Theodore R. Holman Department of Chemistry and Biochemistry University of California-Santa Cruz Biography Publications Institution JoVE Articles Theodore R. Holman has not added a biography. If you are Theodore R. Holman and would like to personalize this page please email our Author Liaison for assistance. Publications Kinetic and Structural Investigations into the Allosteric and PH Effect on the Substrate Specificity of Human Epithelial 15-lipoxygenase-2 Biochemistry. Nov, 2013 | Pubmed ID: 24171444 Discovery of a Novel Dual Fungal CYP51/human 5-lipoxygenase Inhibitor: Implications for Anti-fungal Therapy PloS One. 2013 | Pubmed ID: 23826084 Pseudoperoxidase Investigations of Hydroperoxides and Inhibitors with Human Lipoxygenases Bioorganic & Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23669189 Inhibition of 12/15-lipoxygenase As Therapeutic Strategy to Treat Stroke Annals of Neurology. Jan, 2013 | Pubmed ID: 23192915 Following Experimental Stroke, the Recovering Brain is Vulnerable to Lipoxygenase-dependent Semaphorin Signaling FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2013 | Pubmed ID: 23070608 Investigations of Human Platelet-type 12-lipoxygenase: Role of Lipoxygenase Products in Platelet Activation Journal of Lipid Research. Dec, 2012 | Pubmed ID: 22984144 Integration of Pro-inflammatory Cytokines, 12-lipoxygenase and NOX-1 in Pancreatic Islet Beta Cell Dysfunction Molecular and Cellular Endocrinology. Jul, 2012 | Pubmed ID: 22502743 Protein Kinase C Regulation of 12-lipoxygenase-mediated Human Platelet Activation Molecular Pharmacology. Mar, 2012 | Pubmed ID: 22155783 Discovery of Potent and Selective Inhibitors of Human Platelet-type 12- Lipoxygenase Journal of Medicinal Chemistry. Aug, 2011 | Pubmed ID: 21739938 Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-lipoxygenase-1 Journal of Medicinal Chemistry. Oct, 2010 | Pubmed ID: 20866075 Using Enzyme Assays to Evaluate the Structure and Bioactivity of Sponge-derived Meroterpenes Journal of Natural Products. Oct, 2009 | Pubmed ID: 19848434 Substrate Specificity Effects of Lipoxygenase Products and Inhibitors on Soybean Lipoxygenase-1 Bioorganic & Medicinal Chemistry. Sep, 2009 | Pubmed ID: 19716306 Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-lipoxygenase-2 Biochemistry. Sep, 2009 | Pubmed ID: 19645454 Mechanistic Investigations of Human Reticulocyte 15- and Platelet 12-lipoxygenases with Arachidonic Acid Biochemistry. Jul, 2009 | Pubmed ID: 19469483 Synthesis of 11-thialinoleic Acid and 14-thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases Organic & Biomolecular Chemistry. Nov, 2008 | Pubmed ID: 18972057 Geometric Structure Determination of N694C Lipoxygenase: a Comparative Near-edge X-ray Absorption Spectroscopy and Extended X-ray Absorption Fine Structure Study Inorganic Chemistry. Dec, 2008 | Pubmed ID: 18656914 Substrate Specificity Changes for Human Reticulocyte and Epithelial 15-lipoxygenases Reveal Allosteric Product Regulation Biochemistry. Jul, 2008 | Pubmed ID: 18570379 Isotope Sensitive Branching and Kinetic Isotope Effects in the Reaction of Deuterated Arachidonic Acids with Human 12- and 15-lipoxygenases Biochemistry. Jul, 2008 | Pubmed ID: 18547056 小説リポキシゲナーゼ阻害剤神経保護剤として。 Journal of Neuroscience Research. Mar, 2008 | Pubmed ID: 17960827 Measurement of the Heme Affinity for Yeast Dap1p, and Its Importance in Cellular Function Biochemistry. Dec, 2007 | Pubmed ID: 18031064 Pinpointing Pseurotins from a Marine-derived Aspergillus As Tools for Chemical Genetics Using a Synthetic Lethality Yeast Screen Journal of Natural Products. Oct, 2007 | Pubmed ID: 17929896 Structure-activity Relationship Studies of Flavonoids As Potent Inhibitors of Human Platelet 12-hLO, Reticulocyte 15-hLO-1, and Prostate Epithelial 15-hLO-2 Bioorganic & Medicinal Chemistry. Dec, 2007 | Pubmed ID: 17869117 Discovery of Platelet-type 12-human Lipoxygenase Selective Inhibitors by High-throughput Screening of Structurally Diverse Libraries Bioorganic & Medicinal Chemistry. Nov, 2007 | Pubmed ID: 17826100 Kinetic and Spectroscopic Studies of N694C Lipoxygenase: a Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme Journal of the American Chemical Society. Jun, 2007 | Pubmed ID: 17523638 ハイスループット酵母ハローアッセイを使用した生理活性小分子の発見を加速する Journal of Natural Products. Mar, 2007 | Pubmed ID: 17291044 Pyrroloacridine Alkaloids from Plakortis Quasiamphiaster: Structures and Bioactivity Journal of Natural Products. Jan, 2007 | Pubmed ID: 17253856 Kinetic, Spectroscopic, and Structural Investigations of the Soybean Lipoxygenase-1 First-coordination Sphere Mutant, Asn694Gly Biochemistry. Aug, 2006 | Pubmed ID: 16922498 Baicalein is a Potent in Vitro Inhibitor Against Both Reticulocyte 15-human and Platelet 12-human Lipoxygenases Bioorganic & Medicinal Chemistry. Jun, 2006 | Pubmed ID: 16500106 Novel Human Lipoxygenase Inhibitors Discovered Using Virtual Screening with Homology Models Journal of Medicinal Chemistry. Feb, 2006 | Pubmed ID: 16480270 Spectroscopic and Biochemical Characterization of Heme Binding to Yeast Dap1p and Mouse PGRMC1p Biochemistry. Dec, 2005 | Pubmed ID: 16342963 Stereochemical Determination and Bioactivity Assessment of (S)-(+)-curcuphenol Dimers Isolated from the Marine Sponge Didiscus Aceratus and Synthesized Through Laccase Biocatalysis Bioorganic & Medicinal Chemistry. Oct, 2005 | Pubmed ID: 16039133 A Re(V)-catalyzed C-N Bond-forming Route to Human Lipoxygenase Inhibitors Organic Letters. Jun, 2005 | Pubmed ID: 15932233 Evidence for Downregulation of Calcium Signaling Proteins in Advanced Mouse Adenocarcinoma The Prostate. Jul, 2005 | Pubmed ID: 15666362 Redox Inactivation of Human 15-lipoxygenase by Marine-derived Meroditerpenes and Synthetic Chromanes: Archetypes for a Unique Class of Selective and Recyclable Inhibitors Journal of the American Chemical Society. Nov, 2004 | Pubmed ID: 15535718 Tryptophan 500 and Arginine 707 Define Product and Substrate Active Site Binding in Soybean Lipoxygenase-1 Biochemistry. Oct, 2004 | Pubmed ID: 15476400 An Analysis of Phakellin and Oroidin Structures Stimulated by Further Study of an Agelas Sponge Journal of Natural Products. Aug, 2004 | Pubmed ID: 15332838 Probing the Activity Differences of Simple and Complex Brominated Aryl Compounds Against 15-soybean, 15-human, and 12-human Lipoxygenase Journal of Medicinal Chemistry. Jul, 2004 | Pubmed ID: 15267244 Lipoxygenase Inhibition by Anadanthoflavone, a New Flavonoid from the Aerial Parts of Anadenanthera Colubrina Planta Medica. Mar, 2004 | Pubmed ID: 15114507 Reactions of NO with Mn(II) and Mn(III) Centers Coordinated to Carboxamido Nitrogen: Synthesis of a Manganese Nitrosyl with Photolabile NO Inorganic Chemistry. May, 2004 | Pubmed ID: 15106989 Spectroscopic Characterization of Soybean Lipoxygenase-1 Mutants: the Role of Second Coordination Sphere Residues in the Regulation of Enzyme Activity Biochemistry. Jun, 2003 | Pubmed ID: 12809485 Kinetic Investigations of the Rate-limiting Step in Human 12- and 15-lipoxygenase Biochemistry. May, 2003 | Pubmed ID: 12731864 Stopped-flow Kinetic Investigations of the Activation of Soybean Lipoxygenase-1 and the Influence of Inhibitors on the Allosteric Site Biochemistry. Apr, 2003 | Pubmed ID: 12680771 Exploring Sponge-derived Terpenoids for Their Potency and Selectivity Against 12-human, 15-human, and 15-soybean Lipoxygenases Journal of Natural Products. Feb, 2003 | Pubmed ID: 12608855 Structure-activity Relationship Studies of Nordihydroguaiaretic Acid Inhibitors Toward Soybean, 12-human, and 15-human Lipoxygenase Journal of Medicinal Chemistry. Jun, 2002 | Pubmed ID: 12036375 パーキンソン病における感受性メカニズムのマスク解除を行う遺伝子環境相互作用モデル Vivian P. Chou1, Novie Ko1, Theodore R. Holman2, Amy B. Manning-Boğ1 1Center for Health Sciences, SRI International, 2Department of Chemistry and Biochemistry, University of California-Santa Cruz JoVE 50960 Medicina
パーキンソン病における感受性メカニズムのマスク解除を行う遺伝子環境相互作用モデル Vivian P. Chou1, Novie Ko1, Theodore R. Holman2, Amy B. Manning-Boğ1 1Center for Health Sciences, SRI International, 2Department of Chemistry and Biochemistry, University of California-Santa Cruz JoVE 50960 Medicina