Philip E. Johnson Department of Chemistry York University Biography Publications Institution JoVE Articles Philip E. Johnson has not added a biography. If you are Philip E. Johnson and would like to personalize this page please email our Author Liaison for assistance. Publications Optimizing Stem Length To Improve Ligand Selectivity in a Structure-Switching Cocaine-Binding Aptamer ACS Sensors. Oct, 2017 | Pubmed ID: 28929744 Development of a Thermal-stable Structure-switching Cocaine-binding Aptamer Biochimie. Aug, 2017 | Pubmed ID: 28838608 Comparison of the Free and Ligand-bound Imino Hydrogen Exchange Rates for the Cocaine-binding Aptamer Journal of Biomolecular NMR. May, 2017 | Pubmed ID: 28477231 Salt-mediated Two-site Ligand Binding by the Cocaine-binding Aptamer Nucleic Acids Research. 02, 2017 | Pubmed ID: 28025391 Structure-affinity Relationship of the Cocaine-binding Aptamer with Quinine Derivatives Bioorganic & Medicinal Chemistry. May, 2015 | Pubmed ID: 25858454 Pre-equilibration Kinetic Size-exclusion Chromatography with Mass Spectrometry Detection (peKSEC-MS) for Label-free Solution-based Kinetic Analysis of Protein-small Molecule Interactions The Analyst. Feb, 2015 | Pubmed ID: 25611307 Kinetic Size-exclusion Chromatography with Mass Spectrometry Detection: an Approach for Solution-based Label-free Kinetic Analysis of Protein-small Molecule Interactions Analytical Chemistry. Oct, 2014 | Pubmed ID: 25275785 Quinine Binding by the Cocaine-binding Aptamer. Thermodynamic and Hydrodynamic Analysis of High-affinity Binding of an Off-target Ligand Biochemistry. Dec, 2013 | Pubmed ID: 24175947 Quantitative Affinity Electrophoresis of RNA-small Molecule Interactions by Cross-linking the Ligand to Acrylamide Analytical Biochemistry. Nov, 2013 | Pubmed ID: 23928050 Kinetic Capillary Electrophoresis with Mass-spectrometry Detection (KCE-MS) Facilitates Label-free Solution-based Kinetic Analysis of Protein-small Molecule Binding Chembiochem : a European Journal of Chemical Biology. Nov, 2011 | Pubmed ID: 22012742 Engineering a Structure Switching Mechanism into a Steroid-binding Aptamer and Hydrodynamic Analysis of the Ligand Binding Mechanism Biochemistry. Nov, 2011 | Pubmed ID: 21942676 Identification of RNA-ligand Interactions by Affinity Electrophoresis Analytical Biochemistry. Feb, 2011 | Pubmed ID: 20875777 Finding the Path in an RNA Folding Landscape Structure (London, England : 1993). Dec, 2010 | Pubmed ID: 21134633 Thermodynamic and NMR Analysis of Inhibitor Binding to Dihydrofolate Reductase Bioorganic & Medicinal Chemistry. Dec, 2010 | Pubmed ID: 21084197 Defining the Secondary Structural Requirements of a Cocaine-binding Aptamer by a Thermodynamic and Mutation Study Biophysical Chemistry. Dec, 2010 | Pubmed ID: 21035241 Defining a Stem Length-dependent Binding Mechanism for the Cocaine-binding Aptamer. A Combined NMR and Calorimetry Study Biochemistry. Oct, 2010 | Pubmed ID: 20735071 Structure of the Cytosine-cytosine Mismatch in the Thymidylate Synthase MRNA Binding Site and Analysis of Its Interaction with the Aminoglycoside Paromomycin RNA (New York, N.Y.). May, 2009 | Pubmed ID: 19329536 Enhanced NMR Signal Detection of Imino Protons in RNA Molecules Containing 3' Dangling Nucleotides Journal of Biomolecular NMR. Mar, 2008 | Pubmed ID: 18273681 The Three-dimensional Structure of the Moorella Thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and Its Interaction with the Elongation Factor SelB RNA (New York, N.Y.). Nov, 2007 | Pubmed ID: 17901155 RNA Recognition by the Vts1p SAM Domain Nature Structural & Molecular Biology. Feb, 2006 | Pubmed ID: 16429155 Assembly PCR Oligo Maker: a Tool for Designing Oligodeoxynucleotides for Constructing Long DNA Molecules for RNA Production Nucleic Acids Research. Jul, 2005 | Pubmed ID: 15980526 Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions Robert W. Harkness V1, Philip E. Johnson2, Anthony K. Mittermaier1 1Department of Chemistry, McGill University, 2Department of Chemistry, York University JoVE 55959 Biochimica
Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions Robert W. Harkness V1, Philip E. Johnson2, Anthony K. Mittermaier1 1Department of Chemistry, McGill University, 2Department of Chemistry, York University JoVE 55959 Biochimica