Rosalie C Sears Brenden-Colson Canter for Pancreatic Care Oregon Health & Science University Biography Publications Institution JoVE Articles Rosalie C Sears has not added a biography. If you are Rosalie C Sears and would like to personalize this page please email our Author Liaison for assistance. Publications Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment Pharmaceutics. Nov, 2023 | Pubmed ID: 38139993 Accessible High-throughput Single-cell Whole-genome Sequencing with Paired Chromatin Accessibility Cell Reports Methods. Nov, 2023 | Pubmed ID: 37918402 Unraveling MYC's Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance Pathophysiology : the Official Journal of the International Society for Pathophysiology. Sep, 2023 | Pubmed ID: 37755397 MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer Nature Communications. Sep, 2023 | Pubmed ID: 37704631 Deletion of the MRNA Stability Factor (HuR) in Pancreatic Cancer Cells Disrupts the Tumor Microenvironment Integrity NAR Cancer. Jun, 2023 | Pubmed ID: 37089813 The Ubiquitin-specific Protease USP36 SUMOylates EXOSC10 and Promotes the Nucleolar RNA Exosome Function in RRNA Processing Nucleic Acids Research. May, 2023 | Pubmed ID: 36912080 Robust Biomarker Discovery Through Multiplatform Multiplex Image Analysis of Breast Cancer Clinical Cohorts BioRxiv : the Preprint Server for Biology. May, 2023 | Pubmed ID: 36778343 A Path to Translation: How 3D Patient Tumor Avatars Enable Next Generation Precision Oncology Cancer Cell. Dec, 2022 | Pubmed ID: 36270276 Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL Cancer Research. Sep, 2022 | Pubmed ID: 35819261 The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma Molecular and Cellular Biology. Jul, 2022 | Pubmed ID: 35703534 Microfluidics Formulated Liposomes of Hypoxia Activated Prodrug for Treatment of Pancreatic Cancer Pharmaceutics. Mar, 2022 | Pubmed ID: 35456547 HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms Cancers. Apr, 2022 | Pubmed ID: 35406624 T-cell Dysfunction Upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62 Molecular Cancer Research : MCR. Jul, 2022 | Pubmed ID: 35380701 Metabolic Convergence on Lipogenesis in RAS, BCR-ABL, and MYC-driven Lymphoid Malignancies Cancer & Metabolism. Aug, 2021 | Pubmed ID: 34399819 High-content Single-cell Combinatorial Indexing Nature Biotechnology. Dec, 2021 | Pubmed ID: 34226710 Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics Annual Review of Cancer Biology. Mar, 2021 | Pubmed ID: 34222745 Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy Frontiers in Oncology. 2021 | Pubmed ID: 34178666 Tumor-Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients With Pancreatic Adenocarcinoma JCO Precision Oncology. 2021 | Pubmed ID: 34036232 Detection of Post-translational Modifications on MYC Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34019287 Sulfopin is a Covalent Inhibitor of Pin1 That Blocks Myc-driven Tumors in Vivo Nature Chemical Biology. Sep, 2021 | Pubmed ID: 33972797 Loss of Ambra1 Promotes Melanoma Growth and Invasion Nature Communications. May, 2021 | Pubmed ID: 33953176 AMBRA1 Regulates Cyclin D to Guard S-phase Entry and Genomic Integrity Nature. Apr, 2021 | Pubmed ID: 33854232 The Deubiquitinase USP36 Promotes SnoRNP Group SUMOylation and is Essential for Ribosome Biogenesis EMBO Reports. Jun, 2021 | Pubmed ID: 33852194 Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Cancer Discovery. Aug, 2021 | Pubmed ID: 33727309 Altering MYC Phosphorylation in the Epidermis Increases the Stem Cell Population and Contributes to the Development, Progression, and Metastasis of Squamous Cell Carcinoma Oncogenesis. Sep, 2020 | Pubmed ID: 32895364 Hypoxia: Friend or Foe for Drug Delivery in Pancreatic Cancer Cancer Letters. Nov, 2020 | Pubmed ID: 32822815 Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer Trends in Pharmacological Sciences. Sep, 2020 | Pubmed ID: 32624198 Acidic Fibroblast Growth Factor Underlies Microenvironmental Regulation of MYC in Pancreatic Cancer The Journal of Experimental Medicine. Aug, 2020 | Pubmed ID: 32434218 PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32300594 Deconstructing Pancreatic Adenocarcinoma by Targeting the Conductor, MYC Cancer Discovery. Apr, 2020 | Pubmed ID: 32238397 Deregulating MYC in a Model of HER2+ Breast Cancer Mimics Human Intertumoral Heterogeneity The Journal of Clinical Investigation. Jan, 2020 | Pubmed ID: 31763993 Writing and Erasing MYC Ubiquitination and SUMOylation Genes & Diseases. Dec, 2019 | Pubmed ID: 31832515 Mission Possible: Advances in MYC Therapeutic Targeting in Cancer BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Oct, 2019 | Pubmed ID: 31392631 Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming Cancer Discovery. Sep, 2019 | Pubmed ID: 31266770 The Use of Protein Phosphatase 2A Activators in Combination Therapies for Pancreas Cancer Oncotarget. Mar, 2019 | Pubmed ID: 31007842 Modeling Differentiation-state Transitions Linked to Therapeutic Escape in Triple-negative Breast Cancer PLoS Computational Biology. Mar, 2019 | Pubmed ID: 30856168 A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression Cancer Discovery. May, 2019 | Pubmed ID: 30837243 Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting Cell Reports. Jan, 2019 | Pubmed ID: 30650355 Activation of PP2A and Inhibition of MTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma Cancer Research. Jan, 2019 | Pubmed ID: 30389701 Post-translational Modification Localizes MYC to the Nuclear Pore Basket to Regulate a Subset of Target Genes Involved in Cellular Responses to Environmental Signals Genes & Development. Nov, 2018 | Pubmed ID: 30366908 SUMO Protease SENP1 DeSUMOylates and Stabilizes C-Myc Proceedings of the National Academy of Sciences of the United States of America. Oct, 2018 | Pubmed ID: 30305424 Differentiation-state Plasticity is a Targetable Resistance Mechanism in Basal-like Breast Cancer Nature Communications. 09, 2018 | Pubmed ID: 30232459 Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity Within Medulloblastoma Subgroups Cancer Cell. Sep, 2018 | Pubmed ID: 30205044 Serum Biomarker Signature-Based Liquid Biopsy for Diagnosis of Early-Stage Pancreatic Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2018 | Pubmed ID: 30106639 The Ubiquitin-specific Protease USP36 is a Conserved Histone H2B Deubiquitinase Biochemical and Biophysical Research Communications. Jan, 2018 | Pubmed ID: 29274341 The Tumor Suppressor Phosphatase PP2A-B56α Regulates Stemness and Promotes the Initiation of Malignancies in a Novel Murine Model PloS One. 2017 | Pubmed ID: 29190822 MYC Regulates Ductal-neuroendocrine Lineage Plasticity in Pancreatic Ductal Adenocarcinoma Associated with Poor Outcome and Chemoresistance Nature Communications. 11, 2017 | Pubmed ID: 29170413 Activation of Tumor Suppressor Protein PP2A Inhibits KRAS-driven Tumor Growth The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28504649 Aspirin Therapy Reduces the Ability of Platelets to Promote Colon and Pancreatic Cancer Cell Proliferation: Implications for the Oncoprotein C-MYC American Journal of Physiology. Cell Physiology. Feb, 2017 | Pubmed ID: 27903583 MYC is Not Detected in Highly Proliferating Normal Spermatogonia but is Coupled with CIP2A in Testicular Cancers Matters. Mar, 2016 | Pubmed ID: 29527532 Deubiquitinating C-Myc: USP36 Steps Up in the Nucleolus Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 26697836 Pre-Anchoring of Pin1 to Unphosphorylated C-Myc in a Fuzzy Complex Regulates C-Myc Activity Structure (London, England : 1993). Dec, 2015 | Pubmed ID: 26655473 Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation Cell Reports. Aug, 2015 | Pubmed ID: 26235622 Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity Journal of Medicinal Chemistry. Jun, 2015 | Pubmed ID: 26023867 The Nucleolar Ubiquitin-specific Protease USP36 Deubiquitinates and Stabilizes C-Myc Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25775507 Targeting C-MYC by Antagonizing PP2A Inhibitors in Breast Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2014 | Pubmed ID: 24927563 Targeting Inhibitors of the Tumor Suppressor PP2A for the Treatment of Pancreatic Cancer Molecular Cancer Research : MCR. Jun, 2014 | Pubmed ID: 24667985 MYC Degradation Cold Spring Harbor Perspectives in Medicine. Mar, 2014 | Pubmed ID: 24591536 Diminished WNT -> β-catenin -> C-MYC Signaling is a Barrier for Malignant Progression of BRAFV600E-induced Lung Tumors Genes & Development. Mar, 2014 | Pubmed ID: 24589553 Pin1 Regulates the Dynamics of C-Myc DNA Binding to Facilitate Target Gene Regulation and Oncogenesis Molecular and Cellular Biology. Aug, 2013 | Pubmed ID: 23716601 N Terminus of ASPP2 Binds to Ras and Enhances Ras/Raf/MEK/ERK Activation to Promote Oncogene-induced Senescence Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23248303 A Critical Role for Mnt in Myc-driven T-cell Proliferation and Oncogenesis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23150551 Studying C-Myc Serine 62 Phosphorylation in Leukemia Cells: Concern over Antibody Cross-reactivity Blood. May, 2012 | Pubmed ID: 22653959 PP2A-B56α Controls Oncogene-induced Senescence in Normal and Tumor Human Melanocytic Cells Oncogene. Mar, 2012 | Pubmed ID: 21822300 Ribosomal Protein L11 Recruits MiR-24/miRISC to Repress C-Myc Expression in Response to Ribosomal Stress Molecular and Cellular Biology. Oct, 2011 | Pubmed ID: 21807902 GSK 3 β と Cdk1 による組合せ抑制を介して低酸素誘導アポトーシス抵抗を克服します。 Cancer Research. Aug, 2011 | Pubmed ID: 21646472 Focal Adhesion Kinase is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling Developmental Cell. Aug, 2010 | Pubmed ID: 20708588 The Axin1 Scaffold Protein Promotes Formation of a Degradation Complex for C-Myc The EMBO Journal. Mar, 2009 | Pubmed ID: 19131971 The Life Cycle of C-myc: from Synthesis to Degradation Cell Cycle (Georgetown, Tex.). Sep, 2004 | Pubmed ID: 15467447 Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets Amani Alshaikh1,2, Dmytro Grygoryev3, Dove Keith4, Brett Sheppard4,5, Rosalie C Sears4,6, Jungsun Kim3,6, Abdenour Soufi1 1Centre for Regenerative Medicine, Institute of Regeneration and Repair, Institute of Stem Cell Research, The University of Edinburgh, 2King Abdulaziz City for Science and Technology Health Sector (KACST), 3Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, 4Brenden-Colson Canter for Pancreatic Care, Oregon Health & Science University, 5Department of Surgery, Oregon Health & Science University, 6Department of Molecular & Medical Genetics, Oregon Health & Science University JoVE 65811 Ricerca sul cancro
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets Amani Alshaikh1,2, Dmytro Grygoryev3, Dove Keith4, Brett Sheppard4,5, Rosalie C Sears4,6, Jungsun Kim3,6, Abdenour Soufi1 1Centre for Regenerative Medicine, Institute of Regeneration and Repair, Institute of Stem Cell Research, The University of Edinburgh, 2King Abdulaziz City for Science and Technology Health Sector (KACST), 3Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, 4Brenden-Colson Canter for Pancreatic Care, Oregon Health & Science University, 5Department of Surgery, Oregon Health & Science University, 6Department of Molecular & Medical Genetics, Oregon Health & Science University JoVE 65811 Ricerca sul cancro