Suzanne A. Eccles Division of Cancer Therapeutics The Institute of Cancer Research Biography Publications Institution JoVE Articles Suzanne A. Eccles has not added a biography. If you are Suzanne A. Eccles and would like to personalize this page please email our Author Liaison for assistance. Publications Discovery of Potent, Orally Bioavailable, Small-molecule Inhibitors of WNT Signaling from a Cell-based Pathway Screen Journal of Medicinal Chemistry. Feb, 2015 | Pubmed ID: 25680029 Exploring the Biomechanical Properties of Brain Malignancies and Their Pathologic Determinants in Vivo with Magnetic Resonance Elastography Cancer Research. Apr, 2015 | Pubmed ID: 25672978 Cancer-associated Fibroblasts Induce High Mobility Group Box 1 and Contribute to Resistance to Doxorubicin in Breast Cancer Cells BMC Cancer. 2014 | Pubmed ID: 25512109 HIF-1α-independent Hypoxia-induced Rapid PTK6 Stabilization is Associated with Increased Motility and Invasion Cancer Biology & Therapy. Oct, 2014 | Pubmed ID: 25019382 Preclinical Evaluation of Imaging Biomarkers for Prostate Cancer Bone Metastasis and Response to Cabozantinib Journal of the National Cancer Institute. Apr, 2014 | Pubmed ID: 24634505 Critical Research Gaps and Translational Priorities for the Successful Prevention and Treatment of Breast Cancer Breast Cancer Research : BCR. 2013 | Pubmed ID: 24286369 Structure-based Design of Orally Bioavailable 1H-pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1) Journal of Medicinal Chemistry. Dec, 2013 | Pubmed ID: 24256217 Mode of Cell Death Induced by the HSP90 Inhibitor 17-AAG (tanespimycin) is Dependent on the Expression of Pro-apoptotic BAX Oncotarget. Nov, 2013 | Pubmed ID: 24185264 Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth in Vitro and in Vivo Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 23918606 Kurt Hellmann D. M., D. Phil. Oxon 1922–2013 Clinical & Experimental Metastasis. Jun, 2013 | Pubmed ID: 23844428 A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells Journal of the American Chemical Society. Jul, 2013 | Pubmed ID: 23796364 A Novel Serum Protein Signature Associated with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Head and Neck Squamous Cell Carcinoma European Journal of Cancer (Oxford, England : 1990). Jul, 2013 | Pubmed ID: 23582742 Tumor Spheroid-based Migration Assays for Evaluation of Therapeutic Agents Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23436417 Two-dimensional Vs. Three-dimensional in Vitro Tumor Migration and Invasion Assays Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23436416 Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles As Selective, Orally Bioavailable CHK1 Inhibitors Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23082860 Optimization of Imidazo[4,5-b]pyridine-based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor As an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia Journal of Medicinal Chemistry. Oct, 2012 | Pubmed ID: 23043539 CCT244747 is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2012 | Pubmed ID: 22929806 Erratum To: Kurt Hellmann D.M., D.Phil. Oxon. A Happy 90th Birthday! Clinical & Experimental Metastasis. Aug, 2012 | Pubmed ID: 22872374 The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma Cancer Cell. Jul, 2012 | Pubmed ID: 22789543 AT13148 is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2012 | Pubmed ID: 22781553 Kurt Hellmann D.M., D.Phil. Oxon. A Happy 90th Birthday! Clinical & Experimental Metastasis. Aug, 2012 | Pubmed ID: 22695808 Dependence of Wilms Tumor Cells on Signaling Through Insulin-like Growth Factor 1 in an Orthotopic Xenograft Model Targetable by Specific Receptor Inhibition Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22529373 Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling Journal of Clinical Immunology. Oct, 2012 | Pubmed ID: 22526592 The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage PloS One. 2012 | Pubmed ID: 22523597 Advances in Establishment and Analysis of Three-dimensional Tumor Spheroid-based Functional Assays for Target Validation and Drug Evaluation BMC Biology. 2012 | Pubmed ID: 22439642 Epigenetic Disruption of Cadherin-11 in Human Cancer Metastasis The Journal of Pathology. Feb, 2012 | Pubmed ID: 22374749 Flexible Targeting of ErbB Dimers That Drive Tumorigenesis by Using Genetically Engineered T Cells Molecular Medicine (Cambridge, Mass.). 2012 | Pubmed ID: 22354215 Non-invasive in Vivo Imaging of Vessel Calibre in Orthotopic Prostate Tumour Xenografts International Journal of Cancer. Journal International Du Cancer. Mar, 2012 | Pubmed ID: 21469141 Preclinical Drug Development for Childhood Cancer Expert Opinion on Drug Discovery. Jan, 2011 | Pubmed ID: 22646826 The Epidermal Growth Factor Receptor/Erb-B/HER Family in Normal and Malignant Breast Biology The International Journal of Developmental Biology. 2011 | Pubmed ID: 22161825 Structure-guided Evolution of Potent and Selective CHK1 Inhibitors Through Scaffold Morphing Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22111927 Quantitative Chemical Proteomics Reveals New Potential Drug Targets in Head and Neck Cancer Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 21955398 The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-amplified Neuroblastoma in Vivo Molecular Cancer Therapeutics. Nov, 2011 | Pubmed ID: 21885865 Ca2+ Influx Through Reverse Mode Na+/Ca2+ Exchange is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21873429 Simple Experimental and Spontaneous Metastasis Assays in Mice Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21748685 Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β Molecular Cancer Therapeutics. Aug, 2011 | Pubmed ID: 21659463 Angiogenic Functions of Voltage-gated Na+ Channels in Human Endothelial Cells: Modulation of Vascular Endothelial Growth Factor (VEGF) Signaling The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21385874 Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930 Molecular Cancer Therapeutics. Feb, 2011 | Pubmed ID: 21191045 Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2 IDrugs : the Investigational Drugs Journal. Nov, 2010 | Pubmed ID: 21046523 Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 1 IDrugs : the Investigational Drugs Journal. Nov, 2010 | Pubmed ID: 21046522 Bayesian Estimation of Changes in Transverse Relaxation Rates Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2010 | Pubmed ID: 20806382 Tumour-microenvironmental Interactions: Paths to Progression and Targets for Treatment Seminars in Cancer Biology. Jun, 2010 | Pubmed ID: 20599506 Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies Toward the Identification of an Orally Bioavailable Preclinical Development Candidate Journal of Medicinal Chemistry. Jul, 2010 | Pubmed ID: 20565112 Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma Molecular Cancer Therapeutics. May, 2010 | Pubmed ID: 20457619 Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt) Journal of Medicinal Chemistry. Mar, 2010 | Pubmed ID: 20151677 The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106 Molecular Cancer Therapeutics. Jan, 2010 | Pubmed ID: 20053762 An Open Letter to the FDA and Other Regulatory Agencies: Preclinical Drug Development Must Consider the Impact on Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 25278743 Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage The American Journal of Pathology. Sep, 2009 | Pubmed ID: 19661439 Combining Hit Identification Strategies: Fragment-based and in Silico Approaches to Orally Active 2-aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone Journal of Medicinal Chemistry. Aug, 2009 | Pubmed ID: 19610616 Biological Properties of Potent Inhibitors of Class I Phosphatidylinositide 3-kinases: from PI-103 Through PI-540, PI-620 to the Oral Agent GDC-0941 Molecular Cancer Therapeutics. Jul, 2009 | Pubmed ID: 19584227 Changes in Choline Metabolism As Potential Biomarkers of Phospholipase C{gamma}1 Inhibition in Human Prostate Cancer Cells Molecular Cancer Therapeutics. May, 2009 | Pubmed ID: 19417158 The Identification of Novel PLC-gamma Inhibitors Using Virtual High Throughput Screening Bioorganic & Medicinal Chemistry. Apr, 2009 | Pubmed ID: 19303309 In Vitro Assays for Endothelial Cell Functions Related to Angiogenesis: Proliferation, Motility, Tubular Differentiation, and Proteolysis Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19301670 Determinants of Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Squamous Cell Carcinoma of the Head and Neck The Journal of Pathology. May, 2009 | Pubmed ID: 19197951 Molecular Pharmacology of Phosphatidylinositol 3-kinase Inhibition in Human Glioma Cell Cycle (Georgetown, Tex.). Feb, 2009 | Pubmed ID: 19177002 A MicroRNA DNA Methylation Signature for Human Cancer Metastasis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18768788 The Identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) As a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer Journal of Medicinal Chemistry. Sep, 2008 | Pubmed ID: 18754654 CHR-2797: an Antiproliferative Aminopeptidase Inhibitor That Leads to Amino Acid Deprivation in Human Leukemic Cells Cancer Research. Aug, 2008 | Pubmed ID: 18701491 NVP-AUY922: a Novel Heat Shock Protein 90 Inhibitor Active Against Xenograft Tumor Growth, Angiogenesis, and Metastasis Cancer Research. Apr, 2008 | Pubmed ID: 18413753 An in Vitro and in Vivo Study of the Combination of the Heat Shock Protein Inhibitor 17-allylamino-17-demethoxygeldanamycin and Carboplatin in Human Ovarian Cancer Models Cancer Chemotherapy and Pharmacology. Oct, 2008 | Pubmed ID: 18193424 4,5-diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer Journal of Medicinal Chemistry. Jan, 2008 | Pubmed ID: 18020435 The Bcl-2/Bcl-XL Family Inhibitor ABT-737 Sensitizes Ovarian Cancer Cells to Carboplatin Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056200 AACR-NCI-EORTC--19th Symposium. Molecular Targets and Cancer Therapeutics--Part 4 IDrugs : the Investigational Drugs Journal. Dec, 2007 | Pubmed ID: 18041676 Plexin-B1 Mutations in Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 18024597 Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts Assay and Drug Development Technologies. Jun, 2007 | Pubmed ID: 17638539 Metastasis: Recent Discoveries and Novel Treatment Strategies Lancet. May, 2007 | Pubmed ID: 17512859 The Phosphoinositide-specific Phospholipase C Inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) Spontaneously Forms Conjugates with Common Components of Cell Culture Medium Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2007 | Pubmed ID: 17403917 The Vascular Targeting Property of Paclitaxel is Enhanced by SU6668, a Receptor Tyrosine Kinase Inhibitor, Causing Apoptosis of Endothelial Cells and Inhibition of Angiogenesis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2006 | Pubmed ID: 16551869 Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors Modulate Multiple Functions Required for Tumor Angiogenesis Molecular Cancer Therapeutics. Mar, 2006 | Pubmed ID: 16546966 Identification of Magnetic Resonance Detectable Metabolic Changes Associated with Inhibition of Phosphoinositide 3-kinase Signaling in Human Breast Cancer Cells Molecular Cancer Therapeutics. Jan, 2006 | Pubmed ID: 16432178 Cell Migration/invasion Assays and Their Application in Cancer Drug Discovery Biotechnology Annual Review. 2005 | Pubmed ID: 16216785 The Phosphoinositide 3-kinase Signalling Pathway As a Therapeutic Target in Squamous Cell Carcinoma of the Head and Neck Expert Opinion on Therapeutic Targets. Aug, 2005 | Pubmed ID: 16083342 PLCgamma1 is Essential for Early Events in Integrin Signalling Required for Cell Motility Journal of Cell Science. Jun, 2005 | Pubmed ID: 15944397 Biological Significance of C-erbB Family Oncogenes in Head and Neck Cancer Cancer Metastasis Reviews. Jan, 2005 | Pubmed ID: 15785872 Breast Cancer Metastasis: When, Where, How? Lancet. Mar 19-25, 2005 | Pubmed ID: 15781080 Targeting Key Steps in Metastatic Tumour Progression Current Opinion in Genetics & Development. Feb, 2005 | Pubmed ID: 15661537 Parallels in Invasion and Angiogenesis Provide Pivotal Points for Therapeutic Intervention The International Journal of Developmental Biology. 2004 | Pubmed ID: 15349833 Combination Epidermal Growth Factor Receptor Inhibition and Radical Radiotherapy for NSCLC Expert Review of Anticancer Therapy. Aug, 2004 | Pubmed ID: 15270661 Signaling Pathways Required for Matrix Metalloproteinase-9 Induction by Betacellulin in Head-and-neck Squamous Carcinoma Cells International Journal of Cancer. Journal International Du Cancer. Aug, 2004 | Pubmed ID: 15197768 Phosphoinositide 3-kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis Tumori. Jan-Feb, 2004 | Pubmed ID: 15143962 Use of Plasma MMP-2 and MMP-9 Levels As a Surrogate for Tumour Expression in Colorectal Cancer Patients International Journal of Cancer. Journal International Du Cancer. Nov, 2003 | Pubmed ID: 14520690 The Role of C-erbB Receptors and Ligands in Head and Neck Squamous Cell Carcinoma Oral Oncology. Oct, 2002 | Pubmed ID: 12167415 Three-Dimensional (3D) Tumor Spheroid Invasion Assay Maria Vinci1,2, Carol Box2, Suzanne A. Eccles2 1Division of Molecular Pathology, The Institute of Cancer Research, 2Division of Cancer Therapeutics, The Institute of Cancer Research JoVE 52686 Medicina
Three-Dimensional (3D) Tumor Spheroid Invasion Assay Maria Vinci1,2, Carol Box2, Suzanne A. Eccles2 1Division of Molecular Pathology, The Institute of Cancer Research, 2Division of Cancer Therapeutics, The Institute of Cancer Research JoVE 52686 Medicina