Roland Malli Institute of Molecular Biology and Biochemistry Medical University of Graz Biography Publications Institution JoVE Articles Roland Malli has not added a biography. If you are Roland Malli and would like to personalize this page please email our Author Liaison for assistance. Publications Intact Mitochondrial Ca(2+) Uniport is Essential for Agonist-induced Activation of Endothelial Nitric Oxide Synthase (eNOS) Free Radical Biology & Medicine. Jan, 2017 | Pubmed ID: 27923677 Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin The Journal of Biological Chemistry. Nov, 2016 | Pubmed ID: 27679490 PRMT1-mediated Methylation of MICU1 Determines the UCP2/3 Dependency of Mitochondrial Ca(2+) Uptake in Immortalized Cells Nature Communications. Sep, 2016 | Pubmed ID: 27642082 Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2016 | Pubmed ID: 27606689 Filling a GAP-An Optimized Probe for ER Ca(2+) Imaging In Vivo Cell Chemical Biology. Jun, 2016 | Pubmed ID: 27341431 Development of Novel FP-based Probes for Live-cell Imaging of Nitric Oxide Dynamics Nature Communications. Feb, 2016 | Pubmed ID: 26842907 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Rearrangement of MICU1 Multimers for Activation of MCU is Solely Controlled by Cytosolic Ca(2.) Scientific Reports. Oct, 2015 | Pubmed ID: 26489515 UCP2 Modulates Single-channel Properties of a MCU-dependent Ca(2+) Inward Current in Mitochondria Pflugers Archiv : European Journal of Physiology. Dec, 2015 | Pubmed ID: 26275882 Generation of Red-Shifted Cameleons for Imaging Ca²⁺ Dynamics of the Endoplasmic Reticulum Sensors (Basel, Switzerland). Jun, 2015 | Pubmed ID: 26053751 Assessment of Mitochondrial Ca²⁺ Uptake Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25631032 Oleoyl-lysophosphatidylcholine Limits Endothelial Nitric Oxide Bioavailability by Induction of Reactive Oxygen Species PloS One. 2014 | Pubmed ID: 25419657 TRPV1 Mediates Cellular Uptake of Anandamide and Thus Promotes Endothelial Cell Proliferation and Network-formation Biology Open. Nov, 2014 | Pubmed ID: 25395667 Characterization of Rat Serum Amyloid A4 (SAA4): a Novel Member of the SAA Superfamily Biochemical and Biophysical Research Communications. Aug, 2014 | Pubmed ID: 25044109 IP3-mediated STIM1 Oligomerization Requires Intact Mitochondrial Ca2+ Uptake Journal of Cell Science. Jul, 2014 | Pubmed ID: 24806964 Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24790103 ATP Increases Within the Lumen of the Endoplasmic Reticulum Upon Intracellular Ca2+ Release Molecular Biology of the Cell. Feb, 2014 | Pubmed ID: 24307679 Mitochondrial Ca(2+) Uniporter (MCU)-dependent and MCU-independent Ca(2+) Channels Coexist in the Inner Mitochondrial Membrane Pflugers Archiv : European Journal of Physiology. Jul, 2014 | Pubmed ID: 24162235 Molecularly Distinct Routes of Mitochondrial Ca2+ Uptake Are Activated Depending on the Activity of the Sarco/endoplasmic Reticulum Ca2+ ATPase (SERCA) The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23592775 N-Arachidonoyl Glycine Suppresses Na⁺/Ca²⁺ Exchanger-mediated Ca²⁺ Entry into Endothelial Cells and Activates BK(Ca) Channels Independently of GPCRs British Journal of Pharmacology. Jun, 2013 | Pubmed ID: 23517055 Characterization of Distinct Single-channel Properties of Ca²⁺ Inward Currents in Mitochondria Pflugers Archiv : European Journal of Physiology. Jul, 2013 | Pubmed ID: 23397170 The Endocannabinoid N-arachidonoyl Glycine (NAGly) Inhibits Store-operated Ca2+ Entry by Preventing STIM1-Orai1 Interaction Journal of Cell Science. Feb, 2013 | Pubmed ID: 23239024 Spatiotemporal Correlations Between Cytosolic and Mitochondrial Ca(2+) Signals Using a Novel Red-Shifted Mitochondrial Targeted Cameleon PloS One. 2012 | Pubmed ID: 23029314 Mitochondrial Ca2+ Uptake 1 (MICU1) and Mitochondrial Ca2+ Uniporter (MCU) Contribute to Metabolism-secretion Coupling in Clonal Pancreatic β-cells The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22904319 Acyl Chain-dependent Effect of Lysophosphatidylcholine on Cyclooxygenase (COX)-2 Expression in Endothelial Cells Atherosclerosis. Oct, 2012 | Pubmed ID: 22901457 The Vascular Barrier-protecting Hawthorn Extract WS® 1442 Raises Endothelial Calcium Levels by Inhibition of SERCA and Activation of the IP3 Pathway Journal of Molecular and Cellular Cardiology. Oct, 2012 | Pubmed ID: 22814436 Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22556413 Mutation in NSUN2, Which Encodes an RNA Methyltransferase, Causes Autosomal-recessive Intellectual Disability American Journal of Human Genetics. May, 2012 | Pubmed ID: 22541562 Docosahexaenoic Acid-induced Unfolded Protein Response, Cell Cycle Arrest, and Apoptosis in Vascular Smooth Muscle Cells Are Triggered by Ca²⁺-dependent Induction of Oxidative Stress Free Radical Biology & Medicine. May, 2012 | Pubmed ID: 22391221 Endothelial Mitochondria--less Respiration, More Integration Pflugers Archiv : European Journal of Physiology. Jul, 2012 | Pubmed ID: 22382745 Studying Mitochondrial Ca(2+) Uptake - a Revisit Molecular and Cellular Endocrinology. Apr, 2012 | Pubmed ID: 22100614 Leucine Zipper EF Hand-containing Transmembrane Protein 1 (Letm1) and Uncoupling Proteins 2 and 3 (UCP2/3) Contribute to Two Distinct Mitochondrial Ca2+ Uptake Pathways The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21613221 The GPR55 Agonist Lysophosphatidylinositol Directly Activates Intermediate-conductance Ca2+ -activated K+ Channels Pflugers Archiv : European Journal of Physiology. Aug, 2011 | Pubmed ID: 21603896 Sequential Synthesis and Methylation of Phosphatidylethanolamine Promote Lipid Droplet Biosynthesis and Stability in Tissue Culture and in Vivo The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21454708 Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21196579 Uncoupling Protein 3 Adjusts Mitochondrial Ca(2+) Uptake to High and Low Ca(2+) Signals Cell Calcium. Nov, 2010 | Pubmed ID: 21047682 GPR55-dependent and -independent Ion Signalling in Response to Lysophosphatidylinositol in Endothelial Cells British Journal of Pharmacology. Sep, 2010 | Pubmed ID: 20735417 Acyl Chain-dependent Effect of Lysophosphatidylcholine on Endothelial Prostacyclin Production Journal of Lipid Research. Oct, 2010 | Pubmed ID: 20610733 Mitochondrial Ca2+ Uptake and Not Mitochondrial Motility is Required for STIM1-Orai1-dependent Store-operated Ca2+ Entry Journal of Cell Science. Aug, 2010 | Pubmed ID: 20587595 The Contribution of UCP2 and UCP3 to Mitochondrial Ca(2+) Uptake is Differentially Determined by the Source of Supplied Ca(2+) Cell Calcium. May, 2010 | Pubmed ID: 20403634 Vesicular Calcium Regulates Coat Retention, Fusogenicity, and Size of Pre-Golgi Intermediates Molecular Biology of the Cell. Mar, 2010 | Pubmed ID: 20089833 Mitochondrial Ca2+ Channels: Great Unknowns with Important Functions FEBS Letters. May, 2010 | Pubmed ID: 20074570 Lysophosphatidic Acid Receptor Activation Affects the C13NJ Microglia Cell Line Proteome Leading to Alterations in Glycolysis, Motility, and Cytoskeletal Architecture Proteomics. Jan, 2010 | Pubmed ID: 19899077 Mitochondrial Protein Phosphorylation: Instigator or Target of Lipotoxicity? Trends in Endocrinology and Metabolism: TEM. May, 2009 | Pubmed ID: 19356948 Cytosolic Ca2+ Prevents the Subplasmalemmal Clustering of STIM1: an Intrinsic Mechanism to Avoid Ca2+ Overload Journal of Cell Science. Oct, 2008 | Pubmed ID: 18765567 Integrin Clustering Enables Anandamide-induced Ca2+ Signaling in Endothelial Cells Via GPR55 by Protection Against CB1-receptor-triggered Repression Journal of Cell Science. May, 2008 | Pubmed ID: 18445684 The C-terminal Region of Human Adipose Triglyceride Lipase Affects Enzyme Activity and Lipid Droplet Binding The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18445597 Mitochondrial Ca2+, the Secret Behind the Function of Uncoupling Proteins 2 and 3? Cell Calcium. Jul, 2008 | Pubmed ID: 18282596 Mitochondria and Ca(2+) Signaling: Old Guests, New Functions Pflugers Archiv : European Journal of Physiology. Dec, 2007 | Pubmed ID: 17611770 Uncoupling Proteins 2 and 3 Are Fundamental for Mitochondrial Ca2+ Uniport Nature Cell Biology. Apr, 2007 | Pubmed ID: 17351641 Mg2+ Deprivation Elicits Rapid Ca2+ Uptake and Activates Ca2+/calcineurin Signaling in Saccharomyces Cerevisiae Eukaryotic Cell. Apr, 2007 | Pubmed ID: 17337637 Mitochondria Maintain Maturation and Secretion of Lipoprotein Lipase in the Endoplasmic Reticulum The Biochemical Journal. May, 2006 | Pubmed ID: 16466345 A New Type of Non-Ca2+-buffering Apo(a)-based Fluorescent Indicator for Intraluminal Ca2+ in the Endoplasmic Reticulum The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16368693 Twenty Years of Calcium Imaging: Cell Physiology to Dye For Molecular Interventions. Apr, 2005 | Pubmed ID: 15821159 Hyperglycemic Conditions Affect Shape and Ca2+ Homeostasis of Mitochondria in Endothelial Cells Journal of Cardiovascular Pharmacology. Oct, 2004 | Pubmed ID: 15454850 Kisspeptin-10, a KiSS-1/metastin-derived Decapeptide, is a Physiological Invasion Inhibitor of Primary Human Trophoblasts Journal of Cell Science. Mar, 2004 | Pubmed ID: 15020672 Heterozygous Missense Mutations in BSCL2 Are Associated with Distal Hereditary Motor Neuropathy and Silver Syndrome Nature Genetics. Mar, 2004 | Pubmed ID: 14981520 Anandamide Initiates Ca(2+) Signaling Via CB2 Receptor Linked to Phospholipase C in Calf Pulmonary Endothelial Cells British Journal of Pharmacology. Dec, 2003 | Pubmed ID: 14645143 Sustained Ca2+ Transfer Across Mitochondria is Essential for Mitochondrial Ca2+ Buffering, Sore-operated Ca2+ Entry, and Ca2+ Store Refilling The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12941956 Mitochondria Efficiently Buffer Subplasmalemmal Ca2+ Elevation During Agonist Stimulation The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12529366 Novel High Energy Intermediate Analogues with Triazasterol-related Structures As Inhibitors of Ergosterol Biosynthesis. Part I: Synthesis and Antifungal Activity of N-alkyl-N'-(phenethyl- and Cyclohexenylethyl)guanidines and N2-substituted 2-imidazolinamines Archiv Der Pharmazie. 2002 | Pubmed ID: 12596218 Nitric Oxide Inhibits Capacitative Ca2+ Entry by Suppression of Mitochondrial Ca2+ Handling British Journal of Pharmacology. Nov, 2002 | Pubmed ID: 12411413 Functional Analysis of Histamine Receptor Subtypes Involved in Endothelium-mediated Relaxation of the Human Uterine Artery Clinical and Experimental Pharmacology & Physiology. Aug, 2002 | Pubmed ID: 12100006 Subplasmalemmal Endoplasmic Reticulum Controls K(Ca) Channel Activity Upon Stimulation with a Moderate Histamine Concentration in a Human Umbilical Vein Endothelial Cell Line The Journal of Physiology. Apr, 2002 | Pubmed ID: 11927670 Tissue-specific Expression of Human Lipoprotein Lipase in the Vascular System Affects Vascular Reactivity in Transgenic Mice British Journal of Pharmacology. Jan, 2002 | Pubmed ID: 11786490 Oxidized Phospholipids Stimulate Tissue Factor Expression in Human Endothelial Cells Via Activation of ERK/EGR-1 and Ca(++)/NFAT Blood. Jan, 2002 | Pubmed ID: 11756172 Toepassing van genetisch gecodeerde Fluorescent stikstofoxide (NO •) Probes, de geNOps, voor real-time beeldvorming van NO • Signalen in afzonderlijke cellen Emrah Eroglu1, Rene Rost1, Helmut Bischof1, Sandra Blass1, Anna Schreilechner1, Benjamin Gottschalk1, Maria R. Depaoli1, Christiane Klec1, Suphachai Charoensin1, Corina T. Madreiter-Sokolowski1, Jeta Ramadani1, Markus Waldeck-Weiermair1, Wolfgang F. Graier1, Roland Malli1 1Institute of Molecular Biology and Biochemistry, Medical University of Graz Biologia
Toepassing van genetisch gecodeerde Fluorescent stikstofoxide (NO •) Probes, de geNOps, voor real-time beeldvorming van NO • Signalen in afzonderlijke cellen Emrah Eroglu1, Rene Rost1, Helmut Bischof1, Sandra Blass1, Anna Schreilechner1, Benjamin Gottschalk1, Maria R. Depaoli1, Christiane Klec1, Suphachai Charoensin1, Corina T. Madreiter-Sokolowski1, Jeta Ramadani1, Markus Waldeck-Weiermair1, Wolfgang F. Graier1, Roland Malli1 1Institute of Molecular Biology and Biochemistry, Medical University of Graz Biologia