When the glomerular filtrate passes through the renal tubule, sodium ions are reabsorbed into the blood through ion transporters that are expressed across …
Thiazide-type diuretics feature a benzothiadiazine ring, while thiazide-like diuretics lack the ring structure.
Thiazide-class of diuretics inhibit the …
Liddle syndrome involves hyperactive epithelial sodium channels, enhancing sodium reabsorption and potassium excretion in the nephron.
One of the ways …
Vascular smooth muscle cells feature L-type voltage-gated calcium channels in their plasma membrane.
Upon depolarization, these channels open, and Ca2+ …
Oral vasodilators primarily target arteries and arterioles.
Minoxidil, a prodrug, is converted into its sulfate metabolite by hepatic sulfotransferase.
…
Cardiovascular diseases affect the heart and blood vessels.
Heart disorders impair the organ's functionality, such as blood pumping ability, resulting …
Spontaneously contracting syncytia of cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CM) are a useful model of human cardiac …
Elevated intraocular pressure (IOP) is a well-documented risk factor for glaucoma. Here we describe a novel, effective method for consistently inducing …
The benefits of renal sympathetic denervation (RDN) on blood pressure have been proved in a large number of clinical trials in recent years. However, the …
