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Journal / Neuroscience / Focal Cerebral Ischemia Model by Endovascular…
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Neuroscience
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JoVE Journal Neuroscience
Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
 

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat

Article DOI: 10.3791/1978-v • 13:51 min • February 5th, 2011
February 5th, 2011 •
1, 1, 1, 1, 1
1Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin-Madison

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Surgical induction of ischemic brain damage in the rat is a widely used model for stroke research. Here we demonstrate the induction of focal cerebral ischemia by occlusion of the middle cerebral artery. Visualization of the resulting infarct by histological staining and magnetic resonance imaging is also shown.

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Focal Cerebral Ischemia Model Endovascular Suture Occlusion Middle Cerebral Artery Rat Stroke Reproducibility Experimentally Induced Infarct Volume Animal Model Animal Husbandry Costs Cranial Circulation Middle Cerebral Artery Occlusion Recanalization Reperfusion Endovascular Suture MCAO Model Spontaneously Hypertensive Rat (SHR) Filament With Silicon Tip Coating Optimal Occlusion Period Behavioral Indicators Of Stroke T2-weighted Magnetic Resonance Images Brain Sections Staining
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