Wei Kong Department of Physiology and Pathophysiology, School of Basic Medical Sciences; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education Peking University Biography Publications Institution JoVE Articles Wei Kong has not added a biography. If you are Wei Kong and would like to personalize this page please email our Author Liaison for assistance. Publications Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification Circulation Research. Nov, 2022 | Pubmed ID: 36354004 PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing Circulation Research. Oct, 2022 | Pubmed ID: 36200440 MicroRNA-Disease Network Analysis Repurposes Methotrexate for the Treatment of Abdominal Aortic Aneurysm in Mice Genomics, Proteomics & Bioinformatics. Aug, 2022 | Pubmed ID: 36030000 Matricellular Proteins: Potential Biomarkers and Mechanistic Factors in Aortic Aneurysms Journal of Molecular and Cellular Cardiology. Aug, 2022 | Pubmed ID: 35576729 Endogenous Hydrogen Sulfide Persulfidates Caspase-3 at Cysteine 163 to Inhibit Doxorubicin-Induced Cardiomyocyte Apoptosis Oxidative Medicine and Cellular Longevity. 2022 | Pubmed ID: 35571249 Investigating the Inverse Association Between Glycaemia and Abdominal Aortic Dilatation in a Large Chinese Hypertensive Population: a Cross-sectional Study Annals of Translational Medicine. Apr, 2022 | Pubmed ID: 35530958 Targeting Macrophage TFEB-14-3-3 Epsilon Interface by Naringenin Inhibits Abdominal Aortic Aneurysm Cell Discovery. Mar, 2022 | Pubmed ID: 35228523 Single-cell RNA Sequencing Reveals B Cell-T Cell Interactions in Vascular Adventitia of Hyperhomocysteinemia-accelerated Atherosclerosis Protein & Cell. 07, 2022 | Pubmed ID: 35175542 Vascular Smooth Muscle Cell-derived Hydrogen Sulfide Promotes Atherosclerotic Plaque Stability Via TFEB (transcription Factor EB)-mediated Autophagy Autophagy. 10, 2022 | Pubmed ID: 35090378 COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure Hypertension (Dallas, Tex. : 1979). 03, 2022 | Pubmed ID: 34983194 The Binding of Autotaxin to Integrins Mediates Hyperhomocysteinemia-potentiated Platelet Activation and Thrombosis in Mice and Humans Blood Advances. 01, 2022 | Pubmed ID: 34559203 Association Between Lipid Levels and Risk for Different Types of Aneurysms: A Mendelian Randomization Study Journal of Personalized Medicine. Nov, 2021 | Pubmed ID: 34834523 Pan-HDAC (Histone Deacetylase) Inhibitors Increase Susceptibility of Thoracic Aortic Aneurysm and Dissection in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2021 | Pubmed ID: 34525846 Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation Via Bridging Jagged1-Notch3 Signaling Circulation. 10, 2021 | Pubmed ID: 34315224 Whole-Mount Kidney Clearing and Visualization Reveal Renal Sympathetic Hyperinnervation in Heart Failure Mice Frontiers in Physiology. 2021 | Pubmed ID: 34305650 Identification of COL3A1 Variants Associated with Sporadic Thoracic Aortic Dissection: a Case-control Study Frontiers of Medicine. Jun, 2021 | Pubmed ID: 34047934 Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension Circulation Research. 07, 2021 | Pubmed ID: 33980031 LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice Genes. 03, 2021 | Pubmed ID: 33807332 X-box Binding Protein 1-mediated COL4A1s Secretion Regulates Communication Between Vascular Smooth Muscle and Stem/progenitor Cells The Journal of Biological Chemistry. Jan-Jun, 2021 | Pubmed ID: 33722606 Endogenous SO-dependent Smad3 Redox Modification Controls Vascular Remodeling Redox Biology. 05, 2021 | Pubmed ID: 33647858 Cartilage Oligomeric Matrix Protein is an Endogenous β-arrestin-2-selective Allosteric Modulator of AT1 Receptor Counteracting Vascular Injury Cell Research. 07, 2021 | Pubmed ID: 33510386 Cartilage Oligomeric Matrix Protein Fine-tunes Disturbed Flow-induced Endothelial Activation and Atherogenesis Matrix Biology : Journal of the International Society for Matrix Biology. 01, 2021 | Pubmed ID: 33068727 NSun2 Regulates Aneurysm Formation by Promoting Autotaxin Expression and T Cell Recruitment Cellular and Molecular Life Sciences : CMLS. Feb, 2021 | Pubmed ID: 32734582 Vascular Extracellular Matrix Remodeling and Hypertension Antioxidants & Redox Signaling. 04, 2021 | Pubmed ID: 32460598 Post-translational Modifications of IκBα: The State of the Art Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33224945 FAM3D is Essential for Colon Homeostasis and Host Defense Against Inflammation Associated Carcinogenesis Nature Communications. 11, 2020 | Pubmed ID: 33219235 Naringin Alleviates Atherosclerosis in ApoE Mice by Regulating Cholesterol Metabolism Involved in Gut Microbiota Remodeling Journal of Agricultural and Food Chemistry. Nov, 2020 | Pubmed ID: 33107729 DeSiphering Receptor Core-induced and Ligand-dependent Conformational Changes in Arrestin Via Genetic Encoded Trimethylsilyl H-NMR Probe Nature Communications. 09, 2020 | Pubmed ID: 32978402 Extracellular Matrix Dynamics in Vascular Remodeling American Journal of Physiology. Cell Physiology. 09, 2020 | Pubmed ID: 32579472 Kindlin-2 Deficiency Induces Fatal Intestinal Obstruction in Mice Theranostics. 2020 | Pubmed ID: 32483447 Elevated Serum Cartilage Oligomeric Matrix Protein and the Metalloproteinase-ADAMTS7 Levels Are Associated with Vascular Calcification in Maintenance Hemodialysis Patients Seminars in Dialysis. 07, 2020 | Pubmed ID: 32441044 Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm Arteriosclerosis, Thrombosis, and Vascular Biology. 05, 2020 | Pubmed ID: 32212850 Cellular Signaling in Abdominal Aortic Aneurysm Cellular Signalling. 06, 2020 | Pubmed ID: 32088371 Macrophage-derived Sulfur Dioxide is a Novel Inflammation Regulator Biochemical and Biophysical Research Communications. 04, 2020 | Pubmed ID: 32057367 Hypermethylation of Mitochondrial DNA in Vascular Smooth Muscle Cells Impairs Cell Contractility Cell Death & Disease. 01, 2020 | Pubmed ID: 31959742 PSMP/MSMP Promotes Hepatic Fibrosis Through CCR2 and Represents a Novel Therapeutic Target Journal of Hepatology. 03, 2020 | Pubmed ID: 31813573 B Cell-derived Anti-beta 2 Glycoprotein I Antibody Contributes to Hyperhomocysteinaemia-aggravated Abdominal Aortic Aneurysm Cardiovascular Research. 09, 2020 | Pubmed ID: 31782769 Endothelial Tight Junctions and Their Regulatory Signaling Pathways in Vascular Homeostasis and Disease Cellular Signalling. 02, 2020 | Pubmed ID: 31770579 L-Cystathionine Protects Against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells Oxidative Medicine and Cellular Longevity. 2019 | Pubmed ID: 31885769 Kindlin-2 Suppresses Transcription Factor GATA4 Through Interaction with SUV39H1 to Attenuate Hypertrophy Cell Death & Disease. 11, 2019 | Pubmed ID: 31767831 Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions Through FRET Analytical Chemistry. 12, 2019 | Pubmed ID: 31670502 Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism Cell Metabolism. 11, 2019 | Pubmed ID: 31668872 Endogenous Hydrogen Sulfide Sulfhydrates IKKβ at Cysteine 179 to Control Pulmonary Artery Endothelial Cell Inflammation Clinical Science (London, England : 1979). 10, 2019 | Pubmed ID: 31654061 Macrophage Metabolic Reprogramming Aggravates Aortic Dissection Through the HIF1α-ADAM17 Pathway EBioMedicine. Nov, 2019 | Pubmed ID: 31640947 Ablation of Gut Microbiota Alleviates Obesity-induced Hepatic Steatosis and Glucose Intolerance by Modulating Bile Acid Metabolism in Hamsters Acta Pharmaceutica Sinica. B. Jul, 2019 | Pubmed ID: 31384531 The -methyladenosine (mA)-forming Enzyme METTL3 Facilitates M1 Macrophage Polarization Through the Methylation of MRNA American Journal of Physiology. Cell Physiology. 10, 2019 | Pubmed ID: 31365297 Rapamycin Attenuates a Murine Model of Thoracic Aortic Aneurysm by Downregulating the MiR-126-3p Mediated Activation of MAPK/ERK Signalling Pathway Biochemical and Biophysical Research Communications. 05, 2019 | Pubmed ID: 30904162 Gpihbp1 Deficiency Accelerates Atherosclerosis and Plaque Instability in Diabetic Ldlr Mice Atherosclerosis. 03, 2019 | Pubmed ID: 30721842 DNA Methyltransferase 1 and Krüppel-like Factor 4 Axis Regulates Macrophage Inflammation and Atherosclerosis Journal of Molecular and Cellular Cardiology. 03, 2019 | Pubmed ID: 30659837 Rapamycin Prevents Thoracic Aortic Aneurysm and Dissection in Mice Journal of Vascular Surgery. 03, 2019 | Pubmed ID: 30253896 Postnatal Deficiency of ADAMTS1 Ameliorates Thoracic Aortic Aneurysm and Dissection in Mice Experimental Physiology. 12, 2018 | Pubmed ID: 30191627 Naringenin Inhibits N-nitro-L-arginine Methyl Ester-induced Hypertensive Left Ventricular Hypertrophy by Decreasing Angiotensin-converting Enzyme 1 Expression Experimental and Therapeutic Medicine. Aug, 2018 | Pubmed ID: 30112041 Cartilage Oligomeric Matrix Protein is a Novel Notch Ligand Driving Embryonic Stem Cell Differentiation Towards the Smooth Muscle Lineage Journal of Molecular and Cellular Cardiology. 08, 2018 | Pubmed ID: 29981303 Histone Variant H2A.Z Is Required for the Maintenance of Smooth Muscle Cell Identity As Revealed by Single-Cell Transcriptomics Circulation. 11, 2018 | Pubmed ID: 29871976 COMP-prohibitin 2 Interaction Maintains Mitochondrial Homeostasis and Controls Smooth Muscle Cell Identity Cell Death & Disease. 06, 2018 | Pubmed ID: 29867124 Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development Arteriosclerosis, Thrombosis, and Vascular Biology. 07, 2018 | Pubmed ID: 29853563 The Increased Endogenous Sulfur Dioxide Acts As a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation Frontiers in Immunology. 2018 | Pubmed ID: 29760703 Renal Injury in Seipin-deficient Lipodystrophic Mice and Its Reversal by Adipose Tissue Transplantation or Leptin Administration Alone: Adipose Tissue-kidney Crosstalk FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 10, 2018 | Pubmed ID: 29738274 Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance EBioMedicine. May, 2018 | Pubmed ID: 29735414 Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2 Circulation. 07, 2018 | Pubmed ID: 29453251 Gq Activity- and β-arrestin-1 Scaffolding-mediated ADGRG2/CFTR Coupling Are Required for Male Fertility ELife. 02, 2018 | Pubmed ID: 29393851 Extracellular Matrix Remodeling and Cardiac Fibrosis Matrix Biology : Journal of the International Society for Matrix Biology. 08, 2018 | Pubmed ID: 29371055 Homocysteine Directly Interacts and Activates the Angiotensin II Type I Receptor to Aggravate Vascular Injury Nature Communications. 01, 2018 | Pubmed ID: 29296021 Matrix Stiffness Determines the Phenotype of Vascular Smooth Muscle Cell In vitro and In vivo: Role of DNA Methyltransferase 1 Biomaterials. Feb, 2018 | Pubmed ID: 29182961 Small Infrarenal Aortic Diameter Associated with Lower-extremity Peripheral Artery Disease in Chinese Hypertensive Adults Scientific Reports. 11, 2017 | Pubmed ID: 29109408 Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation Via FoxO4 Interaction Circulation Research. Dec, 2017 | Pubmed ID: 29089350 Hypoxia Decrease Expression of Cartilage Oligomeric Matrix Protein to Promote Phenotype Switching of Pulmonary Arterial Smooth Muscle Cells The International Journal of Biochemistry & Cell Biology. 10, 2017 | Pubmed ID: 28860005 Hyperhomocysteinemia and Vascular Injury: The Advance of Mechanisms and Drug Targets British Journal of Pharmacology. Aug, 2017 | Pubmed ID: 28836260 Basic and Translational Vascular Research in China: Past, Present, and Future Circulation Research. 08, 2017 | Pubmed ID: 28775012 CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2017 | Pubmed ID: 28751569 Transdifferentiated Human Vascular Smooth Muscle Cells Are a New Potential Cell Source for Endothelial Regeneration Scientific Reports. 07, 2017 | Pubmed ID: 28717251 Cardioprotection of Ischemic Preconditioning in Rats Involves Upregulating Adiponectin Journal of Molecular Endocrinology. 05, 2017 | Pubmed ID: 28219936 Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease Current Vascular Pharmacology. 2017 | Pubmed ID: 28155614 ADAM17: A Molecular Switch to Control TNFR2 During Atherogenesis In Vivo Arteriosclerosis, Thrombosis, and Vascular Biology. 02, 2017 | Pubmed ID: 28122773 [The Mechanisms of Medial Vascular Calcification] Sheng Li Xue Bao : [Acta Physiologica Sinica]. Oct, 2016 | Pubmed ID: 27778024 The E3 Ubiquitin Ligase C-Cbl Mediates Integrin β1 Ubiquitination During Dilated Cardiomyopathy Biochemical and Biophysical Research Communications. Oct, 2016 | Pubmed ID: 27693578 Cartilage Oligomeric Matrix Protein Prevents Vascular Aging and Vascular Smooth Muscle Cells Senescence Biochemical and Biophysical Research Communications. Sep, 2016 | Pubmed ID: 27498005 ECM-mimetic Heparin Glycosamioglycan-functionalized Surface Favors Constructing Functional Vascular Smooth Muscle Tissue in Vitro Colloids and Surfaces. B, Biointerfaces. Oct, 2016 | Pubmed ID: 27351139 Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification Circulation Research. Jul, 2016 | Pubmed ID: 27151399 Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage Stem Cells (Dayton, Ohio). 05, 2016 | Pubmed ID: 26867148 A Disintegrin and Metalloproteinase with Thrombospondin Motif 1 (ADAMTS1) Expression Increases in Acute Aortic Dissection Science China. Life Sciences. Jan, 2016 | Pubmed ID: 26563155 Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016 | Pubmed ID: 26543101 Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction PloS One. 2015 | Pubmed ID: 26496478 Mammalian Target of Rapamycin Signaling Inhibition Ameliorates Vascular Calcification Via Klotho Upregulation Kidney International. Oct, 2015 | Pubmed ID: 26061549 Cartilage Oligomeric Matrix Protein is a Natural Inhibitor of Thrombin Blood. Aug, 2015 | Pubmed ID: 26045608 ADAMTS-7 Promotes Vascular Smooth Muscle Cells Proliferation in Vitro and in Vivo Science China. Life Sciences. Jul, 2015 | Pubmed ID: 25921940 ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1 Circulation. Feb, 2015 | Pubmed ID: 25712208 Macrophage Inflammasome Mediates Hyperhomocysteinemia-aggravated Abdominal Aortic Aneurysm Journal of Molecular and Cellular Cardiology. Apr, 2015 | Pubmed ID: 25680906 Disruption of TGF-β Signaling in Smooth Muscle Cell Prevents Flow-induced Vascular Remodeling Biochemical and Biophysical Research Communications. Nov, 2014 | Pubmed ID: 25451249 Disruption of TGF-β Signaling in Smooth Muscle Cell Prevents Elastase-induced Abdominal Aortic Aneurysm Biochemical and Biophysical Research Communications. Nov, 2014 | Pubmed ID: 25450370 Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: a Meta-analysis Cerebrovascular Diseases (Basel, Switzerland). 2014 | Pubmed ID: 24903192 Intermedin Inhibits Macrophage Foam-cell Formation Via Tristetraprolin-mediated Decay of CD36 MRNA Cardiovascular Research. Feb, 2014 | Pubmed ID: 24253523 Deficiency of Cartilage Oligomeric Matrix Protein Causes Dilated Cardiomyopathy Basic Research in Cardiology. Sep, 2013 | Pubmed ID: 23917519 Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue The Journal of Biological Chemistry. Apr, 2013 | Pubmed ID: 23417716 Phosphate-induced Autophagy Counteracts Vascular Calcification by Reducing Matrix Vesicle Release Kidney International. Jun, 2013 | Pubmed ID: 23364520 CTLA4-IgG Ameliorates Homocysteine-accelerated Atherosclerosis by Inhibiting T-cell Overactivation in ApoE(-/-) Mice Cardiovascular Research. Feb, 2013 | Pubmed ID: 23118130 Upregulation of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-7 by MiR-29 Repression Mediates Vascular Smooth Muscle Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2012 | Pubmed ID: 22995515 Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II-induced Abdominal Aortic Aneurysm in Mice Circulation Research. Oct, 2012 | Pubmed ID: 22912384 Fenofibrate Inhibited the Differentiation of T Helper 17 Cells in Vitro PPAR Research. 2012 | Pubmed ID: 22792085 Fenofibrate Enhances the in Vitro Differentiation of Foxp3(+) Regulatory T Cells in Mice PPAR Research. 2012 | Pubmed ID: 22536210 Activation of Nuclear Factor-kappa B Accelerates Vascular Calcification by Inhibiting Ankylosis Protein Homolog Expression Kidney International. Jul, 2012 | Pubmed ID: 22437419 Small-molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction Between Vif and ElonginC Journal of Virology. May, 2012 | Pubmed ID: 22379088 Homocysteine Upregulates Soluble Epoxide Hydrolase in Vascular Endothelium in Vitro and in Vivo Circulation Research. Mar, 2012 | Pubmed ID: 22354938 Mitochondrial Reactive Oxygen Species Promote P65 Nuclear Translocation Mediating High-phosphate-induced Vascular Calcification in Vitro and in Vivo Kidney International. May, 2011 | Pubmed ID: 21368742 Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting with Bone Morphogenetic Protein-2 Circulation Research. Apr, 2011 | Pubmed ID: 21350216 A Novel Mechanism of γ/δ T-lymphocyte and Endothelial Activation by Shear Stress: the Role of Ecto-ATP Synthase β Chain Circulation Research. Feb, 2011 | Pubmed ID: 21193741 [Diabetic Cardiomyopathy] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Feb, 2010 | Pubmed ID: 21417012 [The Role of Adventitia in Atherosclerosis] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jun, 2010 | Pubmed ID: 21416976 Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting with Alpha(7)beta(1) Integrin Circulation Research. Feb, 2010 | Pubmed ID: 20019333 Homocysteine Promotes Vascular Smooth Muscle Cell Migration by Induction of the Adipokine Resistin American Journal of Physiology. Cell Physiology. Dec, 2009 | Pubmed ID: 19828833 Regulatory T Cells Ameliorate Hyperhomocysteinaemia-accelerated Atherosclerosis in ApoE-/- Mice Cardiovascular Research. Oct, 2009 | Pubmed ID: 19502284 ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-injured Rat Arteries Circulation Research. Mar, 2009 | Pubmed ID: 19168437 Regulatory Role of Thioredoxin in Homocysteine-induced Monocyte Chemoattractant Protein-1 Secretion in Monocytes/macrophages FEBS Letters. Nov, 2008 | Pubmed ID: 18976655 [Extracellular Matrix, Matrix-degrading Proteases and Vascular Calcification] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jul, 2008 | Pubmed ID: 18819486 A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model Siting Zhang*1, Zeyu Cai*1, Xu Zhang1, Tianfeng Ma2, Wei Kong1 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, 2Department of Vascular and Endovascular Surgery, the First Medical Centre, Chinese PLA General Hospital JoVE 64173 Biologia
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model Siting Zhang*1, Zeyu Cai*1, Xu Zhang1, Tianfeng Ma2, Wei Kong1 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, 2Department of Vascular and Endovascular Surgery, the First Medical Centre, Chinese PLA General Hospital JoVE 64173 Biologia