Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 Trisomie 21-assoziierte Defekte in Menschlichen Primitiven Blutbildung Durch Induzierte Pluripotente Stammzellen Offenbart Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 Erneuernde Endodermalen Vorläuferzellen Linien Aus Menschlichen Pluripotenten Stammzellen Erzeugt Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 High-Throughput-Screening Assay Für Embryoid Körper Differenzierung Von Humanen Embryonalen Stammzellen Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 Eine Nische Endothelzellen Induziert Hepatische Spezifikation Durch Doppelte Unterdrückung Von Wnt Und Notch Signalisieren Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 Maus ES Und IPS-Zellen Können ähnliche Endgültige Endodermis Trotz Unterschiedlicher Eingeprägten Gene Bilden The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 Eine Hochdurchsatz-Multiplex-Screening Assay Zur Optimierung Serumfreie Differenzierung Protokolle Von Menschlichen Embryonalen Stammzellen Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 Leberregeneration Von Induzierten Pluripotenten Stammzellen Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 Generation Von Transgen-freie Lunge Krankheitsspezifische Menschlichen Induzierten Pluripotenten Stammzellen, Die Mit Eine Einzigen Verbrauchsteuerpflichtiger Lentivirale Stammzell-Kassette Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Transkriptionelle Kompetenz Und Die Aktive Kennzeichnung Von Gewebe-spezifischen Enhancer Von Definierten Transkriptionsfaktoren in Embryonalen Und Induzierten Pluripotenten Stammzellen Genes & Development. Dec, 2009 | Pubmed ID: 20008934 Stammzellen Entschlüsselt, Dottersack Blutbildung Blood. Aug, 2009 | Pubmed ID: 19696206 Generierung Von Monoklonalen Antikörper, Die Spezifisch Für Zelle Oberfläche Moleküle Auf Frühen Maus Endodermis Ausgedrückt Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 Epidermiszellen Rev Neuprogrammierung Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 Taub Vermittelt Die Interaktion Zwischen Wnt Und Notch, Primitive Erythropoetische Spezifikation Aus Der Hämangioblast Zu Modulieren Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 WNT, Activin Und BMP Signalisierung Regeln Unterschiedliche Stationen in Der Entwicklungsbiologie Weg Aus Embryonalen Stammzellen Ins Blut Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 Identifizierung Und Ausrichtung Auf Die ROSA26-Locus in Humanen Embryonalen Stammzellen Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 BMP-4 Ist Für Hepatische Spezifikation Der Maus Embryonale Stammzellen Cell-derived Definitive Endodermis Erforderlich Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 WNT Und TGF-Beta Signalisierung Sind Erforderlich Für Die Induktion Eines In-vitro-Modells Der Primitivstreifen-Formation, Die Verwendung Von Embryonalen Stammzellen Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 Mikrobe-Schicht Induktion Aus Embryonalen Stammzellen Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 Restaurierung Der NK-T-Zell-Entwicklung in Fyn-Mutanten Mäuse Von Einem TCR Offenbart Eine Voraussetzung Für Fyn Während Der Frühen Ontogenese Des NK T-Zelle Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 Die Mer-Rezeptor-Tyrosinkinase: Ausdruck Und Funktion Weisen Auf Eine Rolle in Der Angeborenen Immunität European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 NK T Zelle Vorläufer Differenzielle Cytokine Verordnung Ausstellen Und Itk Für Effiziente Reifung Benötigen Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 Generierung definierter genomischer Modifikationen mit CRISPR-CAS9 in humanen pluripotenten Stammzellen Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetica Generation of Human induzierten pluripotenten Stammzellen aus dem peripheren Blut mit dem STEMCCA Lentivirusvektor Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biologia
Generierung definierter genomischer Modifikationen mit CRISPR-CAS9 in humanen pluripotenten Stammzellen Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetica
Generation of Human induzierten pluripotenten Stammzellen aus dem peripheren Blut mit dem STEMCCA Lentivirusvektor Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biologia