Todd E. Golde Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease University of Florida Biography Publications Institution JoVE Articles Todd E. Golde has not added a biography. If you are Todd E. Golde and would like to personalize this page please email our Author Liaison for assistance. Publications Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2014 | Pubmed ID: 25209277 Intramuscular Injection of α-synuclein Induces CNS α-synuclein Pathology and a Rapid-onset Motor Phenotype in Transgenic Mice Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25002524 Divergent Effects of the H50Q and G51D SNCA Mutations on the Aggregation of α-synuclein Journal of Neurochemistry. Jul, 2014 | Pubmed ID: 24984882 NOTCH1 Can Initiate NF-κB Activation Via Cytosolic Interactions with Components of the T Cell Signalosome Frontiers in Immunology. 2014 | Pubmed ID: 24904593 Amyloidogenic α-synuclein Seeds Do Not Invariably Induce Rapid, Widespread Pathology in Mice Acta Neuropathologica. May, 2014 | Pubmed ID: 24659240 Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2014 | Pubmed ID: 24623762 Complex Relationships Between Substrate Sequence and Sensitivity to Alterations in γ-secretase Processivity Induced by γ-secretase Modulators Biochemistry. Apr, 2014 | Pubmed ID: 24620716 Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells Frontiers in Immunology. 2014 | Pubmed ID: 24611064 Open Questions for Alzheimer's Disease Immunotherapy Alzheimer's Research & Therapy. 2014 | Pubmed ID: 24393284 γ-Secretase Processing and Effects of γ-secretase Inhibitors and Modulators on Long Aβ Peptides in Cells The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24352661 Induction of CNS α-synuclein Pathology by Fibrillar and Non-amyloidogenic Recombinant α-synuclein Acta Neuropathologica Communications. 2013 | Pubmed ID: 24252149 Anti-tau Antibodies: Hitting the Target Neuron. Oct, 2013 | Pubmed ID: 24139027 Accelerated Neurodegeneration Through Chaperone-mediated Oligomerization of Tau The Journal of Clinical Investigation. Oct, 2013 | Pubmed ID: 23999428 Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain PloS One. 2013 | Pubmed ID: 23825679 γ-Secretase Inhibitors and Modulators Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 23791707 Unbiased Screen Reveals Ubiquilin-1 and -2 Highly Associated with Huntingtin Inclusions Brain Research. Jun, 2013 | Pubmed ID: 23774650 Therapeutic Targeting of NOTCH Signaling Ameliorates Immune-mediated Bone Marrow Failure of Aplastic Anemia The Journal of Experimental Medicine. Jul, 2013 | Pubmed ID: 23733784 Progress in Alzheimer's Disease Research Circa 2013: Is the Glass Half Empty or Half Full? Alzheimer's Research & Therapy. 2013 | Pubmed ID: 23731836 Steroids As γ-secretase Modulators FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2013 | Pubmed ID: 23716494 Conformational Templating of α-synuclein Aggregates in Neuronal-glial Cultures Molecular Neurodegeneration. 2013 | Pubmed ID: 23714769 Comment on "ApoE-directed Therapeutics Rapidly Clear β-amyloid and Reverse Deficits in AD Mouse Models" Science (New York, N.Y.). May, 2013 | Pubmed ID: 23704553 Alzheimer's Disease Risk Alleles in TREM2 Illuminate Innate Immunity in Alzheimer's Disease Alzheimer's Research & Therapy. 2013 | Pubmed ID: 23692967 Robust Cytoplasmic Accumulation of Phosphorylated TDP-43 in Transgenic Models of Tauopathy Acta Neuropathologica. Jul, 2013 | Pubmed ID: 23666556 Thinking Laterally About Neurodegenerative Proteinopathies The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23635781 Biomarkers for Alzheimer's Disease in Plasma, Serum and Blood - Conceptual and Practical Problems Alzheimer's Research & Therapy. 2013 | Pubmed ID: 23470193 Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-amyloidosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23447589 Viral Transduction of the Neonatal Brain Delivers Controllable Genetic Mosaicism for Visualising and Manipulating Neuronal Circuits in Vivo The European Journal of Neuroscience. Apr, 2013 | Pubmed ID: 23347239 Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-terminal Fragments in an HEK293 Cell Model PloS One. 2012 | Pubmed ID: 23236391 Targeting the ERAD Pathway Via Inhibition of Signal Peptide Peptidase for Antiparasitic Therapeutic Design Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23236186 Cyanobacterial Peptides As a Prototype for the Design of Potent β-secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases Journal of Medicinal Chemistry. Dec, 2012 | Pubmed ID: 23181502 Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-secretase and Amyloid Precursor Protein (APP) The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 23043097 5-Lipoxygenase Gene Transfer Worsens Memory, Amyloid, and Tau Brain Pathologies in a Mouse Model of Alzheimer Disease Annals of Neurology. Sep, 2012 | Pubmed ID: 23034916 Aβ Alters the Connectivity of Olfactory Neurons in the Absence of Amyloid Plaques in Vivo Nature Communications. 2012 | Pubmed ID: 22910355 Alzheimer's β-secretase (BACE1) Regulates the CAMP/PKA/CREB Pathway Independently of β-amyloid The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012 | Pubmed ID: 22895721 Transient Pharmacologic Lowering of Aβ Production Prior to Deposition Results in Sustained Reduction of Amyloid Plaque Pathology Molecular Neurodegeneration. 2012 | Pubmed ID: 22892055 Hippocampal Expression of Murine IL-4 Results in Exacerbation of Amyloid Deposition Molecular Neurodegeneration. 2012 | Pubmed ID: 22838967 Overlapping Profiles of Aβ Peptides in the Alzheimer's Disease and Pathological Aging Brains Alzheimer's Research & Therapy. 2012 | Pubmed ID: 22621179 Shifting a Complex Debate on γ-secretase Cleavage and Alzheimer's Disease The EMBO Journal. May, 2012 | Pubmed ID: 22505028 Adeno-associated Virus-mediated Brain Delivery of 5-lipoxygenase Modulates the AD-like Phenotype of APP Mice Molecular Neurodegeneration. 2012 | Pubmed ID: 22222029 Anesthetic Propofol Attenuates the Isoflurane-induced Caspase-3 Activation and Aβ Oligomerization PloS One. 2011 | Pubmed ID: 22069482 Substrate Sequence Influences γ-secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21868380 Lysine 624 of the Amyloid Precursor Protein (APP) is a Critical Determinant of Amyloid β Peptide Length: Support for a Sequential Model of γ-secretase Intramembrane Proteolysis and Regulation by the Amyloid β Precursor Protein (APP) Juxtamembrane Region The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21868378 Interferon-γ Induces Progressive Nigrostriatal Degeneration and Basal Ganglia Calcification Nature Neuroscience. Jun, 2011 | Pubmed ID: 21572432 Right Sizing Funding for Alzheimer's Disease Alzheimer's Research & Therapy. 2011 | Pubmed ID: 21554753 Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-beta Immunotherapy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011 | Pubmed ID: 21411653 Hippocampal Expression of Murine TNFα Results in Attenuation of Amyloid Deposition in Vivo Molecular Neurodegeneration. 2011 | Pubmed ID: 21324189 Anti-aβ Therapeutics in Alzheimer's Disease: the Need for a Paradigm Shift Neuron. Jan, 2011 | Pubmed ID: 21262461 Reduced Alzheimer's Disease ß-amyloid Deposition in Transgenic Mice Expressing S-palmitoylation-deficient APH1aL and Nicastrin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21123562 Sorting out Frontotemporal Dementia? Neuron. Nov, 2010 | Pubmed ID: 21092851 Phosphorylation Dynamics Regulate Hsp27-mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2010 | Pubmed ID: 21084594 Inhibition of Notch Signaling Reduces the Stem-like Population of Breast Cancer Cells and Prevents Mammosphere Formation Anticancer Research. Oct, 2010 | Pubmed ID: 21036696 Convection-enhanced Delivery and Systemic Mannitol Increase Gene Product Distribution of AAV Vectors 5, 8, and 9 and Increase Gene Product in the Adult Mouse Brain Journal of Neuroscience Methods. Dec, 2010 | Pubmed ID: 20951738 IFN-gamma Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid Beta Precursor Protein Transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20368278 Massive Gliosis Induced by Interleukin-6 Suppresses Abeta Deposition in Vivo: Evidence Against Inflammation As a Driving Force for Amyloid Deposition FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2010 | Pubmed ID: 19825975 Targeting Abeta and Tau in Alzheimer's Disease, an Early Interim Report Experimental Neurology. Jun, 2010 | Pubmed ID: 19716367 Proteinopathy-induced Neuronal Senescence: a Hypothesis for Brain Failure in Alzheimer's and Other Neurodegenerative Diseases Alzheimer's Research & Therapy. 2009 | Pubmed ID: 19822029 An NSAID-like Compound, FT-9, Preferentially Inhibits Gamma-secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1 Biochemistry. Nov, 2009 | Pubmed ID: 19821615 Suppression of Hippocampal TRPM7 Protein Prevents Delayed Neuronal Death in Brain Ischemia Nature Neuroscience. Oct, 2009 | Pubmed ID: 19734892 Generating Differentially Targeted Amyloid-beta Specific Intrabodies As a Passive Vaccination Strategy for Alzheimer's Disease Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2009 | Pubmed ID: 19638957 Signal Peptide Peptidases: a Family of Intramembrane-cleaving Proteases That Cleave Type 2 Transmembrane Proteins Seminars in Cell & Developmental Biology. Apr, 2009 | Pubmed ID: 19429495 Existing Plaques and Neuritic Abnormalities in APP:PS1 Mice Are Not Affected by Administration of the Gamma-secretase Inhibitor LY-411575 Molecular Neurodegeneration. 2009 | Pubmed ID: 19419556 Medicine. Avoiding Unintended Toxicity Science (New York, N.Y.). May, 2009 | Pubmed ID: 19407192 Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19383787 A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity PloS One. 2009 | Pubmed ID: 19337374 Inhibition of Soluble TNF Signaling in a Mouse Model of Alzheimer's Disease Prevents Pre-plaque Amyloid-associated Neuropathology Neurobiology of Disease. Apr, 2009 | Pubmed ID: 19320056 Identification of Ligand-induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells Cancer Research. Mar, 2009 | Pubmed ID: 19276374 Quantitative and Mechanistic Studies of Abeta Immunotherapy CNS & Neurological Disorders Drug Targets. Mar, 2009 | Pubmed ID: 19275635 Notch Regulates Cytolytic Effector Function in CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19265115 The Therapeutic Importance of Understanding Mechanisms of Neuronal Cell Death in Neurodegenerative Disease Molecular Neurodegeneration. 2009 | Pubmed ID: 19193222 "What Kills Neurons in Neurodegenerative Diseases?", a Review Series in an Open Access Journal Molecular Neurodegeneration. 2009 | Pubmed ID: 19193221 Notch Signaling Mediates G1/S Cell-cycle Progression in T Cells Via Cyclin D3 and Its Dependent Kinases Blood. Feb, 2009 | Pubmed ID: 19001083 Notch1 and TGFbeta1 Cooperatively Regulate Foxp3 Expression and the Maintenance of Peripheral Regulatory T Cells Blood. Sep, 2008 | Pubmed ID: 18550850 Substrate-targeting Gamma-secretase Modulators Nature. Jun, 2008 | Pubmed ID: 18548070 BRI2 (ITM2b) Inhibits Abeta Deposition in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008 | Pubmed ID: 18524908 Using Leucine Zipper to Facilitate Alpha-synuclein Assembly FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2008 | Pubmed ID: 18492724 Independent Generation of Abeta42 and Abeta38 Peptide Species by Gamma-secretase The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18426795 Possible Mechanisms of Action of NSAIDs and Related Compounds That Modulate Gamma-secretase Cleavage Current Topics in Medicinal Chemistry. 2008 | Pubmed ID: 18220932 Notch Signaling is Activated by TLR Stimulation and Regulates Macrophage Functions European Journal of Immunology. Jan, 2008 | Pubmed ID: 18085664 Off the Beaten Pathway: the Complex Cross Talk Between Notch and NF-kappaB Laboratory Investigation; a Journal of Technical Methods and Pathology. Jan, 2008 | Pubmed ID: 18059366 Safety, Tolerability, Pharmacokinetics, and Abeta Levels After Short-term Administration of R-flurbiprofen in Healthy Elderly Individuals Alzheimer Disease and Associated Disorders. Oct-Dec, 2007 | Pubmed ID: 18090435 Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of Gamma-secretase The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17827153 Chronic Administration of R-flurbiprofen Attenuates Learning Impairments in Transgenic Amyloid Precursor Protein Mice BMC Neuroscience. 2007 | Pubmed ID: 17650315 Statins Reduce Amyloid-beta Production Through Inhibition of Protein Isoprenylation The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17646164 Notch Inhibition in Kaposi's Sarcoma Tumor Cells Leads to Mitotic Catastrophe Through Nuclear Factor-kappaB Signaling Molecular Cancer Therapeutics. Jul, 2007 | Pubmed ID: 17604336 Novel Rat Alzheimer's Disease Models Based on AAV-mediated Gene Transfer to Selectively Increase Hippocampal Abeta Levels Molecular Neurodegeneration. 2007 | Pubmed ID: 17559680 The Pathogenesis of Alzheimer's Disease and the Role of Abeta42 CNS Spectrums. Jan, 2007 | Pubmed ID: 17192766 Filling the Gaps in the Abeta Cascade Hypothesis of Alzheimer's Disease Current Alzheimer Research. Dec, 2006 | Pubmed ID: 17168641 Intracranial Adeno-associated Virus-mediated Delivery of Anti-pan Amyloid Beta, Amyloid Beta40, and Amyloid Beta42 Single-chain Variable Fragments Attenuates Plaque Pathology in Amyloid Precursor Protein Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17108166 Signal Peptide Peptidase (SPP) Dimer Formation As Assessed by Fluorescence Lifetime Imaging Microscopy (FLIM) in Intact Cells Molecular Neurodegeneration. 2006 | Pubmed ID: 17105660 Disease Modifying Therapy for AD? Journal of Neurochemistry. Nov, 2006 | Pubmed ID: 17076654 Insights into the Mechanisms of Action of Anti-Abeta Antibodies in Alzheimer's Disease Mouse Models FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2006 | Pubmed ID: 17068112 Sortilin, SorCS1b, and SorLA Vps10p Sorting Receptors, Are Novel Gamma-secretase Substrates Molecular Neurodegeneration. 2006 | Pubmed ID: 16930450 Intramembrane Proteolytic Cleavage by Human Signal Peptide Peptidase Like 3 and Malaria Signal Peptide Peptidase FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006 | Pubmed ID: 16873890 Interleukin-1 Receptor 1 Knockout Has No Effect on Amyloid Deposition in Tg2576 Mice and Does Not Alter Efficacy Following Abeta Immunotherapy Journal of Neuroinflammation. 2006 | Pubmed ID: 16872492 Signal Peptide Peptidase: Biochemical Properties and Modulation by Nonsteroidal Antiinflammatory Drugs Biochemistry. Jul, 2006 | Pubmed ID: 16834339 Inclusion-body Myositis and Alzheimer Disease: Two Sides of the Same Coin, or Different Currencies Altogether? Neurology. Jan, 2006 | Pubmed ID: 16432148 Detection of Presenilin-1 Homodimer Formation in Intact Cells Using Fluorescent Lifetime Imaging Microscopy Biochemical and Biophysical Research Communications. Feb, 2006 | Pubmed ID: 16376853 Anti-Abeta42- and Anti-Abeta40-specific MAbs Attenuate Amyloid Deposition in an Alzheimer Disease Mouse Model The Journal of Clinical Investigation. Jan, 2006 | Pubmed ID: 16341263 Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2006 | Pubmed ID: 16325474 Notch1 Augments NF-kappaB Activity by Facilitating Its Nuclear Retention The EMBO Journal. Jan, 2006 | Pubmed ID: 16319921 C-terminal PAL Motif of Presenilin and Presenilin Homologues Required for Normal Active Site Conformation Journal of Neurochemistry. Jan, 2006 | Pubmed ID: 16305624 Inhibitors of Rho-kinase Modulate Amyloid-beta (Abeta) Secretion but Lack Selectivity for Abeta42 Journal of Neurochemistry. Jan, 2006 | Pubmed ID: 16300630 Inhibitors of Gamma-secretase Block in Vivo and in Vitro T Helper Type 1 Polarization by Preventing Notch Upregulation of Tbx21 Nature Immunology. Jul, 2005 | Pubmed ID: 15991363 Gamma Secretase Inhibitor Blocks Notch Activation and Induces Apoptosis in Kaposi's Sarcoma Tumor Cells Oncogene. Sep, 2005 | Pubmed ID: 15940249 Bringing Amyloid into Focus Nature Biotechnology. May, 2005 | Pubmed ID: 15877070 Diverse Compounds Mimic Alzheimer Disease-causing Mutations by Augmenting Abeta42 Production Nature Medicine. May, 2005 | Pubmed ID: 15834426 The Abeta Hypothesis: Leading Us to Rationally-designed Therapeutic Strategies for the Treatment or Prevention of Alzheimer Disease Brain Pathology (Zurich, Switzerland). Jan, 2005 | Pubmed ID: 15779241 Homing in on Intracellular Abeta? Neuron. Mar, 2005 | Pubmed ID: 15748837 Presenilin Regulates Capacitative Calcium Entry Dependently and Independently of Gamma-secretase Activity Biochemical and Biophysical Research Communications. Oct, 2004 | Pubmed ID: 15336962 A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15252014 Signal Peptide Peptidase Forms a Homodimer That is Labeled by an Active Site-directed Gamma-secretase Inhibitor The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14704149 Amyloid-beta Immunization Effectively Reduces Amyloid Deposition in FcRgamma-/- Knock-out Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2003 | Pubmed ID: 13679422 Intramembrane-cleaving Aspartic Proteases and Disease: Presenilins, Signal Peptide Peptidase and Their Homologs Human Molecular Genetics. Oct, 2003 | Pubmed ID: 12966028 TCR-mediated Notch Signaling Regulates Proliferation and IFN-gamma Production in Peripheral T Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12960327 Immune Responses Against Abeta1-42 in HLA Class II Transgenic Mice: Implications for Abeta1-42 Immune-mediated Therapies Neurobiology of Aging. Nov, 2003 | Pubmed ID: 12928057 NSAIDs and Enantiomers of Flurbiprofen Target Gamma-secretase and Lower Abeta 42 in Vivo The Journal of Clinical Investigation. Aug, 2003 | Pubmed ID: 12897211 Triple-transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Abeta and Synaptic Dysfunction Neuron. Jul, 2003 | Pubmed ID: 12895417 Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid Beta 42 Production by Direct Modulation of Gamma-secretase Activity The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12805356 The Non-cyclooxygenase Targets of Non-steroidal Anti-inflammatory Drugs, Lipoxygenases, Peroxisome Proliferator-activated Receptor, Inhibitor of Kappa B Kinase, and NF Kappa B, Do Not Reduce Amyloid Beta 42 Production The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12805355 Abeta42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling Through the APP Intracellular Domain The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12777371 Peptide-based, Irreversible Inhibitors of Gamma-secretase Activity Biochemical and Biophysical Research Communications. Jun, 2003 | Pubmed ID: 12763025 Overexpression of Nicastrin Increases Abeta Production FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2003 | Pubmed ID: 12692078 Physiologic and Pathologic Events Mediated by Intramembranous and Juxtamembranous Proteolysis Science's STKE : Signal Transduction Knowledge Environment. Mar, 2003 | Pubmed ID: 12621149 Alzheimer Disease Therapy: Can the Amyloid Cascade Be Halted? The Journal of Clinical Investigation. Jan, 2003 | Pubmed ID: 12511580 Open Peer Commentary Regarding Abeta Immunization and CNS Inflammation by Pasinetti Et Al Neurobiology of Aging. Sep-Oct, 2002 | Pubmed ID: 12392769 Inflammation Takes on Alzheimer Disease Nature Medicine. Sep, 2002 | Pubmed ID: 12205453 Identification of a Novel Family of Presenilin Homologues Human Molecular Genetics. May, 2002 | Pubmed ID: 11978763 Inclusion Body Myositis-like Phenotype Induced by Transgenic Overexpression of Beta APP in Skeletal Muscle Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11972038 FAD-linked Mutations in Presenilin 1 Alter the Length of Abeta Peptides Derived from BetaAPP Transmembrane Domain Mutants Biochimica Et Biophysica Acta. Mar, 2002 | Pubmed ID: 11959461 A Physiologic Signaling Role for the Gamma -secretase-derived Intracellular Fragment of APP Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11917117 A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits Gamma-secretase Cleavage of APP and Notch Neurobiology of Disease. Mar, 2002 | Pubmed ID: 11895378 Cholesterol-dependent Gamma-secretase Activity in Buoyant Cholesterol-rich Membrane Microdomains Neurobiology of Disease. Feb, 2002 | Pubmed ID: 11848681 Intracerebroventrikulær Viral Injektion af Neonatal Mouse Hjerne for Vedvarende og Udbredt Neuronal transduktion Ji-Yoen Kim*1, Stacy D. Grunke*1, Yona Levites2, Todd E. Golde2, Joanna L. Jankowsky1,3 1Department of Neuroscience, Baylor College of Medicine, 2Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, 3Department of Neurology and Department of Neurosurgery, Baylor College of Medicine Neuroscienze
Intracerebroventrikulær Viral Injektion af Neonatal Mouse Hjerne for Vedvarende og Udbredt Neuronal transduktion Ji-Yoen Kim*1, Stacy D. Grunke*1, Yona Levites2, Todd E. Golde2, Joanna L. Jankowsky1,3 1Department of Neuroscience, Baylor College of Medicine, 2Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, 3Department of Neurology and Department of Neurosurgery, Baylor College of Medicine Neuroscienze