Troy Stevens Department of Physiology and Cell Biology, College of Medicine University of South Alabama Biography Publications Institution JoVE Articles Troy Stevens has not added a biography. If you are Troy Stevens and would like to personalize this page please email our Author Liaison for assistance. Publications PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells American Journal of Respiratory Cell and Molecular Biology. May, 2023 | Pubmed ID: 37201952 Substrate Stiffness Modulates Migration and Local Intercellular Membrane Motion in Pulmonary Endothelial Cell Monolayers American Journal of Physiology. Cell Physiology. Sep, 2022 | Pubmed ID: 35912996 New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021 American Journal of Respiratory Cell and Molecular Biology. Sep, 2022 | Pubmed ID: 35679511 Carbonic Anhydrase IX Proteoglycan-like and Intracellular Domains Mediate Pulmonary Microvascular Endothelial Cell Repair and Angiogenesis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2022 | Pubmed ID: 35672011 ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 During Infection Toxins. Feb, 2022 | Pubmed ID: 35202178 Cytotoxic Tau Released from Lung Microvascular Endothelial Cells Upon Infection with Pseudomonas Aeruginosa Promotes Neuronal Tauopathy The Journal of Biological Chemistry. Jan, 2022 | Pubmed ID: 34896150 Pneumonia Initiates a Tauopathy FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 09, 2021 | Pubmed ID: 34384141 Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival During Infection American Journal of Respiratory Cell and Molecular Biology. 12, 2021 | Pubmed ID: 34251286 Endothelial Metabolism in Pulmonary Vascular Homeostasis and Acute Respiratory Distress Syndrome American Journal of Physiology. Lung Cellular and Molecular Physiology. 08, 2021 | Pubmed ID: 34159794 Salvaging the Endothelium in Acute Respiratory Distress Syndrome: a Druggable Intersection Between TLR4 and NAD Signalling The European Respiratory Journal. 05, 2021 | Pubmed ID: 33958376 Impact of Na+ Permeation on Collective Migration of Pulmonary Arterial Endothelial Cells PloS One. 2021 | Pubmed ID: 33891591 Cystatin C Regulates the Cytotoxicity of Infection-induced Endothelial-derived β-amyloid FEBS Open Bio. 11, 2020 | Pubmed ID: 33030263 KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability American Journal of Respiratory Cell and Molecular Biology. 10, 2020 | Pubmed ID: 32628869 Development of an Endothelial Cell-restricted Transgenic Reporter Rat: a Resource for Physiological Studies of Vascular Biology American Journal of Physiology. Heart and Circulatory Physiology. 08, 2020 | Pubmed ID: 32589443 Exoenzyme Y Induces Extracellular Active Caspase-7 Accumulation Independent from Apoptosis: Modulation of Transmissible Cytotoxicity American Journal of Physiology. Lung Cellular and Molecular Physiology. 08, 2020 | Pubmed ID: 32579398 Biventricular Diastolic Dysfunction, Thrombocytopenia, and Red Blood Cell Macrocytosis in Experimental Pulmonary Arterial Hypertension Pulmonary Circulation. Apr-Jun, 2020 | Pubmed ID: 32518619 Pneumonia-induced Endothelial Amyloids Reduce Dendritic Spine Density in Brain Neurons Scientific Reports. 06, 2020 | Pubmed ID: 32518286 Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pneumonia in Critically Ill Patients: An Exploratory Study Toxins. 06, 2020 | Pubmed ID: 32512716 Virulent Pseudomonas Aeruginosa Infection Converts Antimicrobial Amyloids into Cytotoxic Prions FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 07, 2020 | Pubmed ID: 32413239 α-Tocopherol Attenuates the Severity of -induced Pneumonia American Journal of Respiratory Cell and Molecular Biology. 08, 2020 | Pubmed ID: 32243761 A Cancer Amidst Us: the Plexiform Lesion in Pulmonary Arterial Hypertension American Journal of Physiology. Lung Cellular and Molecular Physiology. 06, 2020 | Pubmed ID: 32191119 Unleashing Shear: Role of Intercellular Traction and Cellular Moments in Collective Cell Migration Biochemical and Biophysical Research Communications. 02, 2020 | Pubmed ID: 31879014 Mechanical Signaling in a Pulmonary Microvascular Endothelial Cell Monolayer Biochemical and Biophysical Research Communications. 11, 2019 | Pubmed ID: 31514994 Infection-induced Endothelial Amyloids Impair Memory FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 09, 2019 | Pubmed ID: 31211919 Extrinsic Acidosis Suppresses Glycolysis and Migration While Increasing Network Formation in Pulmonary Microvascular Endothelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. 08, 2019 | Pubmed ID: 31042076 Nosocomial Pneumonia Elicits an Endothelial Proteinopathy: Evidence for a Source of Neurotoxic Amyloids in Critically Ill Patients American Journal of Respiratory and Critical Care Medicine. Oct, 2018 | Pubmed ID: 30280916 The Role of Endothelial Leak in Pulmonary Hypertension (2017 Grover Conference Series) Pulmonary Circulation. Oct-Dec, 2018 | Pubmed ID: 30124139 Carbonic Anhydrase IX is a Critical Determinant of Pulmonary Microvascular Endothelial Cell PH Regulation and Angiogenesis During Acidosis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2018 | Pubmed ID: 29631360 Pulmonary Vascular Dysfunction Secondary to Pulmonary Arterial Hypertension: Insights Gained Through Retrograde Perfusion American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2018 | Pubmed ID: 29345199 Single Cell Cloning Generates Lung Endothelial Colonies with Conserved Growth, Angiogenic, and Bioenergetic Characteristics Pulmonary Circulation. Oct-Dec, 2017 | Pubmed ID: 28841087 Infection Liberates Transmissible, Cytotoxic Prion Amyloids FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 07, 2017 | Pubmed ID: 28314768 The Pseudomonas Aeruginosa Exoenzyme Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant Handbook of Experimental Pharmacology. 2017 | Pubmed ID: 28181005 "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop Journal of the American Heart Association. Nov, 2016 | Pubmed ID: 27815267 Endothelial Hyperpermeability in Severe Pulmonary Arterial Hypertension: Role of Store-operated Calcium Entry American Journal of Physiology. Lung Cellular and Molecular Physiology. 09, 2016 | Pubmed ID: 27422996 Transient Receptor Potential Channel 4 Encodes a Vascular Permeability Defect and High-Frequency Ca(2+) Transients in Severe Pulmonary Arterial Hypertension The American Journal of Pathology. 06, 2016 | Pubmed ID: 27083517 Pseudomonas Aeruginosa Exoenzymes U and Y Induce a Transmissible Endothelial Proteinopathy American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2016 | Pubmed ID: 26637633 Transmembrane Proteoglycans Control Stretch-activated Channels to Set Cytosolic Calcium Levels The Journal of Cell Biology. Sep, 2015 | Pubmed ID: 26391658 Heterogeneity of Pulmonary Endothelial Cyclic Nucleotide Response to Pseudomonas Aeruginosa ExoY Infection American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2015 | Pubmed ID: 26386118 Sodium Entry Through Endothelial Store-operated Calcium Entry Channels: Regulation by Orai1 American Journal of Physiology. Cell Physiology. Feb, 2015 | Pubmed ID: 25428882 A Unique Pulmonary Microvascular Endothelial Cell Niche Revealed by Weibel-Palade Bodies and Griffonia Simplicifolia Pulmonary Circulation. Mar, 2014 | Pubmed ID: 25006426 The Pseudomonas Aeruginosa Exoenzyme Y Impairs Endothelial Cell Proliferation and Vascular Repair Following Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2014 | Pubmed ID: 24705722 Studies on the Resolution of Subcellular Free Calcium Concentrations: a Technological Advance. Focus on "detection of Differentially Regulated Subsarcolemmal Calcium Signals Activated by Vasoactive Agonists in Rat Pulmonary Artery Smooth Muscle Cells" American Journal of Physiology. Cell Physiology. Apr, 2014 | Pubmed ID: 24553184 TRPC4 Inactivation Confers a Survival Benefit in Severe Pulmonary Arterial Hypertension The American Journal of Pathology. Dec, 2013 | Pubmed ID: 24113457 Lactate Dehydrogenase a Expression is Necessary to Sustain Rapid Angiogenesis of Pulmonary Microvascular Endothelium PloS One. 2013 | Pubmed ID: 24086675 Pseudomonas Aeruginosa Exotoxin Y-mediated Tau Hyperphosphorylation Impairs Microtubule Assembly in Pulmonary Microvascular Endothelial Cells PloS One. 2013 | Pubmed ID: 24023939 Pseudomonas Aeruginosa Exotoxin Y is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22637478 Orai1 Determines Calcium Selectivity of an Endogenous TRPC Heterotetramer Channel Circulation Research. May, 2012 | Pubmed ID: 22534489 Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection Journal of Virology. Jan, 2012 | Pubmed ID: 22072765 Studies on the Cell Biology of Interendothelial Cell Gaps American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2012 | Pubmed ID: 21964402 Functional and Molecular Heterogeneity of Pulmonary Endothelial Cells Proceedings of the American Thoracic Society. Nov, 2011 | Pubmed ID: 22052919 Filamin A is a Phosphorylation Target of Membrane but Not Cytosolic Adenylyl Cyclase Activity American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2011 | Pubmed ID: 21478251 Cold Exposure Reveals Two Populations of Microtubules in Pulmonary Endothelia American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2011 | Pubmed ID: 20971804 Critical Role for Lactate Dehydrogenase A in Aerobic Glycolysis That Sustains Pulmonary Microvascular Endothelial Cell Proliferation American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2010 | Pubmed ID: 20675437 Protein Kinase A Phosphorylation of Tau-serine 214 Reorganizes Microtubules and Disrupts the Endothelial Cell Barrier American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2010 | Pubmed ID: 20639351 New Developments in Lung Endothelial Heterogeneity: Von Willebrand Factor, P-selectin, and the Weibel-Palade Body Seminars in Thrombosis and Hemostasis. Apr, 2010 | Pubmed ID: 20490980 Perivascular Fluid Cuffs Decrease Lung Compliance by Increasing Tissue Resistance Critical Care Medicine. Jun, 2010 | Pubmed ID: 20400904 Store-operated Calcium Entry Channels in Pulmonary Endothelium: the Emerging Story of TRPCS and Orai1 Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20204728 Development and Pathology of Pulmonary Hypertension Journal of the American College of Cardiology. Jun, 2009 | Pubmed ID: 19555856 Démontage Adénylcyclase Dépendant Microtubule Adénylyl Solubles Révèle Un Nouveau Mécanisme De Rétraction Des Cellules Endothéliales American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2009 | Pubmed ID: 19395666 Type 5 Phosphodiesterase Expression is a Critical Determinant of the Endothelial Cell Angiogenic Phenotype American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2009 | Pubmed ID: 19028977 Le Cytosquelette D'actine Dans Les Phénotypes Des Cellules Endothéliales Microvascular Research. Jan, 2009 | Pubmed ID: 19028505 TRPing on the Lung Endothelium: Calcium Channels That Regulate Barrier Function Antioxidants & Redox Signaling. Apr, 2009 | Pubmed ID: 18783312 Lung Vascular Cell Heterogeneity: Endothelium, Smooth Muscle, and Fibroblasts Proceedings of the American Thoracic Society. Sep, 2008 | Pubmed ID: 18757318 The Cancer Paradigm of Severe Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. Sep, 2008 | Pubmed ID: 18556624 Spectrin-anchored Phosphodiesterase 4D4 Restricts CAMP from Disrupting Microtubules and Inducing Endothelial Cell Gap Formation Journal of Cell Science. Jan, 2008 | Pubmed ID: 18073242 Heterogeneity of Barrier Function in the Lung Reflects Diversity in Endothelial Cell Junctions Microvascular Research. Apr, 2008 | Pubmed ID: 18068735 Endothélium Microvasculaire Pulmonaire Est Enrichie Avec Des Cellules Progénitrices Qui Exposer Capacité Vasculogène American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2008 | Pubmed ID: 18065657 Hydroxyurea Attenuates Activated Neutrophil-mediated Sickle Erythrocyte Membrane Phosphatidylserine Exposure and Adhesion to Pulmonary Vascular Endothelium American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2008 | Pubmed ID: 17993595 Rôle De La Réglementation De L'Assemblée Nucléosomes Protein-1 Dans Le Phénotype Prolifératif Et Vasculogène De L'endothélium Pulmonaire American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2008 | Pubmed ID: 17981956 Phenotypic Heterogeneity in Lung Capillary and Extra-alveolar Endothelial Cells. Increased Extra-alveolar Endothelial Permeability is Sufficient to Decrease Compliance The Journal of Surgical Research. Nov, 2007 | Pubmed ID: 17950075 Microtubule Motors Regulate ISOC Activation Necessary to Increase Endothelial Cell Permeability The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17921144 Regulation of Endothelial Cell Barrier Function by Store-operated Calcium Entry Microcirculation (New York, N.Y. : 1994). Dec, 2006 | Pubmed ID: 17085429 Activé Molécule D'adhérence Cellulaire Des Leucocytes Est Une Composante De La Jonction Endothéliale Impliquée Dans La Migration Des Monocytes Transendothéliale FEBS Letters. May, 2006 | Pubmed ID: 16650408 Soluble Adenylyl Cyclase Reveals the Significance of CAMP Compartmentation on Pulmonary Microvascular Endothelial Cell Barrier Circulation Research. Mar, 2006 | Pubmed ID: 16469954 Adenylyl and Guanylyl Cyclase Assays Current Protocols in Pharmacology. Oct, 2005 | Pubmed ID: 21953389 Molecular and Cellular Determinants of Lung Endothelial Cell Heterogeneity Chest. Dec, 2005 | Pubmed ID: 16373825 Activation Du Magasin Fonctionnant ISOC Ca2 + Canal Endothéliales Nécessite Une Interaction De La Protéine 4.1 Avec TRPC4 Circulation Research. Nov, 2005 | Pubmed ID: 16254212 Essential Role of a Ca2+-selective, Store-operated Current (ISOC) in Endothelial Cell Permeability: Determinants of the Vascular Leak Site Circulation Research. Apr, 2005 | Pubmed ID: 15790951 Activated Leukocyte Cell Adhesion Molecule in Breast Cancer: Prognostic Indicator Breast Cancer Research : BCR. 2004 | Pubmed ID: 15318930 Stat3 Activity is Required for Centrosome Duplication in Chinese Hamster Ovary Cells The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15294906 Paradoxical CAMP-induced Lung Endothelial Hyperpermeability Revealed by Pseudomonas Aeruginosa ExoY Circulation Research. Jul, 2004 | Pubmed ID: 15192021 Potential Role for Activated Leukocyte Cell Adhesion Molecule and Neural Cadherin in Metastasis to the Lung Microcirculation Chest. May, 2004 | Pubmed ID: 15136474 Structural and Functional Characteristics of Lung Macro- and Microvascular Endothelial Cell Phenotypes Microvascular Research. Mar, 2004 | Pubmed ID: 15020205 Cav3.1 (alpha1G) T-type Ca2+ Channels Mediate Vaso-occlusion of Sickled Erythrocytes in Lung Microcirculation Circulation Research. Aug, 2003 | Pubmed ID: 12869394 On the Endothelial Cell I(SOC) Cell Calcium. May-Jun, 2003 | Pubmed ID: 12765679 Coordinate Regulation of Membrane CAMP by Ca2+-inhibited Adenylyl Cyclase and Phosphodiesterase Activities American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2003 | Pubmed ID: 12471013 Dominant Regulation of Interendothelial Cell Gap Formation by Calcium-inhibited Type 6 Adenylyl Cyclase The Journal of Cell Biology. Jun, 2002 | Pubmed ID: 12082084 Essential Control of an Endothelial Cell ISOC by the Spectrin Membrane Skeleton The Journal of Cell Biology. Sep, 2001 | Pubmed ID: 11564759 Boîte à outils intégrative pour analyser les signaux cellulaires: forces, mouvement, morphologie et fluorescence Alyson Nguyen*1, Keith Battle*2,3, Sunita S. Paudel*2,3, Ningyong Xu2, Jessica Bell3, Linn Ayers3, Cassandra Chapman4, Ajay P. Singh5, Srinivas Palanki6, Thomas Rich3,7, Diego F. Alvarez8, Troy Stevens2,3, Dhananjay T. Tambe3,4,7 1Biomedical Sciences, Pat Capps Covey College of Allied Health Professions, University of South Alabama, 2Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, 3Center for Lung Biology, College of Medicine, University of South Alabama, 4William B. Burnsed Jr. Mechanical, Aerospace, and Biomedical Engineering Department, College of Engineering, University of South Alabama, 5Mitchell Cancer Institute, College of Medicine, University of South Alabama, 6Department of Chemical and Biomedical Engineering, West Virginia University, 7Department of Pharmacology, College of Medicine, University of South Alabama, 8Department of Physiology & Pharmacology, College of Osteopathic Medicine, Sam Houston State University JoVE 63095 Biologia Méthodes pour détecter les cytotoxiques amyloïdes suivant Infection de pulmonaire cellules endothéliales par Pseudomonas aeruginosa Ron Balczon1,4, Michael Francis2,4, Silas Leavesley3,4, Troy Stevens2,4 1Department of Biochemistry and Molecular Biology, University of South Alabama, 2Department of Physiology and Cell Biology, University of South Alabama, 3Department of Chemical and Biomolecular Engineering, University of South Alabama, 4Center for Lung Biology, University of South Alabama JoVE 57447 Immunologia e infezioni
Boîte à outils intégrative pour analyser les signaux cellulaires: forces, mouvement, morphologie et fluorescence Alyson Nguyen*1, Keith Battle*2,3, Sunita S. Paudel*2,3, Ningyong Xu2, Jessica Bell3, Linn Ayers3, Cassandra Chapman4, Ajay P. Singh5, Srinivas Palanki6, Thomas Rich3,7, Diego F. Alvarez8, Troy Stevens2,3, Dhananjay T. Tambe3,4,7 1Biomedical Sciences, Pat Capps Covey College of Allied Health Professions, University of South Alabama, 2Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, 3Center for Lung Biology, College of Medicine, University of South Alabama, 4William B. Burnsed Jr. Mechanical, Aerospace, and Biomedical Engineering Department, College of Engineering, University of South Alabama, 5Mitchell Cancer Institute, College of Medicine, University of South Alabama, 6Department of Chemical and Biomedical Engineering, West Virginia University, 7Department of Pharmacology, College of Medicine, University of South Alabama, 8Department of Physiology & Pharmacology, College of Osteopathic Medicine, Sam Houston State University JoVE 63095 Biologia
Méthodes pour détecter les cytotoxiques amyloïdes suivant Infection de pulmonaire cellules endothéliales par Pseudomonas aeruginosa Ron Balczon1,4, Michael Francis2,4, Silas Leavesley3,4, Troy Stevens2,4 1Department of Biochemistry and Molecular Biology, University of South Alabama, 2Department of Physiology and Cell Biology, University of South Alabama, 3Department of Chemical and Biomolecular Engineering, University of South Alabama, 4Center for Lung Biology, University of South Alabama JoVE 57447 Immunologia e infezioni