Xiaozhuo Chen Department of Biological Sciences Ohio University Biography Publications Institution JoVE Articles Xiaozhuo Chen has not added a biography. If you are Xiaozhuo Chen and would like to personalize this page please email our Author Liaison for assistance. Publications A Small-molecule Pan-class I Glucose Transporter Inhibitor Reduces Cancer Cell Proliferation in Vitro and Tumor Growth in Vivo by Targeting Glucose-based Metabolism Cancer & Metabolism. Mar, 2021 | Pubmed ID: 33771231 Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake As a Mechanism Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 2021 | Pubmed ID: 33658814 Isosteres of Ester Derived Glucose Uptake Inhibitors Bioorganic & Medicinal Chemistry Letters. 09, 2020 | Pubmed ID: 32736210 Na/K-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives Journal of Natural Products. 03, 2020 | Pubmed ID: 32096998 The Anti-diabetic Effect of Eight Lagerstroemia Speciosa Leaf Extracts Based on the Contents of Ellagitannins and Ellagic Acid Derivatives Food & Function. Feb, 2020 | Pubmed ID: 32003379 Cytotoxic and Non-cytotoxic Cardiac Glycosides Isolated from the Combined Flowers, Leaves, and Twigs of Streblus Asper Bioorganic & Medicinal Chemistry. 02, 2020 | Pubmed ID: 31953129 Plant-derived Glucose Transport Inhibitors with Potential Antitumor Activity Phytotherapy Research : PTR. May, 2020 | Pubmed ID: 31823431 Extracellular and Macropinocytosis Internalized ATP Work Together to Induce Epithelial-mesenchymal Transition and Other Early Metastatic Activities in Lung Cancer Cancer Cell International. 2019 | Pubmed ID: 31582910 Extracellular ATP, As an Energy and Phosphorylating Molecule, Induces Different Types of Drug Resistances in Cancer Cells Through ATP Internalization and Intracellular ATP Level Increase Oncotarget. Oct, 2017 | Pubmed ID: 29152126 Cardiac Glycoside Constituents of Streblus Asper with Potential Antineoplastic Activity Journal of Natural Products. 03, 2017 | Pubmed ID: 27983842 Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms Molecular Cancer Research : MCR. 11, 2016 | Pubmed ID: 27578770 Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones Induced Apoptosis in RKO Colon Cancer Cells Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2016 | Pubmed ID: 26677729 Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells ChemMedChem. Nov, 2015 | Pubmed ID: 26332543 The Warburg Effect: Evolving Interpretations of an Established Concept Free Radical Biology & Medicine. Feb, 2015 | Pubmed ID: 25277420 Extracellular ATP is Internalized by Macropinocytosis and Induces Intracellular ATP Increase and Drug Resistance in Cancer Cells Cancer Letters. Sep, 2014 | Pubmed ID: 24973521 Biological and Biomedical Functions of Penta-O-galloyl-D-glucose and Its Derivatives Journal of Natural Medicines. Jul, 2014 | Pubmed ID: 24532420 Constituents of an Extract of Cryptocarya Rubra Housed in a Repository with Cytotoxic and Glucose Transport Inhibitory Effects Journal of Natural Products. Mar, 2014 | Pubmed ID: 24344605 Orally Efficacious Novel Small Molecule 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose Selectively and Potently Stimulates Insulin Receptor and Alleviates Diabetes Journal of Molecular Endocrinology. 2013 | Pubmed ID: 23549408 Synthesis and Antitumor Activity of Ellagic Acid Peracetate ACS Medicinal Chemistry Letters. Aug, 2012 | Pubmed ID: 23185648 A Small-molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-cycle Arrest, and Inhibits Cancer Cell Growth in Vitro and in Vivo Molecular Cancer Therapeutics. Aug, 2012 | Pubmed ID: 22689530 A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose Mimics the Antiplatelet Actions of Insulin PloS One. 2011 | Pubmed ID: 22073153 Insulin Receptor Signaling Activated by Penta-O-galloyl-α-D: -glucopyranose Induces P53 and Apoptosis in Cancer Cells Apoptosis : an International Journal on Programmed Cell Death. Sep, 2011 | Pubmed ID: 21671008 Small Compound Inhibitors of Basal Glucose Transport Inhibit Cell Proliferation and Induce Apoptosis in Cancer Cells Via Glucose-deprivation-like Mechanisms Cancer Letters. Dec, 2010 | Pubmed ID: 20678861 Novel Inhibitors of Basal Glucose Transport As Potential Anticancer Agents Bioorganic & Medicinal Chemistry Letters. Apr, 2010 | Pubmed ID: 20194024 Regulation of G(1) Arrest and Apoptosis in Hypoxia by PERK and GCN2-mediated EIF2alpha Phosphorylation Neoplasia (New York, N.Y.). Jan, 2010 | Pubmed ID: 20072654 Antidiabetes and Anti-obesity Activity of Lagerstroemia Speciosa Evidence-based Complementary and Alternative Medicine : ECAM. Dec, 2007 | Pubmed ID: 18227906 Synthesis and Structure-activity Relationship Study of Antidiabetic Penta-O-galloyl-D-glucopyranose and Its Analogues Journal of Medicinal Chemistry. May, 2006 | Pubmed ID: 16640344 Natural Anti-diabetic Compound 1,2,3,4,6-penta-O-galloyl-D-glucopyranose Binds to Insulin Receptor and Activates Insulin-mediated Glucose Transport Signaling Pathway Biochemical and Biophysical Research Communications. Oct, 2005 | Pubmed ID: 16137651 Transcription Regulation of the Vegf Gene by the BMP/Smad Pathway in the Angioblast of Zebrafish Embryos Biochemical and Biophysical Research Communications. Apr, 2005 | Pubmed ID: 15721310 Tannic Acid Stimulates Glucose Transport and Inhibits Adipocyte Differentiation in 3T3-L1 Cells The Journal of Nutrition. Feb, 2005 | Pubmed ID: 15671208 Seryl-histidine As an Alternative DNA Nicking Agent in Nick Translation Yields Superior DNA Probes and Hybridizations Bioorganic & Medicinal Chemistry. Mar, 2002 | Pubmed ID: 11814854 A Ribozyme-mediated, Gene "knockdown" Strategy for the Identification of Gene Function in Zebrafish Proceedings of the National Academy of Sciences of the United States of America. Dec, 1997 | Pubmed ID: 9391103 Fluorescence Microscopy for ATP Internalization Mediated by Macropinocytosis in Human Tumor Cells and Tumor-xenografted Mice Corinne M. Nielsen*1,2,3, Yanrong Qian*4, Subhodip Adhicary1,5, Yunsheng Li4, Pratik Shriwas1,2,4, Xuan Wang1,2,4, Lindsey Bachmann6, Xiaozhuo Chen1,2,4,7 1Department of Biological Sciences, Ohio University, 2Molecular and Cellular Biology Program, Ohio University, 3Neuroscience Program, Ohio University, 4Edison Biotechnology Institute, Ohio University, 5Translational Biomedical Sciences Program, Ohio University, 6Honors Tutorial College, Ohio University, 7Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University JoVE 62768 Ricerca sul cancro
Fluorescence Microscopy for ATP Internalization Mediated by Macropinocytosis in Human Tumor Cells and Tumor-xenografted Mice Corinne M. Nielsen*1,2,3, Yanrong Qian*4, Subhodip Adhicary1,5, Yunsheng Li4, Pratik Shriwas1,2,4, Xuan Wang1,2,4, Lindsey Bachmann6, Xiaozhuo Chen1,2,4,7 1Department of Biological Sciences, Ohio University, 2Molecular and Cellular Biology Program, Ohio University, 3Neuroscience Program, Ohio University, 4Edison Biotechnology Institute, Ohio University, 5Translational Biomedical Sciences Program, Ohio University, 6Honors Tutorial College, Ohio University, 7Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University JoVE 62768 Ricerca sul cancro