Val J. Watts Department of Medicinal Chemistry and Molecular Pharmacology Purdue University Biography Publications Institution JoVE Articles Val J. Watts has not added a biography. If you are Val J. Watts and would like to personalize this page please email our Author Liaison for assistance. Publications Development of a High-throughput Screening Paradigm for the Discovery of Small-molecule Modulators of Adenylyl Cyclase: Identification of an Adenylyl Cyclase 2 Inhibitor The Journal of Pharmacology and Experimental Therapeutics. Nov, 2013 | Pubmed ID: 24008337 Cell-type Specific Increases in Female Hamster Nucleus Accumbens Spine Density Following Female Sexual Experience Brain Structure & Function. Aug, 2013 | Pubmed ID: 23934655 Differential Effects of AGS3 Expression on D(2L) Dopamine Receptor-mediated Adenylyl Cyclase Signaling Cellular and Molecular Neurobiology. May, 2013 | Pubmed ID: 23504261 Bimolecular Fluorescence Complementation Analysis of G Protein-coupled Receptor Dimerization in Living Cells Methods in Enzymology. 2013 | Pubmed ID: 23351744 Discovery of Antagonists of Tick Dopamine Receptors Via Chemical Library Screening and Comparative Pharmacological Analyses Insect Biochemistry and Molecular Biology. Nov, 2012 | Pubmed ID: 23213654 Identification of a 2-phenyl-substituted Octahydrobenzo[f]quinoline As a Dopamine D₃ Receptor-selective Full Agonist Ligand Bioorganic & Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23018094 Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly Journal of Signal Transduction. 2012 | Pubmed ID: 22523680 Ligand-specific Roles for Transmembrane 5 Serine Residues in the Binding and Efficacy of Dopamine D(1) Receptor Catechol Agonists Molecular Pharmacology. May, 2012 | Pubmed ID: 22334593 A "genome-to-lead" Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes Aegypti D(1)-like Dopamine Receptors PLoS Neglected Tropical Diseases. Jan, 2012 | Pubmed ID: 22292096 Comparison of the D₁ Dopamine Full Agonists, Dihydrexidine and Doxanthrine, in the 6-OHDA Rat Model of Parkinson's Disease Psychopharmacology. Jul, 2012 | Pubmed ID: 22222862 Analogues of Doxanthrine Reveal Differences Between the Dopamine D1 Receptor Binding Properties of Chromanoisoquinolines and Hexahydrobenzo[a]phenanthridines European Journal of Medicinal Chemistry. Feb, 2012 | Pubmed ID: 22204903 Assessment of Dopamine D₁ Receptor Affinity and Efficacy of Three Tetracyclic Conformationally-restricted Analogs of SKF38393 Bioorganic & Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21862338 Probing the Steric Space at the Floor of the D1 Dopamine Receptor Orthosteric Binding Domain: 7α-, 7β-, 8α-, and 8β-methyl Substituted Dihydrexidine Analogues Journal of Medicinal Chemistry. Aug, 2011 | Pubmed ID: 21714510 Mapping the Catechol Binding Site in Dopamine D₁ Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues ChemMedChem. Jun, 2011 | Pubmed ID: 21538900 Molecular and Pharmacological Characterization of Two D(1)-like Dopamine Receptors in the Lyme Disease Vector, Ixodes Scapularis Insect Biochemistry and Molecular Biology. Aug, 2011 | Pubmed ID: 21457782 Fluorescent Protein Complementation Assays: New Tools to Study G Protein-coupled Receptor Oligomerization and GPCR-mediated Signaling Molecular and Cellular Endocrinology. Jan, 2011 | Pubmed ID: 20654687 Facile Synthesis of Octahydrobenzo[h]isoquinolines: Novel and Highly Potent D1 Dopamine Agonists Bioorganic & Medicinal Chemistry. Sep, 2010 | Pubmed ID: 20709559 Visualization of G Protein-coupled Receptor (GPCR) Interactions in Living Cells Using Bimolecular Fluorescence Complementation (BiFC) Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [et Al.]. Apr, 2010 | Pubmed ID: 20373507 Ligand-induced Regulation and Localization of Cannabinoid CB1 and Dopamine D2L Receptor Heterodimers The Journal of Pharmacology and Experimental Therapeutics. Mar, 2010 | Pubmed ID: 20016021 The Intracellular II-III Loops of Cav1.2 and Cav1.3 Uncouple L-type Voltage-gated Ca2+ Channels from Glucagon-like Peptide-1 Potentiation of Insulin Secretion in INS-1 Cells Via Displacement from Lipid Rafts The Journal of Pharmacology and Experimental Therapeutics. Jul, 2009 | Pubmed ID: 19351867 Fluorescent and Bioluminescent Protein-fragment Complementation Assays in the Study of G Protein-coupled Receptor Oligomerization and Signaling Molecular Pharmacology. Apr, 2009 | Pubmed ID: 19141658 Comparison of the Enantiomers of (+/-)-doxanthrine, a High Efficacy Full Dopamine D(1) Receptor Agonist, and a Reversal of Enantioselectivity at D(1) Versus Alpha(2C) Adrenergic Receptors European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. Feb, 2009 | Pubmed ID: 19028082 Adenosine A(2A) Receptors Assemble into Higher-order Oligomers at the Plasma Membrane FEBS Letters. Dec, 2008 | Pubmed ID: 19013155 A Point Mutation to Galphai Selectively Blocks GoLoco Motif Binding: Direct Evidence for Galpha.GoLoco Complexes in Mitotic Spindle Dynamics The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18984596 Ligand-dependent Oligomerization of Dopamine D(2) and Adenosine A(2A) Receptors in Living Neuronal Cells Molecular Pharmacology. Sep, 2008 | Pubmed ID: 18524886 Adenylyl Cyclase 5: a New Clue in the Search for the "fountain of Youth"? Science's STKE : Signal Transduction Knowledge Environment. Nov, 2007 | Pubmed ID: 18029912 Adenylyl Cyclase Isoforms As Novel Therapeutic Targets: an Exciting Example of Excitotoxicity Neuroprotection Molecular Interventions. Apr, 2007 | Pubmed ID: 17468386 Trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: Synthesis, Resolution, and Preliminary Pharmacological Characterization of a New Dopamine D1 Receptor Full Agonist Journal of Medicinal Chemistry. Nov, 2006 | Pubmed ID: 17154515 WAY-100635 is a Potent Dopamine D4 Receptor Agonist Psychopharmacology. Oct, 2006 | Pubmed ID: 16915381 Repeated Quinpirole Treatments Produce Neurochemical Sensitization and Associated Behavioral Changes in Female Hamsters Psychopharmacology. Sep, 2006 | Pubmed ID: 16850118 Regulatory Properties of Adenylate Cyclases Type 5 and 6: A Progress Report European Journal of Pharmacology. Mar, 2006 | Pubmed ID: 16527269 Dexamethasone-induced Ras Protein 1 Negatively Regulates Protein Kinase C Delta: Implications for Adenylyl Cyclase 2 Signaling Molecular Pharmacology. May, 2006 | Pubmed ID: 16489124 D2 Dopamine Receptor-induced Sensitization of Adenylyl Cyclase Type 1 is G Alpha(s) Independent Neuropharmacology. Apr, 2006 | Pubmed ID: 16376953 A Bifunctional Galphai/Galphas Modulatory Peptide That Attenuates Adenylyl Cyclase Activity FEBS Letters. Oct, 2005 | Pubmed ID: 16225870 Structure of Galpha(i1) Bound to a GDP-selective Peptide Provides Insight into Guanine Nucleotide Exchange Structure (London, England : 1993). Jul, 2005 | Pubmed ID: 16004878 Sensitization of Adenylate Cyclase by Galpha I/o-coupled Receptors Pharmacology & Therapeutics. Jun, 2005 | Pubmed ID: 15922020 Dexras1 Blocks Receptor-mediated Heterologous Sensitization of Adenylyl Cyclase 1 Biochemical and Biophysical Research Communications. Jul, 2005 | Pubmed ID: 15913563 Galphaq-coupled Receptor Signaling Enhances Adenylate Cyclase Type 6 Activation Biochemical Pharmacology. Jul, 2005 | Pubmed ID: 15885660 Galphaq Potentiation of Adenylate Cyclase Type 9 Activity Through a Ca2+/calmodulin-dependent Pathway Biochemical Pharmacology. Apr, 2005 | Pubmed ID: 15794946 Activation of a Novel PKC Isoform Synergistically Enhances D2L Dopamine Receptor-mediated Sensitization of Adenylate Cyclase Type 6 Cellular Signalling. May, 2005 | Pubmed ID: 15683739 Protein Kinase C and Epidermal Growth Factor Stimulation of Raf1 Potentiates Adenylyl Cyclase Type 6 Activation in Intact Cells Molecular Pharmacology. Jan, 2005 | Pubmed ID: 15470083 Using Molecular Tools to Dissect the Role of Galphas in Sensitization of AC1 Molecular Pharmacology. Dec, 2004 | Pubmed ID: 15361543 Sexual Experience Alters D1 Receptor-mediated Cyclic AMP Production in the Nucleus Accumbens of Female Syrian Hamsters Synapse (New York, N.Y.). Jul, 2004 | Pubmed ID: 15150737 Differentiation-induced Alterations in Cyclic AMP Signaling in the Cath.a Differentiated (CAD) Neuronal Cell Line Journal of Neurochemistry. Mar, 2004 | Pubmed ID: 15009651 Novel Regulatory Properties of Human Type 9 Adenylate Cyclase The Journal of Pharmacology and Experimental Therapeutics. Jul, 2004 | Pubmed ID: 14996950 Sensitization of Neuronal A2A Adenosine Receptors After Persistent D2 Dopamine Receptor Activation The Journal of Pharmacology and Experimental Therapeutics. Jan, 2004 | Pubmed ID: 14566008 Sensitization of Adenylate Cyclase by Short-term Activation of 5-HT1A Receptors Cellular Signalling. Dec, 2003 | Pubmed ID: 14575866 Sensitization of Adenylate Cyclase: a General Mechanism of Neuroadaptation to Persistent Activation of Galpha(i/o)-coupled Receptors? Life Sciences. Oct, 2003 | Pubmed ID: 14519441 A Complex Signaling Cascade Links the Serotonin2A Receptor to Phospholipase A2 Activation: the Involvement of MAP Kinases Journal of Neurochemistry. Aug, 2003 | Pubmed ID: 12887695 Serotonin 5-hydroxytryptamine 2A Receptor-coupled Phospholipase C and Phospholipase A2 Signaling Pathways Have Different Receptor Reserves The Journal of Pharmacology and Experimental Therapeutics. Jan, 2003 | Pubmed ID: 12490596 Heterologous Sensitization of Adenylate Cyclase is Protein Kinase A-dependent in Cath.a Differentiated (CAD)-D2L Cells Journal of Neurochemistry. Sep, 2002 | Pubmed ID: 12358756 Molecular Mechanisms for Heterologous Sensitization of Adenylate Cyclase The Journal of Pharmacology and Experimental Therapeutics. Jul, 2002 | Pubmed ID: 12065693 Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications Jason M. Conley1, Tarsis F. Brust1, Ruqiang Xu1, Kevin D. Burris2, Val J. Watts1 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2Quantitative Biology, Eli Lilly and Company JoVE 51218 Bioingegneria
Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications Jason M. Conley1, Tarsis F. Brust1, Ruqiang Xu1, Kevin D. Burris2, Val J. Watts1 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2Quantitative Biology, Eli Lilly and Company JoVE 51218 Bioingegneria