Masahito Ikawa Laboratory of Reproductive Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science The University of Tokyo Biography Publications Institution JoVE Articles Masahito Ikawa has not added a biography. If you are Masahito Ikawa and would like to personalize this page please email our Author Liaison for assistance. Publications Trim41 is Required to Regulate Chromosome Axis Protein Dynamics and Meiosis in Male Mice PLoS Genetics. 06, 2022 | Pubmed ID: 35648791 TULP2 Deletion Mice Exhibit Abnormal Outer Dense Fiber Structure and Male Infertility Reproductive Medicine and Biology. Jan-Dec, 2022 | Pubmed ID: 35619658 IRGC1, a Testis-enriched Immunity Related GTPase, is Important for Fibrous Sheath Integrity and Sperm Motility in Mice Developmental Biology. 08, 2022 | Pubmed ID: 35618043 Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies Frontiers in Endocrinology. 2022 | Pubmed ID: 35600599 Sperm Membrane Proteins DCST1 and DCST2 Are Required for Sperm-egg Interaction in Mice and Fish Communications Biology. 04, 2022 | Pubmed ID: 35393517 Kastor and Polluks Polypeptides Encoded by a Single Gene Locus Cooperatively Regulate VDAC and Spermatogenesis Nature Communications. 02, 2022 | Pubmed ID: 35228556 The Motor Domain of Testis-enriched Kinesin KIF9 is Essential for Its Localization in the Mouse Flagellum Experimental Animals. Feb, 2022 | Pubmed ID: 34526446 CRISPR/Cas9-mediated Genome Editing Reveals 12 Testis-enriched Genes Dispensable for Male Fertility in Mice Asian Journal of Andrology. May-Jun, 2022 | Pubmed ID: 34290169 Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 35096839 FAM71F1 Binds to RAB2A and RAB2B and is Essential for Acrosome Formation and Male Fertility in Mice Development (Cambridge, England). 11, 2021 | Pubmed ID: 34714330 LRRC23 is a Conserved Component of the Radial Spoke That is Necessary for Sperm Motility and Male Fertility in Mice Journal of Cell Science. 10, 2021 | Pubmed ID: 34585727 The Conserved Fertility Factor SPACA4/Bouncer Has Divergent Modes of Action in Vertebrate Fertilization Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34556579 SPATA33 Localizes Calcineurin to the Mitochondria and Regulates Sperm Motility in Mice Proceedings of the National Academy of Sciences of the United States of America. 08, 2021 | Pubmed ID: 34446558 A Sublethal ATP11A Mutation Associated with Neurological Deterioration Causes Aberrant Phosphatidylcholine Flipping in Plasma Membranes The Journal of Clinical Investigation. 09, 2021 | Pubmed ID: 34403372 Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment Endocrinology. 11, 2021 | Pubmed ID: 34402888 Rubicon Prevents Autophagic Degradation of GATA4 to Promote Sertoli Cell Function PLoS Genetics. 08, 2021 | Pubmed ID: 34351902 Precise CAG Repeat Contraction in a Huntington's Disease Mouse Model is Enabled by Gene Editing with SpCas9-NG Communications Biology. 06, 2021 | Pubmed ID: 34163001 KCTD19 and Its Associated Protein ZFP541 Are Independently Essential for Meiosis in Male Mice PLoS Genetics. 05, 2021 | Pubmed ID: 33961623 ARMC12 Regulates Spatiotemporal Mitochondrial Dynamics During Spermiogenesis and is Required for Male Fertility Proceedings of the National Academy of Sciences of the United States of America. 02, 2021 | Pubmed ID: 33536340 Protocol for Isolation of Spermatids from Mouse Testes STAR Protocols. 03, 2021 | Pubmed ID: 33490974 Astrocytic CAMP Modulates Memory Via Synaptic Plasticity Proceedings of the National Academy of Sciences of the United States of America. 01, 2021 | Pubmed ID: 33452135 CRISPR/CAS9-mediated Amino Acid Substitution Reveals Phosphorylation Residues of RSPH6A Are Not Essential for Male Fertility in Mice† Biology of Reproduction. 10, 2020 | Pubmed ID: 32901808 PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange During Spermiogenesis Cell Reports. 07, 2020 | Pubmed ID: 32726616 RNA-binding Protein Ptbp1 Regulates Alternative Splicing and Transcriptome in Spermatogonia and Maintains Spermatogenesis in Concert with Nanos3 The Journal of Reproduction and Development. Oct, 2020 | Pubmed ID: 32624547 Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility American Journal of Human Genetics. 08, 2020 | Pubmed ID: 32619401 Knockout of Family with Sequence Similarity 170 Member A (Fam170a) Causes Male Subfertility, While Fam170b is Dispensable in Mice† Biology of Reproduction. 08, 2020 | Pubmed ID: 32588889 CRISPR/Cas9-based Genome Editing in Mice Uncovers 13 Testis- or Epididymis-enriched Genes Individually Dispensable for Male Reproduction† Biology of Reproduction. 08, 2020 | Pubmed ID: 32588039 CRISPR/Cas9-mediated Genome-edited Mice Reveal 10 Testis-enriched Genes Are Dispensable for Male Fecundity Biology of Reproduction. 08, 2020 | Pubmed ID: 32561905 Analysis of the Sperm Flagellar Axoneme Using Gene-modified Mice Experimental Animals. 11, 2020 | Pubmed ID: 32554934 Tmprss12 is Required for Sperm Motility and Uterotubal Junction Migration in Mice† Biology of Reproduction. 08, 2020 | Pubmed ID: 32529245 NELL2-mediated Lumicrine Signaling Through OVCH2 is Required for Male Fertility Science (New York, N.Y.). 06, 2020 | Pubmed ID: 32499443 CIB4 is Essential for the Haploid Phase of Spermatogenesis in Mice† Biology of Reproduction. 08, 2020 | Pubmed ID: 32430498 Sperm Proteins SOF1, TMEM95, and SPACA6 Are Required for Sperm-oocyte Fusion in Mice Proceedings of the National Academy of Sciences of the United States of America. 05, 2020 | Pubmed ID: 32393636 Knockout of Serine-rich Single-pass Membrane Protein 1 (Ssmem1) Causes Globozoospermia and Sterility in Male Mice† Biology of Reproduction. 08, 2020 | Pubmed ID: 32301969 Prss55 but Not Prss51 is Required for Male Fertility in Mice† Biology of Reproduction. 08, 2020 | Pubmed ID: 32301961 Spermatozoa Lacking Fertilization Influencing Membrane Protein (FIMP) Fail to Fuse with Oocytes in Mice Proceedings of the National Academy of Sciences of the United States of America. 04, 2020 | Pubmed ID: 32295885 Structural Insights into Tetraspanin CD9 Function Nature Communications. 03, 2020 | Pubmed ID: 32231207 CRISPR/Cas9-Mediated Genome Editing Reveals Family Genes Are Dispensable for Female Fertility in Mice Cells. 03, 2020 | Pubmed ID: 32231122 Testis-enriched Kinesin KIF9 is Important for Progressive Motility in Mouse Spermatozoa FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2020 | Pubmed ID: 32072696 Nexin-Dynein Regulatory Complex Component DRC7 but Not FBXL13 is Required for Sperm Flagellum Formation and Male Fertility in Mice PLoS Genetics. 01, 2020 | Pubmed ID: 31961863 Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice† Biology of Reproduction. 04, 2020 | Pubmed ID: 31916570 Genetic Mutation of Frem3 Does Not CauseFraser Syndrome in Mice Experimental Animals. Jan, 2020 | Pubmed ID: 31554749 The Testis-specific Serine Proteases PRSS44, PRSS46, and PRSS54 Are Dispensable for Male Mouse Fertility† Biology of Reproduction. 02, 2020 | Pubmed ID: 31403672 Male Mice, Caged in the International Space Station for 35 Days, Sire Healthy Offspring Scientific Reports. 09, 2019 | Pubmed ID: 31551430 Identification of Multiple Male Reproductive Tract-specific Proteins That Regulate Sperm Migration Through the Oviduct in Mice Proceedings of the National Academy of Sciences of the United States of America. 09, 2019 | Pubmed ID: 31455729 Physiological Function of Seminal Vesicle Secretions on Male Fecundity Reproductive Medicine and Biology. Jul, 2019 | Pubmed ID: 31312102 Erratum: Publisher Correction: Calaxin is Required for Cilia-driven Determination of Vertebrate Laterality Communications Biology. 2019 | Pubmed ID: 31286071 Calaxin is Required for Cilia-driven Determination of Vertebrate Laterality Communications Biology. 2019 | Pubmed ID: 31240264 CRISPR/Cas9-mediated Genome Editing Reveals 30 Testis-enriched Genes Dispensable for Male Fertility in Mice† Biology of Reproduction. 08, 2019 | Pubmed ID: 31201419 Lvrn Expression is Not Critical for Mouse Placentation The Journal of Reproduction and Development. Jun, 2019 | Pubmed ID: 30745494 Glycerol Kinase 2 is Essential for Proper Arrangement of Crescent-like Mitochondria to Form the Mitochondrial Sheath During Mouse Spermatogenesis The Journal of Reproduction and Development. Apr, 2019 | Pubmed ID: 30662012 An Azoospermic Factor Gene, Ddx3y and Its Paralog, Ddx3x Are Dispensable in Germ Cells for Male Fertility The Journal of Reproduction and Development. Apr, 2019 | Pubmed ID: 30613052 Seminal Vesicle Secretory Protein 7, PATE4, is Not Required for Sperm Function but for Copulatory Plug Formation to Ensure Fecundity† Biology of Reproduction. 04, 2019 | Pubmed ID: 30452524 PTBP1 Contributes to Spermatogenesis Through Regulation of Proliferation in Spermatogonia The Journal of Reproduction and Development. Feb, 2019 | Pubmed ID: 30416150 Chimeric Analysis with Newly Established EGFP/DsRed2-tagged ES Cells Identify HYDIN As Essential for Spermiogenesis in Mice Experimental Animals. Feb, 2019 | Pubmed ID: 30089752 Co-expression of Sperm Membrane Proteins CMTM2A and CMTM2B is Essential for ADAM3 Localization and Male Fertility in Mice Journal of Cell Science. 10, 2018 | Pubmed ID: 30209135 RSPH6A is Required for Sperm Flagellum Formation and Male Fertility in Mice Journal of Cell Science. 10, 2018 | Pubmed ID: 30185526 New Insights into the Molecular Events of Mammalian Fertilization Trends in Biochemical Sciences. 10, 2018 | Pubmed ID: 30170889 Engineered CRISPR-Cas9 Nuclease with Expanded Targeting Space Science (New York, N.Y.). 09, 2018 | Pubmed ID: 30166441 Sperm-borne Phospholipase C Zeta-1 Ensures Monospermic Fertilization in Mice Scientific Reports. 01, 2018 | Pubmed ID: 29358633 Factors Controlling Sperm Migration Through the Oviduct Revealed by Gene-modified Mouse Models Experimental Animals. May, 2018 | Pubmed ID: 29353867 Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models International Journal of Molecular Sciences. Oct, 2017 | Pubmed ID: 29065458 Placenta-specific Gene Manipulation Using Lentiviral Vector and Its Application Placenta. Nov, 2017 | Pubmed ID: 28988726 Genome Editing in Mouse Zygotes and Embryonic Stem Cells by Introducing SgRNA/Cas9 Expressing Plasmids Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28643250 TCTE1 is a Conserved Component of the Dynein Regulatory Complex and is Required for Motility and Metabolism in Mouse Spermatozoa Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28630322 Structural and Functional Insights into IZUMO1 Recognition by JUNO in Mammalian Fertilization Nature Communications. 07, 2016 | Pubmed ID: 27416963 Essential Role of Autoactivation Circuitry on Aurora B-mediated H2AX-pS121 in Mitosis Nature Communications. 07, 2016 | Pubmed ID: 27389782 Ground-based Assessment of JAXA Mouse Habitat Cage Unit by Mouse Phenotypic Studies Experimental Animals. May, 2016 | Pubmed ID: 26822934 Liver-specific γ-glutamyl Carboxylase-deficient Mice Display Bleeding Diathesis and Short Life Span PloS One. 2014 | Pubmed ID: 24520408 Innate Versus Learned Odour Processing in the Mouse Olfactory Bulb Nature. Nov, 2007 | Pubmed ID: 17989651 CRISPR/Cas9-medierad högeffektiv geninriktning i embryonala stamceller för utveckling av genmanipulerade musmodeller Manabu Ozawa*1, Chihiro Emori*2, Masahito Ikawa1,2 1Laboratory of Reproductive Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 2Research Institute for Microbial Diseases, Osaka University JoVE 64385 Biologia dello sviluppo
CRISPR/Cas9-medierad högeffektiv geninriktning i embryonala stamceller för utveckling av genmanipulerade musmodeller Manabu Ozawa*1, Chihiro Emori*2, Masahito Ikawa1,2 1Laboratory of Reproductive Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 2Research Institute for Microbial Diseases, Osaka University JoVE 64385 Biologia dello sviluppo