Thomas E. Edwards Senior Project Leader Emerald Bio Biography Publications Institution JoVE Articles Thomas E. Edwards has not added a biography. If you are Thomas E. Edwards and would like to personalize this page please email our Author Liaison for assistance. Publications Crystal Structure of a Macrophage Migration Inhibitory Factor from Giardia Lamblia Journal of Structural and Functional Genomics. Jun, 2013 | Pubmed ID: 23709284 Structural Insights into the Functional Role of the Hcn Sub-domain Of the Receptor-binding Domain of the Botulinum Neurotoxin Mosaic Serotype C/D Biochimie. Jul, 2013 | Pubmed ID: 23523511 Combining Functional and Structural Genomics to Sample the Essential Burkholderia Structome PloS One. 2013 | Pubmed ID: 23382856 Unique Motifs and Hydrophobic Interactions Shape the Binding of Modified DNA Ligands to Protein Targets Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23139410 Mycobacterium Thermoresistibile As a Source of Thermostable Orthologs of Mycobacterium Tuberculosis Proteins Protein Science : a Publication of the Protein Society. Jul, 2012 | Pubmed ID: 22544630 Structure of Hepatitis C Virus Polymerase in Complex with Primer-template RNA Journal of Virology. Jun, 2012 | Pubmed ID: 22496223 Structural Characterization of a Ribose-5-phosphate Isomerase B from the Pathogenic Fungus Coccidioides Immitis BMC Structural Biology. 2011 | Pubmed ID: 21995815 Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/phosphatase Biochemistry. Sep, 2011 | Pubmed ID: 21870819 Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment Methods in Enzymology. 2011 | Pubmed ID: 21371605 SAD Phasing Using Iodide Ions in a High-throughput Structural Genomics Environment Journal of Structural and Functional Genomics. Jul, 2011 | Pubmed ID: 21359836 Leveraging Structure Determination with Fragment Screening for Infectious Disease Drug Targets: MECP Synthase from Burkholderia Pseudomallei Journal of Structural and Functional Genomics. Jul, 2011 | Pubmed ID: 21359640 Crystal Structure of a DNA Containing the Planar, Phenoxazine-derived Bi-functional Spectroscopic Probe C Nucleic Acids Research. May, 2011 | Pubmed ID: 21252294 Nanovolume Optimization of Protein Crystal Growth Using the Microcapillary Protein Crystallization System Journal of Applied Crystallography. Oct, 2010 | Pubmed ID: 22477778 Structure of a Burkholderia Pseudomallei Trimeric Autotransporter Adhesin Head PloS One. 2010 | Pubmed ID: 20862217 X-ray Structure Determination of the Glycine Cleavage System Protein H of Mycobacterium Tuberculosis Using an Inverse Compton Synchrotron X-ray Source Journal of Structural and Functional Genomics. Mar, 2010 | Pubmed ID: 20364333 Thermodynamic Analysis of Ligand Binding and Ligand Binding-induced Tertiary Structure Formation by the Thiamine Pyrophosphate Riboswitch RNA (New York, N.Y.). Jan, 2010 | Pubmed ID: 19948769 Cocrystal Structure of a Class I PreQ1 Riboswitch Reveals a Pseudoknot Recognizing an Essential Hypermodified Nucleobase Nature Structural & Molecular Biology. Mar, 2009 | Pubmed ID: 19234468 Structural Basis for Specific, High-affinity Tetracycline Binding by an in Vitro Evolved Aptamer and Artificial Riboswitch Chemistry & Biology. Oct, 2008 | Pubmed ID: 18940672 Site-specific Incorporation of Nitroxide Spin-labels into 2'-positions of Nucleic Acids Nature Protocols. 2007 | Pubmed ID: 17703207 Riboswitches: Small-molecule Recognition by Gene Regulatory RNAs Current Opinion in Structural Biology. Jun, 2007 | Pubmed ID: 17574837 Crystal Structures of the Thi-box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-small Molecule Recognition Structure (London, England : 1993). Sep, 2006 | Pubmed ID: 16962976 EPR Spectroscopic Analysis of U7 Hammerhead Ribozyme Dynamics During Metal Ion Induced Folding Biochemistry. Sep, 2005 | Pubmed ID: 16171402 Monitoring Tat Peptide Binding to TAR RNA by Solid-state 31P-19F REDOR NMR Nucleic Acids Research. 2005 | Pubmed ID: 15961729 Identification of Amino Acids That Promote Specific and Rigid TAR RNA-tat Protein Complex Formation Chemistry & Biology. Mar, 2005 | Pubmed ID: 15797217 A New Alpha-helical Extension Promotes RNA Binding by the DsRBD of Rnt1p RNAse III The EMBO Journal. Jul, 2004 | Pubmed ID: 15192703 EPR Spectroscopic Analysis of TAR RNA-metal Ion Interactions Biochemical and Biophysical Research Communications. Apr, 2003 | Pubmed ID: 12659878 Nanometer Distance Measurements on RNA Using PELDOR Journal of the American Chemical Society. Mar, 2003 | Pubmed ID: 12643697 Electron Paramagnetic Resonance Dynamic Signatures of TAR RNA-small Molecule Complexes Provide Insight into RNA Structure and Recognition Biochemistry. Dec, 2002 | Pubmed ID: 12475232 Investigation of RNA-protein and RNA-metal Ion Interactions by Electron Paramagnetic Resonance Spectroscopy. The HIV TAR-Tat Motif Chemistry & Biology. Jun, 2002 | Pubmed ID: 12079781 Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit Brianna L. Armour*1, Steve R. Barnes*2, Spencer O. Moen2, Eric Smith3, Amy C. Raymond4, James W. Fairman5, Lance J. Stewart6, Bart L. Staker7, Darren W. Begley5, Thomas E. Edwards8, Donald D. Lorimer9 1Protein Crystallization Lab, Emerald Bio, 2Molecular Biology Lab, Emerald Bio, 3Scientific Sales Representative, Emerald Bio, 4Group Leader II, Emerald Bio, 5Group Leader I, Emerald Bio, 6Chair of Advisory Board, Emerald Bio, 7Director of Multi-Target Services, Emerald Bio, 8Senior Project Leader, Emerald Bio, 9Project Leader II & SSGCID Site Manager, Emerald Bio JoVE 4225 Immunologia e infezioni
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit Brianna L. Armour*1, Steve R. Barnes*2, Spencer O. Moen2, Eric Smith3, Amy C. Raymond4, James W. Fairman5, Lance J. Stewart6, Bart L. Staker7, Darren W. Begley5, Thomas E. Edwards8, Donald D. Lorimer9 1Protein Crystallization Lab, Emerald Bio, 2Molecular Biology Lab, Emerald Bio, 3Scientific Sales Representative, Emerald Bio, 4Group Leader II, Emerald Bio, 5Group Leader I, Emerald Bio, 6Chair of Advisory Board, Emerald Bio, 7Director of Multi-Target Services, Emerald Bio, 8Senior Project Leader, Emerald Bio, 9Project Leader II & SSGCID Site Manager, Emerald Bio JoVE 4225 Immunologia e infezioni