Michael Reth Max-Planck Institute for Immunobiology und Epigenetics Biography Publications Institution JoVE Articles Michael Reth has not added a biography. If you are Michael Reth and would like to personalize this page please email our Author Liaison for assistance. Publications What Goes Up Must Come Down: A Tripartite Dok-3/Grb2/SHIP1 Inhibitory Module Limits BCR Signaling European Journal of Immunology. Nov, 2016 | Pubmed ID: 27813071 Molecular Requirements of the B-cell Antigen Receptor for Sensing Monovalent Antigens The EMBO Journal. Nov, 2016 | Pubmed ID: 27634959 Corrigendum: Signalling Thresholds and Negative B-cell Selection in Acute Lymphoblastic Leukaemia Nature. 06, 2016 | Pubmed ID: 26958840 Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function Journal of Immunology (Baltimore, Md. : 1950). Mar, 2016 | Pubmed ID: 26843325 Receptor Dissociation and B-Cell Activation Current Topics in Microbiology and Immunology. 2016 | Pubmed ID: 26428245 B Cell Antigen Receptors of the IgM and IgD Classes Are Clustered in Different Protein Islands That Are Altered During B Cell Activation Science Signaling. Sep, 2015 | Pubmed ID: 26373673 Kidins220/ARMS Binds to the B Cell Antigen Receptor and Regulates B Cell Development and Activation The Journal of Experimental Medicine. Sep, 2015 | Pubmed ID: 26324445 Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells Journal of Immunology (Baltimore, Md. : 1950). Aug, 2015 | Pubmed ID: 26157172 Erratum: Responsiveness of B Cells is Regulated by the Hinge Region of IgD Nature Immunology. Jul, 2015 | Pubmed ID: 26086144 Responsiveness of B Cells is Regulated by the Hinge Region of IgD Nature Immunology. May, 2015 | Pubmed ID: 25848865 Signalling Thresholds and Negative B-cell Selection in Acute Lymphoblastic Leukaemia Nature. May, 2015 | Pubmed ID: 25799995 TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-mesenchymal Transition Developmental Cell. Mar, 2015 | Pubmed ID: 25727005 Fundamental Properties of Unperturbed Haematopoiesis from Stem Cells in Vivo Nature. Feb, 2015 | Pubmed ID: 25686605 Preface to Special Issue on Nanoscale Membrane Organisations Biochimica Et Biophysica Acta. Apr, 2015 | Pubmed ID: 25677899 CD19 and BAFF-R Can Signal to Promote B-cell Survival in the Absence of Syk The EMBO Journal. Apr, 2015 | Pubmed ID: 25630702 The Nanoscale Organization of the B Lymphocyte Membrane Biochimica Et Biophysica Acta. Apr, 2015 | Pubmed ID: 25450974 Suboptimal B-cell Antigen Receptor Signaling Activity in Vivo Elicits Germinal Center Counterselection Mechanisms European Journal of Immunology. Feb, 2015 | Pubmed ID: 25382621 The AP-1 Transcription Factor Fra1 Inhibits Follicular B Cell Differentiation into Plasma Cells The Journal of Experimental Medicine. Oct, 2014 | Pubmed ID: 25288397 Production of IgG Autoantibody Requires Expression of Activation-induced Deaminase in Early-developing B Cells in a Mouse Model of SLE European Journal of Immunology. Oct, 2014 | Pubmed ID: 25044405 PDK1 Regulates B Cell Differentiation and Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 24979759 B Cell Activation Involves Nanoscale Receptor Reorganizations and Inside-out Signaling by Syk ELife. Jun, 2014 | Pubmed ID: 24963139 The Role of the Syk/Shp-1 Kinase-phosphatase Equilibrium in B Cell Development and Signaling Journal of Immunology (Baltimore, Md. : 1950). Jul, 2014 | Pubmed ID: 24899508 The Ligand-binding Domain of Siglec-G is Crucial for Its Selective Inhibitory Function on B1 Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24790146 MIF Promotes B Cell Chemotaxis Through the Receptors CXCR4 and CD74 and ZAP-70 Signaling Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24760155 Pillars Article: Antigen Receptor Tail Clue. Nature. 1989. 338: 383-384 Journal of Immunology (Baltimore, Md. : 1950). May, 2014 | Pubmed ID: 24748635 The Protein Tyrosine Phosphatase PTP1B is a Negative Regulator of CD40 and BAFF-R Signaling and Controls B Cell Autoimmunity The Journal of Experimental Medicine. Mar, 2014 | Pubmed ID: 24590766 Signaling Circuits in Early B-cell Development Advances in Immunology. 2014 | Pubmed ID: 24507157 Michael Neuberger (1953-2013) Immunity. Dec, 2013 | Pubmed ID: 24479157 Pre-clustering of the B Cell Antigen Receptor Demonstrated by Mathematically Extended Electron Microscopy Frontiers in Immunology. 2013 | Pubmed ID: 24367367 Proximity Ligation Assay for High-content Profiling of Cell Signaling Pathways on a Microfluidic Chip Molecular & Cellular Proteomics : MCP. Dec, 2013 | Pubmed ID: 24072685 Inhibition of MTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells Cell. Aug, 2013 | Pubmed ID: 23953116 The Serine/threonine Phosphatase PP4 is Required for Pro-B Cell Development Through Its Promotion of Immunoglobulin VDJ Recombination PloS One. 2013 | Pubmed ID: 23874770 Matching Cellular Dimensions with Molecular Sizes Nature Immunology. Aug, 2013 | Pubmed ID: 23867923 CD22 Ligand-binding and Signaling Domains Reciprocally Regulate B-cell Ca2+ Signaling Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23836650 Semi-supervised Prediction of SH2-peptide Interactions from Imbalanced High-throughput Data PloS One. 2013 | Pubmed ID: 23690949 Immunoglobulins Drive Terminal Maturation of Splenic Dendritic Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23345431 Non-cell-autonomous Hedgehog Signaling Promotes Murine B Lymphopoiesis from Hematopoietic Progenitors Blood. Jun, 2012 | Pubmed ID: 22517907 Synthetic Immune Signaling Current Opinion in Biotechnology. Oct, 2012 | Pubmed ID: 22326912 The E3 Ubiquitin Ligase Mule Acts Through the ATM-p53 Axis to Maintain B Lymphocyte Homeostasis The Journal of Experimental Medicine. Jan, 2012 | Pubmed ID: 22213803 The SH2-domain of SHIP1 Interacts with the SHIP1 C-terminus: Impact on SHIP1/Ig-α Interaction Biochimica Et Biophysica Acta. Feb, 2012 | Pubmed ID: 22182704 Drosophila S2 Schneider Cells: a Useful Tool for Rebuilding and Redesigning Approaches in Synthetic Biology Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22083752 B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice Gastroenterology. Jan, 2012 | Pubmed ID: 21983080 Bacillus Subtilis MreB Orthologs Self-organize into Filamentous Structures Underneath the Cell Membrane in a Heterologous Cell System PloS One. 2011 | Pubmed ID: 22069484 B Cell Homeostasis and Plasma Cell Homing Controlled by Krüppel-like Factor 2 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21187409 Syk is a Dual-specificity Kinase That Self-regulates the Signal Output from the B-cell Antigen Receptor Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20940318 The Dissociation Activation Model of B Cell Antigen Receptor Triggering FEBS Letters. Dec, 2010 | Pubmed ID: 20920502 Oligomeric Organization of the B-cell Antigen Receptor on Resting Cells Nature. Sep, 2010 | Pubmed ID: 20818374 N-linked Glycosylation Selectively Regulates Autonomous Precursor BCR Function Nature Immunology. Aug, 2010 | Pubmed ID: 20622883 Arginine Methylation of the B Cell Antigen Receptor Promotes Differentiation The Journal of Experimental Medicine. Apr, 2010 | Pubmed ID: 20231378 Voltage Control for B Cell Activation Nature Immunology. Mar, 2010 | Pubmed ID: 20157299 Analysis of Novel Phospho-ITAM Specific Antibodies in a S2 Reconstitution System for TCR-CD3 Signalling Immunology Letters. May, 2010 | Pubmed ID: 20005895 Autoinhibition and Adapter Function of Syk Immunological Reviews. Nov, 2009 | Pubmed ID: 19909371 Induction of B-cell Development in Adult Mice Reveals the Ability of Bone Marrow to Produce B-1a Cells Blood. Dec, 2009 | Pubmed ID: 19812384 Molecular Components of the B-cell Antigen Receptor Complex of the IgM Class. 1990 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19620316 Regulation of B-cell Proliferation and Differentiation by Pre-B-cell Receptor Signalling Nature Reviews. Immunology. Mar, 2009 | Pubmed ID: 19240758 Genomic Instability Resulting from Blm Deficiency Compromises Development, Maintenance, and Function of the B Cell Lineage Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19109166 Clustering Models Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 19065784 Enhanced B-cell Activation Mediated by TLR4 and BCR Crosstalk European Journal of Immunology. Sep, 2008 | Pubmed ID: 18819072 Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18566414 SLP-65 Regulates Immunoglobulin Light Chain Gene Recombination Through the PI(3)K-PKB-Foxo Pathway Nature Immunology. Jun, 2008 | Pubmed ID: 18488031 The Kinase Syk As an Adaptor Controlling Sustained Calcium Signalling and B-cell Development The EMBO Journal. May, 2008 | Pubmed ID: 18369315 The TCR Binding Site Does Move Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17925433 Mutations of the Igbeta Gene Cause Agammaglobulinemia in Man The Journal of Experimental Medicine. Sep, 2007 | Pubmed ID: 17709424 Immunoreceptors and Integrins Immunological Reviews. Aug, 2007 | Pubmed ID: 17624940 Yin Yang 1 is a Critical Regulator of B-cell Development Genes & Development. May, 2007 | Pubmed ID: 17504937 Survival of Liver Failure Pigs by Transplantation of Reversibly Immortalized Human Hepatocytes with Tamoxifen-mediated Self-recombination Journal of Hepatology. Jul, 2007 | Pubmed ID: 17434229 Association of Protein Kinase C-delta with the B Cell Antigen Receptor Complex Cellular Signalling. Apr, 2007 | Pubmed ID: 17098397 Identification of Disulfide Bonds in the Ig-alpha/Ig-beta Component of the B Cell Antigen Receptor Using the Drosophila S2 Cell Reconstitution System International Immunology. Sep, 2006 | Pubmed ID: 16877534 Canonical NF-kappaB Activity, Dispensable for B Cell Development, Replaces BAFF-receptor Signals and Promotes B Cell Proliferation Upon Activation Immunity. Jun, 2006 | Pubmed ID: 16782029 Human T-cell Leukemia Virus Type-I Oncoprotein Tax Inhibits Fas-mediated Apoptosis by Inducing Cellular FLIP Through Activation of NF-kappaB Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Feb, 2006 | Pubmed ID: 16436054 Two Dimensional Blue Native-/SDS-PAGE Analysis of SLP Family Adaptor Protein Complexes Immunology Letters. Apr, 2006 | Pubmed ID: 16356554 B Cell Signaling and Tumorigenesis Annual Review of Immunology. 2005 | Pubmed ID: 15771577 Postnatal Isl1+ Cardioblasts Enter Fully Differentiated Cardiomyocyte Lineages Nature. Feb, 2005 | Pubmed ID: 15703750 A Leucine Zipper in the N Terminus Confers Membrane Association to SLP-65 Nature Immunology. Feb, 2005 | Pubmed ID: 15654340 Reversible Switching of Immunoglobulin Hypermutation Machinery in a Chicken B Cell Line Biochemical and Biophysical Research Communications. Feb, 2005 | Pubmed ID: 15629431 Adenosine and CAMP Are Potent Inhibitors of the NF-kappa B Pathway Downstream of Immunoreceptors European Journal of Immunology. Jan, 2005 | Pubmed ID: 15580656 Perspectives on the Nature of BCR-mediated Survival Signals Molecular Cell. Jun, 2004 | Pubmed ID: 15200948 B-cell Signal Transduction: Tyrosine Phosphorylation, Kinase Activity, and Calcium Mobilization Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 15146122 Functional Folding of a Cytoplasmic Single-chain Variable Fragment and Its Use As Elutable Protein Purification Tag Immunology Letters. Mar, 2004 | Pubmed ID: 15081544 B Cell Antigen Receptor Assembly and Syk Activation in the S2 Cell Reconstitution System Immunology Letters. Mar, 2004 | Pubmed ID: 15081529 Feedback Regulation of Lymphocyte Signalling Nature Reviews. Immunology. Apr, 2004 | Pubmed ID: 15057785 A Revised and Complete Map of the Chicken C-mil/raf-1 Locus Oncogene. Apr, 2004 | Pubmed ID: 14968114 Activation of the CKI-CDK-Rb-E2F Pathway in Full Genome Hepatitis C Virus-expressing Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14747471 Importance of TRF1 for Functional Telomere Structure The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14559908 Identification of Novel ERK-mediated Feedback Phosphorylation Sites at the C-terminus of B-Raf Oncogene. Dec, 2003 | Pubmed ID: 14654779 Identification of a Pre-BCR Lacking Surrogate Light Chain The Journal of Experimental Medicine. Dec, 2003 | Pubmed ID: 14638847 B Cell Defects in SLP65/BLNK-deficient Mice Can Be Partially Corrected by the Absence of CD22, an Inhibitory Coreceptor for BCR Signaling European Journal of Immunology. Dec, 2003 | Pubmed ID: 14635051 A High-molecular-weight Complex of Membrane Proteins BAP29/BAP31 is Involved in the Retention of Membrane-bound IgD in the Endoplasmic Reticulum Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12886015 Bruton's Tyrosine Kinase Cooperates with the B Cell Linker Protein SLP-65 As a Tumor Suppressor in Pre-B Cells The Journal of Experimental Medicine. Jul, 2003 | Pubmed ID: 12835482 Establishment of Immortalized Human Hepatic Stellate Scavenger Cells to Develop Bioartificial Livers Transplantation. Jun, 2003 | Pubmed ID: 12811248 Deficiency of the Adaptor SLP-65 in Pre-B-cell Acute Lymphoblastic Leukaemia Nature. May, 2003 | Pubmed ID: 12761551 Genetic Changes Occurring in Established Tumors Rapidly Stimulate New Antibody Responses Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003 | Pubmed ID: 12702750 NF-kappaB is Required for Cell Death Induction by Latent Membrane Protein 1 of Epstein-Barr Virus Cellular Signalling. Apr, 2003 | Pubmed ID: 12618217 Essential Role of Src-family Protein Tyrosine Kinases in NF-kappaB Activation During B Cell Development Nature Immunology. Mar, 2003 | Pubmed ID: 12563261 Activation of T Cells Via Tumor Antigen Specific Chimeric Receptors: the Role of the Intracellular Signaling Domain International Journal of Cancer. Jan, 2003 | Pubmed ID: 12471624 The Adaptor Protein SLP-65 Acts As a Tumor Suppressor That Limits Pre-B Cell Expansion Nature Immunology. Jan, 2003 | Pubmed ID: 12436112 Amplification of B Cell Antigen Receptor Signaling by a Syk/ITAM Positive Feedback Loop Molecular Cell. Nov, 2002 | Pubmed ID: 12453414 Hydrogen Peroxide As Second Messenger in Lymphocyte Activation Nature Immunology. Dec, 2002 | Pubmed ID: 12447370 Inducible Gene Deletion Reveals Different Roles for B-Raf and Raf-1 in B-cell Antigen Receptor Signalling The EMBO Journal. Nov, 2002 | Pubmed ID: 12411479 BCR Mutants Deficient in Ligand-independent and More Sensitive for Ligand-dependent Signaling European Journal of Immunology. Jun, 2002 | Pubmed ID: 12115644 B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-alpha and Ig-beta Journal of Immunology (Baltimore, Md. : 1950). Jul, 2002 | Pubmed ID: 12097390 The Role of SHIP in Mast Cell Degranulation and IgE-induced Mast Cell Survival Immunology Letters. Jun, 2002 | Pubmed ID: 12008029 The Procaspase-8 Isoform, Procaspase-8L, Recruited to the BAP31 Complex at the Endoplasmic Reticulum Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11917123 Cre Recombinase-controlled Expression of the Mb-1 Allele Genesis (New York, N.Y. : 2000). Feb, 2002 | Pubmed ID: 11857807 LED Thermo Flow — Combining Optogenetics with Flow Cytometry Kathrin Brenker1,2,3, Kerstin Osthof1,4, Jianying Yang1,3, Michael Reth1,3,5 1Max-Planck Institute for Immunobiology und Epigenetics, 2Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 3Centre for Biological Signaling Studies, BIOSS, University of Freiburg, 4Albert-Ludwigs-Universität, 5Institute for Biology III (Mol. Immunology), Albert-Ludwigs-Universität JoVE 54707 Biologia
LED Thermo Flow — Combining Optogenetics with Flow Cytometry Kathrin Brenker1,2,3, Kerstin Osthof1,4, Jianying Yang1,3, Michael Reth1,3,5 1Max-Planck Institute for Immunobiology und Epigenetics, 2Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 3Centre for Biological Signaling Studies, BIOSS, University of Freiburg, 4Albert-Ludwigs-Universität, 5Institute for Biology III (Mol. Immunology), Albert-Ludwigs-Universität JoVE 54707 Biologia