Michelle Bradley Department of Chemistry and Biochemistry University of California, Los Angeles Biography Publications Institution JoVE Articles Michelle Bradley has not added a biography. If you are Michelle Bradley and would like to personalize this page please email our Author Liaison for assistance. Publications The Treatment of Chronic Coccydynia and Postcoccygectomy Pain With Pelvic Floor Physical Therapy PM & R : the Journal of Injury, Function, and Rehabilitation. Aug, 2016 | Pubmed ID: 27565640 Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy Molecular Pharmacology. May, 2016 | Pubmed ID: 26916831 Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor Molecular Pharmacology. Apr, 2016 | Pubmed ID: 26772612 Interim Estimates of Male Human Papillomavirus Vaccination Coverage in the School-based Program in Australia Communicable Diseases Intelligence Quarterly Report. Jun, 2015 | Pubmed ID: 26234254 Functional Desensitization of the β 2 Adrenoceptor is Not Dependent on Agonist Efficacy Pharmacology Research & Perspectives. Feb, 2015 | Pubmed ID: 25692019 The Identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone As an Inhaled Long-acting β2-adrenoceptor Agonist Bioorganic & Medicinal Chemistry Letters. Sep, 2014 | Pubmed ID: 25065493 The Discovery of Potent, Orally Bioavailable Pyrimidine-5-carbonitrile-6-alkyl CXCR2 Receptor Antagonists Bioorganic & Medicinal Chemistry Letters. Aug, 2014 | Pubmed ID: 24974342 Investigating the Molecular Mechanisms Through Which FTY720-P Causes Persistent S1P1 Receptor Internalization British Journal of Pharmacology. Nov, 2014 | Pubmed ID: 24641481 The Discovery of Potent, Orally Bioavailable Pyrazolo and Triazolopyrimidine CXCR2 Receptor Antagonists Bioorganic & Medicinal Chemistry Letters. Jan, 2014 | Pubmed ID: 24332493 The Effect of Three or Six Years of Denosumab Exposure in Women with Postmenopausal Osteoporosis: Results from the FREEDOM Extension The Journal of Clinical Endocrinology and Metabolism. Nov, 2013 | Pubmed ID: 23979955 An Investigation into the Structure-activity Relationships Associated with the Systematic Modification of the β(2)-adrenoceptor Agonist Indacaterol Bioorganic & Medicinal Chemistry Letters. Oct, 2012 | Pubmed ID: 22932315 Monoamine Oxidase A Expression is Suppressed in Human Cholangiocarcinoma Via Coordinated Epigenetic and IL-6-driven Events Laboratory Investigation; a Journal of Technical Methods and Pathology. Oct, 2012 | Pubmed ID: 22906985 Five Years of Denosumab Exposure in Women with Postmenopausal Osteoporosis: Results from the First Two Years of the FREEDOM Extension Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Mar, 2012 | Pubmed ID: 22113951 Mortality in Carotid Sinus Hypersensitivity: a Cohort Study BMJ Open. Jul, 2011 | Pubmed ID: 22021728 The in Vitro Metabolism of Sphingosine-1-phosphate: Identification; Inhibition and Pharmacological Implications European Journal of Pharmacology. Dec, 2011 | Pubmed ID: 21970805 Design and Synthesis of a Library of Chemokine Antagonists Bioorganic & Medicinal Chemistry Letters. Nov, 2011 | Pubmed ID: 21940167 Constitutive Activation of LXR in Macrophages Regulates Metabolic and Inflammatory Gene Expression: Identification of ARL7 As a Direct Target Journal of Lipid Research. Mar, 2011 | Pubmed ID: 21187453 LXR Promotes the Maximal Egress of Monocyte-derived Cells from Mouse Aortic Plaques During Atherosclerosis Regression The Journal of Clinical Investigation. Dec, 2010 | Pubmed ID: 21041949 A Physical Properties Based Approach for the Exploration of a 4-hydroxybenzothiazolone Series of Beta2-adrenoceptor Agonists As Inhaled Long-acting Bronchodilators Bioorganic & Medicinal Chemistry Letters. Sep, 2010 | Pubmed ID: 20655218 The Identification of Indacaterol As an Ultralong-acting Inhaled Beta2-adrenoceptor Agonist Journal of Medicinal Chemistry. May, 2010 | Pubmed ID: 20402514 Apoptotic Cells Promote Their Own Clearance and Immune Tolerance Through Activation of the Nuclear Receptor LXR Immunity. Aug, 2009 | Pubmed ID: 19646905 T0901317, an LXR Agonist, Augments PKA-induced Vascular Cell Calcification FEBS Letters. Apr, 2009 | Pubmed ID: 19327357 Preserved Glucose Tolerance in High-fat-fed C57BL/6 Mice Transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- Bone Marrow Journal of Lipid Research. Feb, 2009 | Pubmed ID: 18772483 TLR/MyD88 and Liver X Receptor Alpha Signaling Pathways Reciprocally Control Chlamydia Pneumoniae-induced Acceleration of Atherosclerosis Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18981139 LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response Cell. Jul, 2008 | Pubmed ID: 18614014 N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRbeta Journal of Medicinal Chemistry. Aug, 2007 | Pubmed ID: 17665897 Ligand Activation of LXR Beta Reverses Atherosclerosis and Cellular Cholesterol Overload in Mice Lacking LXR Alpha and ApoE The Journal of Clinical Investigation. Aug, 2007 | Pubmed ID: 17657314 Human Ikaros Function in Activated T Cells is Regulated by Coordinated Expression of Its Largest Isoforms The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17135265 MRI of the Ankle: Effect on Diagnostic Confidence and Patient Management AJR. American Journal of Roentgenology. Nov, 2006 | Pubmed ID: 17056924 The Arginase II Gene is an Anti-inflammatory Target of Liver X Receptor in Macrophages The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16943198 Phosphorylation of the Liver X Receptors FEBS Letters. Sep, 2006 | Pubmed ID: 16904112 Expression Profiling of Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Normal and Degenerate Human Achilles Tendon Arthritis and Rheumatism. Mar, 2006 | Pubmed ID: 16508964 Development and Validation of a Rotor-gene Real-time PCR Assay for Detection, Identification, and Quantification of Chlamydia Trachomatis in a Single Reaction Journal of Clinical Microbiology. Jan, 2006 | Pubmed ID: 16390971 A Role for the Apoptosis Inhibitory Factor AIM/Spalpha/Api6 in Atherosclerosis Development Cell Metabolism. Mar, 2005 | Pubmed ID: 16054063 Lesion Macrophages Are a Key Target for the Antiatherogenic Effects of LXR Agonists Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2005 | Pubmed ID: 15626767 LXR-dependent Gene Expression is Important for Macrophage Survival and the Innate Immune Response Cell. Oct, 2004 | Pubmed ID: 15479645 C/EBPbeta Regulation in Lipopolysaccharide-stimulated Macrophages Molecular and Cellular Biology. Jul, 2003 | Pubmed ID: 12832471 Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks Michelle Bradley1, Ivan Ramirez1, Keith Cheung1, Ankur A. Gholkar1, Jorge Z. Torres1,2,3 1Department of Chemistry and Biochemistry, University of California, Los Angeles, 2Molecular Biology Institute, University of California, Los Angeles, 3Jonsson Comprehensive Cancer Center, University of California, Los Angeles JoVE 54870 Biologia
Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks Michelle Bradley1, Ivan Ramirez1, Keith Cheung1, Ankur A. Gholkar1, Jorge Z. Torres1,2,3 1Department of Chemistry and Biochemistry, University of California, Los Angeles, 2Molecular Biology Institute, University of California, Los Angeles, 3Jonsson Comprehensive Cancer Center, University of California, Los Angeles JoVE 54870 Biologia