Lingfeng Qin Department of Surgery Yale University School of Medicine Biography Publications Institution JoVE Articles Lingfeng Qin has not added a biography. If you are Lingfeng Qin and would like to personalize this page please email our Author Liaison for assistance. Publications FGFR1 SUMOylation Coordinates Endothelial Angiogenic Signaling in Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. 06, 2022 | Pubmed ID: 35733256 Readily Available Tissue-Engineered Vascular Grafts Derived From Human Induced Pluripotent Stem Cells Circulation Research. 03, 2022 | Pubmed ID: 35189711 Hexarelin Attenuates Abdominal Aortic Aneurysm Formation by Inhibiting SMC Phenotype Switch and Inflammasome Activation Microvascular Research. 03, 2022 | Pubmed ID: 34856183 CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. 12, 2021 | Pubmed ID: 34670407 Caveolae-mediated Tie2 Signaling Contributes to CCM Pathogenesis in a Brain Endothelial Cell-specific Pdcd10-deficient Mouse Model Nature Communications. 01, 2021 | Pubmed ID: 33495460 H19/TET1 Axis Promotes TGF-β Signaling Linked to Endothelial-to-mesenchymal Transition FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 06, 2020 | Pubmed ID: 32374060 Smooth Muscle Cell Reprogramming in Aortic Aneurysms Cell Stem Cell. 04, 2020 | Pubmed ID: 32243809 Complement-activated Interferon-γ-primed Human Endothelium Transpresents Interleukin-15 to CD8+ T Cells The Journal of Clinical Investigation. 07, 2020 | Pubmed ID: 32191642 Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human IPSCs Cell Stem Cell. 02, 2020 | Pubmed ID: 31956039 Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production Circulation. 02, 2020 | Pubmed ID: 31744330 Endothelial TGF-β Signalling Drives Vascular Inflammation and Atherosclerosis Nature Metabolism. 09, 2019 | Pubmed ID: 31572976 Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium Circulation Research. 06, 2019 | Pubmed ID: 31170059 ZFYVE21 is a Complement-induced Rab5 Effector That Activates Non-canonical NF-κB Via Phosphoinosotide Remodeling of Endosomes Nature Communications. 05, 2019 | Pubmed ID: 31113953 AIP1 Suppresses Transplant Arteriosclerosis Through Inhibition of Vascular Smooth Muscle Cell Inflammatory Response to IFNγ Anatomical Record (Hoboken, N.J. : 2007). 09, 2019 | Pubmed ID: 30471213 Integrin Beta3 Regulates Clonality and Fate of Smooth Muscle-derived Atherosclerotic Plaque Cells Nature Communications. 05, 2018 | Pubmed ID: 29802249 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Ex Vivo Pretreatment of Human Vessels with SiRNA Nanoparticles Provides Protein Silencing in Endothelial Cells Nature Communications. 08, 2017 | Pubmed ID: 28775323 SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling Circulation Research. Sep, 2017 | Pubmed ID: 28760777 MTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2017 | Pubmed ID: 28751568 Improving In vivo Outcomes of Decellularized Vascular Grafts Via Incorporation of a Novel Extracellular Matrix Biomaterials. Oct, 2017 | Pubmed ID: 28667900 The Critical Role of SENP1-mediated GATA2 DeSUMOylation in Promoting Endothelial Activation in Graft Arteriosclerosis Nature Communications. 06, 2017 | Pubmed ID: 28569748 Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency Arteriosclerosis, Thrombosis, and Vascular Biology. 05, 2017 | Pubmed ID: 28254817 Inhibition of the MTOR Pathway in Abdominal Aortic Aneurysm: Implications of Smooth Muscle Cell Contractile Phenotype, Inflammation, and Aneurysm Expansion American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2017 | Pubmed ID: 28213405 Fibroblast Growth Factor (FGF) Signaling Regulates Transforming Growth Factor Beta (TGFβ)-dependent Smooth Muscle Cell Phenotype Modulation Scientific Reports. 09, 2016 | Pubmed ID: 27634335 Endothelial Exocytosis of Angiopoietin-2 Resulting from CCM3 Deficiency Contributes to Cerebral Cavernous Malformation Nature Medicine. 09, 2016 | Pubmed ID: 27548575 Implantable Tissue-engineered Blood Vessels from Human Induced Pluripotent Stem Cells Biomaterials. Sep, 2016 | Pubmed ID: 27336184 Smooth Muscle FGF/TGFβ Cross Talk Regulates Atherosclerosis Progression EMBO Molecular Medicine. 07, 2016 | Pubmed ID: 27189169 Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection JCI Insight. 2016 | Pubmed ID: 26900601 SENP1-mediated NEMO DeSUMOylation in Adipocytes Limits Inflammatory Responses and Type-1 Diabetes Progression Nature Communications. Nov, 2015 | Pubmed ID: 26596471 Endothelial-to-mesenchymal Transition Drives Atherosclerosis Progression The Journal of Clinical Investigation. Oct, 2015 | Pubmed ID: 26517696 Interferon-γ-mediated Allograft Rejection Exacerbates Cardiovascular Disease of Hyperlipidemic Murine Transplant Recipients Circulation Research. Nov, 2015 | Pubmed ID: 26399469 Complement Membrane Attack Complexes Activate Noncanonical NF-κB by Forming an Akt+ NIK+ Signalosome on Rab5+ Endosomes Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26195760 Fibroblast Growth Factor Receptor 1 is a Key Inhibitor of TGFβ Signaling in the Endothelium Science Signaling. Sep, 2014 | Pubmed ID: 25249657 Interacting Mechanisms in the Pathogenesis of Cardiac Allograft Vasculopathy Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2014 | Pubmed ID: 24903097 The Docking Protein FRS2α is a Critical Regulator of VEGF Receptors Signaling Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706887 Rapamycin Antagonizes TNF Induction of VCAM-1 on Endothelial Cells by Inhibiting MTORC2 The Journal of Experimental Medicine. Mar, 2014 | Pubmed ID: 24516119 Tgfbr2 Disruption in Postnatal Smooth Muscle Impairs Aortic Wall Homeostasis The Journal of Clinical Investigation. Feb, 2014 | Pubmed ID: 24401272 SOCS1 Prevents Graft Arteriosclerosis by Preserving Endothelial Cell Function Journal of the American College of Cardiology. Jan 7-14, 2014 | Pubmed ID: 23994402 Rapamycin Inhibits Smooth Muscle Cell Proliferation and Obstructive Arteriopathy Attributable to Elastin Deficiency Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2013 | Pubmed ID: 23493289 Rapamycin-treated Human Endothelial Cells Preferentially Activate Allogeneic Regulatory T Cells The Journal of Clinical Investigation. Apr, 2013 | Pubmed ID: 23478407 AIP1 Suppresses Atherosclerosis by Limiting Hyperlipidemia-induced Inflammation and Vascular Endothelial Dysfunction Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2013 | Pubmed ID: 23413429 FGF Regulates TGF-β Signaling and Endothelial-to-mesenchymal Transition Via Control of Let-7 MiRNA Expression Cell Reports. Dec, 2012 | Pubmed ID: 23200853 Activation of Human Vascular Cells Decreases Their Expression of Transforming Growth Factor-beta Atherosclerosis. Dec, 2011 | Pubmed ID: 21862019 Transforming Growth Factor Beta Expression by Human Vascular Cells Inhibits Interferon Gamma Production and Arterial Media Injury by Alloreactive Memory T Cells American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Nov, 2011 | Pubmed ID: 21812925 AIP1 Prevents Graft Arteriosclerosis by Inhibiting Interferon-γ-dependent Smooth Muscle Cell Proliferation and Intimal Expansion Circulation Research. Aug, 2011 | Pubmed ID: 21700930 CXCR3-dependent Accumulation and Activation of Perivascular Macrophages is Necessary for Homeostatic Arterial Remodeling to Hemodynamic Stresses The Journal of Experimental Medicine. Aug, 2010 | Pubmed ID: 20733031 Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation Via Induction of the G1 Cyclin-retinoblastoma Axis Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2010 | Pubmed ID: 20720195 IFN-gamma Primes Intact Human Coronary Arteries and Cultured Coronary Smooth Muscle Cells to Double-stranded RNA- and Self-RNA-induced Inflammatory Responses by Upregulating TLR3 and Melanoma Differentiation-associated Gene 5 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010 | Pubmed ID: 20562257 JAK2 and SHP2 Reciprocally Regulate Tyrosine Phosphorylation and Stability of Proapoptotic Protein ASK1 The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19287004 Interleukin (IL)-1 Promotes Allogeneic T Cell Intimal Infiltration and IL-17 Production in a Model of Human Artery Rejection The Journal of Experimental Medicine. Dec, 2008 | Pubmed ID: 19075290 MyD88-dependent, Superoxide-initiated Inflammation is Necessary for Flow-mediated Inward Remodeling of Conduit Arteries The Journal of Experimental Medicine. Dec, 2008 | Pubmed ID: 19064699 インターフェロン-γによる血管平滑筋細胞におけるインドールアミン2,3 - ジオキシゲナーゼの誘導は内側免疫特権に貢献 Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17911610 Interferon-gamma Induces Human Vascular Smooth Muscle Cell Proliferation and Intimal Expansion by Phosphatidylinositol 3-kinase Dependent Mammalian Target of Rapamycin Raptor Complex 1 Activation Circulation Research. Sep, 2007 | Pubmed ID: 17656678 低酸素誘発マウス肺動脈高血圧症モデルにおける複数の静脈内ボーラス投与と侵襲的血行動態評価 Lingfeng Qin1, Bo Jiang2, Krisztina Zsebo3, Henricus J. Duckers3, Michael Simons4,5, Pei-Yu Chen4 1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine JoVE 63839 Medicina 動脈瘤高脂血症マウスモデルにおけるオイルレッドO染色全大動脈病変のイメージングと解析 Pei-Yu Chen1, Lingfeng Qin2, Michael Simons1,3 1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 2Department of Surgery, Yale University School of Medicine, 3Department of Cell Biology, Yale University School of Medicine JoVE 61277 Medicina グラフト動脈硬化のマウスモデル Lingfeng Qin1, Luyang Yu2, Wang Min2 1Department of Surgery, Yale University School of Medicine, 2Department of Pathology, Yale University School of Medicine JoVE 50290 Medicina
低酸素誘発マウス肺動脈高血圧症モデルにおける複数の静脈内ボーラス投与と侵襲的血行動態評価 Lingfeng Qin1, Bo Jiang2, Krisztina Zsebo3, Henricus J. Duckers3, Michael Simons4,5, Pei-Yu Chen4 1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine JoVE 63839 Medicina
動脈瘤高脂血症マウスモデルにおけるオイルレッドO染色全大動脈病変のイメージングと解析 Pei-Yu Chen1, Lingfeng Qin2, Michael Simons1,3 1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 2Department of Surgery, Yale University School of Medicine, 3Department of Cell Biology, Yale University School of Medicine JoVE 61277 Medicina
グラフト動脈硬化のマウスモデル Lingfeng Qin1, Luyang Yu2, Wang Min2 1Department of Surgery, Yale University School of Medicine, 2Department of Pathology, Yale University School of Medicine JoVE 50290 Medicina
