Yasuo Ihara Graduate School of Brain Science Doshisha University Biography Publications Institution JoVE Articles Yasuo Ihara has not added a biography. If you are Yasuo Ihara and would like to personalize this page please email our Author Liaison for assistance. Publications Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy Frontiers in Neuroscience. 2018 | Pubmed ID: 29973863 Distinct Deposition of Amyloid-β Species in Brains with Alzheimer's Disease Pathology Visualized with MALDI Imaging Mass Spectrometry Acta Neuropathologica Communications. 10, 2017 | Pubmed ID: 29037261 Semagacestat Is a Pseudo-Inhibitor of γ-Secretase Cell Reports. Oct, 2017 | Pubmed ID: 28978478 Alanine Substitutions in the GXXXG Motif Alter C99 Cleavage by γ-secretase but Not Its Dimerization Journal of Neurochemistry. 03, 2017 | Pubmed ID: 28032911 Curcumin Improves Tau-induced Neuronal Dysfunction of Nematodes Neurobiology of Aging. Mar, 2016 | Pubmed ID: 26923403 Toxic Tau Oligomer Formation Blocked by Capping of Cysteine Residues with 1,2-dihydroxybenzene Groups Nature Communications. Dec, 2015 | Pubmed ID: 26671725 The A673T Mutation in the Amyloid Precursor Protein Reduces the Production of β-amyloid Protein from Its β-carboxyl Terminal Fragment in Cells Acta Neuropathologica Communications. Nov, 2015 | Pubmed ID: 26531305 Identification of Key Amino Acids Responsible for the Distinct Aggregation Properties of Microtubule-associated Protein 2 and Tau Journal of Neurochemistry. Oct, 2015 | Pubmed ID: 26134402 Immunostaining of Oxidized DJ-1 in Human and Mouse Brains Journal of Neuropathology and Experimental Neurology. Jul, 2014 | Pubmed ID: 24918637 Lack of Genetic Association Between TREM2 and Late-onset Alzheimer's Disease in a Japanese Population Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24762945 The Homologous Carboxyl-terminal Domains of Microtubule-associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles PloS One. 2014 | Pubmed ID: 24587039 γ-Secretase Associated with Lipid Rafts: Multiple Interactive Pathways in the Stepwise Processing of β-carboxyl-terminal Fragment The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24375443 Substrate Ectodomain is Critical for Substrate Preference and Inhibition of γ-secretase Nature Communications. 2013 | Pubmed ID: 24108142 Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-secretase Inhibition by Ginsenoside (20S)-Rg3 The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23723072 SORL1 is Genetically Associated with Late-onset Alzheimer's Disease in Japanese, Koreans and Caucasians PloS One. 2013 | Pubmed ID: 23565137 Suspected Limited Efficacy of γ-secretase Modulators Neurobiology of Aging. Apr, 2013 | Pubmed ID: 23058852 The Ubiquitin-proteasome System and the Autophagic-lysosomal System in Alzheimer Disease Cold Spring Harbor Perspectives in Medicine. Aug, 2012 | Pubmed ID: 22908190 Central Nervous System-specific Deletion of Transcription Factor Nrf1 Causes Progressive Motor Neuronal Dysfunction Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jun, 2011 | Pubmed ID: 21554501 Gamma-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of Beta-carboxyl Terminal Fragment The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828817 GAB2 is Not Associated with Late-onset Alzheimer's Disease in Japanese European Journal of Human Genetics : EJHG. May, 2009 | Pubmed ID: 18854865 [Overview on Alzheimer's Disease] Rinsho Shinkeigaku = Clinical Neurology. Nov, 2007 | Pubmed ID: 18210830 माइलॉइड β का विज़ुअलाइज़ेशन मानव मस्तिष्क में मैट्रिक्स-असिस्टेड लेजर डिसोर्टशन के साथ जमा/आयनीकरण इमेजिंग मास स्पेक्ट्रोमेट्री Masaya Ikegawa*1, Takashi Nirasawa*2, Nobuto Kakuda1, Tomohiro Miyasaka1, Yuki Kuzuhara1, Shigeo Murayama3, Yasuo Ihara4 1Department of Life and Medical Systems, Doshisha University, 2Bruker Daltonics K.K., 3The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4Graduate School of Brain Science, Doshisha University JoVE 57645 Neuroscienze
माइलॉइड β का विज़ुअलाइज़ेशन मानव मस्तिष्क में मैट्रिक्स-असिस्टेड लेजर डिसोर्टशन के साथ जमा/आयनीकरण इमेजिंग मास स्पेक्ट्रोमेट्री Masaya Ikegawa*1, Takashi Nirasawa*2, Nobuto Kakuda1, Tomohiro Miyasaka1, Yuki Kuzuhara1, Shigeo Murayama3, Yasuo Ihara4 1Department of Life and Medical Systems, Doshisha University, 2Bruker Daltonics K.K., 3The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4Graduate School of Brain Science, Doshisha University JoVE 57645 Neuroscienze