Valentina Gandin Lady Davis Institute and Department of Oncology McGill University Biography Publications Institution JoVE Articles Valentina Gandin has not added a biography. If you are Valentina Gandin and would like to personalize this page please email our Author Liaison for assistance. Publications Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen-Bond Donor/Acceptor N-Heterocyclic Ligand ChemMedChem. May, 2014 | Pubmed ID: 24799414 In Vitro and in Vivo Anticancer Activity of Copper(I) Complexes with Homoscorpionate Tridentate Tris(pyrazolyl)borate and Auxilliary Monodentate Phosphine Ligands Journal of Medicinal Chemistry. May, 2014 | Pubmed ID: 24793739 Role of Zinc Trafficking in Male Fertility: from Germ to Sperm Human Reproduction (Oxford, England). Jun, 2014 | Pubmed ID: 24771000 Trans,cis,cis-Bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a Prodrug Candidate for the Treatment of Oxaliplatin-Refractory Colorectal Cancer ChemMedChem. Apr, 2014 | Pubmed ID: 24715720 Largen: a Molecular Regulator of Mammalian Cell Size Control Molecular Cell. Mar, 2014 | Pubmed ID: 24656129 Oxygen Sufficiency Controls TOP MRNA Translation Via the TSC-Rheb-mTOR Pathway in a 4E-BP-independent Manner Journal of Molecular Cell Biology. Mar, 2014 | Pubmed ID: 24627160 Inactive C-terminal Telomerase Reverse Transcriptase Insertion Splicing Variants Are Dominant-negative Inhibitors of Telomerase Biochimie. Jun, 2014 | Pubmed ID: 24412622 Selenium Induces a Multi-targeted Cell Death Process in Addition to ROS Formation Journal of Cellular and Molecular Medicine. Apr, 2014 | Pubmed ID: 24400844 Advances in Copper Complexes As Anticancer Agents Chemical Reviews. Jan, 2014 | Pubmed ID: 24102434 RACK1 Function in Cell Motility and Protein Synthesis Genes & Cancer. Sep, 2013 | Pubmed ID: 24349634 MTORC1 Controls Mitochondrial Activity and Biogenesis Through 4E-BP-dependent Translational Regulation Cell Metabolism. Nov, 2013 | Pubmed ID: 24206664 Synthesis and in Vitro Antitumor Activity of Water Soluble Sulfonate- and Ester-functionalized Silver(I) N-heterocyclic Carbene Complexes Journal of Inorganic Biochemistry. Dec, 2013 | Pubmed ID: 24121303 Novel Mixed-ligand Copper(I) Complexes: Role of Diimine Ligands on Cytotoxicity and Genotoxicity Journal of Medicinal Chemistry. Sep, 2013 | Pubmed ID: 23964823 Cell Biology. Trans-HSF1 Express Science (New York, N.Y.). Jul, 2013 | Pubmed ID: 23869008 Distinct Translational Control in CD4+ T Cell Subsets PLoS Genetics. May, 2013 | Pubmed ID: 23658533 Novel Imino Thioether Complexes of Platinum(II): Synthesis, Structural Investigation, and Biological Activity Inorganic Chemistry. May, 2013 | Pubmed ID: 23647564 Degradation of Newly Synthesized Polypeptides by Ribosome-associated RACK1/c-Jun N-terminal Kinase/eukaryotic Elongation Factor 1A2 Complex Molecular and Cellular Biology. Jul, 2013 | Pubmed ID: 23608534 (99m)Tc(N)-DBODC(5), a Potential Radiolabeled Probe for SPECT of Multidrug Resistance: in Vitro Study Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Jun, 2013 | Pubmed ID: 23543234 Neutral and Charged Phosphine/scorpionate Copper(I) Complexes: Effects of Ligand Assembly on Their Antiproliferative Activity European Journal of Medicinal Chemistry. Jan, 2013 | Pubmed ID: 23229057 Methylselenol Formed by Spontaneous Methylation of Selenide is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems PloS One. 2012 | Pubmed ID: 23226364 EIF4E/4E-BP Ratio Predicts the Efficacy of MTOR Targeted Therapies Cancer Research. Dec, 2012 | Pubmed ID: 23100465 Synthesis and Biological Activity of Ester- and Amide-functionalized Imidazolium Salts and Related Water-soluble Coinage Metal N-heterocyclic Carbene Complexes Inorganic Chemistry. Sep, 2012 | Pubmed ID: 22946642 Eukaryotic Initiation Factor 4E-3 is Essential for Meiotic Chromosome Segregation, Cytokinesis and Male Fertility in Drosophila Development (Cambridge, England). Sep, 2012 | Pubmed ID: 22833128 Revisiting [PtCl₂(cis-1,4-DACH)]: an Underestimated Antitumor Drug with Potential Application to the Treatment of Oxaliplatin-refractory Colorectal Cancer Journal of Medicinal Chemistry. Aug, 2012 | Pubmed ID: 22788918 Synthesis and Characterization of Azolate Gold(I) Phosphane Complexes As Thioredoxin Reductase Inhibiting Antitumor Agents Dalton Transactions (Cambridge, England : 2003). May, 2012 | Pubmed ID: 22391922 Nanocrystalline Carbonate-apatites: Role of Ca/P Ratio on the Upload and Release of Anticancer Platinum Bisphosphonates Nanoscale. Jan, 2012 | Pubmed ID: 22075933 Effects of Redox Modulation by Inhibition of Thioredoxin Reductase on Radiosensitivity and Gene Expression Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 22003958 A Novel Copper Complex Induces Paraptosis in Colon Cancer Cells Via the Activation of ER Stress Signalling Journal of Cellular and Molecular Medicine. Jan, 2012 | Pubmed ID: 21388518 Photoreactivity of 5-fluorouracil Under UVB Light: Photolysis and Cytotoxicity Studies Chemical Research in Toxicology. Aug, 2011 | Pubmed ID: 21728355 Nitroimidazole and Glucosamine Conjugated Heteroscorpionate Ligands and Related Copper(II) Complexes. Syntheses, Biological Activity and XAS Studies Dalton Transactions (Cambridge, England : 2003). Oct, 2011 | Pubmed ID: 21709917 Chemistry and Biological Activity of Platinum Amidine Complexes ChemMedChem. Jul, 2011 | Pubmed ID: 21630470 Synthesis, Characterization and Cytotoxic Properties of Platinum(II) Complexes Containing the Nucleosides Adenosine and Cytidine Journal of Inorganic Biochemistry. Jun, 2011 | Pubmed ID: 21514543 Psoralenquinones As a Novel Class of Proteasome Inhibitors: Design, Synthesis and Biological Evaluation ChemMedChem. Jun, 2011 | Pubmed ID: 21472862 Interaction of Selenite and Tellurite with Thiol-dependent Redox Enzymes: Kinetics and Mitochondrial Implications Free Radical Biology & Medicine. Jun, 2011 | Pubmed ID: 21397686 In Vitro Antitumour Activity of Water Soluble Cu(I), Ag(I) and Au(I) Complexes Supported by Hydrophilic Alkyl Phosphine Ligands Journal of Inorganic Biochemistry. Feb, 2011 | Pubmed ID: 21194623 Cytotoxicity in Human Cancer Cells and Mitochondrial Dysfunction Induced by a Series of New Copper(I) Complexes Containing Tris(2-cyanoethyl)phosphines Investigational New Drugs. Dec, 2011 | Pubmed ID: 20567997 A New Class of Antitumor Trans-amine-amidine-Pt(II) Cationic Complexes: Influence of Chemical Structure and Solvent on in Vitro and in Vivo Tumor Cell Proliferation Journal of Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20681543 S6K1 Plays a Critical Role in Early Adipocyte Differentiation Developmental Cell. May, 2010 | Pubmed ID: 20493810 The Relationship Between the Electrospray Ionization Behaviour and Biological Activity of Some Phosphino Cu(I) Complexes Rapid Communications in Mass Spectrometry : RCM. Jun, 2010 | Pubmed ID: 20486256 JNK Inhibition Arrests Cotranslational Degradation Biochimica Et Biophysica Acta. Jul, 2010 | Pubmed ID: 20359507 Cancer Cell Death Induced by Phosphine Gold(I) Compounds Targeting Thioredoxin Reductase Biochemical Pharmacology. Jan, 2010 | Pubmed ID: 19665452 Synthesis, Characterization, and Cytotoxicity of Dinuclear Platinum-bisphosphonate Complexes to Be Used As Prodrugs in the Local Treatment of Bone Tumours Dalton Transactions (Cambridge, England : 2003). Dec, 2009 | Pubmed ID: 20023921 Synthesis and Structural Characterization of Copper(I) Complexes Bearing N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA): Cytotoxic Activity Evaluation of a Series of Water Soluble Cu(I) Derivatives Containing PTA, PTAH and MPTA Ligands Journal of Inorganic Biochemistry. Dec, 2009 | Pubmed ID: 19822369 Cytotoxicity of Cis-platinum(II) Cycloaliphatic Amidine Complexes: Ring Size and Solvent Effects on the Biological Activity Journal of Inorganic Biochemistry. Aug, 2009 | Pubmed ID: 19560209 Treatment of Human Cancer Cells with Selenite or Tellurite in Combination with Auranofin Enhances Cell Death Due to Redox Shift Free Radical Biology & Medicine. Sep, 2009 | Pubmed ID: 19486940 DNA Binding Ellipticine Analogues: Synthesis, Biological Evaluation, and Structure-activity Relationships ChemMedChem. Mar, 2009 | Pubmed ID: 19197924 Effects of the Antioxidant Pycnogenol on Cellular Redox Systems in U1285 Human Lung Carcinoma Cells The FEBS Journal. Jan, 2009 | Pubmed ID: 19077163 Eukaryotic Initiation Factor 6 is Rate-limiting in Translation, Growth and Transformation Nature. Oct, 2008 | Pubmed ID: 18784653 In Vitro Antitumor Activity of the Water Soluble Copper(I) Complexes Bearing the Tris(hydroxymethyl)phosphine Ligand Journal of Medicinal Chemistry. Feb, 2008 | Pubmed ID: 18251492 Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands; Synthesis, Characterization, Structure-activity Relationships, and in Vitro and in Vivo Antitumor Efficacy Journal of Medicinal Chemistry. Sep, 2007 | Pubmed ID: 17713897 Inhibition of Thioredoxin Reductase by Auranofin Induces Apoptosis in Cisplatin-resistant Human Ovarian Cancer Cells Free Radical Biology & Medicine. Mar, 2007 | Pubmed ID: 17320769 Synthesis, Characterization, and in Vitro Antitumor Properties of Tris(hydroxymethyl)phosphine Copper(I) Complexes Containing the New Bis(1,2,4-triazol-1-yl)acetate Ligand Journal of Medicinal Chemistry. Dec, 2006 | Pubmed ID: 17149861 GABP Complex Regulates Transcription of EIF6 (p27BBP), an Essential Trans-acting Factor in Ribosome Biogenesis FEBS Letters. Apr, 2006 | Pubmed ID: 16530192 Fibronectin Controls Cap-dependent Translation Through Beta1 Integrin and Eukaryotic Initiation Factors 4 and 2 Coordinated Pathways Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005 | Pubmed ID: 15961545 Bir genom Ölçeği Polizom Fraksiyonu ve Memeli Translatomes Analizi Valentina Gandin1, Kristina Sikström2, Tommy Alain3, Masahiro Morita3, Shannon McLaughlan1, Ola Larsson2, Ivan Topisirovic1 1Lady Davis Institute and Department of Oncology, McGill University, 2Department of Oncology-Pathology, Karolinska Institutet, 3Goodman Cancer Centre and Department of Biochemistry, McGill University JoVE 51455 Biologia
Bir genom Ölçeği Polizom Fraksiyonu ve Memeli Translatomes Analizi Valentina Gandin1, Kristina Sikström2, Tommy Alain3, Masahiro Morita3, Shannon McLaughlan1, Ola Larsson2, Ivan Topisirovic1 1Lady Davis Institute and Department of Oncology, McGill University, 2Department of Oncology-Pathology, Karolinska Institutet, 3Goodman Cancer Centre and Department of Biochemistry, McGill University JoVE 51455 Biologia