V. Wee Yong Biography Publications JoVE Articles V. Wee Yong has not added a biography. If you are V. Wee Yong and would like to personalize this page please email our Author Liaison for assistance. Publications Fibulin-2 is an Extracellular Matrix Inhibitor of Oligodendrocytes Relevant to Multiple Sclerosis The Journal of Clinical Investigation. May, 2024 | Pubmed ID: 38743490 From Progression to Progress: The Future of Multiple Sclerosis Journal of Central Nervous System Disease. 2024 | Pubmed ID: 38711957 The Cerebroprotection and Prospects of FNDC5/irisin in Stroke Neuropharmacology. Aug, 2024 | Pubmed ID: 38705569 LXR Agonism for CNS Diseases: Promises and Challenges Journal of Neuroinflammation. Apr, 2024 | Pubmed ID: 38627787 Genetically Predicted Hypotaurine Levels Mediate the Relationship Between Immune Cells and Intracerebral Hemorrhage International Immunopharmacology. May, 2024 | Pubmed ID: 38608476 Biology of Neurofibrosis with Focus on Multiple Sclerosis Frontiers in Immunology. 2024 | Pubmed ID: 38596673 Adjudin Protects Blood-brain Barrier Integrity and Attenuates Neuroinflammation Following Intracerebral Hemorrhage in Mice International Immunopharmacology. May, 2024 | Pubmed ID: 38565042 Feasibility Study to Assess Lesion Repair in Relapsing-remitting Multiple Sclerosis: A Randomized Controlled Pilot Clinical Trial of Domperidone Add-on Treatment Multiple Sclerosis and Related Disorders. May, 2024 | Pubmed ID: 38461731 Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis International Journal of Molecular Sciences. Jan, 2024 | Pubmed ID: 38279239 Towards Improving the Prognosis of Stroke Through Targeting the Circadian Clock System International Journal of Biological Sciences. 2024 | Pubmed ID: 38169640 Ion Channel Dysregulation Following Intracerebral Hemorrhage Neuroscience Bulletin. Mar, 2024 | Pubmed ID: 37755675 Crosstalk Between Matrix Metalloproteinases and Their Inducer EMMPRIN/CD147: a Promising Therapeutic Target for Intracerebral Hemorrhage Translational Stroke Research. Dec, 2023 | Pubmed ID: 38100014 Prominent Elevation of Extracellular Matrix Molecules in Intracerebral Hemorrhage Frontiers in Molecular Neuroscience. 2023 | Pubmed ID: 38025264 Early Life Stress Aggravates Disease Pathogenesis in Mice with Experimental Autoimmune Encephalomyelitis: Support for a Two-hit Hypothesis of Multiple Sclerosis Etiology Journal of Neuroimmunology. Dec, 2023 | Pubmed ID: 37951203 Anti-oxidant Effects of Cannabidiol Relevant to Intracerebral Hemorrhage Frontiers in Pharmacology. 2023 | Pubmed ID: 37841923 Tolerability of Subcutaneous Ofatumumab with Long-term Exposure in Relapsing Multiple Sclerosis Multiple Sclerosis Journal - Experimental, Translational and Clinical. 2023 | Pubmed ID: 37829441 The Extracellular Matrix As Modifier of Neuroinflammation and Recovery in Ischemic Stroke and Intracerebral Hemorrhage Neurobiology of Disease. Oct, 2023 | Pubmed ID: 37683956 Omarigliptin Inhibits Brain Cell Ferroptosis After Intracerebral Hemorrhage Scientific Reports. Sep, 2023 | Pubmed ID: 37658227 Distinct Characteristics and Severity of Brain Magnetic Resonance Imaging Lesions in Women and Men with Multiple Sclerosis Assessed Using Verified Texture Analysis Measures Frontiers in Neurology. 2023 | Pubmed ID: 37638198 Iron in Multiple Sclerosis - Neuropathology, Immunology, and Real-world Considerations Multiple Sclerosis and Related Disorders. Oct, 2023 | Pubmed ID: 37579645 Omarigliptin Protects the Integrity of the Blood-Brain Barrier After Intracerebral Hemorrhage in Mice Journal of Inflammation Research. 2023 | Pubmed ID: 37342770 Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2023 | Pubmed ID: 37208177 Enhanced Liver X Receptor Signalling Reduces Brain Injury and Promotes Tissue Regeneration Following Experimental Intracerebral Haemorrhage: Roles of Microglia/macrophages Stroke and Vascular Neurology. Dec, 2023 | Pubmed ID: 37137522 Single Cell Analysis of High-Parameter Histology Images Using Histoflow Cytometry Journal of Immunology (Baltimore, Md. : 1950). Jun, 2023 | Pubmed ID: 37133337 The Promise of Niacin in Neurology Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jul, 2023 | Pubmed ID: 37084148 Single-Cell Spatial Analysis Identifies Regulators of Brain Tumor-Initiating Cells Cancer Research. May, 2023 | Pubmed ID: 37067922 Multiple Sclerosis Progression: Time for a New Mechanism-driven Framework The Lancet. Neurology. Jan, 2023 | Pubmed ID: 36410373 Serum Neurofilament-light and Glial Fibrillary Acidic Protein Levels in Hydroxychloroquine-treated Primary Progressive Multiple Sclerosis European Journal of Neurology. Jan, 2023 | Pubmed ID: 36214614 Detecting Monocyte Trafficking in an Animal Model of Glioblastoma Using R* and Quantitative Susceptibility Mapping Cancer Immunology, Immunotherapy : CII. Mar, 2023 | Pubmed ID: 36194288 Obesity in Acute Ischaemic Stroke Patients Treated with Intravenous Thrombolysis Therapy Neurological Research. Sep, 2023 | Pubmed ID: 34112057 Single-cell and Spatial RNA Sequencing Identify Perturbators of Microglial Functions with Aging Nature Aging. Jun, 2022 | Pubmed ID: 37118444 The Important Role of Zinc in Neurological Diseases Biomolecules. Dec, 2022 | Pubmed ID: 36671413 Therapeutic Strategies for Intracerebral Hemorrhage Frontiers in Neurology. 2022 | Pubmed ID: 36408517 Bladder Dysfunction in Experimental Autoimmune Encephalomyelitis Reflects Clinical Severity: A Pilot Study Journal of Neuroimmunology. Nov, 2022 | Pubmed ID: 36209613 Aging Microglia: Old Friends Greet New Enemies Aging. Sep, 2022 | Pubmed ID: 36173626 Extracellular Matrix Metalloproteinase Inducer in Brain Ischemia and Intracerebral Hemorrhage Frontiers in Immunology. 2022 | Pubmed ID: 36119117 Microglia-T Cell Conversations in Brain Cancer Progression Trends in Molecular Medicine. Nov, 2022 | Pubmed ID: 36075812 Neuroprotective Effects of Chlorogenic Acid in a Mouse Model of Intracerebral Hemorrhage Associated with Reduced Extracellular Matrix Metalloproteinase Inducer Biomolecules. Jul, 2022 | Pubmed ID: 35892330 Expression of Antioxidant Enzymes in Lesions of Multiple Sclerosis and Its Models Scientific Reports. Jul, 2022 | Pubmed ID: 35882921 Microglia in Multiple Sclerosis: Protectors Turn Destroyers Neuron. Nov, 2022 | Pubmed ID: 35882229 Minocycline Treatment in Clinically Isolated Syndrome and Serum NfL, GFAP, and Metalloproteinase Levels Multiple Sclerosis (Houndmills, Basingstoke, England). Nov, 2022 | Pubmed ID: 35848622 Neuroprotection by Ozanimod Following Intracerebral Hemorrhage in Mice Frontiers in Molecular Neuroscience. 2022 | Pubmed ID: 35782389 Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage Frontiers in Molecular Neuroscience. 2022 | Pubmed ID: 35782383 Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage Inhibiting Inflammation and Necroptosis Frontiers in Molecular Neuroscience. 2022 | Pubmed ID: 35721316 Thermoregulatory Dynamics Reveal Sex-specific Inflammatory Responses to Experimental Autoimmune Encephalomyelitis in Mice: Implications for Multiple Sclerosis-induced Fatigue in Females Brain, Behavior, & Immunity - Health. Aug, 2022 | Pubmed ID: 35677535 Microglia in Multiple Sclerosis - Pathogenesis and Imaging Current Opinion in Neurology. Jun, 2022 | Pubmed ID: 35674072 EMMPRIN Promotes the Expression of MMP-9 and Exacerbates Neurological Dysfunction in a Mouse Model of Intracerebral Hemorrhage Neurochemical Research. Aug, 2022 | Pubmed ID: 35608790 Versican Promotes T Helper 17 Cytotoxic Inflammation and Impedes Oligodendrocyte Precursor Cell Remyelination Nature Communications. May, 2022 | Pubmed ID: 35508608 Revisiting Minocycline in Intracerebral Hemorrhage: Mechanisms and Clinical Translation Frontiers in Immunology. 2022 | Pubmed ID: 35401553 Oxidized Phospholipids As Novel Mediators of Neurodegeneration Trends in Neurosciences. Jun, 2022 | Pubmed ID: 35393134 Matrix Metalloproteinase-9 As an Important Contributor to the Pathophysiology of Depression Frontiers in Neurology. 2022 | Pubmed ID: 35370878 Oxidative Stress Following Intracerebral Hemorrhage: From Molecular Mechanisms to Therapeutic Targets Frontiers in Immunology. 2022 | Pubmed ID: 35355999 Exercise Training in Multiple Sclerosis The Lancet. Neurology. Apr, 2022 | Pubmed ID: 35305335 Vildagliptin Improves Neurological Function by Inhibiting Apoptosis and Ferroptosis Following Intracerebral Hemorrhage in Mice Neuroscience Letters. Apr, 2022 | Pubmed ID: 35304193 Modes of Brain Cell Death Following Intracerebral Hemorrhage Frontiers in Cellular Neuroscience. 2022 | Pubmed ID: 35185473 A Distinct Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology Cells. Jan, 2022 | Pubmed ID: 35159249 Remyelination Trial Failures: Repercussions of Ignoring Neurorehabilitation and Exercise in Repair Multiple Sclerosis and Related Disorders. Feb, 2022 | Pubmed ID: 35066276 B Cells in Central Nervous System Disease: Diversity, Locations and Pathophysiology Nature Reviews. Immunology. Aug, 2022 | Pubmed ID: 34903877 Quantitative Analysis of Spinal Cord Neuropathology in Experimental Autoimmune Encephalomyelitis Journal of Neuroimmunology. Jan, 2022 | Pubmed ID: 34823122 Mechanism-based Criteria to Improve Therapeutic Outcomes in Progressive Multiple Sclerosis Nature Reviews. Neurology. Jan, 2022 | Pubmed ID: 34732831 Exercise and the Brain in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jul, 2022 | Pubmed ID: 33124511 Gap Junctions and Hemichannels Composed of Connexins and Pannexins Mediate the Secondary Brain Injury Following Intracerebral Hemorrhage Biology. Dec, 2021 | Pubmed ID: 35053024 PD-1 Independent of PD-L1 Ligation Promotes Glioblastoma Growth Through the NFκB Pathway Science Advances. Nov, 2021 | Pubmed ID: 34739319 The Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis (CanProCo): Rationale, Aims, and Study Design BMC Neurology. Oct, 2021 | Pubmed ID: 34706670 MedXercise: a Promising Strategy to Promote Remyelination Current Opinion in Pharmacology. Dec, 2021 | Pubmed ID: 34688996 Central Nervous System Tissue Regeneration After Intracerebral Hemorrhage: The Next Frontier Cells. Sep, 2021 | Pubmed ID: 34685493 Neuroprotection of Minocycline by Inhibition of Extracellular Matrix Metalloproteinase Inducer Expression Following Intracerebral Hemorrhage in Mice Neuroscience Letters. Nov, 2021 | Pubmed ID: 34666120 Studying the Microglia Response to Oxidized Phosphatidylcholine in Primary Mouse Neuron Culture and Mouse Spinal Cord STAR Protocols. Dec, 2021 | Pubmed ID: 34622221 Hydroxychloroquine for Primary Progressive Multiple Sclerosis Annals of Neurology. Dec, 2021 | Pubmed ID: 34590328 Does Chronic Jet Lag Increase Risk of Cancer? Aging. Sep, 2021 | Pubmed ID: 34586082 Susceptibility Weighted Imaging Detects Prominent Veins That Precede or Coincide with Maximal Motor Disability in a Model of Multiple Sclerosis: A Pilot Study Multiple Sclerosis and Related Disorders. Sep, 2021 | Pubmed ID: 34243102 An X-ray for Myelin Trends in Neurosciences. Aug, 2021 | Pubmed ID: 34148671 The Combination of Deferoxamine and Minocycline Strengthens Neuroprotective Effect on Acute Intracerebral Hemorrhage in Rats Neurological Research. Oct, 2021 | Pubmed ID: 34107863 Repurposing Domperidone in Secondary Progressive Multiple Sclerosis: A Simon 2-Stage Phase 2 Futility Trial Neurology. May, 2021 | Pubmed ID: 34038379 The Extracellular Matrix As Modifier of Neuroinflammation and Remyelination in Multiple Sclerosis Brain : a Journal of Neurology. Aug, 2021 | Pubmed ID: 33889940 Exercise Rapidly Alters Proteomes in Mice Following Spinal Cord Demyelination Scientific Reports. Mar, 2021 | Pubmed ID: 33790323 Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2021 | Pubmed ID: 33712513 Fibrinogen in the Glioblastoma Microenvironment Contributes to the Invasiveness of Brain Tumor-initiating Cells Brain Pathology (Zurich, Switzerland). Sep, 2021 | Pubmed ID: 33694259 Circadian Disruption in Mice Through Chronic Jet Lag-like Conditions Modulates Molecular Profiles of Cancer in Nucleus Accumbens and Prefrontal Cortex Carcinogenesis. Jun, 2021 | Pubmed ID: 33608694 Oxidized Phosphatidylcholines Found in Multiple Sclerosis Lesions Mediate Neurodegeneration and Are Neutralized by Microglia Nature Neuroscience. Apr, 2021 | Pubmed ID: 33603230 Multimodal Peripheral Fluid Biomarker Analysis in Clinically Isolated Syndrome and Early Multiple Sclerosis Multiple Sclerosis and Related Disorders. May, 2021 | Pubmed ID: 33581614 Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2021 | Pubmed ID: 33410109 Neuregulin-1 Beta 1 is Implicated in Pathogenesis of Multiple Sclerosis Brain : a Journal of Neurology. Feb, 2021 | Pubmed ID: 33313801 Metabolic Needs of Brain-infiltrating Leukocytes and Microglia in Multiple Sclerosis Journal of Neurochemistry. Jul, 2021 | Pubmed ID: 33025576 Intracerebral Haemorrhage: from Clinical Settings to Animal Models Stroke and Vascular Neurology. Dec, 2020 | Pubmed ID: 33376200 Neuroinflammation in Intracerebral Haemorrhage: Immunotherapies with Potential for Translation The Lancet. Neurology. Dec, 2020 | Pubmed ID: 33212054 Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic Medication Indapamide The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2020 | Pubmed ID: 33060175 Glioma-derived IL-33 Orchestrates an Inflammatory Brain Tumor Microenvironment That Accelerates Glioma Progression Nature Communications. Oct, 2020 | Pubmed ID: 33020472 Beyond Barrier Functions: Roles of Pericytes in Homeostasis and Regulation of Neuroinflammation Journal of Neuroscience Research. Dec, 2020 | Pubmed ID: 32815569 Author Correction: Single-cell RNA-seq Reveals That Glioblastoma Recapitulates a Normal Neurodevelopmental Hierarchy Nature Communications. Aug, 2020 | Pubmed ID: 32769982 The Glycosyltransferase EXTL2 Promotes Proteoglycan Deposition and Injurious Neuroinflammation Following Demyelination Journal of Neuroinflammation. Jul, 2020 | Pubmed ID: 32703234 Control of Brain Tumor Growth by Reactivating Myeloid Cells with Niacin Science Translational Medicine. Apr, 2020 | Pubmed ID: 32238578 Correction To: Niacin-mediated Rejuvenation of Macrophage/microglia Enhances Remyelination of the Aging Central Nervous System Acta Neuropathologica. May, 2020 | Pubmed ID: 32211925 Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes Frontiers in Immunology. 2020 | Pubmed ID: 32153581 Niacin-mediated Rejuvenation of Macrophage/microglia Enhances Remyelination of the Aging Central Nervous System Acta Neuropathologica. May, 2020 | Pubmed ID: 32030468 Microglia Response Following Acute Demyelination is Heterogeneous and Limits Infiltrating Macrophage Dispersion Science Advances. Jan, 2020 | Pubmed ID: 31998844 Microglia and Macrophage Phenotypes in Intracerebral Haemorrhage Injury: Therapeutic Opportunities Brain : a Journal of Neurology. May, 2020 | Pubmed ID: 31919518 2-arachidonoylglycerol Reduces Chondroitin Sulphate Proteoglycan Production by Astrocytes and Enhances Oligodendrocyte Differentiation Under Inhibitory Conditions Glia. Jun, 2020 | Pubmed ID: 31894889 Exercise in Multiple Sclerosis and Its Models: Focus on the Central Nervous System Outcomes Journal of Neuroscience Research. Mar, 2020 | Pubmed ID: 31486115 Biomarkers of Intestinal Barrier Function in Multiple Sclerosis Are Associated with Disease Activity Multiple Sclerosis (Houndmills, Basingstoke, England). Oct, 2020 | Pubmed ID: 31317818 When Encephalitogenic T Cells Collaborate with Microglia in Multiple Sclerosis Nature Reviews. Neurology. Dec, 2019 | Pubmed ID: 31527807 Targeting the Chondroitin Sulfate Proteoglycans: Evaluating Fluorinated Glucosamines and Xylosides in Screens Pertinent to Multiple Sclerosis ACS Central Science. Jul, 2019 | Pubmed ID: 31404231 Progressive Multiple Sclerosis: from Pathophysiology to Therapeutic Strategies Nature Reviews. Drug Discovery. 12, 2019 | Pubmed ID: 31399729 Central Nervous System Targeted Autoimmunity Causes Regional Atrophy: a 9.4T MRI Study of the EAE Mouse Model of Multiple Sclerosis Scientific Reports. Jun, 2019 | Pubmed ID: 31186441 Domperidone-induced Elevation of Serum Prolactin Levels and Immune Response in Multiple Sclerosis Journal of Neuroimmunology. Sep, 2019 | Pubmed ID: 31174092 Differential Microglia and Macrophage Profiles in Human IDH-mutant and -wild Type Glioblastoma Oncotarget. May, 2019 | Pubmed ID: 31139325 Enhanced Glycolytic Metabolism Supports Transmigration of Brain-infiltrating Macrophages in Multiple Sclerosis The Journal of Clinical Investigation. May, 2019 | Pubmed ID: 31112527 The Benefits of Neuroinflammation for the Repair of the Injured Central Nervous System Cellular & Molecular Immunology. Jun, 2019 | Pubmed ID: 30874626 Efficacy of Minocycline in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Rodent and Clinical Studies Frontiers in Neurology. 2018 | Pubmed ID: 30619060 Microglia Induces Gas1 Expression in Human Brain Tumor-initiating Cells to Reduce Tumorigenecity Scientific Reports. Oct, 2018 | Pubmed ID: 30327548 Focus on the Gut-brain Axis: Multiple Sclerosis, the Intestinal Barrier and the Microbiome World Journal of Gastroenterology. Oct, 2018 | Pubmed ID: 30310254 Brain Tumor-initiating Cells Export Tenascin-C Associated with Exosomes to Suppress T Cell Activity Oncoimmunology. 2018 | Pubmed ID: 30288344 Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α Cell Reports. Sep, 2018 | Pubmed ID: 30232000 Cerebrospinal Fluid Biomarkers in Human Spinal Cord Injury from a Phase II Minocycline Trial Journal of Neurotrauma. Aug, 2018 | Pubmed ID: 30074872 Expanding the Potential Therapeutic Options for Remote Ischemic Preconditioning: Use in Multiple Sclerosis Frontiers in Neurology. 2018 | Pubmed ID: 29971043 MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging Magnetic Resonance Insights. 2018 | Pubmed ID: 29780249 Pro-inflammatory Roles of Chondroitin Sulfate Proteoglycans in Disorders of the Central Nervous System Matrix Biology : Journal of the International Society for Matrix Biology. Apr, 2018 | Pubmed ID: 29702175 The Extracellular Matrix: Focus on Oligodendrocyte Biology and Targeting CSPGs for Remyelination Therapies Glia. Sep, 2018 | Pubmed ID: 29603376 Chondroitin Sulfate Proteoglycans As Novel Drivers of Leucocyte Infiltration in Multiple Sclerosis Brain : a Journal of Neurology. Apr, 2018 | Pubmed ID: 29506186 Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized by Live Multiphoton Imaging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2018 | Pubmed ID: 29363580 Mechanisms of Lysophosphatidylcholine-induced Demyelination: A Primary Lipid Disrupting Myelinopathy Glia. Feb, 2018 | Pubmed ID: 29068088 Unexpected Additive Effects of Minocycline and Hydroxychloroquine in Models of Multiple Sclerosis: Prospective Combination Treatment for Progressive Disease? Multiple Sclerosis (Houndmills, Basingstoke, England). 10, 2018 | Pubmed ID: 28857721 Systematic Screening of Generic Drugs for Progressive Multiple Sclerosis Identifies Clomipramine As a Promising Therapeutic Nature Communications. Dec, 2017 | Pubmed ID: 29259169 Remyelination Therapies: a New Direction and Challenge in Multiple Sclerosis Nature Reviews. Drug Discovery. Sep, 2017 | Pubmed ID: 28685761 Stop Inflammation and You Stop Neurodegeneration in MS - YES Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2017 | Pubmed ID: 28463075 Gestational Bisphenol-A Exposure Lowers the Threshold for Autoimmunity in a Model of Multiple Sclerosis Proceedings of the National Academy of Sciences of the United States of America. 05, 2017 | Pubmed ID: 28439012 Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating Cells Cancer Research. 06, 2017 | Pubmed ID: 28416488 Glioblastoma-associated Microglia and Macrophages: Targets for Therapies to Improve Prognosis Brain : a Journal of Neurology. Jun, 2017 | Pubmed ID: 28334886 Unique Spectral Signatures of the Nucleic Acid Dye Acridine Orange Can Distinguish Cell Death by Apoptosis and Necroptosis The Journal of Cell Biology. Apr, 2017 | Pubmed ID: 28264914 T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints Trends in Immunology. 02, 2017 | Pubmed ID: 27964820 MRI Monitoring of Monocytes to Detect Immune Stimulating Treatment Response in Brain Tumor Neuro-oncology. Mar, 2017 | Pubmed ID: 27571884 Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis Journal of Immunology (Baltimore, Md. : 1950). 11, 2016 | Pubmed ID: 27733550 Evaluating Soluble EMMPRIN As a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid PloS One. 2016 | Pubmed ID: 27727297 Myeloid Cells - Targets of Medication in Multiple Sclerosis Nature Reviews. Neurology. Sep, 2016 | Pubmed ID: 27514287 Regenerative Capacity of Macrophages for Remyelination Frontiers in Cell and Developmental Biology. 2016 | Pubmed ID: 27243011 An Inhibitor of Chondroitin Sulfate Proteoglycan Synthesis Promotes Central Nervous System Remyelination Nature Communications. Apr, 2016 | Pubmed ID: 27115988 Demyelination Induces Transport of Ribosome-containing Vesicles from Glia to Axons: Evidence from Animal Models and MS Patient Brains Molecular Biology Reports. Jun, 2016 | Pubmed ID: 27115494 Activity-Dependent and Experience-Driven Myelination Provide New Directions for the Management of Multiple Sclerosis Trends in Neurosciences. 06, 2016 | Pubmed ID: 27113322 Immunosenescence of Microglia and Macrophages: Impact on the Ageing Central Nervous System Brain : a Journal of Neurology. Mar, 2016 | Pubmed ID: 26912633 Expanding Antigen-specific Regulatory Networks to Treat Autoimmunity Nature. Feb, 2016 | Pubmed ID: 26886799 Monocytes Increase Human Cardiac Myofibroblast-mediated Extracellular Matrix Remodeling Through TGF-β1 American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2016 | Pubmed ID: 26801303 Multi-scale MRI Spectrum Detects Differences in Myelin Integrity Between MS Lesion Types Multiple Sclerosis (Houndmills, Basingstoke, England). Oct, 2016 | Pubmed ID: 26754802 1,25-Dihydroxyvitamin D3 Protects Against Immune-Mediated Killing of Neurons in Culture and in Experimental Autoimmune Encephalomyelitis PloS One. 2015 | Pubmed ID: 26679341 Fluorescent Phosphorus Dendrimer As a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury Macromolecular Bioscience. Nov, 2015 | Pubmed ID: 26175127 Detecting Deoxyhemoglobin in Spinal Cord Vasculature of the Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis Using Susceptibility MRI and Hyperoxygenation PloS One. 2015 | Pubmed ID: 25992667 The Role of EMMPRIN in T Cell Biology and Immunological Diseases Journal of Leukocyte Biology. Jul, 2015 | Pubmed ID: 25977287 Prolactin in Combination with Interferon-β Reduces Disease Severity in an Animal Model of Multiple Sclerosis Journal of Neuroinflammation. Mar, 2015 | Pubmed ID: 25889599 Inefficient Clearance of Myelin Debris by Microglia Impairs Remyelinating Processes The Journal of Experimental Medicine. Mar, 2015 | Pubmed ID: 25779633 The Promise of Futility Trials in Neurological Diseases Nature Reviews. Neurology. Mar, 2015 | Pubmed ID: 25776824 ADAM-9 is a Novel Mediator of Tenascin-C-stimulated Invasiveness of Brain Tumor-initiating Cells Neuro-oncology. Feb, 2015 | Pubmed ID: 25646025 EMMPRIN, an Upstream Regulator of MMPs, in CNS Biology Matrix Biology : Journal of the International Society for Matrix Biology. Jan, 2015 | Pubmed ID: 25644103 Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-stimulating Factor Promotes Remyelination The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2015 | Pubmed ID: 25609628 Serum Neurofilament Light Chain is a Biomarker of Human Spinal Cord Injury Severity and Outcome Journal of Neurology, Neurosurgery, and Psychiatry. Mar, 2015 | Pubmed ID: 24935984 Laquinimod Reduces Neuroaxonal Injury Through Inhibiting Microglial Activation Annals of Clinical and Translational Neurology. Jun, 2014 | Pubmed ID: 25356411 The Battle for the Brain: Brain Tumor-initiating Cells Vs. Microglia/macrophages Oncoimmunology. 2014 | Pubmed ID: 25340004 Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus Cancer Research. Dec, 2014 | Pubmed ID: 25336188 Changes in Tissue Directionality Reflect Differences in Myelin Content After Demyelination in Mice Spinal Cords Journal of Structural Biology. Nov, 2014 | Pubmed ID: 25281497 Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Aug, 2014 | Pubmed ID: 25084178 Iron in Multiple Sclerosis: Roles in Neurodegeneration and Repair Nature Reviews. Neurology. Aug, 2014 | Pubmed ID: 25002107 Understanding Disease Processes in Multiple Sclerosis Through Magnetic Resonance Imaging Studies in Animal Models NeuroImage. Clinical. 2014 | Pubmed ID: 24936425 Patrolling Monocytes Play a Critical Role in CX3CR1-mediated Neuroprotection During Excitotoxicity Brain Structure & Function. Apr, 2014 | Pubmed ID: 24706067 Remyelination After Spinal Cord Injury: is It a Target for Repair? Progress in Neurobiology. Jun, 2014 | Pubmed ID: 24582777 Toll-like Receptor 2-mediated Alternative Activation of Microglia is Protective After Spinal Cord Injury Brain : a Journal of Neurology. Mar, 2014 | Pubmed ID: 24369381 Therapeutic Activation of Macrophages and Microglia to Suppress Brain Tumor-initiating Cells Nature Neuroscience. Jan, 2014 | Pubmed ID: 24316889 Using Magnetic Resonance Imaging in Animal Models to Guide Drug Development in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jan, 2014 | Pubmed ID: 24263386 Active Inflammation Increases the Heterogeneity of MRI Texture in Mice with Relapsing Experimental Allergic Encephalomyelitis Magnetic Resonance Imaging. Feb, 2014 | Pubmed ID: 24246391 High-resolution Fluorescence Microscopy of Myelin Without Exogenous Probes NeuroImage. Feb, 2014 | Pubmed ID: 24188810 Therapeutic Activation of Macrophages and Microglia to Suppress Brain Tumor-initiating Cells Annals of Neurosciences. Oct, 2013 | Pubmed ID: 25206040 The Regulation of Reactive Changes Around Multiple Sclerosis Lesions by Phosphorylated Signal Transducer and Activator of Transcription Journal of Neuropathology and Experimental Neurology. Dec, 2013 | Pubmed ID: 24226263 Screening for Inhibitors of Microglia to Reduce Neuroinflammation CNS & Neurological Disorders Drug Targets. Sep, 2013 | Pubmed ID: 24047520 Pathophysiology of the Brain Extracellular Matrix: a New Target for Remyelination Nature Reviews. Neuroscience. Oct, 2013 | Pubmed ID: 23985834 Treatment Trials in Progressive MS--current Challenges and Future Directions Nature Reviews. Neurology. Sep, 2013 | Pubmed ID: 23897406 Reduction of Microglial Activity in a Model of Multiple Sclerosis by Dipyridamole Journal of Neuroinflammation. 2013 | Pubmed ID: 23866809 The Benefits and Detriments of Macrophages/microglia in Models of Multiple Sclerosis Clinical & Developmental Immunology. 2013 | Pubmed ID: 23840244 Association Between the Cerebral Inflammatory and Matrix Metalloproteinase Responses After Severe Traumatic Brain Injury in Humans Journal of Neurotrauma. Oct, 2013 | Pubmed ID: 23799281 Resistance to Oncolytic Myxoma Virus Therapy in Nf1(-/-)/trp53(-/-) Syngeneic Mouse Glioma Models is Independent of Anti-viral Type-I Interferon PloS One. 2013 | Pubmed ID: 23762429 A Prospective Evaluation of the Temporal Matrix Metalloproteinase Response After Severe Traumatic Brain Injury in Humans Journal of Neurotrauma. Oct, 2013 | Pubmed ID: 23725031 Extracellular Matrix Metalloproteinase Inducer Shows Active Perivascular Cuffs in Multiple Sclerosis Brain : a Journal of Neurology. Jun, 2013 | Pubmed ID: 23687119 Overcoming Neurite-inhibitory Chondroitin Sulfate Proteoglycans in the Astrocyte Matrix Glia. Jun, 2013 | Pubmed ID: 23554135 Reply: To PMID 23034914 Annals of Neurology. Feb, 2013 | Pubmed ID: 23424070 Environmental Factors and Their Regulation of Immunity in Multiple Sclerosis Journal of the Neurological Sciences. Jan, 2013 | Pubmed ID: 23154080 Review: Endocrine Disrupting Chemicals and Immune Responses: a Focus on Bisphenol-A and Its Potential Mechanisms Molecular Immunology. Apr, 2013 | Pubmed ID: 23123408 Remyelination Therapy for Multiple Sclerosis Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2013 | Pubmed ID: 23070731 Susceptibility-weighted Imaging in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Indicates Elevated Deoxyhemoglobin, Iron Deposition and Demyelination Multiple Sclerosis (Houndmills, Basingstoke, England). May, 2013 | Pubmed ID: 23027879 Prolactin in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jan, 2013 | Pubmed ID: 22933621 Cortical Remyelination: a New Target for Repair Therapies in Multiple Sclerosis Annals of Neurology. Dec, 2012 | Pubmed ID: 23076662 Chondroitin Sulfate Proteoglycans in Demyelinated Lesions Impair Remyelination Annals of Neurology. Sep, 2012 | Pubmed ID: 23034914 Immune Cell Infiltrates in Atypical Teratoid/rhabdoid Tumors The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Sep, 2012 | Pubmed ID: 22931701 Kinetics of Proinflammatory Monocytes in a Model of Multiple Sclerosis and Its Perturbation by Laquinimod The American Journal of Pathology. Aug, 2012 | Pubmed ID: 22749771 Results of a Phase II Placebo-controlled Randomized Trial of Minocycline in Acute Spinal Cord Injury Brain : a Journal of Neurology. Apr, 2012 | Pubmed ID: 22505632 Lipocalin 2 is a Novel Immune Mediator of Experimental Autoimmune Encephalomyelitis Pathogenesis and is Modulated in Multiple Sclerosis Glia. Jul, 2012 | Pubmed ID: 22499213 A Novel Anti-EMMPRIN Function-blocking Antibody Reduces T Cell Proliferation and Neurotoxicity: Relevance to Multiple Sclerosis Journal of Neuroinflammation. 2012 | Pubmed ID: 22480370 A Dialog Between Glioma and Microglia That Promotes Tumor Invasiveness Through the CCL2/CCR2/interleukin-6 Axis Carcinogenesis. Feb, 2012 | Pubmed ID: 22159219 Chondroitin Sulphate Proteoglycans: Extracellular Matrix Proteins That Regulate Immunity of the Central Nervous System Autoimmunity Reviews. Oct, 2011 | Pubmed ID: 21664302 The Good, the Bad and the Ugly. Macrophages/microglia with a Focus on Myelin Repair Frontiers in Bioscience (Scholar Edition). Jun, 2011 | Pubmed ID: 21622236 Predominance of Th2 Polarization by Vitamin D Through a STAT6-dependent Mechanism Journal of Neuroinflammation. May, 2011 | Pubmed ID: 21605467 Analysis of the Mitochondrial Proteome in Multiple Sclerosis Cortex Biochimica Et Biophysica Acta. May, 2011 | Pubmed ID: 21295140 EMMPRIN: a Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011 | Pubmed ID: 21228176 The Many Faces of EMMPRIN - Roles in Neuroinflammation Biochimica Et Biophysica Acta. Feb, 2011 | Pubmed ID: 20674741 [Promoting Remyelination by Reducing an Inhibitory Microenvironment] Rinsho Shinkeigaku = Clinical Neurology. Nov, 2010 | Pubmed ID: 21921479 Cleavage of Osteopontin by Matrix Metalloproteinase-12 Modulates Experimental Autoimmune Encephalomyelitis Disease in C57BL/6 Mice The American Journal of Pathology. Sep, 2010 | Pubmed ID: 20651245 Neuroinflammation and Demyelination in Multiple Sclerosis After Allogeneic Hematopoietic Stem Cell Transplantation Archives of Neurology. Jun, 2010 | Pubmed ID: 20558390 Reduction of PrP(C) in Human Cerebrospinal Fluid After Spinal Cord Injury Prion. 2010 | Pubmed ID: 20418657 Normal Human Monocytes Exposed to Glioma Cells Acquire Myeloid-derived Suppressor Cell-like Properties Neuro-oncology. Apr, 2010 | Pubmed ID: 20308313 Improving Outcomes of Neuroprotection by Minocycline: Guides from Cell Culture and Intracerebral Hemorrhage in Mice The American Journal of Pathology. Mar, 2010 | Pubmed ID: 20110416 The Interplay Between the Immune and Central Nervous Systems in Neuronal Injury Neurology. Jan, 2010 | Pubmed ID: 20038767 Reduction of Protein Kinase C Delta Attenuates Tenascin-C Stimulated Glioma Invasion in Three-dimensional Matrix Carcinogenesis. Feb, 2010 | Pubmed ID: 19965895 Taking Advantage of the Systemic Immune System to Cure Brain Diseases Neuron. Oct, 2009 | Pubmed ID: 19840549 Promoting Oligodendrogenesis and Myelin Repair Using the Multiple Sclerosis Medication Glatiramer Acetate Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19815532 Multiexponential T2 and Magnetization Transfer MRI of Demyelination and Remyelination in Murine Spinal Cord NeuroImage. May, 2009 | Pubmed ID: 19349232 Matrix Metalloproteinase-12 Deficiency Worsens Relapsing-remitting Experimental Autoimmune Encephalomyelitis in Association with Cytokine and Chemokine Dysregulation The American Journal of Pathology. Mar, 2009 | Pubmed ID: 19218336 Depletion of Ly6G/Gr-1 Leukocytes After Spinal Cord Injury in Mice Alters Wound Healing and Worsens Neurological Outcome The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2009 | Pubmed ID: 19158301 Targeting MMPs in Acute and Chronic Neurological Conditions Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2007 | Pubmed ID: 17920539 White Matter Plasticity and Enhanced Remyelination in the Maternal CNS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2007 | Pubmed ID: 17314279 Myelin Formation During Development of the CNS is Delayed in Matrix Metalloproteinase-9 and -12 Null Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2006 | Pubmed ID: 16495447 The Expression of Matrix Metalloproteinase-12 by Oligodendrocytes Regulates Their Maturation and Morphological Differentiation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15342725 P2X7-like Receptor Activation in Astrocytes Increases Chemokine Monocyte Chemoattractant Protein-1 Expression Via Mitogen-activated Protein Kinase The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2001 | Pubmed ID: 11549724 Metalloproteinases in Biology and Pathology of the Nervous System Nature Reviews. Neuroscience. Jul, 2001 | Pubmed ID: 11433375 Involvement of P21(Waf1/Cip1) in Protein Kinase C Alpha-induced Cell Cycle Progression Molecular and Cellular Biology. Jul, 2000 | Pubmed ID: 10848585 Matrix Metalloproteinase-9/gelatinase B is Required for Process Outgrowth by Oligodendrocytes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 1999 | Pubmed ID: 10493747 Generating and Analyzing High-Parameter Histology Images with Histoflow Cytometry JoVE 66889 Neuroscienze Experimentell Demyelinisering och remyelinisering av murina ryggmärgs genom Focal Injektion av Lysolecitin Michael B. Keough1, Samuel K. Jensen1, V. Wee Yong1,2 1Department of Clinical Neurosciences, Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology, Hotchkiss Brain Institute at University of Calgary Neuroscienze
Generating and Analyzing High-Parameter Histology Images with Histoflow Cytometry JoVE 66889 Neuroscienze
Experimentell Demyelinisering och remyelinisering av murina ryggmärgs genom Focal Injektion av Lysolecitin Michael B. Keough1, Samuel K. Jensen1, V. Wee Yong1,2 1Department of Clinical Neurosciences, Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology, Hotchkiss Brain Institute at University of Calgary Neuroscienze