Raymond Chang Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine The University of Hong Kong - HKU Biography Publications Institution JoVE Articles Raymond Chang has not added a biography. If you are Raymond Chang and would like to personalize this page please email our Author Liaison for assistance. Publications From Small to Big Molecules: How Do We Prevent and Delay the Progression of Age-related Neurodegeneration? Current Pharmaceutical Design. 2012 | Pubmed ID: 22211681 Lycium Barbarum Polysaccharides Protect Mice Liver from Carbon Tetrachloride-induced Oxidative Stress and Necroinflammation Journal of Ethnopharmacology. Jan, 2012 | Pubmed ID: 22138659 Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease Pathogenesis Journal of Alzheimer's Disease : JAD. Nov, 2011 | Pubmed ID: 22101233 Neurodegeneration of the Retina in Mouse Models of Alzheimer's Disease: What Can We Learn from the Retina? Age (Dordrecht, Netherlands). May, 2011 | Pubmed ID: 21559868 Drug Discovery from Chinese Medicine Against Neurodegeneration in Alzheimer's and Vascular Dementia Chinese Medicine. 2011 | Pubmed ID: 21513513 Lycium Barbarum Polysaccharides Reduce Neuronal Damage, Blood-retinal Barrier Disruption and Oxidative Stress in Retinal Ischemia/reperfusion Injury PloS One. 2011 | Pubmed ID: 21298100 Light Deprivation Induces Depression-like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones Unguiculatus) Cell Transplantation. 2011 | Pubmed ID: 21054936 Temporal Relationship of Autophagy and Apoptosis in Neurons Challenged by Low Molecular Weight β-amyloid Peptide Journal of Cellular and Molecular Medicine. Feb, 2011 | Pubmed ID: 20015199 Sulfur-containing Constituents and One 1H-pyrrole-2-carboxylic Acid Derivative from Pineapple [Ananas Comosus (L.) Merr.] Fruit Phytochemistry. Dec, 2010 | Pubmed ID: 20843530 Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF-alpha-induced Arthritis Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010 | Pubmed ID: 20644167 Modulation of Mitochondrial Calcium As a Pharmacological Target for Alzheimer's Disease Ageing Research Reviews. Oct, 2010 | Pubmed ID: 20553970 Beneficial Effects of Cinnamon Proanthocyanidins on the Formation of Specific Advanced Glycation Endproducts and Methylglyoxal-induced Impairment on Glucose Consumption Journal of Agricultural and Food Chemistry. Jun, 2010 | Pubmed ID: 20476737 The Putative Neurodegenerative Links Between Depression and Alzheimer's Disease Progress in Neurobiology. Aug, 2010 | Pubmed ID: 20441786 Up-regulation of Crystallins is Involved in the Neuroprotective Effect of Wolfberry on Survival of Retinal Ganglion Cells in Rat Ocular Hypertension Model Journal of Cellular Biochemistry. May, 2010 | Pubmed ID: 20336662 Neuroprotective Effects of Polysaccharides from Wolfberry, the Fruits of Lycium Barbarum, Against Homocysteine-induced Toxicity in Rat Cortical Neurons Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20157238 Transcriptional Regulation of Human FE65, a Ligand of Alzheimer's Disease Amyloid Precursor Protein, by Sp1 Journal of Cellular Biochemistry. Mar, 2010 | Pubmed ID: 20091743 Modulation of Morphological Changes of Microglia and Neuroprotection by Monocyte Chemoattractant Protein-1 in Experimental Glaucoma Cellular & Molecular Immunology. Jan, 2010 | Pubmed ID: 20081877 A Pro-drug of the Green Tea Polyphenol (-)-epigallocatechin-3-gallate (EGCG) Prevents Differentiated SH-SY5Y Cells from Toxicity Induced by 6-hydroxydopamine Neuroscience Letters. Jan, 2010 | Pubmed ID: 20026175 Anti-aging Herbal Medicine--how and Why Can They Be Used in Aging-associated Neurodegenerative Diseases? Ageing Research Reviews. Jul, 2010 | Pubmed ID: 19833234 Protective Effects of Pinostilbene, a Resveratrol Methylated Derivative, Against 6-hydroxydopamine-induced Neurotoxicity in SH-SY5Y Cells The Journal of Nutritional Biochemistry. Jun, 2010 | Pubmed ID: 19443200 Erratum: Modulation of Microglia by Wolfberry on the Survival of Retinal Ganglion Cells in a Rat Ocular Hypertension Model Journal of Ocular Biology, Diseases, and Informatics. Sep, 2009 | Pubmed ID: 20046845 Modulation of Neuroimmune Responses on Glia in the Central Nervous System: Implication in Therapeutic Intervention Against Neuroinflammation Cellular & Molecular Immunology. Oct, 2009 | Pubmed ID: 19887044 Could PKR Inhibition Modulate Human Neurodegeneration? Expert Review of Neurotherapeutics. Oct, 2009 | Pubmed ID: 19831834 Modulation of Microglia by Wolfberry on the Survival of Retinal Ganglion Cells in a Rat Ocular Hypertension Model Journal of Ocular Biology, Diseases, and Informatics. Jun, 2009 | Pubmed ID: 19672466 Calcium Dysregulation in Alzheimer's Disease: from Mechanisms to Therapeutic Opportunities Progress in Neurobiology. Nov, 2009 | Pubmed ID: 19664678 Polysaccharides from Wolfberry Antagonizes Glutamate Excitotoxicity in Rat Cortical Neurons Cellular and Molecular Neurobiology. Dec, 2009 | Pubmed ID: 19499323 Low Molecular Weight Abeta Induces Collapse of Endoplasmic Reticulum Molecular and Cellular Neurosciences. May, 2009 | Pubmed ID: 19386229 Effects of All-trans-retinoic Acid on Human SH-SY5Y Neuroblastoma As in Vitro Model in Neurotoxicity Research Neurotoxicology. Jan, 2009 | Pubmed ID: 19056420 Dexras1 Interacts with FE65 to Regulate FE65-amyloid Precursor Protein-dependent Transcription The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18922798 Dietary Oxyresveratrol Prevents Parkinsonian Mimetic 6-hydroxydopamine Neurotoxicity Free Radical Biology & Medicine. Oct, 2008 | Pubmed ID: 18675900 2-Aminobenzophenones As a Novel Class of Bradykinin B1 Receptor Antagonists Journal of Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18553956 Antagonizing Beta-amyloid Peptide Neurotoxicity of the Anti-aging Fungus Ganoderma Lucidum Brain Research. Jan, 2008 | Pubmed ID: 18083148 Alpha-hydroxy Amides As a Novel Class of Bradykinin B1 Selective Antagonists Bioorganic & Medicinal Chemistry Letters. Jan, 2008 | Pubmed ID: 18061443 Use of Anti-aging Herbal Medicine, Lycium Barbarum, Against Aging-associated Diseases. What Do We Know So Far? Cellular and Molecular Neurobiology. Aug, 2008 | Pubmed ID: 17710531 Characterization of the Effects of Anti-aging Medicine Fructus Lycii on Beta-amyloid Peptide Neurotoxicity International Journal of Molecular Medicine. Aug, 2007 | Pubmed ID: 17611646 Characterizing the Neuroprotective Effects of Alkaline Extract of Lycium Barbarum on Beta-amyloid Peptide Neurotoxicity Brain Research. Jul, 2007 | Pubmed ID: 17568570 New Polysaccharide from Nerium Indicum Protects Neurons Via Stress Kinase Signaling Pathway Brain Research. Jun, 2007 | Pubmed ID: 17475226 In Vitro and in Vivo Binding of Neuroactive Steroids to the Sigma-1 Receptor As Measured with the Positron Emission Tomography Radioligand [18F]FPS Synapse (New York, N.Y.). Jul, 2007 | Pubmed ID: 17447254 Potent Bradykinin B1 Receptor Antagonists: 4-substituted Phenyl Cyclohexanes Bioorganic & Medicinal Chemistry Letters. Jun, 2007 | Pubmed ID: 17428657 Neuroprotective Effects of Lycium Barbarum Lynn on Protecting Retinal Ganglion Cells in an Ocular Hypertension Model of Glaucoma Experimental Neurology. Jan, 2007 | Pubmed ID: 17045262 Significance of Molecular Signaling for Protein Translation Control in Neurodegenerative Diseases Neuro-Signals. -2007, 2006 | Pubmed ID: 17496426 Preclinical Acute Toxicity Studies and Dosimetry Estimates of the Novel Sigma-1 Receptor Radiotracer, [18F]SFE Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Sep-Oct, 2006 | Pubmed ID: 16924428 Design, Synthesis, and in Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived from a Series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl Benzamides ChemMedChem. Aug, 2006 | Pubmed ID: 16902933 Cytoprotective Effects of Lycium Barbarum Against Reducing Stress on Endoplasmic Reticulum International Journal of Molecular Medicine. Jun, 2006 | Pubmed ID: 16685430 In Vivo Evaluation in Rats of [(18)F]1-(2-fluoroethyl)-4-[(4-cyanophenoxy)methyl]piperidine As a Potential Radiotracer for PET Assessment of CNS Sigma-1 Receptors Nuclear Medicine and Biology. Feb, 2006 | Pubmed ID: 16546675 Beta-amyloid Peptides Induces Neuronal Apoptosis Via a Mechanism Independent of Unfolded Protein Responses Apoptosis : an International Journal on Programmed Cell Death. May, 2006 | Pubmed ID: 16532272 Cyclopropylamino Acid Amide As a Pharmacophoric Replacement for 2,3-diaminopyridine. Application to the Design of Novel Bradykinin B1 Receptor Antagonists Journal of Medicinal Chemistry. Feb, 2006 | Pubmed ID: 16480259 Novel Neuroprotective Effects of the Aqueous Extracts from Verbena Officinalis Linn Neuropharmacology. May, 2006 | Pubmed ID: 16406021 Inhibition of Acute Nociceptive Responses in Rat Spinal Cord by a Bradykinin B1 Receptor Antagonist European Journal of Pharmacology. Dec, 2005 | Pubmed ID: 16310181 Immune Modulatory Effects of Prunella Vulgaris L. on Monocytes/macrophages International Journal of Molecular Medicine. Dec, 2005 | Pubmed ID: 16273294 Neuroprotective Effects of Anti-aging Oriental Medicine Lycium Barbarum Against Beta-amyloid Peptide Neurotoxicity Experimental Gerontology. Aug-Sep, 2005 | Pubmed ID: 16139464 Stable Expression of EBERs in Immortalized Nasopharyngeal Epithelial Cells Confers Resistance to Apoptotic Stress Molecular Carcinogenesis. Oct, 2005 | Pubmed ID: 16086371 2,3-Diaminopyridine As a Platform for Designing Structurally Unique Nonpeptide Bradykinin B1 Receptor Antagonists Bioorganic & Medicinal Chemistry Letters. May, 2005 | Pubmed ID: 15837330 Immune Modulatory Effects of Prunella Vulgaris L International Journal of Molecular Medicine. Mar, 2005 | Pubmed ID: 15702244 2,3-diaminopyridine Bradykinin B1 Receptor Antagonists Journal of Medicinal Chemistry. Dec, 2004 | Pubmed ID: 15588075 Isolated Cortical Venous Thrombosis Presenting As Subarachnoid Hemorrhage: a Report of Three Cases AJNR. American Journal of Neuroradiology. Nov-Dec, 2004 | Pubmed ID: 15569729 Characterization of Polysaccharides from the Flowers of Nerium Indicum and Their Neuroprotective Effects International Journal of Molecular Medicine. Nov, 2004 | Pubmed ID: 15492866 In Vivo Evaluation of [11C]N-(2-chloro-5-thiomethylphenyl)-N'-(3-methoxy-phenyl)-N'-methylguanidine ([11C]GMOM) As a Potential PET Radiotracer for the PCP/NMDA Receptor Nuclear Medicine and Biology. Oct, 2004 | Pubmed ID: 15464396 Pharmacological Characterization and Radioligand Binding Properties of a High-affinity, Nonpeptide, Bradykinin B1 Receptor Antagonist European Journal of Pharmacology. Sep, 2004 | Pubmed ID: 15363953 Reconstruction of Complex Oncologic Chest Wall Defects: a 10-year Experience Annals of Plastic Surgery. May, 2004 | Pubmed ID: 15096930 Modulation of Calcium/calmodulin Kinase-II Provides Partial Neuroprotection Against Beta-amyloid Peptide Toxicity The European Journal of Neuroscience. Apr, 2004 | Pubmed ID: 15090032 Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat As a Pharmacodynamic Model The Journal of Pharmacology and Experimental Therapeutics. Aug, 2004 | Pubmed ID: 15051800 Comparing Excitatory Backward and Forward Conditioning The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology. Jan, 2004 | Pubmed ID: 14690847 Massive Preexposure and Preexposure in Multiple Contexts Attenuate the Context Specificity of Latent Inhibition Learning & Behavior. Nov, 2003 | Pubmed ID: 14733485 Reduction of Calcium Release from the Endoplasmic Reticulum Could Only Provide Partial Neuroprotection Against Beta-amyloid Peptide Toxicity Journal of Neurochemistry. Dec, 2003 | Pubmed ID: 14713297 Difference in MGluR5 Interaction Between Positive Allosteric Modulators from Two Structural Classes Annals of the New York Academy of Sciences. Nov, 2003 | Pubmed ID: 14684495 Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/threonine Protein Kinase in Beta-amyloid Peptide Neurotoxicity The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 12975376 A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 Molecular Pharmacology. Sep, 2003 | Pubmed ID: 12920211 Backward Conditioning: Mediation by the Context Journal of Experimental Psychology. Animal Behavior Processes. Jul, 2003 | Pubmed ID: 12884677 Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist Journal of the American Chemical Society. Jun, 2003 | Pubmed ID: 12812482 Benzodiazepines As Potent and Selective Bradykinin B1 Antagonists Journal of Medicinal Chemistry. May, 2003 | Pubmed ID: 12723943 Images in Clinical Medicine. "Corkscrew" Esophagus The New England Journal of Medicine. Apr, 2003 | Pubmed ID: 12711742 Trial Spacing is a Determinant of Cue Interaction Journal of Experimental Psychology. Animal Behavior Processes. Jan, 2003 | Pubmed ID: 12561131 BAD and Bcl-2 Regulation Are Early Events Linking Neuronal Endoplasmic Reticulum Stress to Mitochondria-mediated Apoptosis Brain Research. Molecular Brain Research. Dec, 2002 | Pubmed ID: 12531534 Phosphorylation of Eukaryotic Initiation Factor-2alpha (eIF2alpha) is Associated with Neuronal Degeneration in Alzheimer's Disease Neuroreport. Dec, 2002 | Pubmed ID: 12499843 Role of Acupuncture in the Treatment of Female Infertility Fertility and Sterility. Dec, 2002 | Pubmed ID: 12477502 Bioactive Polysaccharides from Traditional Chinese Medicine Herbs As Anticancer Adjuvants Journal of Alternative and Complementary Medicine (New York, N.Y.). Oct, 2002 | Pubmed ID: 12470436 Brain Cancer: a Case of Glioblastoma Multiforme Journal of Alternative and Complementary Medicine (New York, N.Y.). Oct, 2002 | Pubmed ID: 12470435 Asian Therapies for Cancer--coming of Age Journal of Alternative and Complementary Medicine (New York, N.Y.). Oct, 2002 | Pubmed ID: 12470433 Involvement of Double-stranded RNA-dependent Protein Kinase and Phosphorylation of Eukaryotic Initiation Factor-2alpha in Neuronal Degeneration Journal of Neurochemistry. Dec, 2002 | Pubmed ID: 12437593 P38 MAP Kinase is Involved in Lipopolysaccharide-induced Dopaminergic Neuronal Cell Death in Rat Mesencephalic Neuron-glia Cultures Annals of the New York Academy of Sciences. May, 2002 | Pubmed ID: 12076985 Laser-Induced Chronic Ocular Hypertension Model on SD Rats Kin Chiu1, Raymond Chang1, Kwok-Fai So1 1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong - HKU JoVE 549 Biologia
Laser-Induced Chronic Ocular Hypertension Model on SD Rats Kin Chiu1, Raymond Chang1, Kwok-Fai So1 1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong - HKU JoVE 549 Biologia