Renjie Chai MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences Southeast University Biography Publications Institution JoVE Articles Renjie Chai has not added a biography. If you are Renjie Chai and would like to personalize this page please email our Author Liaison for assistance. Publications Stress-Induced Metabolic Disorder in Peripheral CD4 T Cells Leads to Anxiety-like Behavior Cell. Oct, 2019 | Pubmed ID: 31675497 Knockdown of Foxg1 in Supporting Cells Increases the Trans-differentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea Cellular and Molecular Life Sciences : CMLS. Sep, 2019 | Pubmed ID: 31485717 Laminin-Coated Electrospun Regenerated Silk Fibroin Mats Promote Neural Progenitor Cell Proliferation, Differentiation, and Survival Frontiers in Bioengineering and Biotechnology. 2019 | Pubmed ID: 31448271 Frizzled-9+ Supporting Cells Are Progenitors for the Generation of Hair Cells in the Postnatal Mouse Cochlea Frontiers in Molecular Neuroscience. 2019 | Pubmed ID: 31427926 AAV-ie Enables Safe and Efficient Gene Transfer to Inner Ear Cells Nature Communications. Aug, 2019 | Pubmed ID: 31427575 Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jun, 2019 | Pubmed ID: 31380157 TeraVR Empowers Precise Reconstruction of Complete 3-D Neuronal Morphology in the Whole Brain Nature Communications. Aug, 2019 | Pubmed ID: 31375678 The Application of Graphene-based Biomaterials in Biomedicine American Journal of Translational Research. 2019 | Pubmed ID: 31312342 Transcriptomic Profiling of Neural Stem Cell Differentiation on Graphene Substrates Colloids and Surfaces. B, Biointerfaces. Oct, 2019 | Pubmed ID: 31288132 A Humanized Mouse Model, Demonstrating Progressive Hearing Loss Caused by MYO6 P.C442Y, is Inherited in a Semi-dominant Pattern Hearing Research. Aug, 2019 | Pubmed ID: 31103816 Critical Role of Spectrin in Hearing Development and Deafness Science Advances. Apr, 2019 | Pubmed ID: 31001589 Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30915699 Hair Cell Regeneration Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30915698 Deletion of Limk1 and Limk2 in Mice Does Not Alter Cochlear Development or Auditory Function Scientific Reports. Mar, 2019 | Pubmed ID: 30833597 A Cytoskeleton Structure Revealed by Super-resolution Fluorescence Imaging in Inner Ear Hair Cells Cell Discovery. 2019 | Pubmed ID: 30792888 Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea Frontiers in Cellular Neuroscience. 2019 | Pubmed ID: 30733670 Surgery-free Video-oculography in Mouse Models: Enabling Quantitative and Short-interval Longitudinal Assessment of Vestibular Function Neuroscience Letters. 03, 2019 | Pubmed ID: 30597229 The Role of FOXG1 in the Postnatal Development and Survival of Mouse Cochlear Hair Cells Neuropharmacology. 01, 2019 | Pubmed ID: 30336149 Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea Antioxidants & Redox Signaling. Apr, 2019 | Pubmed ID: 29587485 Novel Compounds Protect Auditory Hair Cells Against Gentamycin-induced Apoptosis by Maintaining the Expression Level of H3K4me2 Drug Delivery. Nov, 2018 | Pubmed ID: 30799660 Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells 2018 Neural Plasticity. 2018 | Pubmed ID: 30647730 Designs of Biomaterials and Microenvironments for Neuroengineering Neural Plasticity. 2018 | Pubmed ID: 30627148 Author Correction: An Episomal Vector-based CRISPR/Cas9 System for Highly Efficient Gene Knockout in Human Pluripotent Stem Cells Scientific Reports. Dec, 2018 | Pubmed ID: 30538257 Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice Frontiers in Molecular Neuroscience. 2018 | Pubmed ID: 30333726 Tuberous Sclerosis Complex-mediated MTORC1 Overactivation Promotes Age-related Hearing Loss The Journal of Clinical Investigation. 11, 2018 | Pubmed ID: 30247156 Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell. Aug, 2018 | Pubmed ID: 30122476 Real-Time Multimodal Bioimaging of Cancer Cells and Exosomes Through Biosynthesized Iridium and Iron Nanoclusters ACS Applied Materials & Interfaces. Aug, 2018 | Pubmed ID: 30011179 Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage Frontiers in Cellular Neuroscience. 2018 | Pubmed ID: 29875633 Characterization of Lgr6+ Cells As an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea Frontiers in Molecular Neuroscience. 2018 | Pubmed ID: 29867341 Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle Frontiers in Molecular Neuroscience. 2018 | Pubmed ID: 29760650 Looking into the Future: Toward Advanced 3D Biomaterials for Stem-Cell-Based Regenerative Medicine Advanced Materials (Deerfield Beach, Fla.). Apr, 2018 | Pubmed ID: 29450919 A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro Molecular Neurobiology. 03, 2018 | Pubmed ID: 28283883 Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 29311816 Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 29255404 Autophagy Protects Auditory Hair Cells Against Neomycin-induced Damage Autophagy. 2017 | Pubmed ID: 28968134 Insm1a Regulates Motor Neuron Development in Zebrafish Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 28894416 Is Required for Zebrafish Posterior Lateral Line Development Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 28824372 Auditory Neuropathy After Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors Scientific Reports. 07, 2017 | Pubmed ID: 28743950 Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation In the Developing Mouse Cochlea Stem Cell Reports. 07, 2017 | Pubmed ID: 28669599 Bone Morphogenetic Protein 4 Promotes the Survival and Preserves the Structure of Flow-sorted Bhlhb5+ Cochlear Spiral Ganglion Neurons in Vitro Scientific Reports. 06, 2017 | Pubmed ID: 28615657 An Episomal Vector-based CRISPR/Cas9 System for Highly Efficient Gene Knockout in Human Pluripotent Stem Cells Scientific Reports. 05, 2017 | Pubmed ID: 28539611 Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer International Journal of Biological Sciences. 2017 | Pubmed ID: 28529458 Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells Neural Plasticity. 2017 | Pubmed ID: 28316840 C-Myb Knockdown Increases the Neomycin-induced Damage to Hair-cell-like HEI-OC1 Cells in Vitro Scientific Reports. 01, 2017 | Pubmed ID: 28112219 Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway Molecular Neurobiology. 03, 2017 | Pubmed ID: 26843109 The Somite-secreted Factor Maeg Promotes Zebrafish Embryonic Angiogenesis Oncotarget. Nov, 2016 | Pubmed ID: 27780917 MiR-182-5p Protects Inner Ear Hair Cells from Cisplatin-induced Apoptosis by Inhibiting FOXO3a Cell Death & Disease. 09, 2016 | Pubmed ID: 27607577 Accelerating Bioelectric Functional Development of Neural Stem Cells by Graphene Coupling: Implications for Neural Interfacing with Conductive Materials Biomaterials. 11, 2016 | Pubmed ID: 27566868 Wnt Activation Followed by Notch Inhibition Promotes Mitotic Hair Cell Regeneration in the Postnatal Mouse Cochlea Oncotarget. Oct, 2016 | Pubmed ID: 27564256 Inhibition of ARC Decreases the Survival of HEI-OC-1 Cells After Neomycin Damage in Vitro Oncotarget. Oct, 2016 | Pubmed ID: 27556499 Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 08, 2016 | Pubmed ID: 27535918 Role of Wnt and Notch Signaling in Regulating Hair Cell Regeneration in the Cochlea Frontiers of Medicine. Sep, 2016 | Pubmed ID: 27527363 Spatiotemporal Expression of Ezh2 in the Developing Mouse Cochlear Sensory Epithelium Frontiers of Medicine. Sep, 2016 | Pubmed ID: 27465826 Co-regulation of the Notch and Wnt Signaling Pathways Promotes Supporting Cell Proliferation and Hair Cell Regeneration in Mouse Utricles Scientific Reports. 07, 2016 | Pubmed ID: 27435629 Reduced TRMU Expression Increases the Sensitivity of Hair-cell-like HEI-OC-1 Cells to Neomycin Damage in Vitro Scientific Reports. 07, 2016 | Pubmed ID: 27405449 The Structural Development of Primary Cultured Hippocampal Neurons on a Graphene Substrate Colloids and Surfaces. B, Biointerfaces. Oct, 2016 | Pubmed ID: 27395037 Regeneration of Hair Cells in the Mammalian Vestibular System Frontiers of Medicine. Jun, 2016 | Pubmed ID: 27189205 Characterization of Lgr5+ Progenitor Cell Transcriptomes in the Apical and Basal Turns of the Mouse Cochlea Oncotarget. Jul, 2016 | Pubmed ID: 27070092 The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro Neural Plasticity. 2016 | Pubmed ID: 27057364 Histone Deacetylase 1 is Required for the Development of the Zebrafish Inner Ear Scientific Reports. Feb, 2016 | Pubmed ID: 26832938 MicroRNA-10a/10b Represses a Novel Target Gene Mib1 to Regulate Angiogenesis Cardiovascular Research. May, 2016 | Pubmed ID: 26825552 Mutations in TUBB8 and Human Oocyte Meiotic Arrest The New England Journal of Medicine. Jan, 2016 | Pubmed ID: 26789871 HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish Molecular Neurobiology. 10, 2016 | Pubmed ID: 26395281 LSD1 is Required for Hair Cell Regeneration in Zebrafish Molecular Neurobiology. May, 2016 | Pubmed ID: 26008620 Effects of Local Application of Methylprednisolone Delivered by the C/GP-hydrogel on the Recovery of Facial Nerves Acta Oto-laryngologica. 2015 | Pubmed ID: 26235110 Lgr5+ Cells Regenerate Hair Cells Via Proliferation and Direct Transdifferentiation in Damaged Neonatal Mouse Utricle Nature Communications. Apr, 2015 | Pubmed ID: 25849379 MiRNA-320 in the Human Follicular Fluid is Associated with Embryo Quality in Vivo and Affects Mouse Embryonic Development in Vitro Scientific Reports. Mar, 2015 | Pubmed ID: 25732513 Notch Inhibition Induces Mitotically Generated Hair Cells in Mammalian Cochleae Via Activating the Wnt Pathway Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25535395 Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus Pneumoniae-induced Tympanosclerosis Through the Suppression of TGF-β1 Expression PloS One. 2014 | Pubmed ID: 25360706 In Vivo Overexpression of X-linked Inhibitor of Apoptosis Protein Protects Against Neomycin-induced Hair Cell Loss in the Apical Turn of the Cochlea During the Ototoxic-sensitive Period Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25278835 Ildr1b is Essential for Semicircular Canal Development, Migration of the Posterior Lateral Line Primordium and Hearing Ability in Zebrafish: Implications for a Role in the Recessive Hearing Impairment DFNB42 Human Molecular Genetics. Dec, 2014 | Pubmed ID: 24990150 Spontaneous Hair Cell Regeneration in the Neonatal Mouse Cochlea in Vivo Development (Cambridge, England). Feb, 2014 | Pubmed ID: 24496619 Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea Journal of the Association for Research in Otolaryngology : JARO. Aug, 2011 | Pubmed ID: 21472479 Cochlear Surface Preparation in the Adult Mouse Qiao-Jun Fang1,2, Fan Wu1, Renjie Chai2, Su-Hua Sha1 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University JoVE 60299 Neuroscienze Isolating LacZ-expressing Cells from Mouse Inner Ear Tissues using Flow Cytometry Taha A. Jan1, Renjie Chai1, Zahra N. Sayyid1, Alan G. Cheng1 1Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine JoVE 3432 Neuroscienze
Cochlear Surface Preparation in the Adult Mouse Qiao-Jun Fang1,2, Fan Wu1, Renjie Chai2, Su-Hua Sha1 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University JoVE 60299 Neuroscienze
Isolating LacZ-expressing Cells from Mouse Inner Ear Tissues using Flow Cytometry Taha A. Jan1, Renjie Chai1, Zahra N. Sayyid1, Alan G. Cheng1 1Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine JoVE 3432 Neuroscienze