Lynne Howells Leicester Cancer Research Center University of Leicester Biography Publications Institution JoVE Articles Lynne Howells has not added a biography. If you are Lynne Howells and would like to personalize this page please email our Author Liaison for assistance. Publications Risk of Cancer Incidence and Mortality Associated with Diabetes: A Systematic Review with Trend Analysis of 203 Cohorts Nutrition, Metabolism, and Cardiovascular Diseases : NMCD. Jan, 2021 | Pubmed ID: 33223399 Evaluating and Comparing Immunostaining and Computational Methods for Spatial Profiling of Drug Response in Patient-derived Explants Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2020 | Pubmed ID: 33318618 Association of Type 2 Diabetes With Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People Diabetes Care. Sep, 2020 | Pubmed ID: 32910779 Myeloid Derived Suppressor Cells Are Reduced and T Regulatory Cells Stabilised in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine and Intravenous Omega 3 Annals of Translational Medicine. Mar, 2020 | Pubmed ID: 32309319 New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells Molecules (Basel, Switzerland). Jan, 2020 | Pubmed ID: 31963196 Patient-derived Explants (PDEs) As a Powerful Preclinical Platform for Anti-cancer Drug and Biomarker Discovery British Journal of Cancer. 03, 2020 | Pubmed ID: 31894140 Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial The Journal of Nutrition. 07, 2019 | Pubmed ID: 31132111 Circulating Tumor DNA in Patients with Colorectal Adenomas: Assessment of Detectability and Genetic Heterogeneity Cell Death & Disease. 08, 2018 | Pubmed ID: 30166531 Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes Scientific Reports. 08, 2018 | Pubmed ID: 30108309 Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers Molecular Nutrition & Food Research. 08, 2018 | Pubmed ID: 29943914 An HPLC-UV Method for the Simultaneous Quantification of Curcumin and Its Metabolites in Plasma and Lung Tissue: Potential for Preclinical Applications Biomedical Chromatography : BMC. May, 2018 | Pubmed ID: 29744910 Effects of Omegaven®, EPA, DHA and Oxaliplatin on Oesophageal Adenocarcinoma Cell Lines Growth, Cytokine and Cell Signal Biomarkers Expression Lipids in Health and Disease. Jan, 2018 | Pubmed ID: 29378575 Assessing Barriers to a Rational Chemoprevention Trial Design in Young Patients with Familial Adenomatous Polyposis European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). 07, 2017 | Pubmed ID: 27128580 Curcumin Mediates Oxaliplatin-acquired Resistance Reversion in Colorectal Cancer Cell Lines Through Modulation of CXC-Chemokine/NF-κB Signalling Pathway Scientific Reports. Apr, 2016 | Pubmed ID: 27091625 Targeting Cancer Stem-like Cells Using Dietary-derived Agents - Where Are We Now? Molecular Nutrition & Food Research. 06, 2016 | Pubmed ID: 27060283 Targeting Pancreatic Cancer Using a Combination of Gemcitabine with the Omega-3 Polyunsaturated Fatty Acid Emulsion, Lipidem™ Molecular Nutrition & Food Research. 06, 2016 | Pubmed ID: 26603273 The Role of Stromal Fibroblasts in Lung Carcinogenesis: A Target for Chemoprevention? International Journal of Cancer. Jan, 2016 | Pubmed ID: 25611701 Cancer Chemoprevention: Evidence of a Nonlinear Dose Response for the Protective Effects of Resveratrol in Humans and Mice Science Translational Medicine. Jul, 2015 | Pubmed ID: 26223300 Inhibition of Prostate Cancer Cell Growth by 3',4',5'-trimethoxyflavonol (TMFol) Cancer Chemotherapy and Pharmacology. Jul, 2015 | Pubmed ID: 26017621 Curcumin Inhibits Cancer Stem Cell Phenotypes in Ex Vivo Models of Colorectal Liver Metastases, and is Clinically Safe and Tolerable in Combination with FOLFOX Chemotherapy Cancer Letters. Aug, 2015 | Pubmed ID: 25979230 Combining Curcumin (C3-complex, Sabinsa) with Standard Care FOLFOX Chemotherapy in Patients with Inoperable Colorectal Cancer (CUFOX): Study Protocol for a Randomised Control Trial Trials. Mar, 2015 | Pubmed ID: 25872567 Characterization and Propagation of Tumor Initiating Cells Derived from Colorectal Liver Metastases: Trials, Tribulations and a Cautionary Note PloS One. 2015 | Pubmed ID: 25658706 Potential for Proteomic Approaches in Determining Efficacy Biomarkers Following Administration of Fish Oils Rich in Omega-3 Fatty Acids: Application in Pancreatic Cancers Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition. Jun, 2015 | Pubmed ID: 25616520 Cancer Chemoprevention: Factors Influencing Attitudes Towards Chemopreventive Agents in High-risk Populations European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). Nov, 2014 | Pubmed ID: 25259886 Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies The Journal of Pharmacology and Experimental Therapeutics. Sep, 2014 | Pubmed ID: 24939419 The Role of Cancer Stem Cells in the Anti-carcinogenicity of Curcumin Molecular Nutrition & Food Research. Sep, 2013 | Pubmed ID: 23900994 Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration--a Clinical Pilot Study Including Assessment of Patient Acceptability Cancer Prevention Research (Philadelphia, Pa.). Feb, 2013 | Pubmed ID: 23233733 Phase I Randomized, Double-blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--safety, Pharmacokinetics, and Pharmacodynamics Cancer Prevention Research (Philadelphia, Pa.). Sep, 2011 | Pubmed ID: 21680702 Curcumin Ameliorates Oxaliplatin-induced Chemoresistance in HCT116 Colorectal Cancer Cells in Vitro and in Vivo International Journal of Cancer. Jul, 2011 | Pubmed ID: 20839263 Preclinical Colorectal Cancer Chemopreventive Efficacy and P53-modulating Activity of 3',4',5'-trimethoxyflavonol, a Quercetin Analogue Cancer Prevention Research (Philadelphia, Pa.). Aug, 2010 | Pubmed ID: 20628003 Indole-3-carbinol Enhances Anti-proliferative, but Not Anti-invasive Effects of Oxaliplatin in Colorectal Cancer Cell Lines Biochemical Pharmacology. May, 2008 | Pubmed ID: 18358454 Predicting the Physiological Relevance of in Vitro Cancer Preventive Activities of Phytochemicals Acta Pharmacologica Sinica. Sep, 2007 | Pubmed ID: 17723163 Comparison of Oxaliplatin- and Curcumin-mediated Antiproliferative Effects in Colorectal Cell Lines International Journal of Cancer. Jul, 2007 | Pubmed ID: 17330230 Involvement of Nrf2, P38, B-Raf, and Nuclear Factor-kappaB, but Not Phosphatidylinositol 3-kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols Molecular Pharmacology. Mar, 2006 | Pubmed ID: 16354769 Inhibition of Phosphatidylinositol 3-kinase/protein Kinase B Signaling is Not Sufficient to Account for Indole-3-carbinol-induced Apoptosis in Some Breast and Prostate Tumor Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2005 | Pubmed ID: 16322316 Prospects for Plant-derived Chemopreventive Agents Exhibiting Multiple Mechanisms of Action Current Medicinal Chemistry. Anti-cancer Agents. May, 2005 | Pubmed ID: 15992350 Relevance of Mitogen Activated Protein Kinase (MAPK) and Phosphotidylinositol-3-kinase/protein Kinase B (PI3K/PKB) Pathways to Induction of Apoptosis by Curcumin in Breast Cells Biochemical Pharmacology. Feb, 2003 | Pubmed ID: 12527329 Growth-inhibitory Effects of the Chemopreventive Agent Indole-3-carbinol Are Increased in Combination with the Polyamine Putrescine in the SW480 Colon Tumour Cell Line BMC Cancer. Jan, 2003 | Pubmed ID: 12525265 Indole-3-carbinol Inhibits Protein Kinase B/Akt and Induces Apoptosis in the Human Breast Tumor Cell Line MDA MB468 but Not in the Nontumorigenic HBL100 Line Molecular Cancer Therapeutics. Nov, 2002 | Pubmed ID: 12479697 Espianti tumorali derivati dal paziente come piattaforma preclinica "live" per prevedere la resistenza ai farmaci nei pazienti Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit JoVE 62130 Ricerca sul cancro
Espianti tumorali derivati dal paziente come piattaforma preclinica "live" per prevedere la resistenza ai farmaci nei pazienti Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit JoVE 62130 Ricerca sul cancro