defects in the Effective Treatment of Breast Adenocarcinoma Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2005 | Pubmed ID: 16140040 Herpesviruses and the Innate Immune Response Viral Immunology. 2005 | Pubmed ID: 16035939 Analysis of Anti-interferon Properties of the Herpes Simplex Virus Type I ICP0 Protein Methods in Molecular Medicine. 2005 | Pubmed ID: 16000863 Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication Journal of Virology. Feb, 2004 | Pubmed ID: 14747536 The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-mediated Activation of Interferon-stimulated Genes Journal of Virology. Feb, 2004 | Pubmed ID: 14747533 Activation and Inhibition of Virus and Interferon: the Herpesvirus Story Viral Immunology. 2002 | Pubmed ID: 11952145 Herpes Simplex Virus ICP0 and ICP34.5 Counteract Distinct Interferon-induced Barriers to Virus Replication Journal of Virology. Feb, 2002 | Pubmed ID: 11799195 Manipolazione del Cotton Rat in studi per la valutazione pre-clinica di oncolitici virus Breanne Cuddington1, Meghan Verschoor1, Karen Mossman1 1Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University Medicina
Manipolazione del Cotton Rat in studi per la valutazione pre-clinica di oncolitici virus Breanne Cuddington1, Meghan Verschoor1, Karen Mossman1 1Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University Medicina