Thomas Kodadek Scripps Florida The Scripps Research Institute Biography Publications Institution JoVE Articles Thomas Kodadek has not added a biography. If you are Thomas Kodadek and would like to personalize this page please email our Author Liaison for assistance. Publications Utility of Redundant Combinatorial Libraries in Distinguishing High and Low Quality Screening Hits ACS Combinatorial Science. Jun, 2014 | Pubmed ID: 24749624 Discovery of Biomarkers for Systemic Lupus Erythematosus Using a Library of Synthetic Autoantigen Surrogates Journal of Immunological Methods. Jan, 2014 | Pubmed ID: 24269750 A Liquid Array Platform for the Multiplexed Analysis of Synthetic Molecule-protein Interactions ACS Chemical Biology. Feb, 2014 | Pubmed ID: 24245981 A Jack of All Trades to Combat Drug-resistant Gram-negative Bacteria Chemistry & Biology. Oct, 2013 | Pubmed ID: 24210003 Features of Modularly Assembled Compounds That Impart Bioactivity Against an RNA Target ACS Chemical Biology. Oct, 2013 | Pubmed ID: 24032410 Advances in Blood-based Protein Biomarkers for Alzheimer's Disease Alzheimer's Research & Therapy. 2013 | Pubmed ID: 23659521 Decoding Split and Pool Combinatorial Libraries with Electron-transfer Dissociation Tandem Mass Spectrometry Journal of the American Society for Mass Spectrometry. Jul, 2013 | Pubmed ID: 23636859 Synthesis and Screening of Stereochemically Diverse Combinatorial Libraries of Peptide Tertiary Amides Chemistry & Biology. Mar, 2013 | Pubmed ID: 23521794 Discovery of Peptoid Ligands for Anti-aquaporin 4 Antibodies Chemistry & Biology. Mar, 2013 | Pubmed ID: 23521793 Synthesis of Libraries of Peptidomimetic Compounds Containing a 2-oxopiperazine Unit in the Main Chain Organic & Biomolecular Chemistry. Apr, 2013 | Pubmed ID: 23440085 Submonomer Synthesis of a Hybrid Peptoid-azapeptoid Library ACS Combinatorial Science. Oct, 2012 | Pubmed ID: 22958123 Rapid Development of a Potent Photo-triggered Inhibitor of the Serine Hydrolase RBBP9 Chembiochem : a European Journal of Chemical Biology. Sep, 2012 | Pubmed ID: 22907802 A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry Tetrahedron Letters. May, 2012 | Pubmed ID: 22736872 On-Bead Two-Color (OBTC) Cell Screen for Direct Identification of Highly Selective Cell Surface Receptor Ligands Current Protocols in Chemical Biology. Mar, 2012 | Pubmed ID: 22582145 Incorporation of Heterocycles into the Backbone of Peptoids to Generate Diverse Peptoid-inspired One Bead One Compound Libraries ACS Combinatorial Science. Mar, 2012 | Pubmed ID: 22320121 A Biomimetic Polyketide-inspired Approach to Small-molecule Ligand Discovery Nature Chemistry. Feb, 2012 | Pubmed ID: 22270625 Expanded Polyglutamine-binding Peptoid As a Novel Therapeutic Agent for Treatment of Huntington's Disease Chemistry & Biology. Sep, 2011 | Pubmed ID: 21944750 PDZ Dimerization Brings Proteins Together Chemistry & Biology. Sep, 2011 | Pubmed ID: 21944744 Acyl Hydrazides As Peptoid Sub-monomers Chemical Communications (Cambridge, England). Oct, 2011 | Pubmed ID: 21892506 Peptoid Ligands That Bind Selectively to Phosphoproteins Bioorganic & Medicinal Chemistry Letters. Sep, 2011 | Pubmed ID: 21742492 The Rise, Fall and Reinvention of Combinatorial Chemistry Chemical Communications (Cambridge, England). Sep, 2011 | Pubmed ID: 21701754 Identification of Candidate IgG Biomarkers for Alzheimer's Disease Via Combinatorial Library Screening Cell. Jan, 2011 | Pubmed ID: 21215375 Discovery Of An Orexin Receptor Positive Potentiator Chemical Science (Royal Society of Chemistry : 2010). Jul, 2010 | Pubmed ID: 24409338 MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid-(Gd)8-dendron for Targeting Journal of the American Chemical Society. Sep, 2010 | Pubmed ID: 20795620 Synthetic Receptors with Antibody-like Binding Affinities Current Opinion in Chemical Biology. Dec, 2010 | Pubmed ID: 20674471 Development of Antibody Surrogates for the Treatment of Cancers and Autoimmune Disease Current Opinion in Chemical Biology. Dec, 2010 | Pubmed ID: 20674470 GU81, a VEGFR2 Antagonist Peptoid, Enhances the Anti-tumor Activity of Doxorubicin in the Murine MMTV-PyMT Transgenic Model of Breast Cancer BMC Cancer. 2010 | Pubmed ID: 20673348 Steroid Receptor Coactivator-3 Expression in Lung Cancer and Its Role in the Regulation of Cancer Cell Survival and Proliferation Cancer Research. Aug, 2010 | Pubmed ID: 20663904 The Interface of Chemical Biology and the Nervous System (related to the NIDA Chemical Genomics Symposium) Molecular BioSystems. Aug, 2010 | Pubmed ID: 20582378 Chemistry and Biology of Orexin Signaling Molecular BioSystems. Aug, 2010 | Pubmed ID: 20532299 Potent and Selective Photo-inactivation of Proteins with Peptoid-ruthenium Conjugates Nature Chemical Biology. Apr, 2010 | Pubmed ID: 20228793 Rethinking Screening Nature Chemical Biology. Mar, 2010 | Pubmed ID: 20154660 Seamless Bead to Microarray Screening: Rapid Identification of the Highest Affinity Protein Ligands from Large Combinatorial Libraries Chemistry & Biology. Jan, 2010 | Pubmed ID: 20142039 Rapid Identification of Orexin Receptor Binding Ligands Using Cell-based Screening Accelerated with Magnetic Beads Molecular BioSystems. Jan, 2010 | Pubmed ID: 20024071 No Splicing, No Dicing: Non-proteolytic Roles of the Ubiquitin-proteasome System in Transcription The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19955182 The Hydrophobic Patch of Ubiquitin is Required to Protect Transactivator-promoter Complexes from Destabilization by the Proteasomal ATPases Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19939937 Protein Binding: Antibody Surrogates Click into Place Nature Chemistry. Jun, 2009 | Pubmed ID: 21378844 Isolation of Antagonists of Antigen-specific Autoimmune T Cell Proliferation Chemistry & Biology. Nov, 2009 | Pubmed ID: 19942136 Non-proteolytic Regulation of P53-mediated Transcription Through Destabilization of the Activator.promoter Complex by the Proteasomal ATPases The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19846554 Investigation of the Relative Cellular Permeability of DNA-binding Pyrrole-imidazole Polyamides Journal of Medicinal Chemistry. Aug, 2009 | Pubmed ID: 19610652 Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009 | Pubmed ID: 19535594 Peptoids As Potential Therapeutics Current Opinion in Molecular Therapeutics. Jun, 2009 | Pubmed ID: 19479663 Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins Neuron. May, 2009 | Pubmed ID: 19447090 Rapid Identification of Improved Protein Ligands Using Peptoid Microarrays Bioorganic & Medicinal Chemistry Letters. Jul, 2009 | Pubmed ID: 19380225 Selective Toxin Sequestrants for the Treatment of Bacterial Infections Journal of the American Chemical Society. Apr, 2009 | Pubmed ID: 19351156 Encoded Combinatorial Libraries for the Construction of Cyclic Peptoid Microarrays Chemical Communications (Cambridge, England). Nov, 2008 | Pubmed ID: 19009054 Phosphorylation of the Gal4 DNA-binding Domain is Essential for Activator Mono-ubiquitylation and Efficient Promoter Occupancy Molecular BioSystems. Nov, 2008 | Pubmed ID: 18931787 Rise of the Machines: Bruce Alberts and the Biochemistry of Multi-protein Complexes Molecular BioSystems. Nov, 2008 | Pubmed ID: 18931779 The Pharmacophore of a Peptoid VEGF Receptor 2 Antagonist Includes Both Side Chain and Main Chain Residues Bioorganic & Medicinal Chemistry Letters. Nov, 2008 | Pubmed ID: 18653335 Proteomes Take the Electrophilic Bait Nature Chemical Biology. Jul, 2008 | Pubmed ID: 18560426 Biochemistry: Molecular Cloaking Devices Nature. Jun, 2008 | Pubmed ID: 18548057 Physical and Functional Interactions of Monoubiquitylated Transactivators with the Proteasome The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18515799 A Peptoid Antagonist of VEGF Receptor 2 Recognizes a 'hotspot' in the Extracellular Domain Distinct from the Hormone-binding Site Bioorganic & Medicinal Chemistry. Jun, 2008 | Pubmed ID: 18501615 High-throughput Evaluation of Relative Cell Permeability Between Peptoids and Peptides Bioorganic & Medicinal Chemistry. Jun, 2008 | Pubmed ID: 18490170 A Peptoid "antibody Surrogate" That Antagonizes VEGF Receptor 2 Activity Journal of the American Chemical Society. Apr, 2008 | Pubmed ID: 18386897 Use of Peptide Analogue Diversity Library Beads for Increased Depth of Proteomic Analysis: Application to Cerebrospinal Fluid Journal of Proteome Research. May, 2008 | Pubmed ID: 18357977 Activation Domain-dependent Monoubiquitylation of Gal4 Protein is Essential for Promoter Binding in Vivo The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18326036 Rapid Identification of the Pharmacophore in a Peptoid Inhibitor of the Proteasome Regulatory Particle Chemical Communications (Cambridge, England). Mar, 2008 | Pubmed ID: 18292891 The Detection Limit of a Gd3+-based T1 Agent is Substantially Reduced when Targeted to a Protein Microdomain Magnetic Resonance Imaging. Jun, 2008 | Pubmed ID: 18234462 A General System for Evaluating the Efficiency of Chromophore-assisted Light Inactivation (CALI) of Proteins Reveals Ru(II) Tris-bipyridyl As an Unusually Efficient "warhead" Molecular BioSystems. Jan, 2008 | Pubmed ID: 18075676 Characterization of Proteomic and Metabolomic Responses to Dietary Factors and Supplements The Journal of Nutrition. Dec, 2007 | Pubmed ID: 18029500 The Neurohormone Orexin Stimulates Hypoxia-inducible Factor-1 Activity Genes & Development. Nov, 2007 | Pubmed ID: 18006690 Periodate-triggered Cross-linking Reveals Sug2/Rpt4 As the Molecular Target of a Peptoid Inhibitor of the 19S Proteasome Regulatory Particle Journal of the American Chemical Society. Oct, 2007 | Pubmed ID: 17929816 Dynamics of the Hypoxia-inducible Factor-1-vascular Endothelial Growth Factor Promoter Complex The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17916562 Label Transfer Chemistry for the Characterization of Protein-protein Interactions Journal of the American Chemical Society. Oct, 2007 | Pubmed ID: 17894490 Quantitative Comparison of the Relative Cell Permeability of Cyclic and Linear Peptides Chemistry & Biology. Jun, 2007 | Pubmed ID: 17584614 Identification of a Peptoid Inhibitor of the Proteasome 19S Regulatory Particle Journal of the American Chemical Society. Jun, 2007 | Pubmed ID: 17536803 Design and Synthesis of a Cell-permeable Synthetic Transcription Factor Mimic Journal of Combinatorial Chemistry. Jul-Aug, 2007 | Pubmed ID: 17530904 A Convenient, High-throughput Assay for Measuring the Relative Cell Permeability of Synthetic Compounds Nature Protocols. 2007 | Pubmed ID: 17401333 A Cell-permeable Synthetic Transcription Factor Mimic Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17351994 Quantitative Evaluation of the Relative Cell Permeability of Peptoids and Peptides Journal of the American Chemical Society. Feb, 2007 | Pubmed ID: 17283989 The Role of the Proteasomal ATPases and Activator Monoubiquitylation in Regulating Gal4 Binding to Promoters Genes & Development. Jan, 2007 | Pubmed ID: 17167105 Genome-wide Analysis of Human HSF1 Signaling Reveals a Transcriptional Program Linked to Cellular Adaptation and Survival Molecular BioSystems. Dec, 2006 | Pubmed ID: 17216044 Introduction to Monitoring and Manipulating Signaling Networks Molecular BioSystems. Dec, 2006 | Pubmed ID: 17216040 Isolation and Characterization of Coactivator-binding Peptoids from a Combinatorial Library Molecular BioSystems. Nov, 2006 | Pubmed ID: 17216038 Chemistry of Periodate-mediated Cross-linking of 3,4-dihydroxylphenylalanine-containing Molecules to Proteins Journal of the American Chemical Society. Nov, 2006 | Pubmed ID: 17117875 Keeping Transcriptional Activators Under Control Cell. Oct, 2006 | Pubmed ID: 17055428 Proteolytic Turnover of the Gal4 Transcription Factor is Not Required for Function in Vivo Nature. Aug, 2006 | Pubmed ID: 16929306 Optimized Protocols for the Isolation of Specific Protein-binding Peptides or Peptoids from Combinatorial Libraries Displayed on Beads Molecular BioSystems. Jan, 2006 | Pubmed ID: 16880920 Widespread, but Non-identical, Association of Proteasomal 19 and 20 S Proteins with Yeast Chromatin The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16837462 The Proteasomal ATPase Complex is Required for Stress-induced Transcription in Yeast Nucleic Acids Research. 2006 | Pubmed ID: 16517940 Identification of Gal4 Activation Domain-binding Proteins in the 26S Proteasome by Periodate-triggered Cross-linking Molecular BioSystems. Dec, 2005 | Pubmed ID: 16881005 Simple Reporter Gene-based Assays for Hairpin Poly(amide) Conjugate Permeability and DNA-binding Activity in Living Cells Molecular BioSystems. Oct, 2005 | Pubmed ID: 16880996 NMR Analyses of the Activation of the Arp2/3 Complex by Neuronal Wiskott-Aldrich Syndrome Protein Biochemistry. Nov, 2005 | Pubmed ID: 16285728 Protein "fingerprinting" in Complex Mixtures with Peptoid Microarrays Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16123137 A Potent Transactivation Domain Mimic with Activity in Living Cells Journal of the American Chemical Society. Jun, 2005 | Pubmed ID: 15941237 A High-throughput Assay for Assessing the Cell Permeability of Combinatorial Libraries Nature Biotechnology. Jun, 2005 | Pubmed ID: 15908941 Techniques: Oxidative Cross-linking As an Emergent Tool for the Analysis of Receptor-mediated Signalling Events Trends in Pharmacological Sciences. Apr, 2005 | Pubmed ID: 15808346 Genomic Studies of Transcription Factor-DNA Interactions Current Opinion in Chemical Biology. Feb, 2005 | Pubmed ID: 15701451 Photolithographic Synthesis of Cyclic Peptide Arrays Using a Differential Deprotection Strategy Chemical Communications (Cambridge, England). Feb, 2005 | Pubmed ID: 15672142 The Potential of Protein-detecting Microarrays for Clinical Diagnostics Advances in Clinical Chemistry. 2004 | Pubmed ID: 15521193 Synthetic Molecules As Antibody Replacements Accounts of Chemical Research. Sep, 2004 | Pubmed ID: 15379586 Periodate-triggered Cross-linking of DOPA-containing Peptide-protein Complexes Journal of the American Chemical Society. Sep, 2004 | Pubmed ID: 15366882 Transformation of Low-affinity Lead Compounds into High-affinity Protein Capture Agents Chemistry & Biology. Aug, 2004 | Pubmed ID: 15324814 Toward a General Chemical Method for Rapidly Mapping Multi-protein Complexes Journal of Proteome Research. May-Jun, 2004 | Pubmed ID: 15253422 Target Identification in Chemical Genetics: the (often) Missing Link Chemistry & Biology. May, 2004 | Pubmed ID: 15157870 Physical and Functional Association of RNA Polymerase II and the Proteasome Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15069196 Photolithographic Synthesis of Peptoids Journal of the American Chemical Society. Apr, 2004 | Pubmed ID: 15053581 Peptides As Modulators of Enzymes and Regulatory Proteins Methods (San Diego, Calif.). Apr, 2004 | Pubmed ID: 15003603 Using Oxidative Crosslinking and Proximity Labeling to Quantitatively Characterize Protein-protein and Protein-Peptide Complexes Chemistry & Biology. Nov, 2003 | Pubmed ID: 14652079 Quantum Dots As a Visual Aid for Screening Bead-bound Combinatorial Libraries Chembiochem : a European Journal of Chemical Biology. Nov, 2003 | Pubmed ID: 14613120 Isolation of Protein Ligands from Large Peptoid Libraries Journal of the American Chemical Society. Nov, 2003 | Pubmed ID: 14611236 Transcription Activation by a PNA-peptide Chimera in a Mammalian Cell Extract Chemistry & Biology. Oct, 2003 | Pubmed ID: 14583257 Mixed-element Capture Agents: a Simple Strategy for the Construction of Synthetic, High-affinity Protein Capture Ligands Journal of the American Chemical Society. Aug, 2003 | Pubmed ID: 12903996 Immobilized Peptides As High-affinity Capture Agents for Self-associating Proteins Chemistry & Biology. Mar, 2003 | Pubmed ID: 12670539 Protein Affinity Labeling Mediated by Genetically Encoded Peptide Tags Angewandte Chemie (International Ed. in English). Jan, 2002 | Pubmed ID: 12491432 Microwave-assisted Solid-phase Synthesis of Peptoids Organic Letters. Nov, 2002 | Pubmed ID: 12423085 A Nonproteolytic Function of the 19S Regulatory Subunit of the 26S Proteasome is Required for Efficient Activated Transcription by Human RNA Polymerase II Biochemistry. Oct, 2002 | Pubmed ID: 12379122 Inhibition of Proteolysis and Other Posttranslational Modifications with Substrate-targeted Inhibitors Biopolymers. 2002 | Pubmed ID: 12325163 Physical Association of the APIS Complex and General Transcription Factors Biochemical and Biophysical Research Communications. Aug, 2002 | Pubmed ID: 12200147 Removal of Impurities from Transcription Factor Preparations That Alter Their DNA-binding Properties Nucleic Acids Research. Aug, 2002 | Pubmed ID: 12177316 Development of Protein-detecting Microarrays and Related Devices Trends in Biochemical Sciences. Jun, 2002 | Pubmed ID: 12069789 Recruitment of a 19S Proteasome Subcomplex to an Activated Promoter Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11964484 Magnetic Resonance Imaging Detects a Specific Peptide-protein Binding Event Journal of the American Chemical Society. Apr, 2002 | Pubmed ID: 11929234 Toward Synthetic Transcription Activators: Recruitment of Transcription Factors to DNA by a PNA-peptide Chimera Journal of the American Chemical Society. Mar, 2002 | Pubmed ID: 11866581 Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library Yu Gao1, Thomas Kodadek1 1Scripps Florida, The Scripps Research Institute JoVE 51299 Chimica
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library Yu Gao1, Thomas Kodadek1 1Scripps Florida, The Scripps Research Institute JoVE 51299 Chimica