Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 Trisomia 21-associati Difetti Umani Primitivi Ematopoiesi Rivelato Attraverso Le Cellule Staminali Pluripotenti Indotte Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 Linee Progenitrici Endodermico Autorinnovabile Generate Da Cellule Staminali Pluripotenti Umane Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 High-throughput Screening Test Per La Differenziazione Delle Cellule Staminali Embrionali Umane Embryoid Body Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 Una Nicchia Delle Cellule Endoteliali Induce Epatica Specifica Attraverso La Duplice Repressione Di Wnt E Tacca Di Segnalazione Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 Mouse ES E Le Cellule IPS Possono Formare Simile Endoderma Definitivo Nonostante Le Differenze Nei Geni Imprinted The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 Un Alto-rendimento Multiplexed Test Di Screening Per L'ottimizzazione Di Protocolli Serum-free Di Differenziazione Delle Cellule Staminali Embrionali Umane Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 Rigenerazione Epatica Da Cellule Staminali Pluripotenti Indotte Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 Generazione Del Polmone Privo Di Transgene Specifici Per La Malattia Umana Indotta Staminali Pluripotenti Usando Una Cassetta Singola Ad Accisa Lentivirali Stem Cell Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Competenza Trascrizionale E La Marcatura Attiva Del Tessuto-specifici Rinforzatori Di Fattori Di Trascrizione Definiti in Cellule Staminali Pluripotenti Indotte Ed Embrionale Genes & Development. Dec, 2009 | Pubmed ID: 20008934 Cellule Staminali Unscramble Vitellino Ematopoiesi Blood. Aug, 2009 | Pubmed ID: 19696206 Generazione Di Anticorpi Monoclonali Specifici Per Molecole Di Superficie Cella Espresso Sui Primi Endoderma Del Mouse Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 Cellule Epidermiche Rev Sulla Riprogrammazione Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 Numb Media L'interazione Tra Wnt E Tacca Per Modulare Primitivo Eritropoietica Specifica Dalla Hemangioblast Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 WNT, Activin E Segnalazione BMP Regolano Fasi Distinte Nella Via Dello Sviluppo Da Cellule Staminali Embrionali a Sangue Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 Identificazione E Targeting Del Locus ROSA26 in Cellule Staminali Embrionali Umane Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 BMP-4 è Necessaria Per Epatica Specifica Del Mouse Embryonic Cellule Staminali Derivate Definitivo Endoderma Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 WNT E TGF-beta Segnalazione Sono Necessari Per L'induzione Di Un Modello in Vitro Della Formazione Linea Primitiva Utilizzando Le Cellule Staminali Embrionali Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 Strato Di Germe Induzione Da Cellule Staminali Embrionali Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 Lo Sviluppo Delle Cellule Di Restauro Di T NK in Topi Mutanti Fyn Da Un TCR Rivela Un Requisito Per Fyn Durante L'ontogenesi Di Cellule NK T Precoce Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 La Mer Recettore Tirosina Chinasi: Espressione E Funzione Suggeriscono Un Ruolo Nell'immunità Innata European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 Precursori Delle Cellule NK T Esposizione Regolamento Differenziale Cytokine E Richiedono Itk Per Maturazione Efficiente Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 Generazione di modifiche genomiche definite utilizzando CRISPR-CAS9 nelle cellule staminali pluripotenti umane Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetica Generazione di cellule pluripotenti indotte umane staminali da sangue periferico mediante il STEMCCA lentivirale Vector Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biologia
Generazione di modifiche genomiche definite utilizzando CRISPR-CAS9 nelle cellule staminali pluripotenti umane Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetica
Generazione di cellule pluripotenti indotte umane staminali da sangue periferico mediante il STEMCCA lentivirale Vector Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biologia