Martin McMahon Diller Cancer Research Building University of California, San Francisco Biography Publications Institution JoVE Articles Martin McMahon has not added a biography. If you are Martin McMahon and would like to personalize this page please email our Author Liaison for assistance. Publications BRAFV600E Cooperates with PI3'-Kinase Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation Molecular Cancer Research : MCR. Jan, 2014 | Pubmed ID: 24425783 Abnormal Ras Signaling in Costello Syndrome (CS) Negatively Regulates Enamel Formation Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24057668 Differential AKT Dependency Displayed by Mouse Models of BRAFV600E-initiated Melanoma The Journal of Clinical Investigation. Dec, 2013 | Pubmed ID: 24200692 Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-lineage Cells Resistant to PLX4720 Molecular Cancer Research : MCR. Dec, 2013 | Pubmed ID: 24152792 Phenformin Enhances the Therapeutic Benefit of BRAF(V600E) Inhibition in Melanoma Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24145418 Mutationally Activated PIK3CA(H1047R) Cooperates with BRAF(V600E) to Promote Lung Cancer Progression Cancer Research. Nov, 2013 | Pubmed ID: 24019382 Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-driven Lung Tumors Cancer Discovery. Nov, 2013 | Pubmed ID: 23965987 Modelling Vemurafenib Resistance in Melanoma Reveals a Strategy to Forestall Drug Resistance Nature. Feb, 2013 | Pubmed ID: 23302800 Elucidating Distinct Roles for NF1 in Melanomagenesis Cancer Discovery. Mar, 2013 | Pubmed ID: 23171796 Oncogene-dependent Control of MiRNA Biogenesis and Metastatic Progression in a Model of Undifferentiated Pleomorphic Sarcoma The Journal of Pathology. Jan, 2013 | Pubmed ID: 22951975 An Ultraviolet-radiation-independent Pathway to Melanoma Carcinogenesis in the Red Hair/fair Skin Background Nature. Nov, 2012 | Pubmed ID: 23123854 The Intermediate-activity (L597V)BRAF Mutant Acts As an Epistatic Modifier of Oncogenic RAS by Enhancing Signaling Through the RAF/MEK/ERK Pathway Genes & Development. Sep, 2012 | Pubmed ID: 22892241 B-Raf Activation Cooperates with PTEN Loss to Drive C-Myc Expression in Advanced Prostate Cancer Cancer Research. Sep, 2012 | Pubmed ID: 22836754 Analysis of MRNA Profiles After MEK1/2 Inhibition in Human Pancreatic Cancer Cell Lines Reveals Pathways Involved in Drug Sensitivity Molecular Cancer Research : MCR. Dec, 2012 | Pubmed ID: 22833572 Regulated Temporal-spatial Astrocyte Precursor Cell Proliferation Involves BRAF Signalling in Mammalian Spinal Cord Development (Cambridge, England). Jul, 2012 | Pubmed ID: 22675209 A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma Cancer Discovery. Aug, 2012 | Pubmed ID: 22628411 Cooperative Interactions of BRAFV600E Kinase and CDKN2A Locus Deficiency in Pediatric Malignant Astrocytoma As a Basis for Rational Therapy Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22586120 Abrogation of BRAFV600E-induced Senescence by PI3K Pathway Activation Contributes to Melanomagenesis Genes & Development. May, 2012 | Pubmed ID: 22549727 E-cadherin Regulates the Behavior and Fate of Epithelial Stem Cells and Their Progeny in the Mouse Incisor Developmental Biology. Jun, 2012 | Pubmed ID: 22537490 MEK1/2 Inhibition Elicits Regression of Autochthonous Lung Tumors Induced by KRASG12D or BRAFV600E Cancer Research. Jun, 2012 | Pubmed ID: 22511580 β-catenin Signaling Controls Metastasis in Braf-activated Pten-deficient Melanomas Cancer Cell. Dec, 2011 | Pubmed ID: 22172720 Control of Mitotic Spindle Angle by the RAS-regulated ERK1/2 Pathway Determines Lung Tube Shape Science (New York, N.Y.). Jul, 2011 | Pubmed ID: 21764747 Mutationally Activated BRAF(V600E) Elicits Papillary Thyroid Cancer in the Adult Mouse Cancer Research. Jun, 2011 | Pubmed ID: 21512141 Costello and Cardio-facio-cutaneous Syndromes: Moving Toward Clinical Trials in RASopathies American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. May, 2011 | Pubmed ID: 21495172 Parsing out the Complexity of RAF Inhibitor Resistance Pigment Cell & Melanoma Research. Apr, 2011 | Pubmed ID: 21392366 RAF Translocations Expand Cancer Targets Nature Medicine. Jul, 2010 | Pubmed ID: 20613748 Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver Science Translational Medicine. Jan, 2010 | Pubmed ID: 20371474 Characterization of Melanoma Cells Capable of Propagating Tumors from a Single Cell Cancer Research. Jan, 2010 | Pubmed ID: 20048081 Proceedings from the 2009 Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back American Journal of Medical Genetics. Part A. Jan, 2010 | Pubmed ID: 20014119 Down-regulation of Cdx2 in Colorectal Carcinoma Cells by the Raf-MEK-ERK 1/2 Pathway Cellular Signalling. Dec, 2009 | Pubmed ID: 19686845 Meeting Report: Consensus from the First and Second Global Workshops in Melanoma November 19-20, 2008 Pigment Cell & Melanoma Research. Oct, 2009 | Pubmed ID: 19659612 Braf(V600E) Cooperates with Pten Loss to Induce Metastatic Melanoma Nature Genetics. May, 2009 | Pubmed ID: 19282848 Oncogenic BRAF(V600E) Inhibits BIM Expression to Promote Melanoma Cell Survival Pigment Cell & Melanoma Research. Oct, 2008 | Pubmed ID: 18715233 Meeting Report: Fourth International Congress of the Society for Melanoma Research Pigment Cell & Melanoma Research. Feb, 2008 | Pubmed ID: 18353140 A Model of Intussusceptive Angiogenesis Novartis Foundation Symposium. 2007 | Pubmed ID: 18300412 A New Mouse Model to Explore the Initiation, Progression, and Therapy of BRAFV600E-induced Lung Tumors Genes & Development. Feb, 2007 | Pubmed ID: 17299132 Diverse Toll-like Receptors Utilize Tpl2 to Activate Extracellular Signal-regulated Kinase (ERK) in Hemopoietic Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16484370 Constitutive Activation of Akt by Flt3 Internal Tandem Duplications is Necessary for Increased Survival, Proliferation, and Myeloid Transformation Cancer Research. Nov, 2005 | Pubmed ID: 16266983 The Epidermal Growth Factor Receptor Gene Family As a Target for Therapeutic Intervention in Numerous Cancers: What's Genetics Got to Do with It? Expert Opinion on Therapeutic Targets. Oct, 2005 | Pubmed ID: 16185155 Pharmacologic Inhibition of RAF-->MEK-->ERK Signaling Elicits Pancreatic Cancer Cell Cycle Arrest Through Induced Expression of P27Kip1 Cancer Research. Jun, 2005 | Pubmed ID: 15930308 Analysis of Genomic DNA Alterations and MRNA Expression Patterns in a Panel of Human Pancreatic Cancer Cell Lines Genes, Chromosomes & Cancer. Sep, 2005 | Pubmed ID: 15929091 Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines Cell Cycle (Georgetown, Tex.). Jun, 2005 | Pubmed ID: 15917660 Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor Molecular and Cellular Biology. Jan, 2005 | Pubmed ID: 15601844 Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT Molecular and Cellular Biology. Dec, 2004 | Pubmed ID: 15572689 Effects of a Conditionally Active V-ErbB and an EGF-R Inhibitor on Transformation of NIH-3T3 Cells and Abrogation of Cytokine Dependency of Hematopoietic Cells Oncogene. Oct, 2004 | Pubmed ID: 15361836 Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15128735 Inactivation of Icmt Inhibits Transformation by Oncogenic K-Ras and B-Raf The Journal of Clinical Investigation. Feb, 2004 | Pubmed ID: 14966563 DeltaRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry Molecular and Cellular Biology. Dec, 2003 | Pubmed ID: 14645540 Hedgehog is an Early and Late Mediator of Pancreatic Cancer Tumorigenesis Nature. Oct, 2003 | Pubmed ID: 14520413 Ras-induced Serine Phosphorylation of the Focal Adhesion Protein Paxillin is Mediated by the Raf-->MEK-->ERK Pathway Experimental Cell Research. Jul, 2003 | Pubmed ID: 12837288 Inhibition of the Raf/MEK/ERK Pathway Up-regulates Expression of the Coxsackievirus and Adenovirus Receptor in Cancer Cells Cancer Research. May, 2003 | Pubmed ID: 12727824 Effects of the RAF/MEK/ERK and PI3K/AKT Signal Transduction Pathways on the Abrogation of Cytokine-dependence and Prevention of Apoptosis in Hematopoietic Cells Oncogene. Apr, 2003 | Pubmed ID: 12717425 De Novo Infection and Serial Transmission of Kaposi's Sarcoma-associated Herpesvirus in Cultured Endothelial Cells Journal of Virology. Mar, 2002 | Pubmed ID: 11836422 Induction of Tubulogenesis in Telomerase-immortalized Human Microvascular Endothelial Cells by Glioblastoma Cells Experimental Cell Research. Feb, 2002 | Pubmed ID: 11795943 The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis Jillian M. Silva1, Martin McMahon1 1Diller Cancer Research Building, University of California, San Francisco JoVE 51149 Biologia
The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis Jillian M. Silva1, Martin McMahon1 1Diller Cancer Research Building, University of California, San Francisco JoVE 51149 Biologia