Ronald L. Klein Department of Pharmacology, Toxicology, and Neuroscience Louisiana State University Health Sciences Center Biography Publications Institution JoVE Articles Ronald L. Klein has not added a biography. If you are Ronald L. Klein and would like to personalize this page please email our Author Liaison for assistance. Publications Entorhinal Tau Pathology Disrupts Hippocampal-prefrontal Oscillatory Coupling During Associative Learning Neurobiology of Aging. Jul, 2017 | Pubmed ID: 28735144 P62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration PloS One. 2017 | Pubmed ID: 28076378 Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 28008310 Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 27867348 Severe Respiratory Changes at End Stage in a FUS-induced Disease State in Adult Rats BMC Neuroscience. Oct, 2016 | Pubmed ID: 27793099 Gene Vector 'magic Bullet': Targeted Expression in the Central Nervous System After Peripheral Delivery Using the Synapsin Promoter Expert Opinion on Therapeutic Targets. Oct, 2016 | Pubmed ID: 27424738 Sequential Adeno-Associated Viral Vector Serotype 9-Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum Human Gene Therapy. Jul, 2016 | Pubmed ID: 26847924 AAV9 Supports Wide-scale Transduction of the CNS and TDP-43 Disease Modeling in Adult Rats Molecular Therapy. Methods & Clinical Development. 2015 | Pubmed ID: 26445725 Initial Gene Vector Dosing for Studying Symptomatology of Amyotrophic Lateral Sclerosis in Non-human Primates Journal of Medical Primatology. Apr, 2015 | Pubmed ID: 25639184 Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 KDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013 | Pubmed ID: 28160795 Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013 | Pubmed ID: 23689600 Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction Following Re-Administration in Rat Brain PloS One. 2013 | Pubmed ID: 23667683 Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-induced Xerostomia Human Gene Therapy. Jun, 2013 | Pubmed ID: 23614651 Imaging the Response of the Retina to Electrical Stimulation with Genetically Encoded Calcium Indicators Journal of Neurophysiology. Apr, 2013 | Pubmed ID: 23343890 A Spirulina-enhanced Diet Provides Neuroprotection in an α-synuclein Model of Parkinson's Disease PloS One. 2012 | Pubmed ID: 23028885 Adult-onset Focal Expression of Mutated Human Tau in the Hippocampus Impairs Spatial Working Memory of Rats Behavioural Brain Research. Jul, 2012 | Pubmed ID: 22561128 Isocitrate Dehydrogenase 1 is Downregulated During Early Skin Tumorigenesis Which Can Be Inhibited by Overexpression of Manganese Superoxide Dismutase Cancer Science. Aug, 2012 | Pubmed ID: 22533343 The Advent of AAV9 Expands Applications for Brain and Spinal Cord Gene Delivery Expert Opinion on Biological Therapy. Jun, 2012 | Pubmed ID: 22519910 Frontotemporal Lobar Degeneration-related Proteins Induce Only Subtle Memory-related Deficits when Bilaterally Overexpressed in the Dorsal Hippocampus Experimental Neurology. Feb, 2012 | Pubmed ID: 22177996 Genetic Strategies to Study TDP-43 in Rodents and to Develop Preclinical Therapeutics for Amyotrophic Lateral Sclerosis The European Journal of Neuroscience. Oct, 2011 | Pubmed ID: 21777407 Focal Expression of Mutated Tau in Entorhinal Cortex Neurons of Rats Impairs Spatial Working Memory Behavioural Brain Research. Jan, 2011 | Pubmed ID: 20727915 Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae when TDP-43 is Overexpressed Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20877346 Circulating Neprilysin Clears Brain Amyloid Molecular and Cellular Neurosciences. Oct, 2010 | Pubmed ID: 20558294 Transcriptome Analysis of a Tau Overexpression Model in Rats Implicates an Early Pro-inflammatory Response Experimental Neurology. Jul, 2010 | Pubmed ID: 20346943 Pronounced Microgliosis and Neurodegeneration in Aged Rats After Tau Gene Transfer Neurobiology of Aging. Dec, 2010 | Pubmed ID: 19155101 Versatile Somatic Gene Transfer for Modeling Neurodegenerative Diseases Neurotoxicity Research. Oct, 2009 | Pubmed ID: 19669852 Bilateral Effects of Unilateral GDNF Administration on Dopamine- and GABA-regulating Proteins in the Rat Nigrostriatal System Experimental Neurology. Sep, 2009 | Pubmed ID: 19460370 PET Imaging in Rats to Discern Temporal Onset Differences Between 6-hydroxydopamine and Tau Gene Vector Neurodegeneration Models Brain Research. Mar, 2009 | Pubmed ID: 19368808 Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats Via TDP-43 Overexpression Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2009 | Pubmed ID: 19223871 Effect of CNTF on Retinal Ganglion Cell Survival in Experimental Glaucoma Investigative Ophthalmology & Visual Science. May, 2009 | Pubmed ID: 19060281 Tau Expression Levels from Various Adeno-associated Virus Vector Serotypes Produce Graded Neurodegenerative Disease States The European Journal of Neuroscience. Apr, 2008 | Pubmed ID: 18380664 AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2008 | Pubmed ID: 17955025 Memory-related Deficits Following Selective Hippocampal Expression of Swedish Mutation Amyloid Precursor Protein in the Rat Experimental Neurology. Aug, 2006 | Pubmed ID: 16780838 Parkin is Protective for Substantia Nigra Dopamine Neurons in a Tau Gene Transfer Neurodegeneration Model Neuroscience Letters. Jun, 2006 | Pubmed ID: 16554120 Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2006 | Pubmed ID: 16325474 Tau Gene Transfer, but Not Alpha-synuclein, Induces Both Progressive Dopamine Neuron Degeneration and Rotational Behavior in the Rat Neurobiology of Disease. Oct, 2005 | Pubmed ID: 16137567 Adeno-associated Viruses Containing BFGF or BDNF Are Neuroprotective Against Excitotoxicity Current Eye Research. Dec, 2004 | Pubmed ID: 15764082 Recombinant Adeno-associated Virus Serotype 2 Effectively Transduces Primary Rat Brain Astrocytes and Microglia Brain Research. Brain Research Protocols. Nov, 2004 | Pubmed ID: 15519948 Rapid Neurofibrillary Tangle Formation After Localized Gene Transfer of Mutated Tau The American Journal of Pathology. Jan, 2004 | Pubmed ID: 14695347 Long-term Neuronal Effects and Disposition of Ectopic PreproNGF Gene Transfer into the Rat Septum Human Gene Therapy. Oct, 2003 | Pubmed ID: 14577926 Gene Therapy with Brain-derived Neurotrophic Factor As a Protection: Retinal Ganglion Cells in a Rat Glaucoma Model Investigative Ophthalmology & Visual Science. Oct, 2003 | Pubmed ID: 14507880 Adeno-associated Virus Vector Expressing Nerve Growth Factor Enhances Cholinergic Axonal Sprouting After Cortical Injury in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2003 | Pubmed ID: 12684466 Suppression of Insult-induced Neurogenesis in Adult Rat Brain by Brain-derived Neurotrophic Factor Experimental Neurology. Sep, 2002 | Pubmed ID: 12429205 Particle Detection, Number Estimation, and Feature Measurement in Gene Transfer Studies: Optical Fractionator Stereology Integrated with Digital Image Processing and Analysis Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413429 Measurements of Vector-derived Neurotrophic Factor and Green Fluorescent Protein Levels in the Brain Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413428 Gene Delivery to the Eye Using Adeno-associated Viral Vectors Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413426 Pre- and Post-synaptic Modification by Neurotrophins Neuroscience Research. Jul, 2002 | Pubmed ID: 12103437 Dose and Promoter Effects of Adeno-associated Viral Vector for Green Fluorescent Protein Expression in the Rat Brain Experimental Neurology. Jul, 2002 | Pubmed ID: 12093083 Dopaminergic Cell Loss Induced by Human A30P Alpha-synuclein Gene Transfer to the Rat Substantia Nigra Human Gene Therapy. Mar, 2002 | Pubmed ID: 11916484 Neuropathological and Behavioral Consequences of Adeno-associated Viral Vector-mediated Continuous Intrastriatal Neurotrophin Delivery in a Focal Ischemia Model in Rats Neurobiology of Disease. Mar, 2002 | Pubmed ID: 11895371 Metoder og tupper for intravenøs administrasjon av Adeno-assosiert Virus rotter og evaluering av sentralnervesystemet signaltransduksjon Mychal S. Grames1, Kasey L. Jackson1, Robert D. Dayton1, John A. Stanford2, Ronald L. Klein1 1Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, 2Department of Molecular & Integrative Physiology, University of Kansas Medical Center JoVE 55994 Neuroscienze
Metoder og tupper for intravenøs administrasjon av Adeno-assosiert Virus rotter og evaluering av sentralnervesystemet signaltransduksjon Mychal S. Grames1, Kasey L. Jackson1, Robert D. Dayton1, John A. Stanford2, Ronald L. Klein1 1Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, 2Department of Molecular & Integrative Physiology, University of Kansas Medical Center JoVE 55994 Neuroscienze