Linda Partridge Institute of Healthy Ageing, and GEE University College London - UCL Biography Publications Institution JoVE Articles Linda Partridge has not added a biography. If you are Linda Partridge and would like to personalize this page please email our Author Liaison for assistance. Publications A Double Whammy for Aging? Rapamycin Extends Lifespan and Inhibits Cancer in Inbred Female Mice Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186783 Current Developments at Philosophical Transactions of the Royal Society B Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jan, 2012 | Pubmed ID: 22106421 The Bicoid Stability Factor Controls Polyadenylation and Expression of Specific Mitochondrial MRNAs in Drosophila Melanogaster PLoS Genetics. Oct, 2011 | Pubmed ID: 22022283 Absence of Effects of Sir2 Overexpression on Lifespan in C. Elegans and Drosophila Nature. Sep, 2011 | Pubmed ID: 21938067 Death and Dessert: Nutrient Signalling Pathways and Ageing Current Opinion in Cell Biology. Dec, 2011 | Pubmed ID: 21835601 Dietary Restriction and Aging: a Unifying Perspective Cell Metabolism. Aug, 2011 | Pubmed ID: 21803286 Genome-wide DFOXO Targets and Topology of the Transcriptomic Response to Stress and Insulin Signalling Molecular Systems Biology. 2011 | Pubmed ID: 21694719 Unraveling the Biological Roles of Reactive Oxygen Species Cell Metabolism. Apr, 2011 | Pubmed ID: 21459321 DFOXO-independent Effects of Reduced Insulin-like Signaling in Drosophila Aging Cell. Oct, 2011 | Pubmed ID: 21443682 A Longer and Healthier Life with TOR Down-regulation: Genetics and Drugs Biochemical Society Transactions. Apr, 2011 | Pubmed ID: 21428920 Molecular Basis of Adaptive Shift in Body Size in Drosophila Melanogaster: Functional and Sequence Analyses of the Dca Gene Molecular Biology and Evolution. Aug, 2011 | Pubmed ID: 21393605 Measurement of H2O2 Within Living Drosophila During Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix Cell Metabolism. Mar, 2011 | Pubmed ID: 21356523 Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1 PloS One. 2011 | Pubmed ID: 21283571 The New Science of Ageing Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jan, 2011 | Pubmed ID: 21115524 Lifespan Extension by Increased Expression of the Drosophila Homologue of the IGFBP7 Tumour Suppressor Aging Cell. Feb, 2011 | Pubmed ID: 21108726 Some Highlights of Research on Aging with Invertebrates, 2010 Aging Cell. Feb, 2011 | Pubmed ID: 21078113 Ageing in Drosophila: the Role of the Insulin/Igf and TOR Signalling Network Experimental Gerontology. May, 2011 | Pubmed ID: 20849947 Insulin Signalling Regulates Remating in Female Drosophila Proceedings. Biological Sciences / The Royal Society. Feb, 2011 | Pubmed ID: 20739318 Inhibition of GSK-3 Ameliorates Abeta Pathology in an Adult-onset Drosophila Model of Alzheimer's Disease PLoS Genetics. Sep, 2010 | Pubmed ID: 20824130 Extending Healthy Life Span--from Yeast to Humans Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20395504 Biomarkers of Aging in Drosophila Aging Cell. Aug, 2010 | Pubmed ID: 20367621 Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk PLoS Genetics. Mar, 2010 | Pubmed ID: 20333234 Molecular Evolution and Functional Characterization of Drosophila Insulin-like Peptides PLoS Genetics. Feb, 2010 | Pubmed ID: 20195512 DILP-producing Median Neurosecretory Cells in the Drosophila Brain Mediate the Response of Lifespan to Nutrition Aging Cell. Jun, 2010 | Pubmed ID: 20156206 Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster Cell Metabolism. Jan, 2010 | Pubmed ID: 20074526 The New Biology of Ageing Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jan, 2010 | Pubmed ID: 20008392 A Drosophila Insulin-like Peptide Promotes Growth During Nonfeeding States Developmental Cell. Dec, 2009 | Pubmed ID: 20059956 Amino-acid Imbalance Explains Extension of Lifespan by Dietary Restriction in Drosophila Nature. Dec, 2009 | Pubmed ID: 19956092 Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span Science (New York, N.Y.). Oct, 2009 | Pubmed ID: 19797661 The Endosymbiont Wolbachia Increases Insulin/IGF-like Signalling in Drosophila Proceedings. Biological Sciences / The Royal Society. Nov, 2009 | Pubmed ID: 19692410 Chemical Changes in Aging Drosophila Melanogaster Age (Dordrecht, Netherlands). Dec, 2009 | Pubmed ID: 19585275 Invertebrate Models of Age-related Muscle Degeneration Biochimica Et Biophysica Acta. Oct, 2009 | Pubmed ID: 19563864 Some Highlights of Research on Aging with Invertebrates, 2009 Aging Cell. Sep, 2009 | Pubmed ID: 19558590 Quantification of Food Intake in Drosophila PloS One. 2009 | Pubmed ID: 19557170 Longevity of Indy Mutant Drosophila Not Attributable to Indy Mutation Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19435842 Expression of Human Uncoupling Protein-3 in Drosophila Insulin-producing Cells Increases Insulin-like Peptide (DILP) Levels and Shortens Lifespan Experimental Gerontology. May, 2009 | Pubmed ID: 19385039 Insulin/IGF-like Signalling, the Central Nervous System and Aging The Biochemical Journal. Feb, 2009 | Pubmed ID: 19159343 Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila Melanogaster PloS One. 2009 | Pubmed ID: 19119322 Endocrine Regulation of Aging and Reproduction in Drosophila Molecular and Cellular Endocrinology. Feb, 2009 | Pubmed ID: 18682271 Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation Among DILPs PloS One. 2008 | Pubmed ID: 19005568 Some Highlights of Research on Aging with Invertebrates, 2008 Aging Cell. Oct, 2008 | Pubmed ID: 18631320 Stage Debut for the Elusive Drosophila Insulin-like Growth Factor Binding Protein Journal of Biology. 2008 | Pubmed ID: 18620552 New Model of Health Promotion and Disease Prevention for the 21st Century BMJ (Clinical Research Ed.). 2008 | Pubmed ID: 18614506 Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis" Science (New York, N.Y.). May, 2008 | Pubmed ID: 18497277 Feeding, Fecundity and Lifespan in Female Drosophila Melanogaster Proceedings. Biological Sciences / The Royal Society. Jul, 2008 | Pubmed ID: 18430646 Toward a Control Theory Analysis of Aging Annual Review of Biochemistry. 2008 | Pubmed ID: 18318658 Stress-response Hormesis and Aging: "that Which Does Not Kill Us Makes Us Stronger" Cell Metabolism. Mar, 2008 | Pubmed ID: 18316025 Pitfalls of Measuring Feeding Rate in the Fruit Fly Drosophila Melanogaster Nature Methods. Mar, 2008 | Pubmed ID: 18309307 Role of DFOXO in Lifespan Extension by Dietary Restriction in Drosophila Melanogaster: Not Required, but Its Activity Modulates the Response Aging Cell. Mar, 2008 | Pubmed ID: 18241326 Evidence for Lifespan Extension and Delayed Age-related Biomarkers in Insulin Receptor Substrate 1 Null Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2008 | Pubmed ID: 17928362 Brief Carbon Dioxide Exposure Blocks Heat Hardening but Not Cold Acclimation in Drosophila Melanogaster Journal of Insect Physiology. Jan, 2008 | Pubmed ID: 17884085 Benchmarks for Ageing Studies Nature. Nov, 2007 | Pubmed ID: 17994065 Optimization of Dietary Restriction Protocols in Drosophila The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Oct, 2007 | Pubmed ID: 17921418 Effects of Resveratrol on Lifespan in Drosophila Melanogaster and Caenorhabditis Elegans Mechanisms of Ageing and Development. Oct, 2007 | Pubmed ID: 17875315 Antagonizing Methuselah to Extend Life Span Genome Biology. 2007 | Pubmed ID: 17764591 Some Highlights of Research on Aging with Invertebrates, 2006-2007 Aging Cell. Oct, 2007 | Pubmed ID: 17725687 Evolutionary Conservation of Regulated Longevity Assurance Mechanisms Genome Biology. 2007 | Pubmed ID: 17612391 Mapping Regions Within Cosmopolitan Inversion In(3R)Payne Associated with Natural Variation in Body Size in Drosophila Melanogaster Genetics. Sep, 2007 | Pubmed ID: 17603103 Estimation and Correction of Non-specific Binding in a Large-scale Spike-in Experiment Genome Biology. 2007 | Pubmed ID: 17594493 Correcting for Sequence Biases in Present/absent Calls Genome Biology. 2007 | Pubmed ID: 17594492 No Influence of Indy on Lifespan in Drosophila After Correction for Genetic and Cytoplasmic Background Effects PLoS Genetics. Jun, 2007 | Pubmed ID: 17571923 Dynamics of the Action of DFOXO on Adult Mortality in Drosophila Aging Cell. Aug, 2007 | Pubmed ID: 17465980 Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact? PLoS Genetics. Apr, 2007 | Pubmed ID: 17465680 Role of Insulin-like Signalling in Drosophila Lifespan Trends in Biochemical Sciences. Apr, 2007 | Pubmed ID: 17412594 Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting Calories in Drosophila Dietary Restriction"Exp. Gerontology, Doi:10.1016/j.exger.2006.10.009 Experimental Gerontology. Apr, 2007 | Pubmed ID: 17317064 A Functioning Ovary is Not Required for Sex Peptide to Reduce Receptivity to Mating in D. Melanogaster Journal of Insect Physiology. Apr, 2007 | Pubmed ID: 17303161 Superoxide Dismutase Activities in Long-lived Drosophila Melanogaster Females: Chico1 Genotypes and Dietary Dilution Biogerontology. Apr, 2007 | Pubmed ID: 17103233 Coordinated Multitissue Transcriptional and Plasma Metabonomic Profiles Following Acute Caloric Restriction in Mice Physiological Genomics. Nov, 2006 | Pubmed ID: 16882887 Beyond the Evolutionary Theory of Ageing, from Functional Genomics to Evo-gero Trends in Ecology & Evolution. Jun, 2006 | Pubmed ID: 16769434 No Extension of Lifespan by Ablation of Germ Line in Drosophila Proceedings. Biological Sciences / The Royal Society. Apr, 2006 | Pubmed ID: 16627279 Flight Activity, Mortality Rates, and Lipoxidative Damage in Drosophila The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Feb, 2006 | Pubmed ID: 16510857 The Effect of Dietary Restriction on Mitochondrial Protein Density and Flight Muscle Mitochondrial Morphology in Drosophila The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jan, 2006 | Pubmed ID: 16456193 The Effects of Exogenous Antioxidants on Lifespan and Oxidative Stress Resistance in Drosophila Melanogaster Mechanisms of Ageing and Development. Apr, 2006 | Pubmed ID: 16442589 Patterns of Diversity and Linkage Disequilibrium Within the Cosmopolitan Inversion In(3R)Payne in Drosophila Melanogaster Are Indicative of Coadaptation Genetics. Mar, 2006 | Pubmed ID: 16322502 Genome-wide Gene Expression in Response to Parasitoid Attack in Drosophila Genome Biology. 2005 | Pubmed ID: 16277749 Science Fact and the SENS Agenda. What Can We Reasonably Expect from Ageing Research? EMBO Reports. Nov, 2005 | Pubmed ID: 16264422 Diet, Metabolism and Lifespan in Drosophila Experimental Gerontology. Nov, 2005 | Pubmed ID: 16137851 Isogenic Autosomes to Be Applied in Optimal Screening for Novel Mutants with Viable Phenotypes in Drosophila Melanogaster Journal of Neurogenetics. Apr-Jun, 2005 | Pubmed ID: 16024440 Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila PLoS Biology. Jul, 2005 | Pubmed ID: 16000018 Counting the Calories: the Role of Specific Nutrients in Extension of Life Span by Food Restriction The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. May, 2005 | Pubmed ID: 15972601 Dietary Restriction in Drosophila Mechanisms of Ageing and Development. Sep, 2005 | Pubmed ID: 15935441 Insulin Signaling is Necessary for Vitellogenesis in Drosophila Melanogaster Independent of the Roles of Juvenile Hormone and Ecdysteroids: Female Sterility of the Chico1 Insulin Signaling Mutation is Autonomous to the Ovary Journal of Insect Physiology. Apr, 2005 | Pubmed ID: 15890189 Sex and Death: What is the Connection? Cell. Feb, 2005 | Pubmed ID: 15734679 Longer Lifespan, Altered Metabolism, and Stress Resistance in Drosophila from Ablation of Cells Making Insulin-like Ligands Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15708981 Dietary Restriction, Mortality Trajectories, Risk and Damage Mechanisms of Ageing and Development. Jan, 2005 | Pubmed ID: 15610760 Genetic Variation for Total Fitness in Drosophila Melanogaster: Complex Yet Replicable Patterns Genetics. Mar, 2005 | Pubmed ID: 15545656 Computational Analysis of Alpha-helical Membrane Protein Structure: Implications for the Prediction of 3D Structural Models Protein Engineering, Design & Selection : PEDS. Aug, 2004 | Pubmed ID: 15388845 The Interaction Between FOXO and SIRT1: Tipping the Balance Towards Survival Trends in Cell Biology. Aug, 2004 | Pubmed ID: 15308206 Metabolic Rate is Not Reduced by Dietary-restriction or by Lowered Insulin/IGF-1 Signalling and is Not Correlated with Individual Lifespan in Drosophila Melanogaster Experimental Gerontology. Aug, 2004 | Pubmed ID: 15288688 Lack of Correlation Between Mitochondrial Reactive Oxygen Species Production and Life Span in Drosophila Annals of the New York Academy of Sciences. Jun, 2004 | Pubmed ID: 15247051 Lifespan Extension by Dietary Restriction in Female Drosophila Melanogaster is Not Caused by a Reduction in Vitellogenesis or Ovarian Activity Experimental Gerontology. Jul, 2004 | Pubmed ID: 15236760 Long-lived Drosophila with Overexpressed DFOXO in Adult Fat Body Science (New York, N.Y.). Jul, 2004 | Pubmed ID: 15192154 Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jan, 2004 | Pubmed ID: 14718480 QTL Mapping Reveals a Striking Coincidence in the Positions of Genomic Regions Associated with Adaptive Variation in Body Size in Parallel Clines of Drosophila Melanogaster on Different Continents Evolution; International Journal of Organic Evolution. Nov, 2003 | Pubmed ID: 14686541 Testing for Asymmetrical Gene Flow in a Drosophila Melanogaster Body-size Cline Genetics. Oct, 2003 | Pubmed ID: 14573478 Superoxide and Hydrogen Peroxide Production by Drosophila Mitochondria Free Radical Biology & Medicine. Oct, 2003 | Pubmed ID: 14556858 Demography of Dietary Restriction and Death in Drosophila Science (New York, N.Y.). Sep, 2003 | Pubmed ID: 14500985 The Sex Peptide of Drosophila Melanogaster: Female Post-mating Responses Analyzed by Using RNA Interference Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12893873 Rapid Laboratory Evolution of Adult Wing Area in Drosophila Melanogaster in Response to Humidity Evolution; International Journal of Organic Evolution. Apr, 2003 | Pubmed ID: 12778562 Different Cell Size and Cell Number Contribution in Two Newly Established and One Ancient Body Size Cline of Drosophila Subobscura Evolution; International Journal of Organic Evolution. Mar, 2003 | Pubmed ID: 12703946 Interpreting Interactions Between Treatments That Slow Aging Aging Cell. Oct, 2002 | Pubmed ID: 12882347 Life History Response of Mediterranean Fruit Flies to Dietary Restriction Aging Cell. Dec, 2002 | Pubmed ID: 12882344 A Lethal Side-effect Nature. Aug, 2002 | Pubmed ID: 12198525 The Evolution of Longevity Current Biology : CB. Aug, 2002 | Pubmed ID: 12194832 Genome-wide Transcript Profiles in Aging and Calorically Restricted Drosophila Melanogaster Current Biology : CB. Apr, 2002 | Pubmed ID: 12007414 Mechanisms of Ageing: Public or Private? Nature Reviews. Genetics. Mar, 2002 | Pubmed ID: 11972154 Dietary Restriction in Long-lived Dwarf Flies Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11951037 A Mortality Cost of Virginity at Older Ages in Female Mediterranean Fruit Flies Experimental Gerontology. Apr, 2002 | Pubmed ID: 11830353 Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster Hrvoje Augustin1, Marcus J. Allen2, Linda Partridge1 1Institute of Healthy Ageing, and GEE, University College London - UCL, 2School of Biosciences, University of Kent JoVE 2412 Neuroscienze
Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster Hrvoje Augustin1, Marcus J. Allen2, Linda Partridge1 1Institute of Healthy Ageing, and GEE, University College London - UCL, 2School of Biosciences, University of Kent JoVE 2412 Neuroscienze