Timothy R. Billiar Department of Surgery University of Pittsburgh Biography Publications Institution JoVE Articles Timothy R. Billiar has not added a biography. If you are Timothy R. Billiar and would like to personalize this page please email our Author Liaison for assistance. Publications Changes in Massive Transfusion over Time: An Early Shift in the Right Direction? The Journal of Trauma. Jan, 2012 | Pubmed ID: 22310123 Evolving Role of Endovascular Techniques for Traumatic Vascular Injury: A Changing Landscape? The Journal of Trauma. Jan, 2012 | Pubmed ID: 22310114 Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock Shock (Augusta, Ga.). Jan, 2012 | Pubmed ID: 22293600 Oral Intake of Hydrogen-rich Water Inhibits Intimal Hyperplasia in Arterialized Vein Grafts in Rats Cardiovascular Research. Jan, 2012 | Pubmed ID: 22287575 Splenocyte Apoptosis and Autophagy is Mediated by Interferon Regulatory Factor-1 During Murine Endotoxemia Shock (Augusta, Ga.). Jan, 2012 | Pubmed ID: 22266972 Complement C3 Deficiency Attenuates Chronic Hypoxia-induced Pulmonary Hypertension in Mice PloS One. 2011 | Pubmed ID: 22194859 A Genomic Storm in Critically Injured Humans The Journal of Experimental Medicine. Dec, 2011 | Pubmed ID: 22110166 Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS Stimulated Macrophages Through Nitric Oxide Molecular Medicine (Cambridge, Mass.). Nov, 2011 | Pubmed ID: 22105605 Assessment of Platelet Transfusion for Reversal of Aspirin After Traumatic Brain Injury Surgery. Oct, 2011 | Pubmed ID: 22000198 Hydrogen-enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric Function During Transplantation Transplantation. Nov, 2011 | Pubmed ID: 21956195 Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21940680 Mast Cells Play a Critical Role in the Systemic Inflammatory Response and End-organ Injury Resulting from Trauma Journal of the American College of Surgeons. Nov, 2011 | Pubmed ID: 21920785 Transcriptomic Response of Murine Liver to Severe Injury and Hemorrhagic Shock: a Dual-platform Microarray Analysis Physiological Genomics. Oct, 2011 | Pubmed ID: 21828244 Early Lower Extremity Fracture Fixation and the Risk of Early Pulmonary Embolus: Filter Before Fixation? The Journal of Trauma. Jun, 2011 | Pubmed ID: 21817975 The Effect of Donor Treatment with Hydrogen on Lung Allograft Function in Rats Surgery. Aug, 2011 | Pubmed ID: 21801961 Sepsis: Something Old, Something New, and a Systems View Journal of Critical Care. Jul, 2011 | Pubmed ID: 21798705 Characterization of DISC Formation and TNFR1 Translocation to Mitochondria in TNF-α-treated Hepatocytes The American Journal of Pathology. Sep, 2011 | Pubmed ID: 21741934 Caspase-1 is Hepatoprotective During Trauma and Hemorrhagic Shock by Reducing Liver Injury and Inflammation Molecular Medicine (Cambridge, Mass.). Sep-Oct, 2011 | Pubmed ID: 21666957 High-mobility Group Box 1 is Essential for Mitochondrial Quality Control Cell Metabolism. Jun, 2011 | Pubmed ID: 21641551 A Dynamic View of Trauma/hemorrhage-induced Inflammation in Mice: Principal Drivers and Networks PloS One. 2011 | Pubmed ID: 21573002 Hypoxia-induced Overexpression of BNIP3 is Not Dependent on Hypoxia-inducible Factor 1α in Mouse Hepatocytes Shock (Augusta, Ga.). Aug, 2011 | Pubmed ID: 21558981 Hydrogen Inhalation Reduced Epithelial Apoptosis in Ventilator-induced Lung Injury Via a Mechanism Involving Nuclear Factor-kappa B Activation Biochemical and Biophysical Research Communications. May, 2011 | Pubmed ID: 21473852 Histidine-tryptophan-ketoglutarate or Celsior: Which is More Suitable for Cold Preservation for Cardiac Grafts from Older Donors? The Annals of Thoracic Surgery. Mar, 2011 | Pubmed ID: 21352993 Body Adipose Content is Independently Associated with a Higher Risk of Organ Failure and Nosocomial Infection in the Nonobese Patient Postinjury The Journal of Trauma. Feb, 2011 | Pubmed ID: 21307724 Over Reliance on Computed Tomography Imaging in Patients with Severe Abdominal Injury: is the Delay Worth the Risk? The Journal of Trauma. Feb, 2011 | Pubmed ID: 21307722 Models of Lower Extremity Damage in Mice: Time Course of Organ Damage and Immune Response The Journal of Surgical Research. Apr, 2011 | Pubmed ID: 21276982 DNA Attenuates Enterocyte Toll-like Receptor 4-mediated Intestinal Mucosal Injury After Remote Trauma American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2011 | Pubmed ID: 21233273 TNF/TNF Receptor 1-mediated Apoptosis in Hepatocytes Advances in Experimental Medicine and Biology. 2011 | Pubmed ID: 21153368 Interferon Regulatory Factor 1 Mediates Acetylation and Release of High Mobility Group Box 1 from Hepatocytes During Murine Liver Ischemia-reperfusion Injury Shock (Augusta, Ga.). Mar, 2011 | Pubmed ID: 20856174 Ex Vivo Carbon Monoxide Delivery Inhibits Intimal Hyperplasia in Arterialized Vein Grafts Cardiovascular Research. Feb, 2011 | Pubmed ID: 20851811 Hydrogen Therapy May Reduce the Risks Related to Radiation-induced Oxidative Stress in Space Flight Medical Hypotheses. Jan, 2011 | Pubmed ID: 20851533 Role of Hemorrhage in the Induction of Systemic Inflammation and Remote Organ Damage: Analysis of Combined Pseudo-fracture and Hemorrhagic Shock Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Feb, 2011 | Pubmed ID: 20690183 Systemic Inflammation and Liver Injury Following Hemorrhagic Shock and Peripheral Tissue Trauma Involve Functional TLR9 Signaling on Bone Marrow-derived Cells and Parenchymal Cells Shock (Augusta, Ga.). Feb, 2011 | Pubmed ID: 20577143 Hemorrhagic Shock Activates Lung Endothelial Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase Via Neutrophil NADPH Oxidase American Journal of Respiratory Cell and Molecular Biology. Mar, 2011 | Pubmed ID: 20418360 Toll-like Receptor Signaling in Liver Diseases Gastroenterology Research and Practice. 2010 | Pubmed ID: 21789039 Hydrogen Inhalation Ameliorates Ventilator-induced Lung Injury Critical Care (London, England). 2010 | Pubmed ID: 21184683 Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-induced Ischemia/reperfusion Injury in Rats Transplantation. Dec, 2010 | Pubmed ID: 21048533 Differential Regulation by Fucoidan of IFN-γ-induced NO Production in Glial Cells and Macrophages Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830678 Incidental Radiographic Findings After Injury: Dedicated Attention Results in Improved Capture, Documentation, and Management Surgery. Oct, 2010 | Pubmed ID: 20705305 Complement Factor 3 Deficiency Attenuates Hemorrhagic Shock-related Hepatic Injury and Systemic Inflammatory Response Syndrome American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Nov, 2010 | Pubmed ID: 20702808 Superior Myocardial Preservation with HTK Solution over Celsior in Rat Hearts with Prolonged Cold Ischemia Surgery. Aug, 2010 | Pubmed ID: 20627336 A Critical Role for IFN Regulatory Factor 1 in NKT Cell-mediated Liver Injury Induced by Alpha-galactosylceramide Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010 | Pubmed ID: 20624945 Hepatocytes Express Functional NOD1 and NOD2 Receptors: a Role for NOD1 in Hepatocyte CC and CXC Chemokine Production Journal of Hepatology. Oct, 2010 | Pubmed ID: 20615568 Delay to Therapeutic Interventional Radiology Postinjury: Time is of the Essence The Journal of Trauma. Jun, 2010 | Pubmed ID: 20539172 Dominant Role of the MyD88-dependent Signaling Pathway in Mediating Early Endotoxin-induced Murine Ileus American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2010 | Pubmed ID: 20508155 Analysis of Factorial Time-course Microarrays with Application to a Clinical Study of Burn Injury Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20479259 Pivotal Advance: The Pattern Recognition Receptor Ligands Lipopolysaccharide and Polyinosine-polycytidylic Acid Stimulate Factor B Synthesis by the Macrophage Through Distinct but Overlapping Mechanisms Journal of Leukocyte Biology. Oct, 2010 | Pubmed ID: 20413727 Amelioration of Rat Cardiac Cold Ischemia/reperfusion Injury with Inhaled Hydrogen or Carbon Monoxide, or Both The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. May, 2010 | Pubmed ID: 20036162 Nitric Oxide and Thioredoxin Type 1 Modulate the Activity of Caspase 8 in HepG2 Cells Biochemical and Biophysical Research Communications. Jan, 2010 | Pubmed ID: 20005201 Oral Hydrogen Water Prevents Chronic Allograft Nephropathy in Rats Kidney International. Jan, 2010 | Pubmed ID: 19907413 The Nitric Oxide Donor S-nitrosoglutathione Reduces Apoptotic Primary Liver Cell Loss in a Three-dimensional Perfusion Bioreactor Culture Model Developed for Liver Support Tissue Engineering. Part A. Mar, 2010 | Pubmed ID: 19814591 Toll-like Receptors and Myocardial Ischemia/reperfusion, Inflammation, and Injury Current Cardiology Reviews. Aug, 2009 | Pubmed ID: 20676278 An Adequately Robust Early TNF-alpha Response is a Hallmark of Survival Following Trauma/hemorrhage PloS One. 2009 | Pubmed ID: 20027315 Hemorrhagic Shock Augments Lung Endothelial Cell Activation: Role of Temporal Alterations of TLR4 and TLR2 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2009 | Pubmed ID: 19828841 Nitric Oxide and Dihydrolipoic Acid Modulate the Activity of Caspase 3 in HepG2 Cells FEBS Letters. Nov, 2009 | Pubmed ID: 19822150 Preinjury Statin Use is Associated with a Higher Risk of Multiple Organ Failure After Injury: a Propensity Score Adjusted Analysis The Journal of Trauma. Sep, 2009 | Pubmed ID: 19741387 Fresh Frozen Plasma is Independently Associated with a Higher Risk of Multiple Organ Failure and Acute Respiratory Distress Syndrome The Journal of Trauma. Aug, 2009 | Pubmed ID: 19667872 Orally Administered Nitrite Attenuates Cardiac Allograft Rejection in Rats Surgery. Aug, 2009 | Pubmed ID: 19628069 Activation of Latent Transforming Growth Factor-beta1 by Nitric Oxide in Macrophages: Role of Soluble Guanylate Cyclase and MAP Kinases Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Jul-Aug, 2009 | Pubmed ID: 19614923 Preactivation of NKT Cells with Alpha-GalCer Protects Against Hepatic Ischemia-reperfusion Injury in Mouse by a Mechanism Involving IL-13 and Adenosine A2A Receptor American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2009 | Pubmed ID: 19556359 Low-dose Cisplatin Administration in Murine Cecal Ligation and Puncture Prevents the Systemic Release of HMGB1 and Attenuates Lethality Journal of Leukocyte Biology. Sep, 2009 | Pubmed ID: 19487305 Innate Immune Mechanisms in Ischemia/reperfusion Frontiers in Bioscience (Elite Edition). 2009 | Pubmed ID: 19482628 Mechanisms of Toll-like Receptor 4 (TLR4)-mediated Inflammation After Cold Ischemia/reperfusion in the Heart Transplantation. May, 2009 | Pubmed ID: 19461481 Endotoxin Uptake in Mouse Liver is Blocked by Endotoxin Pretreatment Through a Suppressor of Cytokine Signaling-1-dependent Mechanism Hepatology (Baltimore, Md.). May, 2009 | Pubmed ID: 19296467 Possible Novel Therapy for Malignant Gliomas with Secretable Trimeric TRAIL PloS One. 2009 | Pubmed ID: 19229339 Therapeutic Antioxidant Medical Gas Journal of Clinical Biochemistry and Nutrition. Jan, 2009 | Pubmed ID: 19177183 Expression and Subcellular Localization of BNIP3 in Hypoxic Hepatocytes and Liver Stress American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2009 | Pubmed ID: 19147804 Studies Toward the Analysis of S-nitrosoproteins Organic & Biomolecular Chemistry. Jan, 2009 | Pubmed ID: 19109666 Interacting Neuroendocrine and Innate and Acquired Immune Pathways Regulate Neutrophil Mobilization from Bone Marrow Following Hemorrhagic Shock Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19109190 An FFP:PRBC Transfusion Ratio >/=1:1.5 is Associated with a Lower Risk of Mortality After Massive Transfusion The Journal of Trauma. Nov, 2008 | Pubmed ID: 19001962 Parenteral Calcium for Intensive Care Unit Patients Cochrane Database of Systematic Reviews (Online). 2008 | Pubmed ID: 18843706 Calcium/calmodulin-dependent Protein Kinase (CaMK) IV Mediates Nucleocytoplasmic Shuttling and Release of HMGB1 During Lipopolysaccharide Stimulation of Macrophages Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18802105 Beta2-integrin-induced P38 MAPK Activation is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18701460 Preconditioning with High Mobility Group Box 1 (HMGB1) Induces Lipopolysaccharide (LPS) Tolerance Journal of Leukocyte Biology. Nov, 2008 | Pubmed ID: 18687905 The Role of Fracture-associated Soft Tissue Injury in the Induction of Systemic Inflammation and Remote Organ Dysfunction After Bilateral Femur Fracture Journal of Orthopaedic Trauma. Jul, 2008 | Pubmed ID: 18594302 Patterns of Cytokine Release and Evolution of Remote Organ Dysfunction After Bilateral Femur Fracture Shock (Augusta, Ga.). Jul, 2008 | Pubmed ID: 18562923 Detection and Measurement for the Modification and Inactivation of Caspase by Nitrosative Stress in Vitro and in Vivo Methods in Enzymology. 2008 | Pubmed ID: 18554542 Changes in FADD Levels, Distribution, and Phosphorylation in TNFalpha-induced Apoptosis in Hepatocytes is Caspase-3, Caspase-8 and BID Dependent Apoptosis : an International Journal on Programmed Cell Death. Aug, 2008 | Pubmed ID: 18543108 Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis PloS One. 2008 | Pubmed ID: 18509469 Carbon Monoxide Activates NF-kappaB Via ROS Generation and Akt Pathways to Protect Against Cell Death of Hepatocytes American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2008 | Pubmed ID: 18497334 Local Exposure of Bone Components to Injured Soft Tissue Induces Toll-like Receptor 4-dependent Systemic Inflammation with Acute Lung Injury Shock (Augusta, Ga.). Dec, 2008 | Pubmed ID: 18461022 HMGB1: Endogenous Danger Signaling Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2008 | Pubmed ID: 18431461 Application of Heme Oxygenase-1, Carbon Monoxide and Biliverdin for the Prevention of Intestinal Ischemia/reperfusion Injury Journal of Clinical Biochemistry and Nutrition. Mar, 2008 | Pubmed ID: 18385824 Male Gender is Associated with Excessive IL-6 Expression Following Severe Injury The Journal of Trauma. Mar, 2008 | Pubmed ID: 18332795 Protective Effect of P53 in Vascular Smooth Muscle Cells Against Nitric Oxide-induced Apoptosis is Mediated by Up-regulation of Heme Oxygenase-2 BMB Reports. Feb, 2008 | Pubmed ID: 18315954 Carbon Monoxide Decreases the Level of INOS Protein and Active Dimer in IL-1beta-stimulated Hepatocytes Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Jun, 2008 | Pubmed ID: 18313411 Galantamine and Carbon Monoxide Protect Brain Microvascular Endothelial Cells by Heme Oxygenase-1 Induction Biochemical and Biophysical Research Communications. Mar, 2008 | Pubmed ID: 18174021 Early Events in the Recognition of Danger Signals After Tissue Injury Journal of Leukocyte Biology. Mar, 2008 | Pubmed ID: 18032691 FXR-mediated Regulation of Angiotensin Type 2 Receptor Expression in Vascular Smooth Muscle Cells Cardiovascular Research. Feb, 2008 | Pubmed ID: 18006431 Systemic Inflammation and End Organ Damage Following Trauma Involves Functional TLR4 Signaling in Both Bone Marrow-derived Cells and Parenchymal Cells Journal of Leukocyte Biology. Jan, 2008 | Pubmed ID: 17925504 Toll-like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/reperfusion Transplantation. Nov, 2007 | Pubmed ID: 18049113 HMGB1 Release Induced by Liver Ischemia Involves Toll-like Receptor 4 Dependent Reactive Oxygen Species Production and Calcium-mediated Signaling The Journal of Experimental Medicine. Nov, 2007 | Pubmed ID: 17984303 Increased Interactive Format for Morbidity & Mortality Conference Improves Educational Value and Enhances Confidence Journal of Surgical Education. Sep-Oct, 2007 | Pubmed ID: 17961883 Systemic Inflammation and Remote Organ Injury Following Trauma Require HMGB1 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2007 | Pubmed ID: 17652366 Thioredoxin Catalyzes the Denitrosation of Low-molecular Mass and Protein S-nitrosothiols Biochemistry. Jul, 2007 | Pubmed ID: 17580965 Hypoxia Activates C-Jun N-terminal Kinase Via Rac1-dependent Reactive Oxygen Species Production in Hepatocytes Shock (Augusta, Ga.). Sep, 2007 | Pubmed ID: 17545941 Neutrophil NAD(P)H Oxidase is Required for Hemorrhagic Shock-enhanced TLR2 Up-regulation in Alveolar Macrophages in Response to LPS Shock (Augusta, Ga.). Aug, 2007 | Pubmed ID: 17515854 Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling Journal of Immunology (Baltimore, Md. : 1950). May, 2007 | Pubmed ID: 17475888 A Novel Inhibitory Peptide of Toll-like Receptor Signaling Limits Lipopolysaccharide-induced Production of Inflammatory Mediators and Enhances Survival in Mice Shock (Augusta, Ga.). Apr, 2007 | Pubmed ID: 17414417 Neuronal NOS-mediated Nitration and Inactivation of Manganese Superoxide Dismutase in Brain After Experimental and Human Brain Injury Journal of Neurochemistry. Apr, 2007 | Pubmed ID: 17394464 Making Progress in an Enlightened Era: Opportunities and Obstacles Surgical Infections. Feb, 2007 | Pubmed ID: 17381393 Targeting CD47: NO Limit on Therapeutic Potential Circulation Research. Mar, 2007 | Pubmed ID: 17363705 Carbon Monoxide Signals Via Inhibition of Cytochrome C Oxidase and Generation of Mitochondrial Reactive Oxygen Species FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2007 | Pubmed ID: 17264172 Early Growth Response 1 Mediates the Systemic and Hepatic Inflammatory Response Initiated by Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2007 | Pubmed ID: 17224790 Increasing Numbers of Hepatic Dendritic Cells Promote HMGB1-mediated Ischemia-reperfusion Injury Journal of Leukocyte Biology. Jan, 2007 | Pubmed ID: 17062605 The Role of Initial Trauma in the Host's Response to Injury and Hemorrhage: Insights from a Correlation of Mathematical Simulations and Hepatic Transcriptomic Analysis Shock (Augusta, Ga.). Dec, 2006 | Pubmed ID: 17117135 Emerging Paradigm: Toll-like Receptor 4-sentinel for the Detection of Tissue Damage Shock (Augusta, Ga.). Nov, 2006 | Pubmed ID: 17047512 In Silico and in Vivo Approach to Elucidate the Inflammatory Complexity of CD14-deficient Mice Molecular Medicine (Cambridge, Mass.). Apr-Jun, 2006 | Pubmed ID: 16953560 Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival After Hemorrhagic Shock Molecular Medicine (Cambridge, Mass.). Apr-Jun, 2006 | Pubmed ID: 16953558 Ischemic Preconditioning of the Murine Liver Protects Through the Akt Kinase Pathway Hepatology (Baltimore, Md.). Sep, 2006 | Pubmed ID: 16941697 In Silico Models of Acute Inflammation in Animals Shock (Augusta, Ga.). Sep, 2006 | Pubmed ID: 16912648 Carbon Monoxide Reverses Established Pulmonary Hypertension The Journal of Experimental Medicine. Sep, 2006 | Pubmed ID: 16908624 Low-dose Carbon Monoxide Inhalation Prevents Ischemia/reperfusion Injury of Transplanted Rat Lung Grafts Surgery. Aug, 2006 | Pubmed ID: 16904967 Leukocyte-derived Inducible Nitric Oxide Synthase Mediates Murine Postoperative Ileus Annals of Surgery. Aug, 2006 | Pubmed ID: 16858184 Cutting Edge: High-mobility Group Box 1 Preconditioning Protects Against Liver Ischemia-reperfusion Injury Journal of Immunology (Baltimore, Md. : 1950). Jun, 2006 | Pubmed ID: 16751357 The Role of RAGE in the Pathogenesis of Intestinal Barrier Dysfunction After Hemorrhagic Shock American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2006 | Pubmed ID: 16751175 Systemic Inflammation and Remote Organ Damage Following Bilateral Femur Fracture Requires Toll-like Receptor 4 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2006 | Pubmed ID: 16675630 Carbon Monoxide Protects Hepatocytes from TNF-alpha/Actinomycin D by Inhibition of the Caspase-8-mediated Apoptotic Pathway Biochemical and Biophysical Research Communications. Jun, 2006 | Pubmed ID: 16647044 Toll-like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock Journal of the American College of Surgeons. Mar, 2006 | Pubmed ID: 16500244 Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493066 Hemorrhagic Shock-activated Neutrophils Augment TLR4 Signaling-induced TLR2 Upregulation in Alveolar Macrophages: Role in Hemorrhage-primed Lung Inflammation American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2006 | Pubmed ID: 16272176 Nitric Oxide: a Clinical Primer Critical Care Medicine. Dec, 2005 | Pubmed ID: 16340431 Hepatic Ischemia/reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2005 | Pubmed ID: 16301676 Thioredoxin and Lipoic Acid Catalyze the Denitrosation of Low Molecular Weight and Protein S-nitrosothiols Journal of the American Chemical Society. Nov, 2005 | Pubmed ID: 16277524 Glutathione Depletion Renders Rat Hepatocytes Sensitive to Nitric Oxide Donor-mediated Toxicity Hepatology (Baltimore, Md.). Sep, 2005 | Pubmed ID: 16116630 Biliverdin Administration Prevents the Formation of Intimal Hyperplasia Induced by Vascular Injury Circulation. Jul, 2005 | Pubmed ID: 16027253 The Role of Hepatic Type 1 Plasminogen Activator Inhibitor (PAI-1) During Murine Hemorrhagic Shock Hepatology (Baltimore, Md.). Aug, 2005 | Pubmed ID: 16025510 The Acute Inflammatory Response in Diverse Shock States Shock (Augusta, Ga.). Jul, 2005 | Pubmed ID: 15988324 Carbon Monoxide Prevents Multiple Organ Injury in a Model of Hemorrhagic Shock and Resuscitation Shock (Augusta, Ga.). Jun, 2005 | Pubmed ID: 15897805 Hepatocytes Enhance Effects of Lipopolysaccharide on Liver Nonparenchymal Cells Through Close Cell Interactions Shock (Augusta, Ga.). May, 2005 | Pubmed ID: 15834312 Induction of IL-6 Within the Rodent Intestinal Muscularis After Intestinal Surgical Stress Surgery. Apr, 2005 | Pubmed ID: 15800492 The Nuclear Factor HMGB1 Mediates Hepatic Injury After Murine Liver Ischemia-reperfusion The Journal of Experimental Medicine. Apr, 2005 | Pubmed ID: 15795240 Enhanced Oxidative Stress in INOS-deficient Mice After Traumatic Brain Injury: Support for a Neuroprotective Role of INOS Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jun, 2005 | Pubmed ID: 15716856 Protection Against Ischemia/reperfusion Injury in Cardiac and Renal Transplantation with Carbon Monoxide, Biliverdin and Both American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Feb, 2005 | Pubmed ID: 15643987 Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: in Vivo, in Vitro, and in Silico Studies Current Molecular Medicine. Nov, 2004 | Pubmed ID: 15579022 Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating P53 Cancer Research. Nov, 2004 | Pubmed ID: 15520210 IFN-gamma Enhances TRAIL-induced Apoptosis Through IRF-1 European Journal of Biochemistry / FEBS. Nov, 2004 | Pubmed ID: 15511228 Tissue Hypoxia Activates JNK in the Liver During Hemorrhagic Shock Shock (Augusta, Ga.). Oct, 2004 | Pubmed ID: 15377896 Nitric Oxide Suppresses Inducible Nitric Oxide Synthase Expression by Inhibiting Post-translational Modification of IkappaB Experimental & Molecular Medicine. Aug, 2004 | Pubmed ID: 15365250 The Secretable Form of Trimeric TRAIL, a Potent Inducer of Apoptosis Biochemical and Biophysical Research Communications. Sep, 2004 | Pubmed ID: 15358116 Nitric Oxide Facilitates Cardiomyogenesis in Mouse Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15304656 Hypoxia Inhibits Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Blocking Bax Translocation Cancer Research. Jun, 2004 | Pubmed ID: 15205314 The Department of Surgery at the School of Medicine at the University Of Pittsburgh, Pittsburgh, Pa Archives of Surgery (Chicago, Ill. : 1960). May, 2004 | Pubmed ID: 15136344 'Til Cell Death Do Us Part: Nitric Oxide and Mechanisms of Hepatotoxicity Biological Chemistry. Jan, 2004 | Pubmed ID: 14977041 Adenoviral Gene Transfer of the Human Inducible Nitric Oxide Synthase Gene Enhances the Radiation Response of Human Colorectal Cancer Associated with Alterations in Tumor Vascularity Cancer Research. Feb, 2004 | Pubmed ID: 14973054 Blood Soluble Drag-reducing Polymers Prevent Lethality from Hemorrhagic Shock in Acute Animal Experiments Biorheology. 2004 | Pubmed ID: 14967890 IRF-1 Expression Induces Apoptosis and Inhibits Tumor Growth in Mouse Mammary Cancer Cells in Vitro and in Vivo Oncogene. Feb, 2004 | Pubmed ID: 14762441 Induced Nitric Oxide Promotes Intestinal Inflammation Following Hemorrhagic Shock American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2004 | Pubmed ID: 14715517 Carbon Monoxide Inhibits T Lymphocyte Proliferation Via Caspase-dependent Pathway Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14707100 Selective Jejunal Manipulation Causes Postoperative Pan-enteric Inflammation and Dysmotility Gastroenterology. Jan, 2004 | Pubmed ID: 14699497 Carbon Monoxide Protects Against Liver Failure Through Nitric Oxide-induced Heme Oxygenase 1 The Journal of Experimental Medicine. Dec, 2003 | Pubmed ID: 14657222 Role of Nitric Oxide in Liver Injury Current Molecular Medicine. Sep, 2003 | Pubmed ID: 14527083 A Role for Angiotensin II in the Activation of Extracellular Signal-regulated Kinases in the Liver During Hemorrhagic Shock Shock (Augusta, Ga.). Oct, 2003 | Pubmed ID: 14501944 Nitric Oxide-mediated Inhibition of Caspase-dependent T Lymphocyte Proliferation Journal of Leukocyte Biology. Sep, 2003 | Pubmed ID: 12949244 RhoA Influences the Nuclear Localization of Extracellular Signal-regulated Kinases to Modulate P21Waf/Cip1 Expression Circulation. Aug, 2003 | Pubmed ID: 12874183 Fas-associating Death Domain Protein Overexpression Induces Apoptosis in Lung Cancer Cells The Journal of Thoracic and Cardiovascular Surgery. Jun, 2003 | Pubmed ID: 12830053 Nitric Oxide and Wound Repair The Surgical Clinics of North America. Jun, 2003 | Pubmed ID: 12822723 Nitric Oxide Prevents 6-hydroxydopamine-induced Apoptosis in PC12 Cells Through CGMP-dependent PI3 Kinase/Akt Activation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2003 | Pubmed ID: 12773486 There's NO Business Like P53 Business: Nitric Oxide Regulates Phosphorylation of P53 in Chronic Inflammatory Disease Cell Cycle (Georgetown, Tex.). Mar-Apr, 2003 | Pubmed ID: 12695658 Autologous Nitric Oxide Protects Mouse and Human Keratinocytes from Ultraviolet B Radiation-induced Apoptosis American Journal of Physiology. Cell Physiology. May, 2003 | Pubmed ID: 12676653 Heme Oxygenase-1: a Cellular Hercules Hepatology (Baltimore, Md.). Apr, 2003 | Pubmed ID: 12668964 Regulation of Tissue Factor Expression in Smooth Muscle Cells with Nitric Oxide Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter. Mar, 2003 | Pubmed ID: 12618706 Intra-abdominal Activation of a Local Inflammatory Response Within the Human Muscularis Externa During Laparotomy Annals of Surgery. Mar, 2003 | Pubmed ID: 12616113 Ultraviolet Irradiation Increases FADD Protein in Apoptotic Human Keratinocytes Biochemical and Biophysical Research Communications. Mar, 2003 | Pubmed ID: 12604344 Characterization of the Expression of Inducible Nitric Oxide Synthase in Rat and Human Liver During Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2003 | Pubmed ID: 12578118 Carbon Monoxide Suppresses Arteriosclerotic Lesions Associated with Chronic Graft Rejection and with Balloon Injury Nature Medicine. Feb, 2003 | Pubmed ID: 12539038 Maternity Policy and Practice During Surgery Residency: How We Do It Surgery. Oct, 2002 | Pubmed ID: 12407353 A DNA Microarray Study of Nitric Oxide-induced Genes in Mouse Hepatocytes: Implications for Hepatic Heme Oxygenase-1 Expression in Ischemia/reperfusion Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Nov, 2002 | Pubmed ID: 12381414 Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12359727 Nitric Oxide and Wound Repair: Role of Cytokines? Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Aug, 2002 | Pubmed ID: 12175813 A Brief Episode of Hypotension Increases Mortality in Critically Ill Trauma Patients The Journal of Trauma. Aug, 2002 | Pubmed ID: 12169927 Hepatocyte Fas-associating Death Domain Protein/mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12167637 Peroxisomal Localization of Inducible Nitric Oxide Synthase in Hepatocytes Hepatology (Baltimore, Md.). Jul, 2002 | Pubmed ID: 12085352 Mechanisms of Hepatoprotection by Nitric Oxide Annals of the New York Academy of Sciences. May, 2002 | Pubmed ID: 12076992 Role of Toll-like Receptors in Changes in Gene Expression and NF-kappa B Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide Infection and Immunity. Jul, 2002 | Pubmed ID: 12065483 Signaling and Function of Caspase and C-jun N-terminal Kinase in Cisplatin-induced Apoptosis Molecules and Cells. Apr, 2002 | Pubmed ID: 12018840 Requirements for NF-kappaB Activation in Hemorrhagic Shock Archives of Orthopaedic and Trauma Surgery. Feb, 2002 | Pubmed ID: 11995880 Inducible Nitric Oxide Synthase: from Cloning to Therapeutic Applications World Journal of Surgery. Jul, 2002 | Pubmed ID: 11960209 Role of Galectin-3 in Breast Cancer Metastasis: Involvement of Nitric Oxide The American Journal of Pathology. Mar, 2002 | Pubmed ID: 11891203 IFN-gamma Inhibition of TRAIL-induced IAP-2 Upregulation, a Possible Mechanism of IFN-gamma-enhanced TRAIL-induced Apoptosis Biochemical and Biophysical Research Communications. Feb, 2002 | Pubmed ID: 11846395 A Nitric Oxide Scavenger Protects Against Pulmonary Inflammation Following Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2002 | Pubmed ID: 11837796 TRISS Unexpected Survivors: an Outdated Standard? The Journal of Trauma. Feb, 2002 | Pubmed ID: 11834980 Potentiation of Nitric Oxide-induced Apoptosis in P53-/- Vascular Smooth Muscle Cells American Journal of Physiology. Cell Physiology. Mar, 2002 | Pubmed ID: 11832348 Hypoxia Inhibition of Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Biochemical and Biophysical Research Communications. Feb, 2002 | Pubmed ID: 11829475 The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock Shock (Augusta, Ga.). Jan, 2002 | Pubmed ID: 11795663 Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock Lauryn K. Kohut1, Sophie S. Darwiche1, John M. Brumfield1, Alicia M. Frank1, Timothy R. Billiar1 1Department of Surgery, University of Pittsburgh JoVE 2068 Medicina
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock Lauryn K. Kohut1, Sophie S. Darwiche1, John M. Brumfield1, Alicia M. Frank1, Timothy R. Billiar1 1Department of Surgery, University of Pittsburgh JoVE 2068 Medicina