Margaret A. Goodell Stem Cells & Regenerative Medicine Center Baylor College of Medicine Biography Publications Institution JoVE Articles Margaret A. Goodell has not added a biography. If you are Margaret A. Goodell and would like to personalize this page please email our Author Liaison for assistance. Publications Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo Cell Reports. Apr, 2018 | Pubmed ID: 29617651 Loss of Capicua Alters Early T Cell Development and Predisposes Mice to T Cell Lymphoblastic Leukemia/lymphoma Proceedings of the National Academy of Sciences of the United States of America. Feb, 2018 | Pubmed ID: 29382756 DNA Epigenome Editing Using CRISPR-Cas SunTag-directed DNMT3A Genome Biology. Sep, 2017 | Pubmed ID: 28923089 Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28735485 Targeted DNA Methylation in Vivo Using an Engineered DCas9-MQ1 Fusion Protein Nature Communications. Jul, 2017 | Pubmed ID: 28695892 DNMT3A in Leukemia Cold Spring Harbor Perspectives in Medicine. Feb, 2017 | Pubmed ID: 28003281 Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9 Cell Reports. 10, 2016 | Pubmed ID: 27783956 Oncometabolite D-2-hydroxyglutarate Impairs α-ketoglutarate Dehydrogenase and Contractile Function in Rodent Heart Proceedings of the National Academy of Sciences of the United States of America. Sep, 2016 | Pubmed ID: 27582470 DNMT3A and TET2 Compete and Cooperate to Repress Lineage-specific Transcription Factors in Hematopoietic Stem Cells Nature Genetics. 09, 2016 | Pubmed ID: 27428748 DOT1L As a Therapeutic Target for the Treatment of DNMT3A-mutant Acute Myeloid Leukemia Blood. 08, 2016 | Pubmed ID: 27335278 DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias Cancer Cell. 06, 2016 | Pubmed ID: 27300438 Mixed-phenotype Acute Leukemia (MPAL) Exhibits Frequent Mutations in DNMT3A and Activated Signaling Genes Experimental Hematology. 08, 2016 | Pubmed ID: 27208809 Noncoding Regulatory RNAs in Hematopoiesis Current Topics in Developmental Biology. 2016 | Pubmed ID: 27137659 Stem Cells and Healthy Aging Science (New York, N.Y.). Dec, 2015 | Pubmed ID: 26785478 Acute Loss of TET Function Results in Aggressive Myeloid Cancer in Mice Nature Communications. Nov, 2015 | Pubmed ID: 26607761 Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice Comparative Medicine. Jun, 2015 | Pubmed ID: 26141441 Comparative Long-term Effects of Interferon α and Hydroxyurea on Human Hematopoietic Progenitor Cells Experimental Hematology. Oct, 2015 | Pubmed ID: 26072330 Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin and Intestinal Stem Cell Compartments Nature Reviews. Molecular Cell Biology. May, 2015 | Pubmed ID: 25907613 Long Non-coding RNAs Control Hematopoietic Stem Cell Function Cell Stem Cell. Apr, 2015 | Pubmed ID: 25772072 DNMT3A in Haematological Malignancies Nature Reviews. Cancer. Mar, 2015 | Pubmed ID: 25693834 Dnmt3a Loss Predisposes Murine Hematopoietic Stem Cells to Malignant Transformation Blood. Jan, 2015 | Pubmed ID: 25416277 Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells Cell Stem Cell. Sep, 2014 | Pubmed ID: 25130491 New Answers to Old Questions from Genome-wide Maps of DNA Methylation in Hematopoietic Cells Experimental Hematology. Aug, 2014 | Pubmed ID: 24993071 A Gallon of Sweat to Make a Pint of Blood The Journal of Experimental Medicine. Jun, 2014 | Pubmed ID: 24980745 MTORC1 Controls the Adaptive Transition of Quiescent Stem Cells from G0 to G(Alert) Nature. Jun, 2014 | Pubmed ID: 24870234 Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes During Aging That Reinforce Self-renewal Cell Stem Cell. May, 2014 | Pubmed ID: 24792119 MOABS: Model Based Analysis of Bisulfite Sequencing Data Genome Biology. Feb, 2014 | Pubmed ID: 24565500 Hematopoietic Stem Cell Development: an Epigenetic Journey Current Topics in Developmental Biology. 2014 | Pubmed ID: 24439802 Large Conserved Domains of Low DNA Methylation Maintained by Dnmt3a Nature Genetics. Jan, 2014 | Pubmed ID: 24270360 A DNMT3A Mutation Common in AML Exhibits Dominant-negative Effects in Murine ES Cells Blood. Dec, 2013 | Pubmed ID: 24167195 Parental Permissions: H19 and Keeping the Stem Cell Progeny Under Control Cell Stem Cell. Aug, 2013 | Pubmed ID: 23910078 Ten-eleven Translocation 1 (Tet1) is Regulated by O-linked N-acetylglucosamine Transferase (Ogt) for Target Gene Repression in Mouse Embryonic Stem Cells The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23729667 Rising from the Crypt: Decreasing DNA Methylation During Differentiation of the Small Intestine Genome Biology. May, 2013 | Pubmed ID: 23714004 Perspectives and Future Directions for Epigenetics in Hematology Blood. Jun, 2013 | Pubmed ID: 23692857 Ataxin1L is a Regulator of HSC Function Highlighting the Utility of Cross-tissue Comparisons for Gene Discovery PLoS Genetics. Mar, 2013 | Pubmed ID: 23555280 Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association Between Hypomethylation and Genomic Instability PLoS Genetics. 2013 | Pubmed ID: 23468659 Isolation and Characterization of Mouse Side Population Cells Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23179831 Gpr171, a Putative P2Y-like Receptor, Negatively Regulates Myeloid Differentiation in Murine Hematopoietic Progenitors Experimental Hematology. Jan, 2013 | Pubmed ID: 23022127 Flow Cytometry Analysis of Murine Hematopoietic Stem Cells Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Jan, 2013 | Pubmed ID: 22736515 Less is More: Unveiling the Functional Core of Hematopoietic Stem Cells Through Knockout Mice Cell Stem Cell. Sep, 2012 | Pubmed ID: 22958929 The Transcription Factor Lyl-1 Regulates Lymphoid Specification and the Maintenance of Early T Lineage Progenitors Nature Immunology. Jul, 2012 | Pubmed ID: 22772404 Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome PLoS Genetics. 2012 | Pubmed ID: 22615578 The Hematopoietic Expression Viewer: Expanding Mobile Apps As a Scientific Tool Bioinformatics (Oxford, England). Jul, 2012 | Pubmed ID: 22576171 Rantes/Ccl5 Influences Hematopoietic Stem Cell Subtypes and Causes Myeloid Skewing Blood. Mar, 2012 | Pubmed ID: 22289892 Dnmt3a is Essential for Hematopoietic Stem Cell Differentiation Nature Genetics. Jan, 2012 | Pubmed ID: 22138693 Imprinted Genes That Regulate Early Mammalian Growth Are Coexpressed in Somatic Stem Cells PloS One. 2011 | Pubmed ID: 22039481 Bridge over Troubled Stem Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 21964307 CD81 is Essential for the Re-entry of Hematopoietic Stem Cells to Quiescence Following Stress-induced Proliferation Via Deactivation of the Akt Pathway PLoS Biology. Sep, 2011 | Pubmed ID: 21931533 Inflammatory Modulation of HSCs: Viewing the HSC As a Foundation for the Immune Response Nature Reviews. Immunology. Sep, 2011 | Pubmed ID: 21904387 Irgm1 Protects Hematopoietic Stem Cells by Negative Regulation of IFN Signaling Blood. Aug, 2011 | Pubmed ID: 21633090 Hematopoietic Stem Cell Characterization and Isolation Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21618082 CD48 on Hematopoietic Progenitors Regulates Stem Cells and Suppresses Tumor Formation Blood. Jul, 2011 | Pubmed ID: 21576698 TIMP-1 Deficiency Subverts Cell-cycle Dynamics in Murine Long-term HSCs Blood. Jun, 2011 | Pubmed ID: 21521782 Investigating the Role of Hematopoietic Stem and Progenitor Cells in Regulating the Osteogenic Differentiation of Mesenchymal Stem Cells in Vitro Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Oct, 2011 | Pubmed ID: 21495066 A New Allele of Lyl1 Confirms Its Important Role in Hematopoietic Stem Cell Function Genesis (New York, N.Y. : 2000). Jun, 2011 | Pubmed ID: 21387538 Direct Conversion of Skin Cells into Blood: Alchemy or Science? Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011 | Pubmed ID: 21289635 Polymorphic Allele of Human IRGM1 is Associated with Susceptibility to Tuberculosis in African Americans PloS One. Jan, 2011 | Pubmed ID: 21283700 Inflammatory Signals Regulate Hematopoietic Stem Cells Trends in Immunology. Feb, 2011 | Pubmed ID: 21233016 The Expansion of T-cells and Hematopoietic Progenitors As a Result of Overexpression of the Lymphoblastic Leukemia Gene, Lyl1 Can Support Leukemia Formation Leukemia Research. Mar, 2011 | Pubmed ID: 20705338 The Orphan Nuclear Receptor Nurr1 Restricts the Proliferation of Haematopoietic Stem Cells Nature Cell Biology. Dec, 2010 | Pubmed ID: 21076412 LYL1 Degradation by the Proteasome is Directed by a N-terminal PEST Rich Site in a Phosphorylation-independent Manner PloS One. Sep, 2010 | Pubmed ID: 20844761 Quiescent Haematopoietic Stem Cells Are Activated by IFN-gamma in Response to Chronic Infection Nature. Jun, 2010 | Pubmed ID: 20535209 Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-beta1 Cell Stem Cell. Mar, 2010 | Pubmed ID: 20207229 Runx1 Isoforms Show Differential Expression Patterns During Hematopoietic Development but Have Similar Functional Effects in Adult Hematopoietic Stem Cells Experimental Hematology. May, 2010 | Pubmed ID: 20206228 Selective Elimination of a Chemoresistant Side Population of B-CLL Cells by Cytotoxic T Lymphocytes in Subjects Receiving an Autologous HCD40L/IL-2 Tumor Vaccine Leukemia. Mar, 2010 | Pubmed ID: 20072155 Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis PloS One. Jan, 2010 | Pubmed ID: 20052416 Mechanisms of Hematopoietic Stem Cell Aging Experimental Gerontology. Apr, 2010 | Pubmed ID: 20034552 Enhanced Generation of Myeloid Lineages in Hematopoietic Differentiation from Embryonic Stem Cells by Silencing Transcriptional Repressor Twist-2 Cloning and Stem Cells. Dec, 2009 | Pubmed ID: 20025523 Selective Depletion of a Minor Subpopulation of B-chronic Lymphocytic Leukemia Cells is Followed by a Delayed but Progressive Loss of Bulk Tumor Cells and Disease Regression Molecular Cancer. Nov, 2009 | Pubmed ID: 19922650 Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival Cell Stem Cell. Feb, 2009 | Pubmed ID: 19200805 Identification and Characterization of Side Population Cells in Embryonic Stem Cell Cultures Stem Cells and Development. Oct, 2009 | Pubmed ID: 19113897 Mouse Hematopoietic Stem Cell Identification and Analysis Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Jan, 2009 | Pubmed ID: 19023891 Promiscuous Expression of H2B-GFP Transgene in Hematopoietic Stem Cells PloS One. Jun, 2008 | Pubmed ID: 18523660 CD150- Side Population Cells Represent a Functionally Distinct Population of Long-term Hematopoietic Stem Cells Blood. Feb, 2008 | Pubmed ID: 18055867 Efficacy of Delayed Administration of Post-chemotherapy Granulocyte Colony-stimulating Factor: Evidence from Murine Studies of Bone Marrow Cell Kinetics Experimental Hematology. Jan, 2008 | Pubmed ID: 17949891 Hematopoietic Fingerprints: an Expression Database of Stem Cells and Their Progeny Cell Stem Cell. Nov, 2007 | Pubmed ID: 18371395 An Argument Against a Role for Oct4 in Somatic Stem Cells Cell Stem Cell. Oct, 2007 | Pubmed ID: 18371372 Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation PLoS Biology. Aug, 2007 | Pubmed ID: 17676974 Molecular Profiling of Hematopoietic Stem Cells Methods in Molecular Medicine. 2007 | Pubmed ID: 17666739 Pluripotentiality and Conditional Transgene Regulation in Human Embryonic Stem Cells Expressing Insulated Tetracycline-ON Transactivator Stem Cells (Dayton, Ohio). Oct, 2007 | Pubmed ID: 17628023 Retroviral Vector Insertion Sites Associated with Dominant Hematopoietic Clones Mark "stemness" Pathways Blood. Mar, 2007 | Pubmed ID: 17119121 The Impact of Altered P53 Dosage on Hematopoietic Stem Cell Dynamics During Aging Blood. Feb, 2007 | Pubmed ID: 17032926 Purification of Hematopoietic Stem Cells Using the Side Population Methods in Enzymology. 2006 | Pubmed ID: 17161700 Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells PLoS Genetics. Sep, 2006 | Pubmed ID: 17009876 Differential MRNA Processing in Hematopoietic Stem Cells Stem Cells (Dayton, Ohio). Mar, 2006 | Pubmed ID: 16373690 Hematopoietic Stem Cells Do Not Engraft with Absolute Efficiencies Blood. Jan, 2006 | Pubmed ID: 16204316 Stem Cell Identification and Sorting Using the Hoechst 33342 Side Population (SP) Current Protocols in Cytometry. Nov, 2005 | Pubmed ID: 18770827 Plasticity and Tissue Regenerative Potential of Bone Marrow-derived Cells Stem Cell Reviews. 2005 | Pubmed ID: 17132877 Roles of Sca-1 in Hematopoietic Stem/progenitor Cell Function Experimental Hematology. Jul, 2005 | Pubmed ID: 15963860 Isolation and Characterization of Side Population Cells Methods in Molecular Biology (Clifton, N.J.). 2005 | Pubmed ID: 15361673 Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells PLoS Biology. Oct, 2004 | Pubmed ID: 15459755 Circulating Hematopoietic Stem Cells Do Not Efficiently Home to Bone Marrow During Homeostasis Experimental Hematology. Sep, 2004 | Pubmed ID: 15345289 Hematopoietic Myelomonocytic Cells Are the Major Source of Hepatocyte Fusion Partners The Journal of Clinical Investigation. May, 2004 | Pubmed ID: 15124017 Myeloproliferative Disease in Mice with Reduced Presenilin Gene Dosage: Effect of Gamma-secretase Blockage Biochemistry. May, 2004 | Pubmed ID: 15122901 Skeletal Muscle Fiber-specific Green Autofluorescence: Potential for Stem Cell Engraftment Artifacts Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 14990857 An in Vivo Propagated Human Acute Myeloid Leukemia Expressing ABCA3 Leukemia Research. Mar, 2004 | Pubmed ID: 14687625 Primitive Adult Hematopoietic Stem Cells Can Function As Osteoblast Precursors Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14673088 Single Hematopoietic Stem Cells Generate Skeletal Muscle Through Myeloid Intermediates Nature Medicine. Dec, 2003 | Pubmed ID: 14625546 Isolation and Characterization of Functional Mammary Gland Stem Cells Cell Proliferation. Oct, 2003 | Pubmed ID: 14521513 Altered Phenotype and Reduced Function of Muscle-derived Hematopoietic Stem Cells Experimental Hematology. Sep, 2003 | Pubmed ID: 12962727 Transient RNA Interference in Hematopoietic Progenitors with Functional Consequences Genesis (New York, N.Y. : 2000). Aug, 2003 | Pubmed ID: 12929091 Phenotype and Hematopoietic Potential of Side Population Cells Throughout Embryonic Development Blood. Oct, 2003 | Pubmed ID: 12805065 Complement-fixing CD45 Monoclonal Antibodies to Facilitate Stem Cell Transplantation in Mouse and Man Annals of the New York Academy of Sciences. May, 2003 | Pubmed ID: 12799286 Stem-cell "plasticity": Befuddled by the Muddle Current Opinion in Hematology. May, 2003 | Pubmed ID: 12690288 Adenoviral Transduction of Mouse Hematopoietic Stem Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2003 | Pubmed ID: 12668129 Techniques for the Study of Adult Stem Cells: Be Fruitful and Multiply BioTechniques. Mar, 2003 | Pubmed ID: 12661162 Tracing the Origin of Non-hematopoietic Cells Using CD45 PCR Restriction Fragment Length Polymorphisms BioTechniques. Jan, 2003 | Pubmed ID: 12545553 Distinct Progenitor Populations in Skeletal Muscle Are Bone Marrow Derived and Exhibit Different Cell Fates During Vascular Regeneration The Journal of Clinical Investigation. Jan, 2003 | Pubmed ID: 12511590 Anti-CD45-mediated Cytoreduction to Facilitate Allogeneic Stem Cell Transplantation Blood. Mar, 2003 | Pubmed ID: 12433683 Failure of Bone Marrow Cells to Transdifferentiate into Neural Cells in Vivo Science (New York, N.Y.). Aug, 2002 | Pubmed ID: 12193778 The Therapeutic Potential of Stem Cells from Adults BMJ (Clinical Research Ed.). Aug, 2002 | Pubmed ID: 12183311 Use of CD9 Expression to Enrich for Porcine Hematopoietic Progenitors Experimental Hematology. Jul, 2002 | Pubmed ID: 12135680 Stem Cells: a Minireview Journal of Cellular Biochemistry. Supplement. 2002 | Pubmed ID: 12046843 Sca-1(pos) Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population Developmental Biology. May, 2002 | Pubmed ID: 11969254 Muscle-derived Hematopoietic Stem Cells Are Hematopoietic in Origin Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11830662 Regeneration of Ischemic Cardiac Muscle and Vascular Endothelium by Adult Stem Cells The Journal of Clinical Investigation. Jun, 2001 | Pubmed ID: 11390421 Hematopoietic Potential of Stem Cells Isolated from Murine Skeletal Muscle Proceedings of the National Academy of Sciences of the United States of America. Dec, 1999 | Pubmed ID: 10588731 تعطيل الجينات ذات كفاءة عالية من الخلايا السلف مورين والبشرية المكونة للدم قبل كريسبر/Cas9 Lorenzo Brunetti*1,2,3, Michael C. Gundry*1,2,4, Ayumi Kitano4, Daisuke Nakada1,2,4, Margaret A. Goodell1,2,4,5 1Stem Cells & Regenerative Medicine Center, Baylor College of Medicine, 2Center for Cell and Gene Therapy, Baylor College of Medicine, 3Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, 4Department of Molecular & Human Genetics, Baylor College of Medicine, 5Texas Children's Hospital & Houston Methodist Hospital JoVE 57278 Genetica
تعطيل الجينات ذات كفاءة عالية من الخلايا السلف مورين والبشرية المكونة للدم قبل كريسبر/Cas9 Lorenzo Brunetti*1,2,3, Michael C. Gundry*1,2,4, Ayumi Kitano4, Daisuke Nakada1,2,4, Margaret A. Goodell1,2,4,5 1Stem Cells & Regenerative Medicine Center, Baylor College of Medicine, 2Center for Cell and Gene Therapy, Baylor College of Medicine, 3Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, 4Department of Molecular & Human Genetics, Baylor College of Medicine, 5Texas Children's Hospital & Houston Methodist Hospital JoVE 57278 Genetica