Yibin Wang Department of Anesthesiology University of California Biography Publications Institution JoVE Articles Yibin Wang has not added a biography. If you are Yibin Wang and would like to personalize this page please email our Author Liaison for assistance. Publications Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis Frontiers in Cardiovascular Medicine. 2019 | Pubmed ID: 31417910 Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure JACC. Basic to Translational Science. Jun, 2019 | Pubmed ID: 31312763 Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance Diabetes. Sep, 2019 | Pubmed ID: 31167878 Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure JACC. Basic to Translational Science. Apr, 2019 | Pubmed ID: 31061918 Effects of Branched-chain Amino Acids on Glucose Metabolism in Obese, Prediabetic Men and Women: a Randomized, Crossover Study The American Journal of Clinical Nutrition. Jun, 2019 | Pubmed ID: 31005973 Epigenetics in Dilated Cardiomyopathy Current Opinion in Cardiology. May, 2019 | Pubmed ID: 30973397 RBFox2-miR-34a-Jph2 Axis Contributes to Cardiac Decompensation During Heart Failure Proceedings of the National Academy of Sciences of the United States of America. 03, 2019 | Pubmed ID: 30867288 Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure Circulation Research. Jan, 2019 | Pubmed ID: 30605412 Epigenomic Regulation of Heart Failure: Integrating Histone Marks, Long Noncoding RNAs, and Chromatin Architecture F1000Research. 2018 | Pubmed ID: 30416708 EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs Current Gene Therapy. 2018 | Pubmed ID: 30295189 Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans G3 (Bethesda, Md.). 11, 2018 | Pubmed ID: 30201759 Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis Circulation. 09, 2018 | Pubmed ID: 29950403 Humanin Analog Enhances the Protective Effect of Dexrazoxane Against Doxorubicin-induced Cardiotoxicity American Journal of Physiology. Heart and Circulatory Physiology. 09, 2018 | Pubmed ID: 29775411 The Serine/threonine-protein Kinase/endoribonuclease IRE1α Protects the Heart Against Pressure Overload-induced Heart Failure The Journal of Biological Chemistry. 06, 2018 | Pubmed ID: 29769316 A Personalized, Multiomics Approach Identifies Genes Involved in Cardiac Hypertrophy and Heart Failure NPJ Systems Biology and Applications. 2018 | Pubmed ID: 29507758 A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart JACC. Basic to Translational Science. Mar, 2017 | Pubmed ID: 29057374 Wnt11 Regulates Cardiac Chamber Development and Disease During Perinatal Maturation JCI Insight. 09, 2017 | Pubmed ID: 28878122 Untangle a Broken Heart Via Janus Kinase 1 Circulation Research. 09, 2017 | Pubmed ID: 28860312 The Calcineurin-FoxO-MuRF1 Signaling Pathway Regulates Myofibril Integrity in Cardiomyocytes ELife. 08, 2017 | Pubmed ID: 28826496 High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure Circulation. Oct, 2017 | Pubmed ID: 28802249 Cardiac Myocyte P38α Kinase Regulates Angiogenesis Via Myocyte-endothelial Cell Cross-talk During Stress-induced Remodeling in the Heart The Journal of Biological Chemistry. 08, 2017 | Pubmed ID: 28637870 A Path to Implement Precision Child Health Cardiovascular Medicine Frontiers in Cardiovascular Medicine. 2017 | Pubmed ID: 28620608 Inflammatory and Apoptotic Remodeling in Autonomic Nervous System Following Myocardial Infarction PloS One. 2017 | Pubmed ID: 28542617 A Systems Genetics Approach Identifies As a Link Between Cardiomyocyte Glucose Utilization and Hypertrophic Response American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2017 | Pubmed ID: 28235788 Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification Cell Stem Cell. 02, 2017 | Pubmed ID: 27867037 Systems Genetics Approach Identifies Gene Pathways and Adamts2 As Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice Cell Systems. Jan, 2017 | Pubmed ID: 27866946 Operationalizing Precision Cardiovascular Medicine: Three Innovations Circulation Research. 10, 2016 | Pubmed ID: 27737942 Deconvolution of the Human Endothelial Transcriptome Cell Systems. Sep, 2016 | Pubmed ID: 27684186 The Chromatin-binding Protein Smyd1 Restricts Adult Mammalian Heart Growth American Journal of Physiology. Heart and Circulatory Physiology. 11, 2016 | Pubmed ID: 27663768 Branched Chain Amino Acid Metabolic Reprogramming in Heart Failure Biochimica Et Biophysica Acta. 12, 2016 | Pubmed ID: 27639835 The Long Noncoding RNA Chaer Defines an Epigenetic Checkpoint in Cardiac Hypertrophy Nature Medicine. 10, 2016 | Pubmed ID: 27618650 Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery Circulation. Cardiovascular Genetics. Oct, 2016 | Pubmed ID: 27591185 Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model PLoS Genetics. Jul, 2016 | Pubmed ID: 27385019 Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA Organic Letters. 06, 2016 | Pubmed ID: 27191599 The Hybrid Mouse Diversity Panel: a Resource for Systems Genetics Analyses of Metabolic and Cardiovascular Traits Journal of Lipid Research. Jun, 2016 | Pubmed ID: 27099397 Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure Circulation. May, 2016 | Pubmed ID: 27059949 Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy Hypertension (Dallas, Tex. : 1979). May, 2016 | Pubmed ID: 27021013 DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States Circulation Research. Mar, 2016 | Pubmed ID: 26838786 P38 MAP Kinases in the Heart Gene. Jan, 2016 | Pubmed ID: 26390817 M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production Scientific Reports. Nov, 2015 | Pubmed ID: 26615759 The Elusive Philosopher's Stone in Young Blood Circulation Research. Nov, 2015 | Pubmed ID: 26541677 Activation of Notch3 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation Via Hes1/p27Kip1 Signaling Pathway FEBS Open Bio. 2015 | Pubmed ID: 26380809 Deletion of MLIP (muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26359501 A H(a)rd Way to Adapt in Cardiac Hypertrophy Circulation Research. Aug, 2015 | Pubmed ID: 26316602 The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets Journal of Cardiothoracic and Vascular Anesthesia. Oct, 2015 | Pubmed ID: 25976605 Hypertrophic Preconditioning: Short-term Tricks for Long-term Gain Circulation. Apr, 2015 | Pubmed ID: 25820337 Genetics of Common Forms of Heart Failure: Challenges and Potential Solutions Current Opinion in Cardiology. May, 2015 | Pubmed ID: 25768955 Dawn of the Epi-LncRNAs: New Path from Myheart Circulation Research. Jan, 2015 | Pubmed ID: 25593274 Mapping Genetic Contributions to Cardiac Pathology Induced by Beta-adrenergic Stimulation in Mice Circulation. Cardiovascular Genetics. Feb, 2015 | Pubmed ID: 25480693 Repression of Sox9 by Jag1 is Continuously Required to Suppress the Default Chondrogenic Fate of Vascular Smooth Muscle Cells Developmental Cell. Dec, 2014 | Pubmed ID: 25535917 IRE1 Phosphatase PP2Ce Regulates Adaptive ER Stress Response in the Postpartum Mammary Gland PloS One. 2014 | Pubmed ID: 25369058 Blind Dates in Sciences: Dealing with Rejection in Peer Review Circulation Research. Mar, 2014 | Pubmed ID: 24625725 Decoding the Noncoding Transcripts in Human Heart Failure Circulation. Mar, 2014 | Pubmed ID: 24429689 Interferon Regulatory Factors in Heart: Stress Response Beyond Inflammation Hypertension (Dallas, Tex. : 1979). Apr, 2014 | Pubmed ID: 24396026 Systems Proteomics of Cardiac Chromatin Identifies Nucleolin As a Regulator of Growth and Cellular Plasticity in Cardiomyocytes American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2013 | Pubmed ID: 24077883 Mechanism-based Engineering Against Anthracycline Cardiotoxicity Circulation. Jul, 2013 | Pubmed ID: 23757311 Nuclear Phosphatase PPM1G in Cellular Survival and Neural Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2013 | Pubmed ID: 23723158 Endothelial Deletion of Murine Jag1 Leads to Valve Calcification and Congenital Heart Defects Associated with Alagille Syndrome Development (Cambridge, England). Dec, 2012 | Pubmed ID: 23095891 Hybrid Mouse Diversity Panel: a Panel of Inbred Mouse Strains Suitable for Analysis of Complex Genetic Traits Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012 | Pubmed ID: 22892838 Global Impact of RNA Splicing on Transcriptome Remodeling in the Heart Journal of Zhejiang University. Science. B. Aug, 2012 | Pubmed ID: 22843179 Prostaglandin E2 in Remote Control of Myocardial Remodeling Circulation. Jun, 2012 | Pubmed ID: 22589382 Quantitative Analysis of the Chromatin Proteome in Disease Reveals Remodeling Principles and Identifies High Mobility Group Protein B2 As a Regulator of Hypertrophic Growth Molecular & Cellular Proteomics : MCP. Jan, 2012 | Pubmed ID: 22270000 P38γ Activity is Required for Maintenance of Slow Skeletal Muscle Size Muscle & Nerve. Feb, 2012 | Pubmed ID: 22246884 Systems-based Approaches to Cardiovascular Disease Nature Reviews. Cardiology. Jan, 2012 | Pubmed ID: 22231714 Cdc37/Hsp90 Protein-mediated Regulation of IRE1α Protein Activity in Endoplasmic Reticulum Stress Response and Insulin Synthesis in INS-1 Cells The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22199355 Analysis of Transcriptome Complexity Through RNA Sequencing in Normal and Failing Murine Hearts Circulation Research. Dec, 2011 | Pubmed ID: 22034492 Restriction of Big Hearts by a Small RNA Circulation Research. Feb, 2011 | Pubmed ID: 21293005 Absence of Progeria-like Disease Phenotypes in Knock-in Mice Expressing a Non-farnesylated Version of Progerin Human Molecular Genetics. Feb, 2011 | Pubmed ID: 21088111 Mitogen-activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-breaking Tale Physiological Reviews. Oct, 2010 | Pubmed ID: 20959622 Electrochemical Properties and Myocyte Interaction of Carbon Nanotube Microelectrodes Nano Letters. Nov, 2010 | Pubmed ID: 20954739 Differential Regulation of Proteasome Function in Isoproterenol-induced Cardiac Hypertrophy Circulation Research. Oct, 2010 | Pubmed ID: 20814020 Targeted Disruption of Mapk14 (p38MAPKalpha) in Granulosa Cells and Cumulus Cells Causes Cell-specific Changes in Gene Expression Profiles That Rescue COC Expansion and Maintain Fertility Molecular Endocrinology (Baltimore, Md.). Sep, 2010 | Pubmed ID: 20610537 An Accumulation of Non-farnesylated Prelamin A Causes Cardiomyopathy but Not Progeria Human Molecular Genetics. Jul, 2010 | Pubmed ID: 20421363 MAPK-activated Protein Kinase-2 in Cardiac Hypertrophy and Cyclooxygenase-2 Regulation in Heart Circulation Research. Apr, 2010 | Pubmed ID: 20339119 Specific Regulation of Noncanonical P38alpha Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte Circulation Research. Apr, 2010 | Pubmed ID: 20299663 Compensatory Hypertrophy Induced by Ventricular Cardiomyocyte-specific COX-2 Expression in Mice Journal of Molecular and Cellular Cardiology. Jul, 2010 | Pubmed ID: 20170663 Post-translational Regulation of Calsarcin-1 During Pressure Overload-induced Cardiac Hypertrophy Journal of Molecular and Cellular Cardiology. Jun, 2010 | Pubmed ID: 20170660 Mice Carrying a Conditional Serca2(flox) Allele for the Generation of Ca(2+) Handling-deficient Mouse Models Cell Calcium. Sep, 2009 | Pubmed ID: 19692123 Inducible and Cardiac Specific PTEN Inactivation Protects Ischemia/reperfusion Injury Journal of Molecular and Cellular Cardiology. Feb, 2009 | Pubmed ID: 19038262 Zebrafish As a Model for Cardiovascular Development and Disease Drug Discovery Today. Disease Models. 2008 | Pubmed ID: 22275951 Proteomic Insights into Cardiac Cell Death and Survival Proteomics. Clinical Applications. Jun, 2008 | Pubmed ID: 21136883 Mitogen-activated Protein Kinases in Heart Development and Diseases Circulation. Sep, 2007 | Pubmed ID: 17875982 Gi Alpha 1-mediated Cardiac Electrophysiological Remodeling and Arrhythmia in Hypertrophic Cardiomyopathy Circulation. Aug, 2007 | Pubmed ID: 17646583 A Novel Mitochondrial Matrix Serine/threonine Protein Phosphatase Regulates the Mitochondria Permeability Transition Pore and is Essential for Cellular Survival and Development Genes & Development. Apr, 2007 | Pubmed ID: 17374715 Role of an Alternatively Spliced Form of AlphaII-spectrin in Localization of Connexin 43 in Cardiomyocytes and Regulation by Stress-activated Protein Kinase Journal of Molecular and Cellular Cardiology. Mar, 2007 | Pubmed ID: 17276456 Overexpression of Bone Morphogenetic Protein 10 in Myocardium Disrupts Cardiac Postnatal Hypertrophic Growth The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16798733 JNK Activation Decreases PP2A Regulatory Subunit B56alpha Expression and MRNA Stability and Increases AUF1 Expression in Cardiomyocytes American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2006 | Pubmed ID: 16603688 Cholesterol-induced Macrophage Apoptosis Requires ER Stress Pathways and Engagement of the Type A Scavenger Receptor The Journal of Cell Biology. Oct, 2005 | Pubmed ID: 16203857 Molecular and Functional Signature of Heart Hypertrophy During Pregnancy Circulation Research. Jun, 2005 | Pubmed ID: 15905459 P38 MAP Kinase Inhibition Enables Proliferation of Adult Mammalian Cardiomyocytes Genes & Development. May, 2005 | Pubmed ID: 15870258 Oxidant Stress from Nitric Oxide Synthase-3 Uncoupling Stimulates Cardiac Pathologic Remodeling from Chronic Pressure Load The Journal of Clinical Investigation. May, 2005 | Pubmed ID: 15841206 Nitric Oxide Donors Protect Murine Myocardium Against Infarction Via Modulation of Mitochondrial Permeability Transition American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2005 | Pubmed ID: 15528225 Return of Calcium: Manipulating Intracellular Calcium to Prevent Cardiac Pathologies Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15079064 Stress-activated MAP Kinases in Cardiac Remodeling and Heart Failure; New Insights from Transgenic Studies Trends in Cardiovascular Medicine. Feb, 2004 | Pubmed ID: 15030789 Chronic Suppression of Heart-failure Progression by a Pseudophosphorylated Mutant of Phospholamban Via in Vivo Cardiac RAAV Gene Delivery Nature Medicine. Aug, 2002 | Pubmed ID: 12134142 RelB Modulation of IkappaBalpha Stability As a Mechanism of Transcription Suppression of Interleukin-1alpha (IL-1alpha), IL-1beta, and Tumor Necrosis Factor Alpha in Fibroblasts Molecular and Cellular Biology. Nov, 1999 | Pubmed ID: 10523657 Enhanced Galphaq Signaling: a Common Pathway Mediates Cardiac Hypertrophy and Apoptotic Heart Failure Proceedings of the National Academy of Sciences of the United States of America. Aug, 1998 | Pubmed ID: 9707614 Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice Shuxun Ren1, Sunny Chang2, Alex Tran3, Arianna Mandelli4, Yibin Wang1, Jessica J. Wang2 1Department of Anesthesiology, University of California, 2Department of Medicine, University of California, 3Department of Microbiology, Immunology & Molecular Genetics, University of California, 4Department of Molecular, Cell, and Developmental Biology, University of California JoVE 59646 Medicina
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice Shuxun Ren1, Sunny Chang2, Alex Tran3, Arianna Mandelli4, Yibin Wang1, Jessica J. Wang2 1Department of Anesthesiology, University of California, 2Department of Medicine, University of California, 3Department of Microbiology, Immunology & Molecular Genetics, University of California, 4Department of Molecular, Cell, and Developmental Biology, University of California JoVE 59646 Medicina