Michael M Seidman Laboratory of Molecular Gerontology, National Institute on Aging National Institutes of Health Biography Publications Institution JoVE Articles Michael M Seidman has not added a biography. If you are Michael M Seidman and would like to personalize this page please email our Author Liaison for assistance. Publications DONSON and FANCM Associate with Different Replisomes Distinguished by Replication Timing and Chromatin Domain Nature Communications. 08, 2020 | Pubmed ID: 32769987 Replisome Structure Suggests Mechanism for Continuous Fork Progression and Post-replication Repair DNA Repair. 09, 2019 | Pubmed ID: 31303546 Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2 Cell Reports. May, 2019 | Pubmed ID: 31067464 Imaging Cellular Responses to Antigen Tagged DNA Damage DNA Repair. 11, 2018 | Pubmed ID: 30166246 R-loops Cause Genomic Instability in T Helper Lymphocytes from Patients with Wiskott-Aldrich Syndrome The Journal of Allergy and Clinical Immunology. 07, 2018 | Pubmed ID: 29248492 Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair ACS Chemical Biology. 07, 2017 | Pubmed ID: 28535027 Fanconi Anemia: A DNA Repair Disorder Characterized by Accelerated Decline of the Hematopoietic Stem Cell Compartment and Other Features of Aging Ageing Research Reviews. Jan, 2017 | Pubmed ID: 27223997 Single Molecule Analysis of Laser Localized Interstrand Crosslinks Frontiers in Genetics. 2016 | Pubmed ID: 27242893 Fan1 Deficiency Results in DNA Interstrand Cross-link Repair Defects, Enhanced Tissue Karyomegaly, and Organ Dysfunction Genes & Development. Mar, 2016 | Pubmed ID: 26980189 FANCM Interacts with PCNA to Promote Replication Traverse of DNA Interstrand Crosslinks Nucleic Acids Research. Apr, 2016 | Pubmed ID: 26825464 Catalytic Strand Separation by RECQ1 is Required for RPA-mediated Response to Replication Stress Current Biology : CB. Nov, 2015 | Pubmed ID: 26455304 MERIT40 Cooperates with BRCA2 to Resolve DNA Interstrand Cross-links Genes & Development. Sep, 2015 | Pubmed ID: 26338419 UHRF1 Contributes to DNA Damage Repair As a Lesion Recognition Factor and Nuclease Scaffold Cell Reports. Mar, 2015 | Pubmed ID: 25818288 CSB Interacts with SNM1A and Promotes DNA Interstrand Crosslink Processing Nucleic Acids Research. Jan, 2015 | Pubmed ID: 25505141 Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-strand Break Repair Journal of the American Chemical Society. Sep, 2014 | Pubmed ID: 25170678 The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks Molecular Cell. Nov, 2013 | Pubmed ID: 24207054 ATR-dependent Phosphorylation of FANCM at Serine 1045 is Essential for FANCM Functions Cancer Research. Jul, 2013 | Pubmed ID: 23698467 NEIL1 Responds and Binds to Psoralen-induced DNA Interstrand Crosslinks The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23508956 Age-related Disease Association of Endogenous γ-H2AX Foci in Mononuclear Cells Derived from Leukapheresis PloS One. 2012 | Pubmed ID: 23029205 A Ubiquitin-binding Protein, FAAP20, Links RNF8-mediated Ubiquitination to the Fanconi Anemia DNA Repair Network Molecular Cell. Jul, 2012 | Pubmed ID: 22705371 Sequence Conversion by Single Strand Oligonucleotide Donors Via Non-homologous End Joining in Mammalian Cells The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20489199 A Histone-fold Complex and FANCM Form a Conserved DNA-remodeling Complex to Maintain Genome Stability Molecular Cell. Mar, 2010 | Pubmed ID: 20347428 A Novel Link to Base Excision Repair? Trends in Biochemical Sciences. May, 2010 | Pubmed ID: 20172733 DNA Interstrand Crosslink Repair in Mammalian Cells: Step by Step Critical Reviews in Biochemistry and Molecular Biology. Feb, 2010 | Pubmed ID: 20039786 Repair of Laser-localized DNA Interstrand Cross-links in G1 Phase Mammalian Cells The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19684342 Selectivity and Affinity of DNA Triplex Forming Oligonucleotides Containing the Nucleoside Analogues 2'-O-methyl-5-(3-amino-1-propynyl)uridine and 2'-O-methyl-5-propynyluridine Organic & Biomolecular Chemistry. Nov, 2008 | Pubmed ID: 18972052 Correction of a Splice-site Mutation in the Beta-globin Gene Stimulated by Triplex-forming Peptide Nucleic Acids Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18757759 Interstrand Cross-link Formation in Duplex and Triplex DNA by Modified Pyrimidines Journal of the American Chemical Society. Aug, 2008 | Pubmed ID: 18620398 Human Replication Protein A Melts a DNA Triple Helix Structure in a Potent and Specific Manner Biochemistry. May, 2008 | Pubmed ID: 18410127 Targeted Gene Knock in and Sequence Modulation Mediated by a Psoralen-linked Triplex-forming Oligonucleotide The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18303025 Extensive Sugar Modification Improves Triple Helix Forming Oligonucleotide Activity in Vitro but Reduces Activity in Vivo Biochemistry. Sep, 2007 | Pubmed ID: 17691818 Targeted Cross-linking of the Human Beta-globin Gene in Living Cells Mediated by a Triple Helix Forming Oligonucleotide Biochemistry. Feb, 2006 | Pubmed ID: 16460044 The Development of Bioactive Triple Helix-forming Oligonucleotides Annals of the New York Academy of Sciences. Nov, 2005 | Pubmed ID: 16394131 Triplex Targeted Genomic Crosslinks Enter Separable Deletion and Base Substitution Pathways Nucleic Acids Research. 2005 | Pubmed ID: 16186129 Oligonucleotide Mediated Gene Targeting in Mammalian Cells Current Pharmaceutical Biotechnology. Oct, 2004 | Pubmed ID: 15544490 Werner Syndrome Protein 1367 Variants and Disposition Towards Coronary Artery Disease in Caucasian Patients Mechanisms of Ageing and Development. Jul, 2004 | Pubmed ID: 15246744 The Werner Syndrome Helicase and Exonuclease Cooperate to Resolve Telomeric D Loops in a Manner Regulated by TRF1 and TRF2 Molecular Cell. Jun, 2004 | Pubmed ID: 15200954 Linkage Between Werner Syndrome Protein and the Mre11 Complex Via Nbs1 The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15026416 Importance of Clustered 2'-O-(2-aminoethyl) Residues for the Gene Targeting Activity of Triple Helix-forming Oligonucleotides Biochemistry. Feb, 2004 | Pubmed ID: 14756571 Gene Targeting by Triple Helix-forming Oligonucleotides Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 14751832 Enhancement and Inhibition by 2'-O-hydroxyethyl Residues of Gene Targeting Mediated by Triple Helix Forming Oligonucleotides Nucleosides, Nucleotides & Nucleic Acids. Oct, 2003 | Pubmed ID: 14609232 Site-specific Mutagenesis by Triple Helix-forming Oligonucleotides Containing a Reactive Nucleoside Analog Nucleic Acids Research. Mar, 2003 | Pubmed ID: 12626730 Cell Cycle Modulation of Gene Targeting by a Triple Helix-forming Oligonucleotide The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12538585 Minimum Number of 2'-O-(2-aminoethyl) Residues Required for Gene Knockout Activity by Triple Helix Forming Oligonucleotides Biochemistry. Jun, 2002 | Pubmed ID: 12056903 Triple-helix Formation Induces Recombination in Mammalian Cells Via a Nucleotide Excision Repair-dependent Pathway Molecular and Cellular Biology. Feb, 2000 | Pubmed ID: 10629056 Visualisering af gentagne møder med en antigenmærket blokerende læsion Jing Zhang*1, Jing Huang*2, Ishani Majumdar1, Ryan C. James3, Julia Gichimu1, Manikandan Paramasivam4, Durga Pokharel5, Himabindu Gali6, Marina A. Bellani1, Michael M Seidman1 1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 2Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 3Department of Molecular Biology and Genetics, Cornell University, 4Department of Cellular and Molecular Medicine, University of Copenhagen, 5Horizon Discovery, 6Boston University School of Medicine JoVE 61689 Biologia
Visualisering af gentagne møder med en antigenmærket blokerende læsion Jing Zhang*1, Jing Huang*2, Ishani Majumdar1, Ryan C. James3, Julia Gichimu1, Manikandan Paramasivam4, Durga Pokharel5, Himabindu Gali6, Marina A. Bellani1, Michael M Seidman1 1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 2Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 3Department of Molecular Biology and Genetics, Cornell University, 4Department of Cellular and Molecular Medicine, University of Copenhagen, 5Horizon Discovery, 6Boston University School of Medicine JoVE 61689 Biologia