Stephen C Cunnane Research Center on Aging and Department of Physiology and Biophysics Université de Sherbrooke Biography Publications Institution JoVE Articles Stephen C Cunnane has not added a biography. If you are Stephen C Cunnane and would like to personalize this page please email our Author Liaison for assistance. Publications Ageing and ApoE Change DHA Homeostasis: Relevance to Age-related Cognitive Decline The Proceedings of the Nutrition Society. Oct, 2013 | Pubmed ID: 24103099 Brain Docosahexaenoic Acid [DHA] Incorporation and Blood Flow Are Increased in Chronic Alcoholics: A Positron Emission Tomography Study Corrected for Cerebral Atrophy PloS One. 2013 | Pubmed ID: 24098376 Long-term Calorie Restriction Has Minimal Impact on Brain Metabolite and Fatty Acid Profiles in Aged Rats on a Western-style Diet Neurochemistry International. Nov, 2013 | Pubmed ID: 23974047 Relationship Between Diet and Plasma Long-chain N-3 PUFAs in Older People: Impact of Apolipoprotein E Genotype Journal of Lipid Research. Sep, 2013 | Pubmed ID: 23801662 Daily Flaxseed Consumption Improves Glycemic Control in Obese Men and Women with Pre-diabetes: a Randomized Study Nutrition Research (New York, N.Y.). May, 2013 | Pubmed ID: 23684438 Thyroid Function and Cognition in the Euthyroid Elderly: A Case-control Study Embedded in Quebec Longitudinal Study - NuAge Psychoneuroendocrinology. Mar, 2013 | Pubmed ID: 23507188 Stimulation of Mild, Sustained Ketonemia by Medium-chain Triacylglycerols in Healthy Humans: Estimated Potential Contribution to Brain Energy Metabolism Nutrition (Burbank, Los Angeles County, Calif.). Apr, 2013 | Pubmed ID: 23274095 Dietary Oils and FADS1-FADS2 Genetic Variants Modulate [13C]α-linolenic Acid Metabolism and Plasma Fatty Acid Composition The American Journal of Clinical Nutrition. Jan, 2013 | Pubmed ID: 23221573 Docosahexaenoic Acid Homeostasis, Brain Aging and Alzheimer's Disease: Can We Reconcile the Evidence? Prostaglandins, Leukotrienes, and Essential Fatty Acids. Jan, 2013 | Pubmed ID: 22575581 The Ketogenic Diet Increases Brain Glucose and Ketone Uptake in Aged Rats: a Dual Tracer PET and Volumetric MRI Study Brain Research. Dec, 2012 | Pubmed ID: 23063891 Plasma Long-chain Omega-3 Fatty Acids and Atrophy of the Medial Temporal Lobe Neurology. Aug, 2012 | Pubmed ID: 22855869 N-3 PUFA Status Affects Expression of Genes Involved in Neuroenergetics Differently in the Fronto-parietal Cortex Compared to the CA1 Area of the Hippocampus: Effect of Rest and Neuronal Activation in the Rat Prostaglandins, Leukotrienes, and Essential Fatty Acids. Jun, 2012 | Pubmed ID: 22579067 Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2012 | Pubmed ID: 22466064 Mild Experimental Ketosis Increases Brain Uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a Dual-tracer PET Imaging Study in Rats Nutritional Neuroscience. Mar, 2011 | Pubmed ID: 21605500 N-3 Fatty Acids and Cardiovascular Events The New England Journal of Medicine. Mar, 2011 | Pubmed ID: 21366485 Plasma Incorporation, Apparent Retroconversion and β-oxidation of 13C-docosahexaenoic Acid in the Elderly Nutrition & Metabolism. 2011 | Pubmed ID: 21272363 Increased Postprandial Nonesterified Fatty Acid Appearance and Oxidation in Type 2 Diabetes is Not Fully Established in Offspring of Diabetic Subjects PloS One. 2010 | Pubmed ID: 20532041 Image-derived Input Function in Dynamic Human PET/CT: Methodology and Validation with 11C-acetate and 18F-fluorothioheptadecanoic Acid in Muscle and 18F-fluorodeoxyglucose in Brain European Journal of Nuclear Medicine and Molecular Imaging. Aug, 2010 | Pubmed ID: 20437239 Bezafibrate Mildly Stimulates Ketogenesis and Fatty Acid Metabolism in Hypertriglyceridemic Subjects The Journal of Pharmacology and Experimental Therapeutics. Jul, 2010 | Pubmed ID: 20404010 Maternal Dietary Fat Determines Metabolic Profile and the Magnitude of Endocannabinoid Inhibition of the Stress Response in Neonatal Rat Offspring Endocrinology. Apr, 2010 | Pubmed ID: 20160134 N-3 Fatty Acid Intake from Marine Food Products Among Quebecers: Comparison to Worldwide Recommendations Public Health Nutrition. Jan, 2010 | Pubmed ID: 19433004 Plasma N-3 Fatty Acid Response to an N-3 Fatty Acid Supplement is Modulated by ApoE Epsilon4 but Not by the Common PPAR-alpha L162V Polymorphism in Men The British Journal of Nutrition. Oct, 2009 | Pubmed ID: 19828088 Alpha-Linolenic Acid Supplementation and Conversion to N-3 Long-chain Polyunsaturated Fatty Acids in Humans Prostaglandins, Leukotrienes, and Essential Fatty Acids. Feb-Mar, 2009 | Pubmed ID: 19269799 Towards Establishing Dietary Reference Intakes for Eicosapentaenoic and Docosahexaenoic Acids The Journal of Nutrition. Apr, 2009 | Pubmed ID: 19244379 Eicosapentaenoic Acid Decreases Postprandial Beta-hydroxybutyrate and Free Fatty Acid Responses in Healthy Young and Elderly Nutrition (Burbank, Los Angeles County, Calif.). Mar, 2009 | Pubmed ID: 19036560 Ketones and Brain Function: Possible Link to Polyunsaturated Fatty Acids and Availability of a New Brain PET Tracer, 11C-acetoacetate Epilepsia. Nov, 2008 | Pubmed ID: 19049595 Heterogeneity in Randomized Controlled Trials of Long Chain (fish) Omega-3 Fatty Acids in Restenosis, Secondary Prevention and Ventricular Arrhythmias Journal of the American College of Nutrition. Jun, 2008 | Pubmed ID: 18838524 Plasma Omega-3 Fatty Acid Response to a Fish Oil Supplement in the Healthy Elderly Lipids. Nov, 2008 | Pubmed ID: 18795357 Conjugated Linoleic Acids: Why the Discrepancy Between Animal and Human Studies? Nutrition Reviews. Jul, 2008 | Pubmed ID: 18667017 Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial Journal of the American College of Nutrition. Feb, 2008 | Pubmed ID: 18460483 [11C] Acetoacetate Utilization by Breast and Prostate Tumors: a PET and Biodistribution Study in Mice Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jul-Aug, 2008 | Pubmed ID: 18454299 An Emerging Risk Factor for Obesity: Does Disequilibrium of Polyunsaturated Fatty Acid Metabolism Contribute to Excessive Adipose Tissue Development? The British Journal of Nutrition. Sep, 2008 | Pubmed ID: 18307824 Fish-oil Supplementation in Patients with Implantable Cardioverter Defibrillators: a Meta-analysis CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Jan, 2008 | Pubmed ID: 18195289 Flaxseed on Cardiovascular Disease Markers in Healthy Menopausal Women: a Randomized, Double-blind, Placebo-controlled Trial Nutrition (Burbank, Los Angeles County, Calif.). Jan, 2008 | Pubmed ID: 17981439 Unresolved Issues in the Link Between Docosahexaenoic Acid and Alzheimer's Disease Prostaglandins, Leukotrienes, and Essential Fatty Acids. Nov-Dec, 2007 | Pubmed ID: 18036804 Extremely Limited Synthesis of Long Chain Polyunsaturates in Adults: Implications for Their Dietary Essentiality and Use As Supplements Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme. Aug, 2007 | Pubmed ID: 17622276 Docosahexaenoic Acid and Shore-based Diets in Hominin Encephalization: a Rebuttal American Journal of Human Biology : the Official Journal of the Human Biology Council. Jul-Aug, 2007 | Pubmed ID: 17546620 Automated Synthesis of 11C-acetoacetic Acid, a Key Alternate Brain Fuel to Glucose Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine. Aug, 2007 | Pubmed ID: 17544283 Biosynthetic Production of Universally (13)C-labelled Polyunsaturated Fatty Acids As Reference Materials for Natural Health Product Research Analytical and Bioanalytical Chemistry. Sep, 2007 | Pubmed ID: 17486321 Docosahexaenoic Acid and Human Brain Evolution: Missing the Forest for the Trees--comments by Cunnane The British Journal of Nutrition. May, 2007 | Pubmed ID: 17408531 Alpha-Linolenic Acid and Fish Oil N-3 Fatty Acids and Cardiovascular Disease Risk The American Journal of Clinical Nutrition. Mar, 2007 | Pubmed ID: 17344517 Comparison of Composition and Absorption of Sugarcane Policosanols The British Journal of Nutrition. Feb, 2007 | Pubmed ID: 17298709 Markedly Raised Intake of Saturated and Monounsaturated Fatty Acids in Rats on a High-fat Ketogenic Diet Does Not Inhibit Carbon Recycling of 13C-alpha-linolenate Lipids. Oct, 2006 | Pubmed ID: 17180881 Omega-3 Fatty Acids, Energy Substrates, and Brain Function During Aging Prostaglandins, Leukotrienes, and Essential Fatty Acids. Sep, 2006 | Pubmed ID: 16829066 [Survival of the Fattest: the Key to Human Brain Evolution] Médecine Sciences : M/S. Jun-Jul, 2006 | Pubmed ID: 16828044 Suckling Rats Actively Recycle Carbon from Alpha-linolenate into Newly Synthesized Lipids Even During Extreme Dietary Deficiency of N-3 Polyunsaturates Pediatric Research. Jan, 2006 | Pubmed ID: 16326997 Breath Acetone Predicts Plasma Ketone Bodies in Children with Epilepsy on a Ketogenic Diet Nutrition (Burbank, Los Angeles County, Calif.). Jan, 2006 | Pubmed ID: 16183255 Despite Transient Ketosis, the Classic High-fat Ketogenic Diet Induces Marked Changes in Fatty Acid Metabolism in Rats Metabolism: Clinical and Experimental. Sep, 2005 | Pubmed ID: 16125522 Origins and Evolution of the Western Diet: Implications of Iodine and Seafood Intakes for the Human Brain The American Journal of Clinical Nutrition. Aug, 2005 | Pubmed ID: 16087997 Effects of a Diet High in Plant Sterols, Vegetable Proteins, and Viscous Fibers (dietary Portfolio) on Circulating Sterol Levels and Red Cell Fragility in Hypercholesterolemic Subjects Lipids. Feb, 2005 | Pubmed ID: 15884765 Dietary 18:3omega3 Influences Immune Function and the Tissue Fatty Acid Response to Antigens and Adjuvant Immunology Letters. Aug, 2004 | Pubmed ID: 15325802 Claims to Identify Detrimental Effects of the Ketogenic Diet (KD) on Cognitive Function in Rats Pediatric Research. Oct, 2004 | Pubmed ID: 15319466 Lovastatin Exacerbates Atypical Absence Seizures with Only Minimal Effects on Brain Sterols Journal of Lipid Research. Nov, 2004 | Pubmed ID: 15314096 Metabolism of Polyunsaturated Fatty Acids and Ketogenesis: an Emerging Connection Prostaglandins, Leukotrienes, and Essential Fatty Acids. Mar, 2004 | Pubmed ID: 14769482 Intramuscular Injection of Antigens and Adjuvant Preferentially Decreases 18:2n-6 and 18:3n-3 in Pig Neck Muscle Lipids. Dec, 2003 | Pubmed ID: 14870924 Dietary Alpha-linolenic Acid Increases the N-3 PUFA Content of Sow's Milk and the Tissues of the Suckling Piglet Lipids. Oct, 2003 | Pubmed ID: 14669969 Problems with Essential Fatty Acids: Time for a New Paradigm? Progress in Lipid Research. Nov, 2003 | Pubmed ID: 14559071 Survival of the Fattest: Fat Babies Were the Key to Evolution of the Large Human Brain Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. Sep, 2003 | Pubmed ID: 14527626 Why is Carbon from Some Polyunsaturates Extensively Recycled into Lipid Synthesis? Lipids. Apr, 2003 | Pubmed ID: 12848297 Whole-body Utilization of N-3 PUFA in N-6 PUFA-deficient Rats Lipids. Feb, 2003 | Pubmed ID: 12733752 Whole-body Beta-oxidation of 18:2omega6 and 18:3omega3 in the Pig Varies Markedly with Weaning Strategy and Dietary 18:3omega3 Journal of Lipid Research. Feb, 2003 | Pubmed ID: 12576513 Alpha-linolenic Acid, Linoleic Acid, Coronary Artery Disease, and Overall Mortality The American Journal of Clinical Nutrition. Feb, 2003 | Pubmed ID: 12540417 Effects of High- and Low-isoflavone Soyfoods on Blood Lipids, Oxidized LDL, Homocysteine, and Blood Pressure in Hyperlipidemic Men and Women The American Journal of Clinical Nutrition. Aug, 2002 | Pubmed ID: 12145008 Breath Acetone is a Reliable Indicator of Ketosis in Adults Consuming Ketogenic Meals The American Journal of Clinical Nutrition. Jul, 2002 | Pubmed ID: 12081817 Soluble Fiber Intake at a Dose Approved by the US Food and Drug Administration for a Claim of Health Benefits: Serum Lipid Risk Factors for Cardiovascular Disease Assessed in a Randomized Controlled Crossover Trial The American Journal of Clinical Nutrition. May, 2002 | Pubmed ID: 11976156 Brain-specific Lipids from Marine, Lacustrine, or Terrestrial Food Resources: Potential Impact on Early African Homo Sapiens Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. Apr, 2002 | Pubmed ID: 11923081 Brain Sterols in the AY-9944 Rat Model of Atypical Absence Seizures Epilepsia. Jan, 2002 | Pubmed ID: 11879380 Arachidonate Metabolism in Neonates Pediatric Research. Mar, 2002 | Pubmed ID: 11861928 Breath Acetone As a Measure of Systemic Ketosis Assessed in a Rat Model of the Ketogenic Diet Clinical Chemistry. Jan, 2002 | Pubmed ID: 11751546 En Dual Tracer PET-MR-protokollen for kvantitativ måling af Regional Brain Energy Substrater Optagelse i Rat Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke Neuroscienze
En Dual Tracer PET-MR-protokollen for kvantitativ måling af Regional Brain Energy Substrater Optagelse i Rat Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke Neuroscienze