Takeo Nakanishi Membrane Transport and Biopharmaceutics, School of Pharmaceutical Sciences Kanazawa University Biography Publications Institution JoVE Articles Takeo Nakanishi has not added a biography. If you are Takeo Nakanishi and would like to personalize this page please email our Author Liaison for assistance. Publications Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue Journal of Pharmaceutical Sciences. Feb, 2016 | Pubmed ID: 26869437 Role of OATP2A1 in PGE2 Secretion from Human Colorectal Cancer Cells Via Exocytosis in Response to Oxidative Stress Experimental Cell Research. Feb, 2016 | Pubmed ID: 26850138 Prostaglandin Transporter (OATP2A1/SLCO2A1) Contributes to Local Disposition of Eicosapentaenoic Acid-derived PGE3 Prostaglandins & Other Lipid Mediators. Jan, 2016 | Pubmed ID: 26692285 Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2016 | Pubmed ID: 26526067 Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2016 | Pubmed ID: 26502773 Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2016 | Pubmed ID: 26467765 Interaction of Drug or Food with Drug Transporters in Intestine and Liver Current Drug Metabolism. 2015 | Pubmed ID: 26630906 OATP2A1/SLCO2A1-mediated Prostaglandin E2 Loading into Intracellular Acidic Compartments of Macrophages Contributes to Exocytotic Secretion Biochemical Pharmacology. Dec, 2015 | Pubmed ID: 26474801 [(14)C]Fluciclovine (alias Anti-[(14)C]FACBC) Uptake and ASCT2 Expression in Castration-resistant Prostate Cancer Cells Nuclear Medicine and Biology. Nov, 2015 | Pubmed ID: 26278491 Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2 Journal of Pharmaceutical Sciences. Sep, 2015 | Pubmed ID: 26037416 Modeling Approach for Multiple Transporters-mediated Drug-drug Interactions in Sandwich-cultured Human Hepatocytes: Effect of Cyclosporin A on Hepatic Disposition of Mycophenolic Acid Phenyl-glucuronide Drug Metabolism and Pharmacokinetics. Apr, 2015 | Pubmed ID: 25989889 Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy Journal of Pharmaceutical Sciences. Sep, 2015 | Pubmed ID: 25959076 Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis PloS One. 2015 | Pubmed ID: 25923111 Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells Journal of Pharmaceutical Sciences. Sep, 2015 | Pubmed ID: 25900515 Organic Anion Transporting Polypeptide 2B1 Expression Correlates with Uptake of Estrone-3-sulfate and Cell Proliferation in Estrogen Receptor-positive Breast Cancer Cells Drug Metabolism and Pharmacokinetics. Apr, 2015 | Pubmed ID: 25857231 Functional Cyclic AMP Response Element in the Breast Cancer Resistance Protein (BCRP/ABCG2) Promoter Modulates Epidermal Growth Factor Receptor Pathway- or Androgen Withdrawal-mediated BCRP/ABCG2 Transcription in Human Cancer Cells Biochimica Et Biophysica Acta. Mar, 2015 | Pubmed ID: 25615818 In-vitro Evidence of Enhanced Breast Cancer Resistance Protein-mediated Intestinal Urate Secretion by Uremic Toxins in Caco-2 Cells The Journal of Pharmacy and Pharmacology. Feb, 2015 | Pubmed ID: 25515305 Putative Roles of Organic Anion Transporting Polypeptides (OATPs) in Cell Survival and Progression of Human Cancers Biopharmaceutics & Drug Disposition. Nov, 2014 | Pubmed ID: 25156339 SGLT2 Inhibitor Lowers Serum Uric Acid Through Alteration of Uric Acid Transport Activity in Renal Tubule by Increased Glycosuria Biopharmaceutics & Drug Disposition. Oct, 2014 | Pubmed ID: 25044127 Accumulation of Trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic Acid in Prostate Cancer Due to Androgen-induced Expression of Amino Acid Transporters Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Dec, 2014 | Pubmed ID: 24943499 Transport Mechanisms of Hepatic Uptake and Bile Excretion in Clinical Hepatobiliary Scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan Nuclear Medicine and Biology. Apr, 2014 | Pubmed ID: 24607436 Substrate- and Dose-dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1 Pharmaceutical Research. Aug, 2014 | Pubmed ID: 24549825 Mathematical Modeling of the in Vitro Hepatic Disposition of Mycophenolic Acid and Its Glucuronide in Sandwich-cultured Human Hepatocytes Molecular Pharmaceutics. Feb, 2014 | Pubmed ID: 24320552 How Does Whisky Lower Serum Urate Level? Phytotherapy Research : PTR. May, 2014 | Pubmed ID: 24022993 More Relevant Prediction for in Vivo Drug Interaction of Candesartan Cilexetil on Hepatic Bile Acid Transporter BSEP Using Sandwich-cultured Hepatocytes Drug Metabolism and Pharmacokinetics. 2014 | Pubmed ID: 23877105 Bcrp1 Transcription in Mouse Testis is Controlled by a Promoter Upstream of a Novel First Exon (E1U) Regulated by Steroidogenic Factor-1 Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 24189494 OATP Transporter-mediated Drug Absorption and Interaction Current Opinion in Pharmacology. Dec, 2013 | Pubmed ID: 24060700 Major Active Components in Grapefruit, Orange, and Apple Juices Responsible for OATP2B1-mediated Drug Interactions Journal of Pharmaceutical Sciences. Sep, 2013 | Pubmed ID: 23794501 In Vivo Evidence of Organic Cation Transporter-mediated Tracheal Accumulation of the Anticholinergic Agent Ipratropium in Mice Journal of Pharmaceutical Sciences. Sep, 2013 | Pubmed ID: 23686692 Kinetic Analyses of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic Acid Transport in Xenopus Laevis Oocytes Expressing Human ASCT2 and SNAT2 Nuclear Medicine and Biology. Jul, 2013 | Pubmed ID: 23647854 A Role of Prostaglandin Transporter in Regulating PGE₂ Release from Human Bronchial Epithelial BEAS-2B Cells in Response to LPS The Journal of Endocrinology. Jun, 2013 | Pubmed ID: 23528477 Functional Cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in Renal Reabsorption of Urate Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Mar, 2013 | Pubmed ID: 23291366 Long-lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-mediated Drug Absorption Drug Metabolism and Disposition: the Biological Fate of Chemicals. Mar, 2013 | Pubmed ID: 23264447 Major Active Components in Grapefruit, Orange, and Apple Juices Responsible for OATP2B1-mediated Drug Interactions Journal of Pharmaceutical Sciences. Jan, 2013 | Pubmed ID: 23132664 Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate Drug Metabolism and Pharmacokinetics. 2013 | Pubmed ID: 22971602 Active Intestinal Absorption of Fluoroquinolone Antibacterial Agent Ciprofloxacin by Organic Anion Transporting Polypeptide, Oatp1a5 Biopharmaceutics & Drug Disposition. Sep, 2012 | Pubmed ID: 22899169 Enhanced Expression of Organic Anion Transporting Polypeptides (OATPs) in Androgen Receptor-positive Prostate Cancer Cells: Possible Role of OATP1A2 in Adaptive Cell Growth Under Androgen-depleted Conditions Biochemical Pharmacology. Oct, 2012 | Pubmed ID: 22864060 Application of Quantitative Time-lapse Imaging (QTLI) for Evaluation of Mrp2-based Drug-drug Interaction Induced by Liver Metabolites Toxicology and Applied Pharmacology. Sep, 2012 | Pubmed ID: 22766462 Extra-renal Elimination of Uric Acid Via Intestinal Efflux Transporter BCRP/ABCG2 PloS One. 2012 | Pubmed ID: 22348008 Species Differences in the Pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: Formation of Hydrolyzed Metabolite in Human and Animals Xenobiotica; the Fate of Foreign Compounds in Biological Systems. Jul, 2012 | Pubmed ID: 22324379 Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites Drug Metabolism and Pharmacokinetics. 2012 | Pubmed ID: 22201122 Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of Drugs Drug Metabolism and Pharmacokinetics. 2012 | Pubmed ID: 22185815 Effect of Back Pressure on Emulsification of Lipid Nanodispersions in a High-pressure Homogenizer International Journal of Pharmaceutics. Jan, 2012 | Pubmed ID: 22108638 Breast Cancer Resistance Protein (BCRP/ABCG2): Its Role in Multidrug Resistance and Regulation of Its Gene Expression Chinese Journal of Cancer. Feb, 2012 | Pubmed ID: 22098950 Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells (PTCs) in Primary Culture Molecular Pharmaceutics. Dec, 2011 | Pubmed ID: 21999946 Carnitine Precursor γ-butyrobetaine is a Novel Substrate of the Na(+)- and Cl(-)-dependent GABA Transporter Gat2 Drug Metabolism and Pharmacokinetics. 2011 | Pubmed ID: 21997971 Identification and Characterization of the Major Alternative Promoter Regulating Bcrp1/Abcg2 Expression in the Mouse Intestine Biochimica Et Biophysica Acta. Jul, 2011 | Pubmed ID: 21718815 Solute Carrier Transporters As Targets for Drug Delivery and Pharmacological Intervention for Chemotherapy Journal of Pharmaceutical Sciences. Sep, 2011 | Pubmed ID: 21630275 Oxaliplatin Transport Mediated by Organic Cation/carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons The Journal of Pharmacology and Experimental Therapeutics. Aug, 2011 | Pubmed ID: 21606177 Putative Transport Mechanism and Intracellular Fate of Trans-1-amino-3-18F-fluorocyclobutanecarboxylic Acid in Human Prostate Cancer Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2011 | Pubmed ID: 21536930 Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide And/or P-glycoprotein Journal of Pharmaceutical Sciences. Sep, 2011 | Pubmed ID: 21520088 Quantitative Time-lapse Imaging-based Analysis of Drug-drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-associated Protein 2, in Sandwich-cultured Rat Hepatocytes Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2011 | Pubmed ID: 21415249 Total Syntheses of (-)- and (+)-goniomitine Organic Letters. Apr, 2011 | Pubmed ID: 21375315 Drug Efflux by Breast Cancer Resistance Protein is a Mechanism of Resistance to the Benzimidazole Insulin-like Growth Factor Receptor/insulin Receptor Inhibitor, BMS-536924 Molecular Cancer Therapeutics. Jan, 2011 | Pubmed ID: 21220496 Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-glycoprotein/multidrug Resistance 1 Drug Metabolism and Pharmacokinetics. 2011 | Pubmed ID: 21206133 Identification and Functional Characterization of Uric Acid Transporter Urat1 (Slc22a12) in Rats Biochimica Et Biophysica Acta. Jun, 2011 | Pubmed ID: 21074513 Organic Cation Transporter-mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2011 | Pubmed ID: 20962061 A Novel Xenobiotic Responsive Element Regulated by Aryl Hydrocarbon Receptor is Involved in the Induction of BCRP/ABCG2 in LS174T Cells Biochemical Pharmacology. Dec, 2010 | Pubmed ID: 20804740 Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide Pharmaceutical Research. Oct, 2010 | Pubmed ID: 20686826 Uptake Transporter Organic Anion Transporting Polypeptide 1B3 Contributes to the Growth of Estrogen-dependent Breast Cancer The Journal of Steroid Biochemistry and Molecular Biology. Oct, 2010 | Pubmed ID: 20615467 Impact of System L Amino Acid Transporter 1 (LAT1) on Proliferation of Human Ovarian Cancer Cells: a Possible Target for Combination Therapy with Anti-proliferative Aminopeptidase Inhibitors Biochemical Pharmacology. Sep, 2010 | Pubmed ID: 20510678 Methods to Evaluate Transporter Activity in Cancer Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20419431 Involvement of Choline Transporter-like Proteins, CTL1 and CTL2, in Glucocorticoid-induced Acceleration of Phosphatidylcholine Synthesis Via Increased Choline Uptake Biological & Pharmaceutical Bulletin. 2010 | Pubmed ID: 20410607 Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human Biological & Pharmaceutical Bulletin. 2010 | Pubmed ID: 20190416 Transport of Ipratropium, an Anti-chronic Obstructive Pulmonary Disease Drug, is Mediated by Organic Cation/carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-mediated Pulmonary Absorption Molecular Pharmaceutics. Feb, 2010 | Pubmed ID: 20020740 Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 19949928 Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol Between Human and Rat The Journal of Pharmacology and Experimental Therapeutics. Jan, 2010 | Pubmed ID: 19779132 Hepatic Uptake of Gamma-butyrobetaine, a Precursor of Carnitine Biosynthesis, in Rats American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2009 | Pubmed ID: 19679820 Organic Anion Transporter OAT1 is Involved in Renal Handling of Citrulline American Journal of Physiology. Renal Physiology. Jul, 2009 | Pubmed ID: 19403644 Transport Characteristics of L-citrulline in Renal Apical Membrane of Proximal Tubular Cells Biopharmaceutics & Drug Disposition. Apr, 2009 | Pubmed ID: 19322909 Preclinical Studies of Vorinostat (suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2009 | Pubmed ID: 19223502 The 44-kDa Pim-1 Kinase Phosphorylates BCRP/ABCG2 and Thereby Promotes Its Multimerization and Drug-resistant Activity in Human Prostate Cancer Cells The Journal of Biological Chemistry. Feb, 2008 | Pubmed ID: 18056989 Drug Transporters As Targets for Cancer Chemotherapy Cancer Genomics & Proteomics. May-Jun, 2007 | Pubmed ID: 17878527 Alterations in the Mitochondrial Proteome of Adriamycin Resistant MCF-7 Breast Cancer Cells Journal of Proteome Research. Sep, 2006 | Pubmed ID: 16944951 Thapsigargin Resistance in Human Prostate Cancer Cells Cancer. Aug, 2006 | Pubmed ID: 16770788 Novel 5' Untranslated Region Variants of BCRP MRNA Are Differentially Expressed in Drug-selected Cancer Cells and in Normal Human Tissues: Implications for Drug Resistance, Tissue-specific Expression, and Alternative Promoter Usage Cancer Research. May, 2006 | Pubmed ID: 16707421 Complex Interaction of BCRP/ABCG2 and Imatinib in BCR-ABL-expressing Cells: BCRP-mediated Resistance to Imatinib is Attenuated by Imatinib-induced Reduction of BCRP Expression Blood. Jul, 2006 | Pubmed ID: 16543472 The ErbB3-binding Protein Ebp1 Suppresses Androgen Receptor-mediated Gene Transcription and Tumorigenesis of Prostate Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 15994225 Involvement of OCTN1 (SLC22A4) in PH-dependent Transport of Organic Cations Molecular Pharmaceutics. Jan, 2004 | Pubmed ID: 15832501 Breast Cancer Resistance Protein (BCRP/MXR/ABCG2) in Adult Acute Lymphoblastic Leukaemia: Frequent Expression and Possible Correlation with Shorter Disease-free Survival British Journal of Haematology. Nov, 2004 | Pubmed ID: 15521915 The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival Through Interactions with Heme The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15044468 Functional Characterization of Human Breast Cancer Resistance Protein (BCRP, ABCG2) Expressed in the Oocytes of Xenopus Laevis Molecular Pharmacology. Dec, 2003 | Pubmed ID: 14645676 急性白血病患者における乳がん耐性タンパク質とフラボピリドールに対する細胞の抵抗の定量分析 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2003 | Pubmed ID: 12960118 フラボピリドールと急性白血病の時限連続療法:第I相臨床試験のためのin Vitroモデル Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2003 | Pubmed ID: 12538483 Evaluation of Blood-brain Barrier Transporters by Co-culture of Brain Capillary Endothelial Cells with Astrocytes Drug Metabolism and Pharmacokinetics. 2002 | Pubmed ID: 15618650 Transport of D-serine Via the Amino Acid Transporter ATB(0,+) Expressed in the Colon Biochemical and Biophysical Research Communications. Feb, 2002 | Pubmed ID: 11846403 代替プロモーターの使用およびマウスBcrp1の転写調節を発見する方法 Karthika Natarajan1,2, Yi Xie1,3, Takeo Nakanishi4, Rebecca S. Moreci5,6, Pancharatnam Jeyasuria7, Arif Hussain1,3,8,9, Douglas D. Ross1,3,8,9,10,11 1Greenebaum Cancer Center, University of Maryland School of Medicine, 2Pharmaceutical Sciences, University of Maryland School of Pharmacy, 3Baltimore VA Medical Center, 4Membrane Transport and Biopharmaceutics, School of Pharmaceutical Sciences, Kanazawa University, 5Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, 6Magee Women's Research Institute, 7Obstetrics, Gynecology, Perinatal Research Branch (NICHD), Wayne State University School of Medicine, 8Medicine, University of Maryland School of Medicine, 9Pathology, University of Maryland School of Medicine, 10Pharmacology, University of Maryland School of Medicine, 11Experimental Therapeutics, University of Maryland School of Medicine JoVE 53827 Biologia
代替プロモーターの使用およびマウスBcrp1の転写調節を発見する方法 Karthika Natarajan1,2, Yi Xie1,3, Takeo Nakanishi4, Rebecca S. Moreci5,6, Pancharatnam Jeyasuria7, Arif Hussain1,3,8,9, Douglas D. Ross1,3,8,9,10,11 1Greenebaum Cancer Center, University of Maryland School of Medicine, 2Pharmaceutical Sciences, University of Maryland School of Pharmacy, 3Baltimore VA Medical Center, 4Membrane Transport and Biopharmaceutics, School of Pharmaceutical Sciences, Kanazawa University, 5Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, 6Magee Women's Research Institute, 7Obstetrics, Gynecology, Perinatal Research Branch (NICHD), Wayne State University School of Medicine, 8Medicine, University of Maryland School of Medicine, 9Pathology, University of Maryland School of Medicine, 10Pharmacology, University of Maryland School of Medicine, 11Experimental Therapeutics, University of Maryland School of Medicine JoVE 53827 Biologia