Keigi Fujiwara Department of Cardiology, Division of Internal Medicine University of Texas MD Anderson Cancer Center Biography Publications Institution JoVE Articles Keigi Fujiwara has not added a biography. If you are Keigi Fujiwara and would like to personalize this page please email our Author Liaison for assistance. Publications STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2017 | Pubmed ID: 28302626 Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases Advances in Experimental Medicine and Biology. 2017 | Pubmed ID: 28197922 Sub-cellular Localization Specific SUMOylation in the Heart Biochimica Et Biophysica Acta. Jan, 2017 | Pubmed ID: 28130202 Flow Signaling and Atherosclerosis Cellular and Molecular Life Sciences : CMLS. May, 2017 | Pubmed ID: 28039525 PECAM1 Regulates Flow-mediated Gab1 Tyrosine Phosphorylation and Signaling Cellular Signalling. Mar, 2016 | Pubmed ID: 26706435 Mechanosignaling in the Vasculature: Emerging Concepts in Sensing, Transduction and Physiological Responses American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2015 | Pubmed ID: 25862828 Mitochondrial Dynamics Regulate Neointima Formation Cardiovascular Research. May, 2015 | Pubmed ID: 25800033 Disturbed Flow-activated P90RSK Kinase Accelerates Atherosclerosis by Inhibiting SENP2 Function The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25689261 Identification of Activators of ERK5 Transcriptional Activity by High-throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014 | Pubmed ID: 25187658 ERK5 Activation in Macrophages Promotes Efferocytosis and Inhibits Atherosclerosis Circulation. Jul, 2014 | Pubmed ID: 25001623 Intima Modifier Locus 2 Controls Endothelial Cell Activation and Vascular Permeability Physiological Genomics. Sep, 2014 | Pubmed ID: 24986958 Shear Stress and Atherosclerosis Molecules and Cells. Jun, 2014 | Pubmed ID: 24781409 De-SUMOylation Enzyme of Sentrin/SUMO-specific Protease 2 Regulates Disturbed Flow-induced SUMOylation of ERK5 and P53 That Leads to Endothelial Dysfunction and Atherosclerosis Circulation Research. Mar, 2013 | Pubmed ID: 23381569 A Crucial Role for P90RSK-mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis Circulation. Jan, 2013 | Pubmed ID: 23243209 Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) by MAPK-activated Protein Kinase-2 Inhibits Endothelial Inflammation Via Increasing Both PIAS1 Transrepression and SUMO E3 Ligase Activity Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23202365 P62 Binding to Protein Kinase C ζ Regulates Tumor Necrosis Factor α-induced Apoptotic Pathway in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2012 | Pubmed ID: 23023376 Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation International Journal of Inflammation. 2012 | Pubmed ID: 22991685 Glucagon-like Peptide-1 and Its Cardiovascular Effects Current Atherosclerosis Reports. Oct, 2012 | Pubmed ID: 22878937 Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-like Factor 2 Circulation Research. Feb, 2012 | Pubmed ID: 22267843 P90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction Circulation Research. Feb, 2012 | Pubmed ID: 22267842 Disturbed-flow-mediated Vascular Reactive Oxygen Species Induce Endothelial Dysfunction Circulation Journal : Official Journal of the Japanese Circulation Society. 2011 | Pubmed ID: 22076424 Cyclic Nucleotide Phosphodiesterase 1A: a Key Regulator of Cardiac Fibroblast Activation and Extracellular Matrix Remodeling in the Heart Basic Research in Cardiology. Nov, 2011 | Pubmed ID: 22012077 PKCζ Mediates Disturbed Flow-induced Endothelial Apoptosis Via P53 SUMOylation The Journal of Cell Biology. May, 2011 | Pubmed ID: 21624955 MK2 SUMOylation Regulates Actin Filament Remodeling and Subsequent Migration in Endothelial Cells by Inhibiting MK2 Kinase and HSP27 Phosphorylation Blood. Feb, 2011 | Pubmed ID: 21131586 PKCzeta Decreases ENOS Protein Stability Via Inhibitory Phosphorylation of ERK5 Blood. Sep, 2010 | Pubmed ID: 20538799 Collagen I Matrix Turnover is Regulated by Fibronectin Polymerization American Journal of Physiology. Cell Physiology. May, 2010 | Pubmed ID: 20107040 Physiologic Stress-mediated Signaling in the Endothelium Methods in Enzymology. 2008 | Pubmed ID: 18772009 Mechanotransduction in an Extracted Cell Model: Fyn Drives Stretch- and Flow-elicited PECAM-1 Phosphorylation The Journal of Cell Biology. Aug, 2008 | Pubmed ID: 18710921 Phosphorylation and Localization of Protein-zero Related (PZR) in Cultured Endothelial Cells Endothelium : Journal of Endothelial Cell Research. May-Jun, 2008 | Pubmed ID: 18568953 ECM Remodeling in Hypertensive Heart Disease The Journal of Clinical Investigation. Mar, 2007 | Pubmed ID: 17332884 Down-regulation of ERK but Not MEK Phosphorylation in Cultured Endothelial Cells by Repeated Changes in Cyclic Stretch Cardiovascular Research. Mar, 2007 | Pubmed ID: 17289004 Serum Response Factor: Master Regulator of the Actin Cytoskeleton and Contractile Apparatus American Journal of Physiology. Cell Physiology. Jan, 2007 | Pubmed ID: 16928770 Endothelial Cell-cell Adhesion and Mechanosignal Transduction Endothelium : Journal of Endothelial Cell Research. Jan-Feb, 2004 | Pubmed ID: 15203879 Mechanical Stresses Keep Endothelial Cells Healthy: Beneficial Effects of a Physiological Level of Cyclic Stretch on Endothelial Barrier Function American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2003 | Pubmed ID: 12959924 Evidence for a Role of Platelet Endothelial Cell Adhesion Molecule-1 in Endothelial Cell Mechanosignal Transduction: is It a Mechanoresponsive Molecule? The Journal of Cell Biology. Aug, 2002 | Pubmed ID: 12177047 Vascular Endothelial Cells That Express Dystroglycan Are Involved in Angiogenesis Journal of Cell Science. Apr, 2002 | Pubmed ID: 11896196 En Face Preparation of Mouse Blood Vessels Kyung Ae Ko1, Keigi Fujiwara1, Sunil Krishnan2, Jun-ichi Abe1 1Department of Cardiology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, 2Department of Radiation Oncology, University of Texas MD Anderson Cancer Center JoVE 55460 Biologia
En Face Preparation of Mouse Blood Vessels Kyung Ae Ko1, Keigi Fujiwara1, Sunil Krishnan2, Jun-ichi Abe1 1Department of Cardiology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, 2Department of Radiation Oncology, University of Texas MD Anderson Cancer Center JoVE 55460 Biologia